Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Phosphodiesterase 4A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to a group of Candida orfs that show weak similarity to Leucine-rich repeat viral proteins | Phosphodiesterase 4A | 118 aa | 97 aa | 26.8 % |
Onchocerca volvulus | SH3 domain-binding glutamic acid-rich protein homolog | Phosphodiesterase 4A | 118 aa | 112 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0196 | 0.1775 | 0.1775 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0109 | 0.0355 | 0.1299 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0196 | 0.1775 | 0.1775 |
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.0109 | 0.0355 | 0.2001 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0196 | 0.1775 | 0.1775 |
Trypanosoma brucei | thymidine kinase | 0.0255 | 0.2733 | 1 |
Onchocerca volvulus | 0.0109 | 0.0355 | 1 | |
Leishmania major | thymidine kinase, putative | 0.0255 | 0.2733 | 1 |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.0109 | 0.0355 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0255 | 0.2733 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0196 | 0.1775 | 1 |
Treponema pallidum | adenosine deaminase | 0.0087 | 0 | 0.5 |
Entamoeba histolytica | thymidine kinase, putative | 0.0255 | 0.2733 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0701 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0255 | 0.2733 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0255 | 0.2733 | 1 |
Giardia lamblia | Thymidine kinase | 0.0255 | 0.2733 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0087 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0255 | 0.2733 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0255 | 0.2733 | 1 |
Brugia malayi | cytidine deaminase, identical | 0.0109 | 0.0355 | 0.2001 |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.0109 | 0.0355 | 1 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0196 | 0.1775 | 0.5972 |
Mycobacterium ulcerans | cytidine deaminase | 0.0109 | 0.0355 | 1 |
Echinococcus granulosus | cytidine deaminase | 0.0109 | 0.0355 | 0.0355 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0196 | 0.1775 | 1 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0196 | 0.1775 | 0.1775 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0109 | 0.0355 | 0.1299 |
Leishmania major | cytidine deaminase-like protein | 0.0109 | 0.0355 | 0.1299 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1775 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0196 | 0.1775 | 0.1775 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0196 | 0.1775 | 1 |
Onchocerca volvulus | 0.0109 | 0.0355 | 1 | |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0196 | 0.1775 | 0.1775 |
Plasmodium falciparum | adenosine deaminase | 0.0087 | 0 | 0.5 |
Entamoeba histolytica | cytidine deaminase, putative | 0.0109 | 0.0355 | 0.1299 |
Echinococcus multilocularis | cytidine deaminase | 0.0109 | 0.0355 | 0.0355 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0196 | 0.1775 | 0.1775 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0701 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.2 uM | Inhibitory potency against pig aortic PDE IV | ChEMBL. | 8201604 |
IC50 (binding) | = 1.2 uM | Inhibitory potency against pig aortic PDE IV | ChEMBL. | 8201604 |
IC50 (binding) | > 200 uM | Inhibitory potency against pig aortic PDE I. | ChEMBL. | 8201604 |
IC50 (binding) | > 200 uM | Inhibitory potency against pig aortic PDE III. | ChEMBL. | 8201604 |
IC50 (binding) | > 200 uM | Inhibitory potency against pig aortic PDE V. | ChEMBL. | 8201604 |
IC50 (binding) | > 200 uM | Inhibitory potency against pig aortic PDE I. | ChEMBL. | 8201604 |
IC50 (binding) | > 200 uM | Inhibitory potency against pig aortic PDE V. | ChEMBL. | 8201604 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.