Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | 0.0689 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0066 | 0.06 | 0.5844 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0241 | 0.0963 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0094 | 0.1015 | 0.9274 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0141 | 0.1733 | 0.1727 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0094 | 0.1015 | 0.9274 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0094 | 0.1015 | 1 |
Onchocerca volvulus | 0.0027 | 0.0016 | 0.0086 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0016 | 0.0035 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.01 | 0.1116 | 0.1109 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2505 | 0.2499 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.007 | 0.0657 | 0.6421 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0007 | 0.003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2505 | 0.2499 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0966 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0657 | 0.2624 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0241 | 0.0234 |
Onchocerca volvulus | 0.0027 | 0.0016 | 0.0086 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0007 | 0.003 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0027 | 0.0016 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0241 | 0.0963 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0016 | 0.0035 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0027 | 0.0016 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0016 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0657 | 0.2624 |
Onchocerca volvulus | 0.0027 | 0.0016 | 0.0086 | |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.1093 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1015 | 0.4051 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0192 | 0.2505 | 1 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0027 | 0.0016 | 0.0009 |
Brugia malayi | RNA binding protein | 0.0192 | 0.2505 | 1 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.4584 | 0.458 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2505 | 0.2499 |
Echinococcus multilocularis | geminin | 0.033 | 0.4584 | 0.458 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0966 | 0.0959 |
Plasmodium falciparum | acyl-CoA synthetase | 0.007 | 0.0657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0016 | 0.0064 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0016 | 0.0035 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0141 | 0.1733 | 0.1727 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0027 | 0.0016 | 0.0064 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.1015 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0066 | 0.06 | 0.5844 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.007 | 0.0657 | 0.6421 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0241 | 0.0234 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0027 | 0.0016 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0027 | 0.0016 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0966 | 0.0959 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.1002 | 0.0996 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.1015 | 0.4033 |
Brugia malayi | TAR-binding protein | 0.0192 | 0.2505 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0027 | 0.0016 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0218 | 0.0211 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0218 | 0.0211 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0094 | 0.1015 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0016 | 0.0035 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0241 | 0.0234 |
Loa Loa (eye worm) | TAR-binding protein | 0.0192 | 0.2505 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0657 | 0.2624 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.0966 | 0.3856 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0094 | 0.1015 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.1093 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0218 | 0.0211 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0027 | 0.0016 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0966 | 0.0959 |
Mycobacterium ulcerans | hypothetical protein | 0.0094 | 0.1015 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0385 | 0.1538 |
Loa Loa (eye worm) | RNA binding protein | 0.0192 | 0.2505 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0094 | 0.1015 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0027 | 0.0016 | 0.0009 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0966 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1015 | 0.4051 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.1093 | 0.1086 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0027 | 0.0016 | 0.0009 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.007 | 0.0657 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0027 | 0.0016 | 0.0035 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0241 | 0.0234 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0094 | 0.1015 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.007 | 0.0657 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0094 | 0.1015 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.1093 | 0.4346 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 0.1015 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0218 | 0.0211 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 0.1015 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0066 | 0.06 | 0.5844 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2505 | 0.2499 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.1015 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.1015 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.0966 | 0.3837 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0094 | 0.1015 | 0.9274 |
Onchocerca volvulus | 0.0027 | 0.0016 | 0.0086 | |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.1002 | 0.0996 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 0.1015 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0966 | 0.0959 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0689 | 1 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0027 | 0.0016 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.4584 | 0.458 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0241 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0657 | 0.2624 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0027 | 0.0016 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.1015 | 0.4033 |
Onchocerca volvulus | 0.0094 | 0.1015 | 1 | |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0027 | 0.0016 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1015 | 0.4051 |
Echinococcus granulosus | geminin | 0.033 | 0.4584 | 0.458 |
Echinococcus multilocularis | tar DNA binding protein | 0.0192 | 0.2505 | 0.2499 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0027 | 0.0016 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0966 | 0.0959 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.1015 | 0.4033 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0094 | 0.1015 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0027 | 0.0016 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0241 | 0.0234 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0094 | 0.1015 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0192 | 0.2505 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0657 | 0.2624 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0332 | 0.0325 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0066 | 0.06 | 0.5844 |
Toxoplasma gondii | propionate-CoA ligase | 0.0027 | 0.0016 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2505 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1093 | 0.4363 |
Echinococcus granulosus | tar DNA binding protein | 0.0192 | 0.2505 | 0.2499 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.