Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acyl coenzyme A:cholesterol acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma mansoni | sterol O-acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma japonicum | ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus granulosus | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Neospora caninum | sterol O-acyltransferase, putative | Acyl coenzyme A:cholesterol acyltransferase 1 | 545 aa | 510 aa | 21.2 % |
Dictyostelium discoideum | diacylglycerol O-acyltransferase 1 | Acyl coenzyme A:cholesterol acyltransferase 1 | 545 aa | 547 aa | 22.3 % |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | Acyl coenzyme A:cholesterol acyltransferase 1 | 545 aa | 510 aa | 24.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0264 | 0.3221 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.029 | 0.5602 | 1 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0264 | 0.3221 | 1 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0264 | 0.3221 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.3221 | 0.4932 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.5075 | 0.8878 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 63 % | Percent control of serum cholesterol in cholesterol | ChEMBL. | 2033594 |
Control (functional) | = 75 % | Percent control of serum cholesterol in cholesterol | ChEMBL. | 2033594 |
Control (functional) | = 90 % | Percent control of serum cholesterol in cholesterol | ChEMBL. | 2033594 |
IC50 (binding) | = 2.1 ug ml-1 | In vitro inhibition of Fu5AH acyl coenzyme A:cholesterol acyltransferase. | ChEMBL. | 2033594 |
IC50 (binding) | = 2.1 ug ml-1 | In vitro inhibition of Fu5AH acyl coenzyme A:cholesterol acyltransferase. | ChEMBL. | 2033594 |
Inhibition (binding) | = 83 % | Inhibition of Fu5AH Acyl coenzyme A:cholesterol acyltransferase at the concentration of 10 ug/mL | ChEMBL. | 2033594 |
Inhibition (binding) | = 83 % | Inhibition of Fu5AH Acyl coenzyme A:cholesterol acyltransferase at the concentration of 10 ug/mL | ChEMBL. | 2033594 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.