Detailed information for compound 676152

Basic information

Technical information
  • TDR Targets ID: 676152
  • Name: N-(2-hydroxyethyl)-3-phenyl-2-(3-phenylprop-2 -enoylamino)prop-2-enamide
  • MW: 336.384 | Formula: C20H20N2O3
  • H donors: 3 H acceptors: 3 LogP: 2.41 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNC(=O)/C(=C\c1ccccc1)/NC(=O)/C=C/c1ccccc1
  • InChi: 1S/C20H20N2O3/c23-14-13-21-20(25)18(15-17-9-5-2-6-10-17)22-19(24)12-11-16-7-3-1-4-8-16/h1-12,15,23H,13-14H2,(H,21,25)(H,22,24)/b12-11+,18-15+
  • InChiKey: ZCIUVZJNNASTOB-OBMWWMMPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-(2-hydroxyethyl)-3-phenyl-2-[[(E)-3-phenylprop-2-enoyl]amino]prop-2-enamide
  • N-(2-hydroxyethyl)-2-[(1-oxo-3-phenylprop-2-enyl)amino]-3-phenylprop-2-enamide
  • (E)-N-(2-hydroxyethyl)-2-[[(E)-1-oxo-3-phenylprop-2-enyl]amino]-3-phenylprop-2-enamide
  • N-(2-hydroxyethyl)-3-phenyl-2-[(3-phenylacryloyl)amino]acrylamide
  • (E)-N-(2-hydroxyethyl)-3-phenyl-2-[[(E)-3-phenylacryloyl]amino]acrylamide
  • 2-(cinnamoylamino)-N-(2-hydroxyethyl)-3-phenylacrylamide
  • MLS000575774
  • SMR000208966
  • ZINC02997601

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0022 0.0081 0.0081
Echinococcus multilocularis neuroligin 0.0106 0.0677 0.0677
Mycobacterium tuberculosis Putative ferredoxin reductase 0.054 0.3738 0.8963
Onchocerca volvulus 0.015 0.0984 0.1412
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0082 0.0507 0.3083
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0013
Brugia malayi Carboxylesterase family protein 0.0106 0.0677 0.1108
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0037 0.0109
Onchocerca volvulus Sepiapterin reductase homolog 0.0013 0.002 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0027 0.0016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.001 0.001
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Echinococcus multilocularis acetylcholinesterase 0.0629 0.4364 0.4364
Brugia malayi Retinol dehydrogenase 12 0.0013 0.002 0.0033
Leishmania major cytochrome p450-like protein 0.0023 0.0088 0.0428
Leishmania major trypanothione reductase 0.0237 0.1598 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0048 0.0179
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0048 0.0079
Echinococcus granulosus neuroligin 0.0106 0.0677 0.0677
Brugia malayi Carboxylesterase family protein 0.0106 0.0677 0.1108
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0022 0.0081 0.0148
Schistosoma mansoni myo inositol monophosphatase 0.0016 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Onchocerca volvulus 0.0126 0.0819 0.1176
Schistosoma mansoni thyroid hormone receptor 0.0012 0.001 0.001
Mycobacterium tuberculosis Probable monophosphatase 0.0016 0.0043 0.0055
Echinococcus multilocularis cpg binding protein 0.0035 0.0174 0.0174
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0162 0.1066 0.1744
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.001 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0351 0.0351
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0695 0.0695
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0819 0.0819
Mycobacterium tuberculosis Probable reductase 0.054 0.3738 0.8963
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0106 0.0677 0.1108
Schistosoma mansoni glutamate synthase 0.0022 0.0081 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1231 0.8607 1
Mycobacterium leprae putative cytochrome p450 0.0014 0.0027 0.0016
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0027 0.0016
Schistosoma mansoni carbonyl reductase 0.0013 0.002 0.002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0082 0.0507 0.0507
Plasmodium falciparum thioredoxin reductase 0.0082 0.0507 0.3083
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0022 0.0081 0.0148
Echinococcus granulosus protein C ets 2 0.0012 0.0013 0.0013
Entamoeba histolytica disulphide oxidoreductase, putative 0.0022 0.0081 0.0072
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0156 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0677 0.1108
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.0884 0.5476
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0027 0.0016
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0027 0.0016
Schistosoma mansoni hypothetical protein 0.0022 0.0081 0.0081
Trichomonas vaginalis set domain proteins, putative 0.0999 0.6967 0.809
Brugia malayi Inositol-1 0.0156 0.1025 0.1676
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0022 0.0081 0.0611
Brugia malayi transcription factor E74 isoform 0.0012 0.0013 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Plasmodium vivax thioredoxin reductase, putative 0.0237 0.1598 1
Entamoeba histolytica hypothetical protein 0.0039 0.0202 0.0212
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.006 0.0353 0.0577
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0013 0.0013
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0208 0.1395 0.2002
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0027 0.0041
Echinococcus granulosus GPCR family 2 0.0017 0.0048 0.0048
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0022 0.0081 0.0389
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0106 0.0677 0.1585
Trichomonas vaginalis inositol monophosphatase, putative 0.0156 0.1025 0.117
Plasmodium vivax SET domain protein, putative 0.0126 0.0819 0.5066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0648 0.0648
Echinococcus granulosus glutamate synthase 0.0022 0.0081 0.0081
Onchocerca volvulus 0.0013 0.002 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0062 0.0062
Schistosoma mansoni inositol monophosphatase 0.0156 0.1025 0.1025
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0308 0.0335
Loa Loa (eye worm) histone methyltransferase 0.0015 0.0033 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.001 0.0016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0232 0.0232
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0156 0.1025 0.6412
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0083 0.0516 0.0845
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0033 0.0033
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0106 0.0677 0.0766
Trypanosoma brucei unspecified product 0.0013 0.0021 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0022 0.0081 0.0072
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0022 0.0081 0.0389
Loa Loa (eye worm) thioredoxin reductase 0.0237 0.1598 0.2614
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0022 0.0081 0.0081
Mycobacterium tuberculosis Probable dehydrogenase 0.054 0.3738 0.8963
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0082 0.0507 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.001 0.0014
Loa Loa (eye worm) inositol-1 0.0156 0.1025 0.1676
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.001 0.0016
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.002 0.002
Onchocerca volvulus 0.0013 0.002 0.0029
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0156 0.1025 0.117
Schistosoma mansoni ets 0.0012 0.0013 0.0013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0082 0.0507 0.3083
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0507 0.3083
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0016 0.0043 0.0144
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0022 0.0081 0.0148
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0048 0.0179
Entamoeba histolytica hypothetical protein 0.0039 0.0202 0.0212
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0022 0.0081 0.0148
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0032 0.0052
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0139 0.091 0.2145
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0016 0.0043 0.0026
Entamoeba histolytica hypothetical protein 0.0039 0.0202 0.0212
Leishmania major hypothetical protein, conserved 0.0022 0.0081 0.0389
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0013 0.0013
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0125
Echinococcus multilocularis muscleblind protein 0.0162 0.1066 0.1066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.001 0.0016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0237 0.1598 0.3804
Trichomonas vaginalis mercuric reductase, putative 0.0082 0.0507 0.0567
Echinococcus multilocularis muscleblind protein 1 0.0162 0.1066 0.1066
Brugia malayi MH2 domain containing protein 0.0138 0.0898 0.1469
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0013 0.0013
Brugia malayi nuclear hormone receptor 0.0012 0.001 0.0016
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0037 0.0233
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0013 0.0022
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0022 0.0081 0.0072
Onchocerca volvulus 0.0106 0.0677 0.0972
Mycobacterium tuberculosis Monophosphatase CysQ 0.0016 0.0043 0.0055
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0695 0.428
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1231 0.8607 1
Entamoeba histolytica hypothetical protein 0.0039 0.0202 0.0212
Leishmania major DNA polymerase eta, putative 0.0019 0.0062 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0695 0.0787
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1025 0.6367
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0081 0.0072
Giardia lamblia Hypothetical protein 0.0016 0.0043 0.0026
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0022 0.0081 0.0389
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0048 0.0048
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0695 0.428
Brugia malayi jmjC domain containing protein 0.0058 0.0338 0.0553
Schistosoma mansoni hypothetical protein 0.0471 0.3252 0.3252
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0013 0.0018 0.0018
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.0677 0.0677
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1231 0.8607 1
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Trypanosoma cruzi trypanothione reductase, putative 0.0237 0.1598 1
Onchocerca volvulus 0.0106 0.0677 0.0972
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1231 0.8607 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.002 0.002
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1231 0.8607 1
Schistosoma mansoni retinal dehydrogenase 0.0013 0.002 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.001 0.0016
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0022 0.0081 0.0148
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0013 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0208 0.1395 0.2282
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0013 0.002 0.002
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.012 0.077 0.126
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0062 0.0049
Echinococcus multilocularis dna polymerase eta 0.0019 0.0062 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0819 0.0819
Brugia malayi Carboxylesterase family protein 0.0629 0.4364 0.7139
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0013 0.002 0.0029
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0027 0.0016
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0695 0.0787
Schistosoma mansoni sulfide quinone reductase 0.0022 0.0081 0.0081
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Mycobacterium ulcerans hypothetical protein 0.0022 0.0081 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.001 0.0016
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.002 0.002
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0027 0.0016
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0156 0.1025 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0004
Onchocerca volvulus 0.0033 0.0161 0.0231
Schistosoma mansoni thyroid hormone receptor 0.0012 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.001 0.0016
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0082 0.0507 0.3083
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0027 0.0016
Schistosoma mansoni carbonyl reductase 0.0013 0.002 0.002
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0054 0.0308 0.0503
Loa Loa (eye worm) dehydrogenase 0.0013 0.002 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0062 0.0102
Loa Loa (eye worm) programmed cell death 8 0.0022 0.0081 0.0133
Brugia malayi Carboxylesterase family protein 0.0629 0.4364 0.7139
Brugia malayi Doublecortin family protein 0.015 0.0984 0.161
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0027 0.0016
Echinococcus granulosus WW domain containing oxidoreductase 0.0013 0.002 0.002
Onchocerca volvulus 0.015 0.0984 0.1412
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.002 0.002
Plasmodium falciparum glutathione reductase 0.0082 0.0507 0.3083
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0232 0.1346
Leishmania major hypothetical protein, conserved 0.0016 0.0037 0.0109
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0022 0.0081 0.0148
Loa Loa (eye worm) hypothetical protein 0.0106 0.0677 0.1108
Schistosoma mansoni microtubule-associated protein tau 0.1429 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.015 0.0984 0.0984
Schistosoma mansoni hypothetical protein 0.0039 0.0202 0.0202
Mycobacterium ulcerans monophosphatase 0.0016 0.0043 0.0055
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0082 0.0507 0.1173
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0082 0.0507 0.3083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0308 0.0503
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0133 0.0863 0.0863
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0013 0.002 0.0033
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0338 0.0338
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.002 0.002
Schistosoma mansoni acetylcholinesterase 0.0106 0.0677 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0232 0.0247
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0695 0.0787
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0622 0.4311 0.4311
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Onchocerca volvulus 0.0013 0.002 0.0029
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0027 0.0041
Schistosoma mansoni rab6-interacting 0.015 0.0984 0.0984
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0048 0.0048
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0022 0.0081 0.0148
Loa Loa (eye worm) hypothetical protein 0.0629 0.4364 0.7139
Trichomonas vaginalis glutathione reductase, putative 0.0082 0.0507 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0062 0.0102
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0695 0.1138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0507 0.3083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.001 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0648 0.0648
Plasmodium vivax glutathione reductase, putative 0.0237 0.1598 1
Entamoeba histolytica thioredoxin reductase, putative 0.0022 0.0081 0.0072
Brugia malayi glutamate synthase 0.0022 0.0081 0.0133
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0027 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.0884 0.5532
Toxoplasma gondii selenide, water dikinase 0.0022 0.0081 0.051
Brugia malayi Inositol monophosphatase family protein 0.0016 0.0043 0.007
Loa Loa (eye worm) doublecortin family protein 0.015 0.0984 0.161
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0232 0.1346
Brugia malayi jmjC domain containing protein 0.0016 0.0037 0.0061
Leishmania major cytochrome p450-like protein 0.0014 0.0027 0.0041
Giardia lamblia Glutamate synthase 0.0022 0.0081 0.0072
Brugia malayi hypothetical protein 0.0013 0.002 0.0033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0048 0.0079
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0648 0.0648
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0081 0.0389
Brugia malayi isocitrate dehydrogenase 0.0017 0.0048 0.0079
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0037 0.0037
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0013 0.002 0.0029
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0022 0.0081 0.0072
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.001 0.001
Echinococcus granulosus FTZ F1 alpha 0.0012 0.001 0.001
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0081 0.0389
Brugia malayi Dehydrogenases, short chain protein 2 0.0013 0.002 0.0033
Trichomonas vaginalis inositol monophosphatase, putative 0.0016 0.0043 0.0026
Echinococcus granulosus mixed lineage leukemia protein mll 0.0013 0.0018 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0308 0.0503
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0022 0.0081 0.0072
Toxoplasma gondii thioredoxin reductase 0.0237 0.1598 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0018 0.0018
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0106 0.0677 0.0677
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Echinococcus multilocularis GPCR, family 2 0.0017 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.015 0.0984 0.161
Echinococcus multilocularis conserved hypothetical protein 0.0013 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0014 0.0027 0.0027
Loa Loa (eye worm) acetylcholinesterase 1 0.0629 0.4364 0.7139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0269
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1025 0.6367
Brugia malayi hypothetical protein 0.0106 0.0677 0.1108
Echinococcus multilocularis microtubule associated protein 2 0.1429 1 1
Brugia malayi hypothetical protein 0.0013 0.002 0.0033
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0022 0.0081 0.0148
Plasmodium falciparum ferrodoxin reductase-like protein 0.0022 0.0081 0.0389
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0016 0.0043 0.0144
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.005 0.005
Trichomonas vaginalis glutamate synthase, putative 0.0022 0.0081 0.0072
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0048 0.0068
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0081 0.051
Trypanosoma cruzi NADH dehydrogenase, putative 0.0022 0.0081 0.0389
Loa Loa (eye worm) hypothetical protein 0.0162 0.1066 0.1744
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0088 0.0163
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0027 0.0016
Echinococcus multilocularis glutamate synthase 0.0022 0.0081 0.0081
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0935 0.6517 0.6517
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0125
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0027 0.0016
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0016 0.0043 0.0055
Toxoplasma gondii carbonyl reductase 1, putative 0.0013 0.002 0.0125
Toxoplasma gondii oxidoreductase, putative 0.0013 0.002 0.0125
Plasmodium falciparum glutathione reductase 0.0237 0.1598 1
Chlamydia trachomatis thioredoxin reductase 0.0022 0.0081 0.0834
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.054 0.3738 0.8963
Onchocerca volvulus 0.0013 0.002 0.0029
Echinococcus multilocularis inositol monophosphatase 1 0.0156 0.1025 0.1025
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0081 0.051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0403 0.2519
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Brugia malayi oxidoreductase 0.0013 0.002 0.0033
Schistosoma mansoni loxhd1 0.015 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Schistosoma mansoni gliotactin 0.0106 0.0677 0.0677
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.001 0.001
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0037 0.0233
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0061
Echinococcus granulosus RUN 0.015 0.0984 0.0984
Echinococcus multilocularis BC026374 protein (S09 family) 0.0106 0.0677 0.0677
Schistosoma mansoni pap-inositol-14-phosphatase 0.0016 0.0043 0.0043
Schistosoma mansoni polycystin 1-related 0.015 0.0984 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0695 0.0787
Schistosoma mansoni lipoxygenase 0.0352 0.2409 0.2409
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0027 0.0016
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0022 0.0081 0.0148
Echinococcus granulosus muscleblind protein 0.0162 0.1066 0.1066
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0338 0.0338
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0048 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0048 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0898 0.1469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1231 0.8607 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0048 0.0048
Echinococcus granulosus carbonyl reductase 1 0.0013 0.002 0.002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0081 0.0072
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.002 0.002
Leishmania major NADH dehydrogenase, putative 0.0022 0.0081 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.001 0.0016
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0022 0.0081 0.0072
Brugia malayi Thioredoxin reductase 0.0237 0.1598 0.2614
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0061
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0013 0.002 0.0125
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0351 0.0351
Mycobacterium tuberculosis Carboxylesterase LipT 0.0106 0.0677 0.1585
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.001 0.0016
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0338 0.0338
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0022 0.0081 0.0148
Brugia malayi cytochrome P450 0.0014 0.0027 0.0043
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0013 0.002 0.0033
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0022 0.0081 0.0133
Loa Loa (eye worm) hypothetical protein 0.0106 0.0677 0.1108
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0027 0.0016
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0133 0.0863 0.1411
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0027 0.0016
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0022 0.0081 0.051
Brugia malayi dehydrogenases, short chain protein 9 0.0013 0.002 0.0033
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.001 0.001
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0081 0.051
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.001 0.001
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0088 0.0428
Echinococcus granulosus BC026374 protein S09 family 0.0106 0.0677 0.0677
Giardia lamblia Fructose-bisphosphate aldolase 0.1231 0.8607 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0048 0.0079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0877 0.6113 1
Trypanosoma brucei trypanothione reductase 0.0237 0.1598 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.001 0.001
Echinococcus granulosus phd:f box containing protein 0.0016 0.0037 0.0037
Brugia malayi Ets-domain containing protein 0.0012 0.0013 0.0022
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0082 0.0507 0.3083
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0126 0.0819 0.0819
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0037 0.0037
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0022 0.0081 0.0072
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0013 0.0013
Plasmodium falciparum LCCL domain-containing protein 0.015 0.0984 0.6109
Leishmania major cytochrome p450-like protein 0.0014 0.0027 0.0041
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0062 0.0269
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0013 0.002 0.002
Onchocerca volvulus 0.0013 0.002 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0695 0.0787
Onchocerca volvulus 0.0999 0.6967 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.001 0.001
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0027 0.0016
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0601 0.4168 1
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0037 0.0037
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0022 0.0081 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.001 0.0016
Schistosoma mansoni ets-related 0.0012 0.0013 0.0013
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0027 0.0016
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0081 0.0072
Toxoplasma gondii NADPH-glutathione reductase 0.0082 0.0507 0.317
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0027 0.0016
Schistosoma mansoni inositol monophosphatase 0.0156 0.1025 0.1025
Onchocerca volvulus 0.0013 0.002 0.0029
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0232 0.0232
Onchocerca volvulus 0.0013 0.002 0.0029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0088 0.0143
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0027 0.0016
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0125
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0202 0.0202
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0082 0.0507 0.3083
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0048 0.0048
Trypanosoma cruzi NADH dehydrogenase, putative 0.0022 0.0081 0.0389
Mycobacterium ulcerans monophosphatase CysQ 0.0016 0.0043 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0037 0.0061
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0082 0.0507 0.4843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.001 0.0016
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0507 0.3083
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Giardia lamblia DINP protein human, muc B family 0.0019 0.0062 0.0049
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0062 0.0062
Trichomonas vaginalis inositol monophosphatase, putative 0.0016 0.0043 0.0026
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0601 0.4163 0.9988
Loa Loa (eye worm) carboxylesterase 0.0106 0.0677 0.1108
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0013 0.0022
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0016 0.0043 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0648 0.0648
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.001 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0601 0.4163 0.9988
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0062 0.0102
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0088 0.0143
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0022 0.0081 0.0081
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0232 0.0232
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0022 0.0081 0.0081
Echinococcus granulosus carbonyl reductase 1 0.0013 0.002 0.002
Echinococcus granulosus cpg binding protein 0.0035 0.0174 0.0174
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.001 0.001
Plasmodium vivax multidomain scavenger receptor, putative 0.015 0.0984 0.6109
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.001 0.0016
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0062 0.0102
Trichomonas vaginalis glutamate synthase, putative 0.0022 0.0081 0.0072
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.002 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0293 0.0479
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0269
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0156 0.1025 0.2422
Plasmodium falciparum thioredoxin reductase 0.0237 0.1598 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0048 0.0079
Brugia malayi CXXC zinc finger family protein 0.0033 0.0161 0.0264
Echinococcus granulosus thioredoxin glutathione reductase 0.0238 0.1606 0.1606
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0048 0.0179
Schistosoma mansoni carbonyl reductase 0.0013 0.002 0.002
Echinococcus multilocularis 0.0014 0.0027 0.0027
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0016 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0106 0.0677 0.1108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.001 0.0016
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0022 0.0081 0.0133
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0082 0.0507 0.317
Leishmania major hypothetical protein, conserved 0.0022 0.0081 0.0389
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.0819 0.5128
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0125
Schistosoma mansoni rab6-interacting 0.015 0.0984 0.0984
Onchocerca volvulus 0.0106 0.0677 0.0972
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0048 0.0048
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Leishmania major myo-inositol-1 phosphatase, putative 0.0016 0.0043 0.0144
Brugia malayi Cytochrome P450 family protein 0.0023 0.0088 0.0143
Brugia malayi Inositol monophosphatase family protein 0.0016 0.0043 0.007
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0022 0.0081 0.0389
Onchocerca volvulus 0.0013 0.002 0.0029
Echinococcus multilocularis dnaJ subfamily B 0.0471 0.3252 0.3252
Schistosoma mansoni cytochrome P450 0.0014 0.0027 0.0027
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0022 0.0081 0.0389
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0082 0.0507 0.3083
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0695 0.0787
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.005 0.005
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0048 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1231 0.8607 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.001 0.0016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0081 0.0389
Echinococcus multilocularis thioredoxin glutathione reductase 0.0238 0.1606 0.1606
Echinococcus granulosus dna polymerase eta 0.0019 0.0062 0.0062
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0081 0.0072
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0082 0.0507 0.1173
Onchocerca volvulus 0.0013 0.002 0.0029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.001 0.0016
Schistosoma mansoni cpg binding protein 0.0035 0.0174 0.0174
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0022 0.0081 0.0148
Schistosoma mansoni hypothetical protein 0.0017 0.0048 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0269
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0013 0.0022
Echinococcus granulosus carboxylesterase 5A 0.0629 0.4364 0.4364
Trypanosoma brucei unspecified product 0.0019 0.0062 0.0269
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0062 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Brugia malayi hypothetical protein 0.0338 0.2308 0.3775
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0037 0.0037
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0048 0.0302
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0048 0.0302
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0695 0.428
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0022 0.0081 0.0072
Brugia malayi steroid hormone receptor 0.0012 0.001 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.001 0.001
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0016 0.0043 0.0061
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0037 0.0109
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0027 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0027 0.0016
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0037 0.0037
Echinococcus multilocularis para nitrobenzyl esterase 0.0106 0.0677 0.0677
Echinococcus granulosus hypothetical protein 0.0013 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Giardia lamblia NADH oxidase lateral transfer candidate 0.0082 0.0507 0.0567
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0022 0.0081 0.0611
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0133 0.0863 0.534
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.001 0.0016
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0695 0.0695
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0022 0.0081 0.0389
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0062 0.0102
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0082 0.0507 0.3083
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0062 0.0062
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0022 0.0081 0.0133
Trypanosoma brucei polo-like protein kinase 0.0109 0.0695 0.428
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0027 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0027 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0027 0.0016
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Echinococcus granulosus dna polymerase kappa 0.0019 0.0062 0.0062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0133 0.0863 0.2032
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0695 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0082 0.0507 0.3083
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.002 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.001 0.0014
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0022 0.0081 0.0081
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0027 0.0016
Schistosoma mansoni hypothetical protein 0.015 0.0984 0.0984
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0188 0.0307
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0022 0.0081 0.0148
Schistosoma mansoni nuclear hormone receptor 0.0012 0.001 0.001
Schistosoma mansoni lipoxygenase 0.0622 0.4311 0.4311
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0022 0.0081 0.0081
Treponema pallidum NADH oxidase 0.0082 0.0507 0.0499
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0133 0.0863 0.2032
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0601 0.4163 0.9988
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0081 0.0389
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1231 0.8607 1
Echinococcus multilocularis retinol dehydrogenase 13 0.0013 0.002 0.002
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0016 0.0043 0.0144
Echinococcus granulosus inositol monophosphatase 0.0016 0.0043 0.0043
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0062 0.0102
Schistosoma mansoni hypothetical protein 0.0017 0.0048 0.0048
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0013 0.0013
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0027 0.0016
Brugia malayi Cytochrome P450 family protein 0.0014 0.0027 0.0043
Echinococcus granulosus dnaJ subfamily B 0.0471 0.3252 0.3252
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.001 0.0016
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0022 0.0081 0.0148
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.006 0.0353 0.0577
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Echinococcus multilocularis carboxylesterase 5A 0.0629 0.4364 0.4364
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0022 0.0081 0.0072
Echinococcus granulosus carbonyl reductase 1 0.0013 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.015 0.0984 0.161
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0027 0.0016
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0016 0.0043 0.0144
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0884 0.0884
Loa Loa (eye worm) hypothetical protein 0.0629 0.4364 0.7139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.001 0.001
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0232 0.0232
Echinococcus granulosus hypothetical protein 0.0013 0.002 0.002
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0088 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0455 0.0455
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0088 0.0428
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0082 0.0507 0.0829
Schistosoma mansoni cpg binding protein 0.0035 0.0174 0.0174
Brugia malayi Muscleblind-like protein 0.0162 0.1066 0.1744
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0082 0.0507 0.0507
Echinococcus multilocularis lipoxygenase domain containing protein 0.015 0.0984 0.0984
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0139 0.091 0.2145
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0622 0.4311 0.4311
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0601 0.4168 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0884 0.2083
Schistosoma mansoni disulfide oxidoreductase 0.0022 0.0081 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0695 0.0787
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Loa Loa (eye worm) glutathione reductase 0.0237 0.1598 0.2614
Mycobacterium ulcerans ferredoxin reductase 0.0022 0.0081 0.0148
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0133
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0013 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.001 0.0016
Giardia lamblia Kinase, PLK 0.0109 0.0695 0.0787
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0695 0.0695
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0106 0.0677 0.1108
Mycobacterium ulcerans carboxylesterase, LipT 0.0106 0.0677 0.1585
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0133 0.0863 0.2032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0648 0.0648
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.001 0.0014
Onchocerca volvulus 0.0022 0.0081 0.0117
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0232 0.1346
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0037 0.0109
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0232 0.0232
Mycobacterium leprae Probable monophosphatase 0.0016 0.0043 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0033 0.0033
Loa Loa (eye worm) carboxylesterase 0.0629 0.4364 0.7139
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.0677 0.0677
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0081 0.0072
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0013 0.002 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0081 0.0389
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0648 0.106
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.001 0.001
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0013 0.002 0.002
Onchocerca volvulus 0.0013 0.002 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0507 0.3083
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0126 0.0819 0.0819
Brugia malayi jmjC domain containing protein 0.006 0.0351 0.0575
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0022 0.0081 0.0148
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0016 0.0043 0.0026
Plasmodium vivax ferrodoxin reductase, putative 0.0022 0.0081 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.001 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0202 0.0202
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.002 0.002
Brugia malayi hypothetical protein 0.015 0.0984 0.161
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1025 0.6367
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0351 0.0351
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0013 0.002 0.002
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0106 0.0677 0.1585
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.001 0.001
Echinococcus granulosus para nitrobenzyl esterase 0.0106 0.0677 0.0677
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0629 0.4364 0.4364
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0027 0.0016
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0027 0.0041
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0022 0.0081 0.0072
Schistosoma mansoni DNA polymerase eta 0.0019 0.0062 0.0062
Trypanosoma brucei NADH dehydrogenase 0.0022 0.0081 0.0389
Schistosoma mansoni glutamate synthase 0.0022 0.0081 0.0081
Plasmodium vivax JmjC domain containing protein 0.0016 0.0037 0.0109
Echinococcus multilocularis inositol monophosphatase 0.0016 0.0043 0.0043
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.0884 0.0884
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0018 0.0018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0048 0.0048
Onchocerca volvulus 0.0013 0.002 0.0029
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0027 0.0016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Brugia malayi Pre-SET motif family protein 0.0877 0.6113 1
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0022 0.0081 0.0611
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Trypanosoma brucei unspecified product 0.0013 0.0021 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0082 0.0507 0.3083
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0016 0.0043 0.0055
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0022 0.0081 0.0148
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0013 0.002 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0022 0.0081 0.0389
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0884 0.2083
Echinococcus multilocularis RUN 0.015 0.0984 0.0984
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Schistosoma mansoni BC026374 protein (S09 family) 0.0106 0.0677 0.0677
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0022 0.0081 0.0081
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0232 0.038
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0062 0.0049
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0027 0.0041
Echinococcus granulosus steroid dehydrogenase 0.0013 0.002 0.002
Brugia malayi glutathione reductase 0.0237 0.1598 0.2614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0308 0.0503
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0048 0.0079
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.002 0.002
Leishmania major DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0022
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0232 0.0247
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0695 0.0998
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0048 0.0179
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0125
Mycobacterium ulcerans NADH dehydrogenase 0.0022 0.0081 0.0148
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0082 0.0507 0.3083
Schistosoma mansoni glutamate synthase 0.0022 0.0081 0.0081
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Onchocerca volvulus 0.0013 0.002 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.001 0.001
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0106 0.0677 0.0677
Schistosoma mansoni hypothetical protein 0.0037 0.0188 0.0188
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0082 0.0507 0.3083
Echinococcus granulosus histone lysine methyltransferase setb 0.0126 0.0819 0.0819
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0082 0.0507 0.1173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Echinococcus multilocularis acetylcholinesterase 0.0629 0.4364 0.4364
Brugia malayi Ets-domain containing protein 0.0083 0.0516 0.0845
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0022 0.0081 0.0389
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0161 0.0264
Brugia malayi Cytochrome P450 family protein 0.0052 0.0293 0.0479
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0037 0.0037
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0013 0.002 0.0029
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0013 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0202 0.0202
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0027 0.0016
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0601 0.4163 0.9988
Mycobacterium ulcerans dehydrogenase 0.0022 0.0081 0.0148
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0027 0.0027
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0027 0.0016
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0022 0.0081 0.0072
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0884 0.0884
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1231 0.8607 1
Echinococcus granulosus lipoxygenase domain containing protein 0.015 0.0984 0.0984
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.0043
Schistosoma mansoni kinase 0.0055 0.0318 0.0318
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0037 0.0061
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0062 0.0269
Mycobacterium ulcerans glutamate synthase subunit beta 0.0022 0.0081 0.0148
Toxoplasma gondii hypothetical protein 0.0016 0.0043 0.0267
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.001 0.0016
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.001 0.001
Brugia malayi Fli-1 protein 0.0253 0.1714 0.2804
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0648 0.0648
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0022 0.0081 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0232 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0004
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0013 0.0013
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0082 0.0507 0.3083
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0018 0.0018
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0013 0.002 0.002
Schistosoma mansoni elf1 0.0012 0.0013 0.0013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0062 0.0269
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0133 0.0863 0.0863
Trichomonas vaginalis spcc417.12 protein, putative 0.0106 0.0677 0.0766
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0106 0.0677 0.0677
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0016 0.0043 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0022 0.0081 0.0081
Brugia malayi jmjC domain containing protein 0.0016 0.0037 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0081 0.0389
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0013 0.0013
Onchocerca volvulus 0.0012 0.001 0.0014
Mycobacterium ulcerans monoxygenase 0.0022 0.0081 0.0148
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0082 0.0507 0.3083
Echinococcus multilocularis lipoxygenase domain containing protein 0.015 0.0984 0.0984
Brugia malayi hypothetical protein 0.0039 0.0202 0.033
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.0884 0.2083
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0022 0.0081 0.0133
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0037 0.0061
Brugia malayi nuclear receptor NHR-88 0.0012 0.001 0.0016
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0022 0.0081 0.0148
Brugia malayi ecdysteroid receptor 0.0012 0.001 0.0016
Loa Loa (eye worm) fli-1 protein 0.0253 0.1714 0.2804
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0048 0.0048
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0013 0.002 0.002
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0048 0.0179
Brugia malayi dehydrogenases, short chain protein 2 0.0013 0.002 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.001 0.001
Echinococcus multilocularis protein C ets 2 0.0012 0.0013 0.0013
Trichomonas vaginalis apoptosis inducing factor, putative 0.0022 0.0081 0.0072
Echinococcus multilocularis ets variant gene 4 0.0012 0.0013 0.0013
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.054 0.3738 0.8963
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0027 0.0016
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0082 0.0507 0.0507
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0013 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0507 0.3083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.001 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0648 0.106
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0082 0.0507 0.1173
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.001 0.0016
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0022 0.0081 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0648 0.0648
Toxoplasma gondii oxidoreductase, putative 0.0013 0.002 0.0125
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.054 0.3738 0.8963
Brugia malayi N-terminal motif family protein 0.0208 0.1395 0.2282
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1025 0.6367
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0133 0.0863 0.0863
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.002 0.0125
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0013 0.002 0.002
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0022 0.0081 0.0389
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.038
Onchocerca volvulus 0.0106 0.0677 0.0972
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0102
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0017 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0307
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0819 0.0819
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.0819 0.0819
Treponema pallidum fructose-bisphosphate aldolase 0.1231 0.8607 1
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0088 0.0428
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0048 0.0179
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0027 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0156 0.1025 0.117
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0898 0.1469
Schistosoma mansoni coup transcription factor 0.0012 0.001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0269
Brugia malayi jmjC domain containing protein 0.0016 0.0037 0.0061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.002 0.0033
Schistosoma mansoni ets-related 0.0253 0.1714 0.1714
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0082 0.0507 0.4843
Loa Loa (eye worm) hypothetical protein 0.0106 0.0677 0.1108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.001 0.0016
Giardia lamblia Thioredoxin reductase 0.0022 0.0081 0.0072
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0016 0.0043 0.0026
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0232 0.0247
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0062 0.0049
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0601 0.4168 1
Loa Loa (eye worm) carboxylesterase 0.0106 0.0677 0.1108
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0782 0.0782
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0027 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1231 0.8607 1
Onchocerca volvulus 0.0013 0.002 0.0029
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0027 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0308 0.0335
Loa Loa (eye worm) hypothetical protein 0.0338 0.2308 0.3775
Leishmania major hypothetical protein, conserved 0.0022 0.0081 0.0389
Loa Loa (eye worm) dehydrogenase 0.0013 0.002 0.0033
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0013 0.002 0.002
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0071 0.0431 0.0705
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0037 0.0037
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0048 0.0048
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0351 0.0575
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0037 0.0109
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.007
Onchocerca volvulus 0.0338 0.2308 0.3312
Loa Loa (eye worm) cytochrome P450 0.0014 0.0027 0.0043
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.007
Schistosoma mansoni neuroligin 3 (S09 family) 0.0106 0.0677 0.0677
Schistosoma mansoni hypothetical protein 0.0017 0.0048 0.0048
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0022 0.0081 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0027 0.0016
Brugia malayi Pre-SET motif family protein 0.0126 0.0819 0.134
Mycobacterium ulcerans monophosphatase CysQ 0.0016 0.0043 0.0055
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0022 0.0081 0.0389
Echinococcus granulosus Polycystic kidney disease protein 0.015 0.0984 0.0984
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0022 0.0081 0.051
Echinococcus granulosus acetylcholinesterase 0.0629 0.4364 0.4364
Brugia malayi Carboxylesterase family protein 0.0106 0.0677 0.1108
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.001 0.001
Echinococcus granulosus acetylcholinesterase 0.0629 0.4364 0.4364
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.0043
Brugia malayi Carboxylesterase family protein 0.0106 0.0677 0.1108
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0027 0.0016
Onchocerca volvulus 0.0106 0.0677 0.0972
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0507 0.3083
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0695 0.1138
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0022 0.0081 0.0148
Brugia malayi Cytochrome P450 family protein 0.0023 0.0088 0.0143
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0048 0.0179
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0082 0.0507 0.3083
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0037 0.0037
Echinococcus granulosus oxidoreductase 0.0013 0.002 0.002
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0037 0.0037
Brugia malayi Dehydrogenases, short chain protein 30 0.0013 0.002 0.0033
Echinococcus multilocularis oxidoreductase 0.0013 0.002 0.002
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0016 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0126 0.0819 0.134
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0232 0.0247
Echinococcus granulosus carbonyl reductase 1 0.0013 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0004
Loa Loa (eye worm) oxidoreductase 0.0013 0.002 0.0033
Echinococcus multilocularis GA binding protein alpha chain 0.0083 0.0516 0.0516
Echinococcus granulosus lipoxygenase domain containing protein 0.015 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.001 0.0016
Brugia malayi hypothetical protein 0.015 0.0984 0.161
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0022 0.0081 0.0081
Brugia malayi jmjC domain containing protein 0.0016 0.0037 0.0061
Echinococcus granulosus GA binding protein alpha chain 0.0083 0.0516 0.0516
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.054 0.3738 0.8963
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.001 0.001
Schistosoma mansoni cpg binding protein 0.0033 0.0161 0.0161
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0027 0.0016
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0338 0.0338
Schistosoma mansoni short chain dehydrogenase 0.0013 0.002 0.002
Schistosoma mansoni gabp alpha 0.0083 0.0516 0.0516
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0013 0.0013
Echinococcus granulosus inositol monophosphatase 1 0.0156 0.1025 0.1025
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0232 0.1346
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0013 0.0022
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0037 0.0037
Schistosoma mansoni sulfide quinone reductase 0.0022 0.0081 0.0081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0884 0.2083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.0884 0.0884
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0027 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0081 0.0389
Brugia malayi Ets-domain containing protein 0.0083 0.0516 0.0845
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0081 0.0072
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0232 0.0247
Schistosoma mansoni steroid dehydrogenase 0.0013 0.002 0.002
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.001 0.001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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