TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 350.638 | Formula: C16H13BrClNO
H donors: 1 H acceptors: 1 LogP: 4.62 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=Nc1ccc(c(c1)Br)Cl)/C=C(/c1ccccc1)\O
InChi: 1S/C16H13BrClNO/c1-11(9-16(20)12-5-3-2-4-6-12)19-13-7-8-15(18)14(17)10-13/h2-10,20H,1H3
InChiKey: JJOJVLINTKFVIB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0049	0.0346	0.0872
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.0762	0.0697
Trypanosoma brucei	PAB1-binding protein , putative	0.0049	0.0346	0.087
Echinococcus multilocularis	neuropeptide s receptor	0.0464	0.5747	0.5717
Plasmodium falciparum	importin beta, putative	0.0028	0.0069	0.0319
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.2939	0.3039
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0061	0.0503	0.0437
Schistosoma mansoni	hypothetical protein	0.0046	0.0308	0.0252
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0094	0.0925	0.102
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0172	0.1949	0.2151
Onchocerca volvulus		0.0035	0.0162	0.0139
Brugia malayi	Fli-1 protein	0.0216	0.2518	0.4274
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.1167	0.1929
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0166	0.0274
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0046	0.0308	0.0416
Brugia malayi	Ets-domain containing protein	0.0071	0.063	0.0979
Echinococcus multilocularis	peregrin	0.0029	0.0079	0.001
Onchocerca volvulus		0.0093	0.091	0.1391
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.2939	0.3039
Schistosoma mansoni	inositol monophosphatase	0.0074	0.0667	0.0633
Echinococcus granulosus	survival motor neuron protein 1	0.0468	0.5799	0.6068
Echinococcus multilocularis	geminin	0.0666	0.8383	0.8371
Echinococcus multilocularis	neuropeptide receptor A26	0.0464	0.5747	0.5717
Onchocerca volvulus		0.0073	0.0656	0.0966
Schistosoma mansoni	hypothetical protein	0.01	0.1009	0.0995
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1167	0.1916
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0188	0.2147	1
Trypanosoma brucei	protein kinase, putative	0.0054	0.0411	0.1034
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0081	0.0758	0.0693
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.041	0.0343
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.0411	0.1036
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0166	0.0418
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0411	0.0596
Leishmania major	mitochondrial DNA polymerase beta	0.0327	0.3967	1
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0166	0.0418
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0074	0.0667	0.3105
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0074	0.0667	0.3105
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0191	0.0129
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0495	0.0429
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0112	0.1167	0.1163
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0166	0.2488
Schistosoma mansoni	inositol monophosphatase	0.0074	0.0667	0.0633
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.041	0.5039	0.8674
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0001	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0147	0.1613	0.2695
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0166	0.2488
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0411	0.0362
Loa Loa (eye worm)	MH2 domain-containing protein	0.0233	0.2739	0.466
Schistosoma mansoni	chromobox protein	0.0072	0.0635	0.0599
Onchocerca volvulus		0.0095	0.0946	0.1453
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0166	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0308	0.0416
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0185	0.0203
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0079	0.0363
Mycobacterium ulcerans	beta-lactamase	0.0112	0.1167	0.5435
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0495	0.2303
Brugia malayi	RNA recognition motif domain containing protein	0.0248	0.2939	0.5008
Mycobacterium tuberculosis	Probable hydrolase	0.0112	0.1167	0.1288
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0166	0.0274
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0156	0.0087
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0495	0.0451
Echinococcus granulosus	snurportin 1	0.03	0.3612	0.3752
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.1167	0.1929
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0303	0.0763
Loa Loa (eye worm)	hypothetical protein	0.004	0.0225	0.0272
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0495	0.1248
Schistosoma mansoni	hypothetical protein	0.03	0.3612	0.3752
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0081	0.0758	0.1201
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0094	0.0925	0.102
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0226	0.0166
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.0411	0.1034
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0667	0.1682
Brugia malayi	latrophilin 2 splice variant baaae	0.01	0.1009	0.164
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1167	0.1916
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0225	0.0372
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0503	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0112	0.0075
Brugia malayi	hypothetical protein	0.0035	0.0156	0.0151
Echinococcus granulosus	chromobox protein 1	0.0072	0.0635	0.0599
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0188	0.2147	1
Mycobacterium tuberculosis	Conserved protein	0.0112	0.1167	0.1288
Echinococcus granulosus	histone lysine methyltransferase setb	0.0061	0.0503	0.0459
Brugia malayi	hypothetical protein	0.0032	0.0118	0.0085
Onchocerca volvulus		0.0112	0.1167	0.1822
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0495	0.0451
Trichomonas vaginalis	esterase, putative	0.0112	0.1167	0.1929
Brugia malayi	PAS domain containing protein	0.0048	0.0323	0.0442
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0166	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1613	0.2695
Brugia malayi	Glycosyl hydrolases family 31 protein	0.016	0.1789	0.3002
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0265	0.0312
Echinococcus multilocularis	GPCR, family 2	0.0046	0.0308	0.024
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0166	0.0274
Schistosoma mansoni	alpha glucosidase	0.0036	0.0166	0.0102
Mycobacterium leprae	conserved hypothetical protein	0.0112	0.1167	0.5435
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0667	0.1682
Echinococcus multilocularis	survival motor neuron protein 1	0.0468	0.5799	0.577
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0112	0.1167	0.1288
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0046	0.0308	0.0252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.041	0.5039	0.5263
Mycobacterium ulcerans	esterase/lipase LipP	0.0112	0.1167	0.5435
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0046	0.0308	0.0416
Schistosoma mansoni	hypothetical protein	0.0046	0.0308	0.0252
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.3612	0.6183
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0185	0.0857
Brugia malayi	hypothetical protein	0.016	0.1781	0.2988
Plasmodium vivax	SET domain protein, putative	0.0061	0.0503	0.234
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0166	0.0274
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.041	0.5039	0.5263
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0069	0.0172
Brugia malayi	Bromodomain containing protein	0.0029	0.0079	0.0017
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0166	0.0097
Echinococcus granulosus	chromobox protein 1	0.0072	0.0635	0.0599
Schistosoma mansoni	hypothetical protein	0.0046	0.0308	0.0252
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0495	0.2303
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0185	0.0857
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0411	0.0344
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.0925	0.102
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0411	0.0679
Entamoeba histolytica	hypothetical protein	0.0023	0.0001	0.0013
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0188	0.2147	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0158	0.0155
Brugia malayi	TAR-binding protein	0.0248	0.2939	0.5008
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0112	0.1167	0.1288
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0074	0.0667	0.3105
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.0681	0.0648
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0303	0.0763
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0155	0.1721	0.4338
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0166	0.0274
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0495	0.0451
Echinococcus granulosus	single minded 2	0.0035	0.0162	0.0098
Echinococcus granulosus	neuropeptide receptor A26	0.0464	0.5747	0.6013
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0156	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0073	0.012
Schistosoma mansoni	hypothetical protein	0.0035	0.0156	0.0092
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.1605	0.1547
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0073	0.0656	0.0621
Schistosoma mansoni	microtubule-associated protein tau	0.0753	0.9512	1
Schistosoma mansoni	ets-related	0.0216	0.2518	0.2593
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.063	0.0594
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.1167	0.2942
Schistosoma mansoni	single-minded	0.0048	0.0323	0.0268
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0155	0.1721	0.4337
Loa Loa (eye worm)	transcription factor SMAD2	0.0233	0.2739	0.466
Onchocerca volvulus		0.0081	0.0762	0.1144
Loa Loa (eye worm)	fli-1 protein	0.0216	0.2518	0.4274
Onchocerca volvulus		0.0112	0.1167	0.1822
Schistosoma mansoni	gabp alpha	0.0071	0.063	0.0594
Echinococcus granulosus	beta LACTamase domain containing family member	0.0112	0.1167	0.1163
Brugia malayi	Thioredoxin reductase	0.0037	0.0185	0.0202
Mycobacterium tuberculosis	Conserved protein	0.0112	0.1167	0.1288
Trichomonas vaginalis	penicillin-binding protein, putative	0.0112	0.1167	0.1929
Onchocerca volvulus		0.0031	0.0112	0.0056
Loa Loa (eye worm)	heterochromatin protein 1	0.0072	0.0635	0.0987
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0346	0.0483
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.0162	0.0093
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0147	0.162	0.2707
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0112	0.1167	0.1163
Brugia malayi	MAP kinase sur-1	0.0054	0.0411	0.0596
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0667	0.1682
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0226	0.0158
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0166	0.0274
Schistosoma mansoni	hypothetical protein	0.0666	0.8383	0.8804
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1605	0.2681
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0185	0.0202
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.0934	0.087
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.0934	0.0915
Echinococcus multilocularis	inositol monophosphatase 1	0.0074	0.0667	0.0602
Brugia malayi	hypothetical protein	0.0049	0.0346	0.0483
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0112	0.1167	0.1288
Schistosoma mansoni	hypothetical protein	0.0046	0.0308	0.0252
Schistosoma mansoni	hypothetical protein	0.0081	0.0758	0.0729
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0331	0.0277
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0495	0.0546
Schistosoma mansoni	hypothetical protein	0.0029	0.0079	0.001
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0503	0.0757
Echinococcus multilocularis	lysosomal alpha glucosidase	0.016	0.1789	0.1732
Mycobacterium ulcerans	hypothetical protein	0.0112	0.1167	0.5435
Brugia malayi	jmjC domain containing protein	0.0035	0.0158	0.0155
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0156	0.0092
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.2939	0.3039
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0495	0.2303
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0188	0.2147	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0248	0.2939	0.5008
Trichomonas vaginalis	set domain proteins, putative	0.0487	0.6051	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.041	0.0361
Toxoplasma gondii	hypothetical protein	0.0053	0.0391	0.1817
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0081	0.0758	0.0729
Schistosoma mansoni	aryl hydrocarbon receptor	0.0048	0.0323	0.0268
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0802	0.0885
Schistosoma mansoni	hypothetical protein	0.0081	0.0758	0.0729
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0073	0.012
Echinococcus granulosus	inositol monophosphatase 1	0.0074	0.0667	0.0633
Entamoeba histolytica	hypothetical protein	0.0035	0.0156	0.2336
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0081	0.0758	0.0729
Mycobacterium ulcerans	hypothetical protein	0.0172	0.1949	0.9077
Loa Loa (eye worm)	apoptosis regulator protein	0.0081	0.0758	0.1201
Echinococcus multilocularis	microtubule associated protein 2	0.0753	0.9512	0.9509
Leishmania major	hypothetical protein, conserved	0.0112	0.1167	0.2942
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0081	0.0758	0.0729
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0191	0.0123
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0069	0.0319
Echinococcus multilocularis	muscleblind protein	0.0146	0.1605	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1627	0.2719
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0185	0.0857
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0166	0.0274
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0346	0.0872
Onchocerca volvulus		0.0112	0.1167	0.1822
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0327	0.3967	1
Echinococcus multilocularis	snurportin 1	0.03	0.3612	0.3567
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0503	0.0459
Brugia malayi	Ets-domain containing protein	0.0071	0.063	0.0979
Plasmodium vivax	hypothetical protein, conserved	0.0112	0.1167	0.5435
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0303	0.0763
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.041	0.5039	0.5263
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0166	0.0274
Loa Loa (eye worm)	beta-lactamase	0.0112	0.1167	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1167	0.1916
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0346	0.0872
Mycobacterium tuberculosis	Probable esterase LipL	0.0112	0.1167	0.1288
Onchocerca volvulus		0.0148	0.1627	0.2593
Brugia malayi	hypothetical protein	0.0148	0.1627	0.2719
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0188	0.2147	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0411	0.1036
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0346	0.1608
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1605	0.2681
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.1167	0.1929
Toxoplasma gondii	ABC1 family protein	0.0112	0.1167	0.5435
Brugia malayi	glutathione reductase	0.0037	0.0185	0.0202
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0411	0.0362
Schistosoma mansoni	survival motor neuron protein	0.0095	0.0946	0.0929
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0802	0.0885
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0074	0.0667	0.1103
Echinococcus multilocularis	lysosomal alpha glucosidase	0.016	0.1789	0.1732
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0802	0.0885
Loa Loa (eye worm)	hypothetical protein	0.0468	0.5799	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.041	0.5039	0.8674
Brugia malayi	jmjC domain containing protein	0.0094	0.0934	0.1509
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0496	0.0744
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.041	0.5039	0.5004
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0069	0.0172
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0112	0.1167	0.1106
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0074	0.0667	0.1103
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0066	0.0566	0.2635
Schistosoma mansoni	hypothetical protein	0.0666	0.8383	0.8804
Loa Loa (eye worm)	hypothetical protein	0.016	0.1781	0.2988
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0074	0.0667	1
Echinococcus granulosus	tar DNA binding protein	0.0248	0.2939	0.3039
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0225	0.0372
Brugia malayi	hypothetical protein	0.0468	0.5799	1
Brugia malayi	chromobox protein homolog 3	0.004	0.0225	0.0272
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0079	0.0363
Brugia malayi	Inositol-1	0.0074	0.0667	0.1044
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0112	0.1167	0.1916
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0479	0.0715
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0046	0.0308	0.0252
Brugia malayi	RNA, U transporter 1	0.008	0.0744	0.1178
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0112	0.1167	0.1916
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0265	0.0438
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.1167	0.2942
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0331	0.0457
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0428	0.528	0.9095
Brugia malayi	Pre-SET motif family protein	0.0061	0.0503	0.0757
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0225	0.0245
Trichomonas vaginalis	inositol monophosphatase, putative	0.0074	0.0667	0.1103
Echinococcus granulosus	microtubule associated protein 2	0.0753	0.9512	1
Trypanosoma brucei	hypothetical protein, conserved	0.0112	0.1167	0.2941
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0411	0.0679
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0061	0.0503	0.0437
Trypanosoma brucei	trypanothione reductase	0.0037	0.0185	0.0464
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0001	0.0002
Entamoeba histolytica	hypothetical protein	0.0035	0.0156	0.2336
Echinococcus granulosus	GPCR family 2	0.0046	0.0308	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0079	0.0017
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0667	0.168
Brugia malayi	Pre-SET motif family protein	0.0428	0.528	0.9095
Mycobacterium ulcerans	lipase LipD	0.0112	0.1167	0.5435
Brugia malayi	beta-lactamase	0.0112	0.1167	0.1916
Echinococcus multilocularis	tumor protein p63	0.0329	0.3994	0.3952
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1167	0.1916
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0166	0.0102
Plasmodium vivax	ataxin-2 like protein, putative	0.0049	0.0346	0.1608
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.0635	0.1049
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0061	0.0503	0.234
Brugia malayi	Latrophilin receptor protein 2	0.0046	0.0308	0.0416
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.0762	0.0733
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0112	0.1167	0.5435
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0411	0.1036
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0188	0.2147	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0158	0.0094
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0303	0.0761
Echinococcus granulosus	lysosomal alpha glucosidase	0.016	0.1789	0.1821
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0079	0.001
Mycobacterium tuberculosis	Probable lipase LipD	0.0112	0.1167	0.1288
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.0762	0.1209
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0079	0.0363
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.041	0.5039	0.5263
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0411	0.0344
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.0762	0.0733
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0265	0.0438
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0411	0.0362
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0066	0.0566	0.0624
Schistosoma mansoni	hypothetical protein	0.0081	0.0758	0.0729
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0327	0.3967	1
Mycobacterium leprae	Probable lipase LipE	0.0112	0.1167	0.5435
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0069	0.0319
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0094	0.0925	0.4304
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0147	0.1613	0.2695
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0059	0.0474	0.0428
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0166	0.0769
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0081	0.0758	0.0693
Onchocerca volvulus		0.0487	0.6051	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.016	0.1789	0.3002
Trichomonas vaginalis	hypothetical protein	0.0188	0.2147	0.3548
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0079	0.001
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.0635	0.1049
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0166	0.0169
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.0411	0.1036
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.041	0.5039	0.5263
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0166	0.0169
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0802	0.0885
Echinococcus multilocularis	tar DNA binding protein	0.0248	0.2939	0.289
Mycobacterium tuberculosis	Conserved protein	0.0112	0.1167	0.1288
Giardia lamblia	Kinase, CMGC MAPK	0.0054	0.0411	1
Trypanosoma brucei	glucosidase, putative	0.0036	0.0166	0.0416
Schistosoma mansoni	chromobox protein	0.0072	0.0635	0.0599
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.063	0.0565
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.2939	0.3039
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.0162	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0762	0.1209
Brugia malayi	beta-lactamase family protein	0.0112	0.1167	0.1916
Echinococcus granulosus	neuropeptide s receptor	0.0464	0.5747	0.6013
Brugia malayi	beta-lactamase family protein	0.0112	0.1167	0.1916
Loa Loa (eye worm)	hypothetical protein	0.01	0.1009	0.164
Entamoeba histolytica	hypothetical protein	0.0035	0.0156	0.2336
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0495	0.2303
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0158	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0347	0.0485
Echinococcus granulosus	muscleblind protein	0.0146	0.1605	0.1627
Brugia malayi	Heterochromatin protein 1	0.0072	0.0635	0.0987
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0802	0.0885
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0079	0.001
Echinococcus granulosus	geminin	0.0666	0.8383	0.8804
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.041	0.5039	0.5004
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0079	0.0363
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0411	0.0679
Brugia malayi	MH2 domain containing protein	0.0233	0.2739	0.466
Schistosoma mansoni	hypothetical protein	0.0095	0.0946	0.0929
Schistosoma mansoni	tar DNA-binding protein	0.0248	0.2939	0.3039
Onchocerca volvulus		0.0048	0.0331	0.0422
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0802	0.0885
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0185	0.0202
Echinococcus multilocularis	chromobox protein 1	0.0072	0.0635	0.0569
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0046	0.0308	0.024
Schistosoma mansoni	alpha-glucosidase	0.0138	0.1499	0.1514
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.063	0.0979
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0327	0.3967	1
Brugia malayi	RNA binding protein	0.0248	0.2939	0.5008
Mycobacterium tuberculosis	Probable lipase LipE	0.0112	0.1167	0.1288
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0434	0.1093
Entamoeba histolytica	hypothetical protein	0.0035	0.0156	0.2336
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.0411	0.1036
Loa Loa (eye worm)	inositol-1	0.0074	0.0667	0.1044
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0095	0.0946	0.1531
Brugia malayi	hypoxia-induced factor 1	0.0147	0.162	0.2707
Trichomonas vaginalis	penicillin-binding protein, putative	0.0112	0.1167	0.1929
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0185	0.0857
Echinococcus granulosus	peregrin	0.0029	0.0079	0.001
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1167	0.1916
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0155	0.1721	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0758	0.1201
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0188	0.2147	0.237
Plasmodium falciparum	glutathione reductase	0.0037	0.0185	0.0857
Schistosoma mansoni	apoptosis regulator bax	0.0081	0.0758	0.0729
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.0802	0.3733
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0079	0.0017
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0346	0.1608
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.0411	0.1036
Toxoplasma gondii	LsmAD domain-containing protein	0.0049	0.0346	0.1608
Loa Loa (eye worm)	RNA binding protein	0.0248	0.2939	0.5008
Leishmania major	trypanothione reductase	0.0037	0.0185	0.0466
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0185	0.0466
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0158	0.0094
Echinococcus granulosus	tumor protein p63	0.0329	0.3994	0.4156
Brugia malayi	PHD-finger family protein	0.0029	0.0079	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1167	0.1916
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0411	0.1911
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0411	0.0679
Schistosoma mansoni	alpha-glucosidase	0.0138	0.1499	0.1514
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0188	0.2147	1
Loa Loa (eye worm)	TAR-binding protein	0.0248	0.2939	0.5008
Mycobacterium ulcerans	putative regulatory protein	0.0035	0.0162	0.0749
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0147	0.1613	0.2695
Schistosoma mansoni	lipoxygenase	0.0054	0.041	0.0361
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0718	0.9057	1
Echinococcus multilocularis	chromobox protein 1	0.0072	0.0635	0.0569
Brugia malayi	Muscleblind-like protein	0.0146	0.1605	0.2681
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0158	0.0094
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0046	0.0308	0.024
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0503	0.0459

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 676872