Detailed information for compound 676580

Basic information

Technical information
  • TDR Targets ID: 676580
  • Name: N'-(2-chlorophenyl)-N-[(3-methylphenyl)methyl ]oxamide
  • MW: 302.756 | Formula: C16H15ClN2O2
  • H donors: 2 H acceptors: 2 LogP: 3.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)CNC(=O)C(=O)Nc1ccccc1Cl
  • InChi: 1S/C16H15ClN2O2/c1-11-5-4-6-12(9-11)10-18-15(20)16(21)19-14-8-3-2-7-13(14)17/h2-9H,10H2,1H3,(H,18,20)(H,19,21)
  • InChiKey: CKIDPLGTZBVZGH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(2-chlorophenyl)-N-(3-methylbenzyl)oxamide
  • N'-(2-chlorophenyl)-N-[(3-methylphenyl)methyl]ethanediamide
  • ZINC03005251

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Trichomonas vaginalis aldo/keto reductase, putative 0.023 0.2879 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.1095 0.1061
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0955 0.1142
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.023 0.2879 1
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0395 0.0453
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Brugia malayi NADH-dependent xylose reductase 0.0067 0.0797 0.0941
Brugia malayi CXXC zinc finger family protein 0.0028 0.0309 0.0319
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0309 0.0317
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Trypanosoma cruzi aldo/keto reductase, putative 0.023 0.2879 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0067 0.0797 0.0941
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0144 0.0109
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus multilocularis aldo keto reductase 0.023 0.2879 0.2852
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Schistosoma mansoni hypothetical protein 0.0167 0.2075 0.2623
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0088 0.0111
Entamoeba histolytica aldose reductase, putative 0.023 0.2879 1
Brugia malayi hypothetical protein 0.0035 0.0395 0.0428
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.0088 0.0064
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0133 0.1645 0.2042
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0088 0.0038
Echinococcus granulosus GPCR family 2 0.0015 0.0144 0.0135
Giardia lamblia Aldose reductase 0.023 0.2879 1
Echinococcus multilocularis epidermal growth factor receptor 0.0061 0.072 0.0685
Mycobacterium ulcerans oxidoreductase 0.023 0.2879 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0088 0.0203
Loa Loa (eye worm) hypothetical protein 0.0015 0.0144 0.0107
Onchocerca volvulus 0.023 0.2879 0.3382
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0067 0.0797 1
Onchocerca volvulus 0.023 0.2879 0.3382
Echinococcus multilocularis insulin receptor 0.0133 0.1645 0.1614
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.023 0.2879 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.0088 0.0064
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0631 0.1946
Echinococcus multilocularis cpg binding protein 0.003 0.0329 0.0292
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0955 0.1166
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Brugia malayi Protein kinase domain containing protein 0.0625 0.791 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Plasmodium vivax aldehyde reductase, putative 0.0067 0.0797 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Echinococcus granulosus aldo keto reductase 0.023 0.2879 0.3609
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Schistosoma mansoni tyrosine kinase 0.0059 0.0707 0.0893
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0144 0.0107
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0088 0.0203
Trypanosoma cruzi aldo/keto reductase, putative 0.0067 0.0797 0.2541
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0088 0.0038
Plasmodium falciparum aldehyde reductase, putative 0.0067 0.0797 1
Schistosoma mansoni hypothetical protein 0.0015 0.0144 0.0182
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.0797 0.2693
Echinococcus multilocularis aldo keto reductase 0.023 0.2879 0.2852
Onchocerca volvulus 0.023 0.2879 0.3382
Onchocerca volvulus 0.023 0.2879 0.3382
Schistosoma mansoni tyrosine kinase 0.0061 0.072 0.0911
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Loa Loa (eye worm) hypothetical protein 0.023 0.2879 0.3591
Loa Loa (eye worm) hypothetical protein 0.0011 0.0088 0.0036
Brugia malayi Protein kinase domain containing protein 0.0133 0.1645 0.2021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.006 0.0028
Schistosoma mansoni hypothetical protein 0.0015 0.0144 0.0182
Echinococcus multilocularis aldehyde reductase 0.0163 0.203 0.2
Echinococcus granulosus cpg binding protein 0.003 0.0329 0.037
Onchocerca volvulus 0.023 0.2879 0.3382
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.009 0.1095 0.1384
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0088 0.0111
Entamoeba histolytica alcohol dehydrogenase, putative 0.0067 0.0797 0.1621
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0088 0.0064
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni aldo-keto reductase 0.023 0.2879 0.364
Trypanosoma brucei aldo-keto reductase, putative 0.023 0.2879 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0625 0.791 0.7902
Schistosoma mansoni hypothetical protein 0.0015 0.0144 0.0182
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0061 0.072 0.0867
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0144 0.0107
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.023 0.2879 0.3593
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0371 0.0398
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Loa Loa (eye worm) oxidoreductase 0.023 0.2879 0.3591
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0567 0.0646
Echinococcus granulosus aldehyde reductase 0.0163 0.203 0.2531
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0038 0.0048
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni hypothetical protein 0.0035 0.0395 0.0499
Trypanosoma brucei prostaglandin f synthase 0.023 0.2879 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni cpg binding protein 0.003 0.0329 0.0416
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.0088 0.0111
Toxoplasma gondii aldose reductase, putative 0.023 0.2879 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0625 0.791 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0133 0.1645 0.1614
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.023 0.2879 0.3593
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0625 0.791 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.0088 0.0038
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.0088 0.0111
Trypanosoma brucei aldo/keto reductase, putative 0.0067 0.0797 0.2541
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0088 0.0064
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0088 0.0111
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Loa Loa (eye worm) TK/EGFR protein kinase 0.0061 0.072 0.0841
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0067 0.0797 0.0965
Trypanosoma cruzi aldo-keto reductase 0.023 0.2879 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Brugia malayi Protein kinase domain containing protein 0.0074 0.0887 0.1055
Entamoeba histolytica aldose reductase, putative 0.023 0.2879 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0011 0.0088 0.0111
Schistosoma mansoni cpg binding protein 0.003 0.0329 0.0416
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0625 0.791 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0395 0.0358
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.1095 0.1061
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0088 0.005
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.023 0.2879 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus granulosus epidermal growth factor receptor 0.0061 0.072 0.0867
Schistosoma mansoni cpg binding protein 0.0028 0.0309 0.039
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni hypothetical protein 0.0167 0.2075 0.2623
Echinococcus granulosus epidermal growth factor receptor 0.0061 0.072 0.0867
Echinococcus granulosus hypothetical protein 0.023 0.2879 0.3609
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni tyrosine kinase 0.0059 0.0707 0.0893
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.023 0.2879 0.3593
Echinococcus multilocularis epidermal growth factor receptor 0.0061 0.072 0.0685
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Loa Loa (eye worm) hypothetical protein 0.009 0.1095 0.1319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.009 0.1095 0.3608
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.1095 0.1343
Schistosoma mansoni tyrosine kinase 0.0059 0.0707 0.0893
Schistosoma mansoni hypothetical protein 0.0015 0.0144 0.0182
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.0797 0.2693
Echinococcus granulosus dnaJ subfamily B 0.0403 0.5081 0.6406
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.0088 0.005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0144 0.0109
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.023 0.2879 0.3593
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0088 0.0111
Trichomonas vaginalis aldo/keto reductase, putative 0.023 0.2879 1
Schistosoma mansoni tyrosine kinase 0.0061 0.072 0.0911
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0088 0.0111
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0011 0.0088 0.0038
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0088 0.005
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Loa Loa (eye worm) PDE1B protein 0.0011 0.0088 0.0036
Loa Loa (eye worm) oxidoreductase 0.023 0.2879 0.3591
Echinococcus granulosus insulin receptor 0.0133 0.1645 0.2042
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.023 0.2879 1
Schistosoma mansoni serine/threonine protein kinase 0.0625 0.791 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0088 0.0203
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.0088 0.005
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Toxoplasma gondii aldo-keto reductase 0.0067 0.0797 0.2541
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0067 0.0797 0.2541
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0088 0.005
Mycobacterium leprae Conserved hypothetical protein 0.0163 0.203 0.5922
Echinococcus multilocularis geminin 0.0167 0.2075 0.2044
Schistosoma mansoni hypothetical protein 0.0033 0.0371 0.0469
Onchocerca volvulus 0.0067 0.0797 0.0643
Echinococcus granulosus geminin 0.0167 0.2075 0.2587
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0088 0.0038
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0625 0.791 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0955 0.0921
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.5081 0.5062
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Leishmania major prostaglandin f synthase, putative 0.023 0.2879 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Echinococcus multilocularis voltage gated potassium channel subunit 0.0067 0.0797 0.0762
Echinococcus multilocularis aldo keto reductase 0.023 0.2879 0.2852
Loa Loa (eye worm) TK/INSR protein kinase 0.0133 0.1645 0.202
Echinococcus granulosus aldo keto reductase family 1 member B4 0.023 0.2879 0.3609
Entamoeba histolytica aldose reductase, putative 0.023 0.2879 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0067 0.0797 0.0939
Schistosoma mansoni tyrosine kinase 0.0133 0.1645 0.208
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0067 0.0797 0.2693
Loa Loa (eye worm) oxidoreductase 0.023 0.2879 0.3591
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.023 0.2879 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.006 0.0022
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.0088 0.0038
Echinococcus granulosus voltage gated potassium channel subunit 0.0067 0.0797 0.0965
Loa Loa (eye worm) hypothetical protein 0.0011 0.0088 0.0036
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0088 0.0064
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.0088 0.0064
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0625 0.791 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0713 0.0901
Onchocerca volvulus 0.023 0.2879 0.3382
Echinococcus multilocularis 0.0017 0.017 0.0133
Echinococcus multilocularis GPCR, family 2 0.0015 0.0144 0.0107
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Schistosoma mansoni tyrosine kinase 0.0061 0.072 0.0911
Echinococcus granulosus aldo keto reductase 0.023 0.2879 0.3609
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.0797 0.2693
Entamoeba histolytica alcohol dehydrogenase, putative 0.0067 0.0797 0.1621
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0144 0.0135
Brugia malayi Furin-like cysteine rich region family protein 0.0061 0.072 0.0843
Schistosoma mansoni hypothetical protein 0.0403 0.5081 0.6423
Echinococcus granulosus aldo keto reductase 0.023 0.2879 0.3609
Plasmodium falciparum aldo-keto reductase, putative 0.0067 0.0797 1
Mycobacterium tuberculosis Probable oxidoreductase 0.023 0.2879 1
Trichomonas vaginalis aldo-keto reductase, putative 0.023 0.2879 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Echinococcus multilocularis aldo keto reductase 0.023 0.2879 0.2852
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0567 0.0647
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0088 0.0111
Schistosoma mansoni aldo-keto reductase 0.023 0.2879 0.364
Schistosoma mansoni tyrosine kinase 0.0133 0.1645 0.208
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0067 0.0797 0.2541
Schistosoma mansoni pol-related 0.023 0.2879 0.364
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0144 0.0135
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0955 0.1141
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0067 0.0797 0.2541
Loa Loa (eye worm) hypothetical protein 0.0011 0.0088 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.0567 0.0646
Loa Loa (eye worm) oxidoreductase 0.023 0.2879 0.3591
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0395 0.0499
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Loa Loa (eye worm) hypothetical protein 0.0073 0.0873 0.1036
Giardia lamblia Aldose reductase 0.023 0.2879 1
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0797 0.2693
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.023 0.2879 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Loa Loa (eye worm) oxidoreductase 0.023 0.2879 0.3591
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.0088 0.0111
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0088 0.0203
Leishmania major aldo-keto reductase-like protein 0.023 0.2879 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.009 0.1095 0.3608
Schistosoma mansoni potassium channel beta 0.0067 0.0797 0.1008
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.1095 0.1343
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0144 0.0107
Trichomonas vaginalis aldo/keto reductase, putative 0.023 0.2879 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0088 0.0203
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0567 0.0647
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.023 0.2879 0.2852
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.0088 0.0036
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.0088 0.005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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