Detailed information for compound 675976

Basic information

Technical information
  • TDR Targets ID: 675976
  • Name: N-[2-(4-methoxyphenyl)-1,3-benzoxazol-5-yl]-2 -phenylacetamide
  • MW: 358.39 | Formula: C22H18N2O3
  • H donors: 1 H acceptors: 2 LogP: 4.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1oc2c(n1)cc(cc2)NC(=O)Cc1ccccc1
  • InChi: 1S/C22H18N2O3/c1-26-18-10-7-16(8-11-18)22-24-19-14-17(9-12-20(19)27-22)23-21(25)13-15-5-3-2-4-6-15/h2-12,14H,13H2,1H3,(H,23,25)
  • InChiKey: HUTITASUSVCAME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-methoxyphenyl)-1,3-benzoxazol-5-yl]-2-phenyl-acetamide
  • N-[2-(4-methoxyphenyl)-1,3-benzoxazol-5-yl]-2-phenyl-ethanamide
  • Oprea1_560866
  • STK184410
  • ZINC01158171

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.004 0.0228 0.0215
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0228 0.0228
Mycobacterium ulcerans lipase LipD 0.004 0.0228 0.2295
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0228 0.1247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0314 0.0314
Echinococcus multilocularis Excitatory amino acid transporter 0.1272 1 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.023 0.023
Brugia malayi Importin beta-1 subunit 0.0029 0.0144 0.013
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0107 0.4894
Plasmodium vivax glutathione reductase, putative 0.0037 0.0204 0.8862
Loa Loa (eye worm) hypothetical protein 0.0029 0.0144 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0314 0.0314
Onchocerca volvulus 0.0029 0.0143 0.0112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0076
Mycobacterium ulcerans beta-lactamase 0.004 0.0228 0.2295
Trichomonas vaginalis importin beta-1, putative 0.0024 0.01 0.05
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.01 0.3988
Brugia malayi MH2 domain containing protein 0.0132 0.0959 0.0946
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0107 0.4894
Schistosoma mansoni ap endonuclease 0.0018 0.0058 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.023 0.1254
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.023 0.1254
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0058 0.2043
Echinococcus granulosus sodium:dicarboxylate symporter 0.1272 1 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0031 0.0099
Treponema pallidum glutamate/aspartate transporter 0.0564 0.4384 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.0948 0.0948
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0314 0.0284
Echinococcus granulosus Excitatory amino acid transporter 0.1272 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0228 0.0198
Chlamydia trachomatis glutamate symporter 0.1272 1 1
Brugia malayi hypothetical protein 0.0024 0.0107 0.0093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0134 0.0134
Echinococcus granulosus geminin 0.0164 0.1216 0.1216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0143 0.0143
Loa Loa (eye worm) glutathione reductase 0.0037 0.0204 0.0173
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0228 0.0215
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0083 0.0052
Loa Loa (eye worm) hypothetical protein 0.0315 0.2415 0.2391
Toxoplasma gondii thioredoxin reductase 0.0037 0.0204 0.2034
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0083 0.3188
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.0948 0.0948
Leishmania major GTP-binding protein, putative 0.0021 0.0083 0.0736
Leishmania major alpha glucosidase II subunit, putative 0.004 0.023 0.2309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0143 0.0143
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0577 0.0564
Echinococcus multilocularis neutral amino acid transporter A 0.1272 1 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0083 0.3208
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0083 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0083 0.0069
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.023 0.1254
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0228 0.2295
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0014 0.0014
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1272 1 1
Brugia malayi glutathione reductase 0.0037 0.0204 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0228 0.1247
Echinococcus granulosus muscleblind protein 0.0315 0.2415 0.2415
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.0948 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0228 0.1247
Brugia malayi RNA, U transporter 1 0.0083 0.0568 0.0555
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0948 1
Echinococcus multilocularis Excitatory amino acid transporter 0.1272 1 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0083 0.2601
Loa Loa (eye worm) excitatory amino acid transporter 0.1272 1 1
Leishmania major importin beta-1 subunit, putative 0.0024 0.01 0.0921
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.134 0.1328
Echinococcus granulosus neutral amino acid transporter A 0.1272 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0651 0.0638
Trypanosoma brucei trypanothione reductase 0.0037 0.0204 0.8808
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0083 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0228 0.994
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0031 0.0099
Echinococcus multilocularis excitatory amino acid transporter 2 0.1272 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0314 0.0314
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.134 0.134
Schistosoma mansoni hypothetical protein 0.0164 0.1216 0.1216
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1272 1 1
Leishmania major trypanothione reductase 0.0037 0.0204 0.2034
Onchocerca volvulus 0.004 0.0228 0.0198
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0144 0.6008
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0564 0.4384 0.4384
Echinococcus granulosus excitatory amino acid transporter 2 0.1272 1 1
Schistosoma mansoni ran 0.0021 0.0083 0.0083
Echinococcus granulosus neutral amino acid transporter 0.1272 1 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0143 0.0129
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0228 0.1247
Plasmodium vivax importin-beta 2, putative 0.0029 0.0144 0.6044
Trichomonas vaginalis ran, putative 0.0021 0.0083 0.04
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0031 0.0793
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0948 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0143 0.0143
Brugia malayi Pre-SET motif family protein 0.0202 0.1513 0.1502
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.023 1
Brugia malayi beta-lactamase family protein 0.004 0.0228 0.0215
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0143 0.1378
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.1927 0.1916
Schistosoma mansoni alpha-glucosidase 0.0155 0.1141 0.1141
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0564 0.4384 0.4384
Toxoplasma gondii exonuclease III APE 0.0018 0.0058 0.0469
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0099
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0228 0.0228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0143 0.0143
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0564 0.4384 0.4384
Echinococcus multilocularis snurportin 1 0.031 0.2373 0.2373
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0058 0.0058
Mycobacterium tuberculosis Probable reductase 0.0084 0.0577 0.0564
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0099
Trypanosoma brucei glucosidase, putative 0.004 0.023 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0208 0.0208
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0228 0.2295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0314 0.0314
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0577 0.8247
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1272 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.0948 0.0936
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0948 0.0948
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0959 0.093
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0058 0.0469
Echinococcus granulosus excitatory amino acid transporter 2 0.1272 1 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0228 0.0215
Plasmodium falciparum importin beta, putative 0.0029 0.0144 0.6821
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1272 1 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.023 0.1254
Mycobacterium ulcerans hypothetical protein 0.004 0.0228 0.2295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0314 0.0314
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0058 0.0469
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.023 0.023
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0228 0.0215
Echinococcus multilocularis muscleblind protein 1 0.0315 0.2415 0.2415
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0058 0.01
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0577 0.0564
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0228 0.994
Schistosoma mansoni ran 0.0021 0.0083 0.0083
Echinococcus granulosus Excitatory amino acid transporter 0.1272 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.134 0.134
Echinococcus multilocularis excitatory amino acid transporter 3 0.1272 1 1
Chlamydia trachomatis neutral amino acid transporter 0.0564 0.4384 0.4376
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0651 0.0638
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0058 0.0044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.01 0.05
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0107 0.4311
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.023 0.0216
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0564 0.4384 0.4384
Echinococcus granulosus excitatory amino acid transporter 3 0.1272 1 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0031 0.0793
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0058 0.0255
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0314 0.03
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0058 0.203
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0058 0.1344
Mycobacterium tuberculosis Conserved protein 0.004 0.0228 0.0215
Loa Loa (eye worm) hypothetical protein 0.004 0.0228 0.0198
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0577 0.0564
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.023 0.2309
Loa Loa (eye worm) follicle stimulating hormone receptor 0.048 0.3722 0.3703
Echinococcus multilocularis geminin 0.0164 0.1216 0.1216
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0083 0.0736
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1513 0.1487
Onchocerca volvulus 0.0048 0.0293 0.0263
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.023 0.0199
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0143 0.0143
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0143 0.0143
Loa Loa (eye worm) beta-lactamase 0.004 0.0228 0.0198
Loa Loa (eye worm) hypothetical protein 0.0315 0.2415 0.2391
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0651 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.0024 0.0107 0.0996
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0058 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0031 0.0099
Brugia malayi follicle stimulating hormone receptor 0.048 0.3722 0.3714
Echinococcus multilocularis neutral amino acid transporter A 0.1272 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0228 0.1247
Onchocerca volvulus 0.023 0.1735 0.1709
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.134 0.1313
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.023 0.1254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0314 0.0314
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0293 0.0293
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0228 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0314 0.0314
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0577 0.0564
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0144 0.6008
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0204 0.8862
Treponema pallidum glutamate transporter 0.0564 0.4384 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0959 0.093
Loa Loa (eye worm) hypothetical protein 0.004 0.0228 0.0198
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1272 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0228 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0164 0.1216 0.1216
Onchocerca volvulus 0.004 0.0228 0.0198
Entamoeba histolytica hypothetical protein 0.0024 0.01 0.347
Schistosoma mansoni alpha-glucosidase 0.0155 0.1141 0.1141
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0058 0.6368
Leishmania major hypothetical protein, conserved 0.004 0.0228 0.2295
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0107 0.4311
Brugia malayi Thioredoxin reductase 0.0037 0.0204 0.019
Schistosoma mansoni hypothetical protein 0.031 0.2373 0.2373
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0228 0.0215
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.023 0.1254
Loa Loa (eye worm) hypothetical protein 0.004 0.0228 0.0198
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0208 0.0208
Brugia malayi beta-lactamase 0.004 0.0228 0.0215
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0014 0.0014
Echinococcus granulosus importin subunit beta 1 0.0029 0.0144 0.0144
Schistosoma mansoni ap endonuclease 0.0018 0.0058 0.0058
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0031 0.0793
Brugia malayi Muscleblind-like protein 0.0315 0.2415 0.2405
Onchocerca volvulus 0.0104 0.0738 0.0709
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0107 0.4311
Schistosoma mansoni importin beta-1 0.0029 0.0144 0.0144
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0144 0.1387
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.023 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.023 0.1254
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0058 0.203
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0031 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0228 0.994
Loa Loa (eye worm) hypothetical protein 0.004 0.0228 0.0198
Brugia malayi beta-lactamase family protein 0.004 0.0228 0.0215
Trichomonas vaginalis esterase, putative 0.004 0.0228 0.1247
Plasmodium vivax hypothetical protein, conserved 0.004 0.0228 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.023 0.1254
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0144 0.0144
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0228 0.0215
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0014 0.0014
Echinococcus multilocularis neutral amino acid transporter A 0.1272 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0058 0.2305
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0107 0.0996
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0228 0.0228
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0058 0.0255
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0107 0.4337
Trichomonas vaginalis set domain proteins, putative 0.023 0.1735 1
Toxoplasma gondii ABC1 family protein 0.004 0.0228 0.2295
Loa Loa (eye worm) hypothetical protein 0.0048 0.0293 0.0263
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0058 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0948 0.0948
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1272 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0577 0.0564
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0099
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0204 0.019
Echinococcus granulosus tumor protein p63 0.0328 0.2511 0.2511
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0058 0.0027
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0031 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0651 0.0638
Loa Loa (eye worm) hypothetical protein 0.0029 0.0143 0.0112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0228 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.023 1
Onchocerca volvulus 0.004 0.0228 0.0198
Plasmodium falciparum thioredoxin reductase 0.0037 0.0204 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0948 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0083 0.362
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.2373 0.2349
Echinococcus multilocularis muscleblind protein 0.0315 0.2415 0.2415
Plasmodium falciparum glutathione reductase 0.0037 0.0204 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.023 0.1254
Echinococcus multilocularis excitatory amino acid transporter 2 0.1272 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0058 0.203
Loa Loa (eye worm) hypothetical protein 0.004 0.0228 0.0198
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.134 0.134
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0083 0.3188
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.023 1
Echinococcus granulosus neutral amino acid transporter A 0.1272 1 1
Schistosoma mansoni alpha glucosidase 0.004 0.023 0.023
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.0948 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0083 0.3188
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0228 0.0215
Echinococcus granulosus snurportin 1 0.031 0.2373 0.2373
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0058 0.0044
Brugia malayi hypothetical protein 0.0016 0.0038 0.0024
Echinococcus multilocularis tumor protein p63 0.0328 0.2511 0.2511
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0099
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0228 0.0215
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.01 0.05
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0204 0.8808
Plasmodium vivax SET domain protein, putative 0.0029 0.0143 0.6002
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0204 0.0173
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0228 0.0215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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