Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0232 | 0.0232 |
Echinococcus granulosus | geminin | 0.019 | 0.6981 | 0.691 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.2084 | 0.1896 |
Schistosoma mansoni | lamin | 0.003 | 0.0564 | 0.0492 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0232 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.1522 | 0.1522 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2658 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0232 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0232 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0082 | 0.2658 | 0.2484 |
Echinococcus multilocularis | lamin | 0.003 | 0.0564 | 0.034 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0232 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0564 | 0.034 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0082 | 0.2658 | 0.2484 |
Onchocerca volvulus | 0.0054 | 0.1522 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0564 | 0.034 |
Echinococcus multilocularis | geminin | 0.019 | 0.6981 | 0.691 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.1522 | 0.1911 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0232 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0542 | 0.0542 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0265 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0082 | 0.2658 | 0.2658 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2658 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1522 | 0.1911 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0265 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0564 | 0.0564 |
Schistosoma mansoni | lamin | 0.003 | 0.0564 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.6981 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0232 | 0.0232 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0082 | 0.2658 | 0.3594 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0564 | 0.0492 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0232 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2658 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0232 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0564 | 0.0564 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0232 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0564 | 0.0564 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.2084 | 0.1896 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.2084 | 0.2745 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0564 | 0.0564 |
Echinococcus multilocularis | musashi | 0.003 | 0.0564 | 0.034 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.2084 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0232 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0232 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.2084 | 0.2745 |
Echinococcus granulosus | lamin | 0.003 | 0.0564 | 0.034 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.2658 | 0.3594 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.6981 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0564 | 0.034 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2658 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.