Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0064 | 0.0202 | 0.0592 |
Brugia malayi | thymidylate synthase | 0.0105 | 0.1103 | 0.115 |
Echinococcus granulosus | muscleblind protein | 0.0165 | 0.2405 | 0.2299 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2405 | 0.2818 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.3444 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1762 | 0.2065 |
Brugia malayi | Dihydrofolate reductase | 0.0211 | 0.3417 | 0.3905 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0064 | 0.0202 | 0.0592 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0211 | 0.3417 | 0.4003 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.0138 | 0.0403 |
Echinococcus multilocularis | muscleblind protein | 0.0165 | 0.2405 | 0.2299 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1762 | 0.2065 |
Echinococcus granulosus | dihydrofolate reductase | 0.0211 | 0.3417 | 0.3325 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0064 | 0.0202 | 0.0592 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0138 | 0.0161 |
Schistosoma mansoni | dihydrofolate reductase | 0.0211 | 0.3417 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0211 | 0.3417 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0064 | 0.0202 | 0.0066 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0211 | 0.3417 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.3444 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.3444 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0513 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0105 | 0.1103 | 0.0979 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0064 | 0.0202 | 0.0066 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0211 | 0.3417 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0061 | 0.0138 | 0.0403 |
Onchocerca volvulus | 0.0105 | 0.1103 | 0.1117 | |
Brugia malayi | dihydrofolate reductase family protein | 0.0211 | 0.3417 | 0.3905 |
Onchocerca volvulus | Huntingtin homolog | 0.0135 | 0.1762 | 0.1784 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0213 | 0.3444 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0165 | 0.2405 | 0.27 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.3444 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.3444 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0211 | 0.3417 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0258 | 0.4443 | 0.5205 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0165 | 0.2405 | 0.2299 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0513 | 1 | 1 |
Onchocerca volvulus | 0.0064 | 0.0202 | 0.0205 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0105 | 0.1103 | 0.1293 |
Brugia malayi | follicle stimulating hormone receptor | 0.0258 | 0.4443 | 0.5127 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0105 | 0.1103 | 0.3229 |
Brugia malayi | Pre-SET motif family protein | 0.0064 | 0.0202 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2405 | 0.2818 |
Trichomonas vaginalis | set domain proteins, putative | 0.0508 | 0.988 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0211 | 0.3417 | 0.3325 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0064 | 0.0202 | 0.0066 |
Brugia malayi | hypothetical protein | 0.0135 | 0.1762 | 0.1935 |
Echinococcus multilocularis | thymidylate synthase | 0.0105 | 0.1103 | 0.0979 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0446 | 0.8536 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0446 | 0.8536 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0374 | 0.6958 | 0.6915 |
Onchocerca volvulus | Huntingtin homolog | 0.0135 | 0.1762 | 0.1784 |
Onchocerca volvulus | 0.0508 | 0.988 | 1 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0062 | 0.0151 | 0.0014 |
Echinococcus multilocularis | tumor protein p63 | 0.0374 | 0.6958 | 0.6915 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0513 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0064 | 0.0202 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0202 | 0.0237 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.0138 | 0.0403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.