Detailed information for compound 677269

Basic information

Technical information
  • TDR Targets ID: 677269
  • Name: 2-[(3,4-dimethoxyphenyl)-phenylsulfonylamino] -N-(4-ethylphenyl)acetamide
  • MW: 454.539 | Formula: C24H26N2O5S
  • H donors: 1 H acceptors: 3 LogP: 4.27 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)CN(S(=O)(=O)c1ccccc1)c1ccc(c(c1)OC)OC
  • InChi: 1S/C24H26N2O5S/c1-4-18-10-12-19(13-11-18)25-24(27)17-26(32(28,29)21-8-6-5-7-9-21)20-14-15-22(30-2)23(16-20)31-3/h5-16H,4,17H2,1-3H3,(H,25,27)
  • InChiKey: KLJNARYBOFBBET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3,4-dimethoxyphenyl)-phenylsulfonyl-amino]-N-(4-ethylphenyl)acetamide
  • 2-[(3,4-dimethoxyphenyl)-phenylsulfonyl-amino]-N-(4-ethylphenyl)ethanamide
  • ZINC01112360
  • STK239499

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 4-coumarate:coa ligase-like protein 0.0146 0.0814 0.1758
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0043 0.0127 0.0648
Toxoplasma gondii ABC1 family protein 0.0038 0.0095 0.2361
Echinococcus granulosus flap endonuclease 1 0.0026 0.0013 0.0013
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0278 0.0583
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0034 0.0389
Echinococcus multilocularis protein patched 0.0193 0.1126 0.1126
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0043 0.0127 0.0098
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0243 0.0243
Leishmania major C-8 sterol isomerase-like protein 0.0711 0.457 1
Brugia malayi AMP-binding enzyme family protein 0.0146 0.0814 0.1758
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0095 0.0241
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0261 0.0261
Trypanosoma brucei glucosidase, putative 0.0036 0.0079 0.0146
Loa Loa (eye worm) hypothetical protein 0.0364 0.2259 0.4927
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0043 0.0127 0.025
Echinococcus granulosus Niemann Pick C1 protein 0.0193 0.1126 0.1126
Onchocerca volvulus 0.0043 0.0127 0.0673
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0079 0.0196
Loa Loa (eye worm) hypothetical protein 0.0109 0.0568 0.1218
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.022 0.1305 0.3806
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0127 0.025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0159 0.0159
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0359 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0067 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.0128 0.0252
Echinococcus granulosus peregrin 0.0032 0.0051 0.0051
Schistosoma mansoni glutaminase 0.0537 0.3408 0.3408
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0786 0.9654
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0243 0.0506
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0359 0.0359
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0043 0.0127 0.0098
Loa Loa (eye worm) RNA binding protein 0.0063 0.0261 0.0544
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0034 0.0047
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0127 0.025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0146 0.0814 0.2171
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0043 0.0127 0.0289
Echinococcus granulosus sterol regulatory element binding protein 0.0193 0.1126 0.1126
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0711 0.457 1
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0469 0.2961 0.6469
Brugia malayi PHD-finger family protein 0.0029 0.0034 0.0047
Mycobacterium tuberculosis Conserved protein 0.0038 0.0095 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0159 0.0159
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0359 0.4272
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.022 0.1305 0.3806
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0094 0.0094
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0278 0.0278
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0359 0.1932
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1776 0.5193
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0127 0.025
Loa Loa (eye worm) hypothetical protein 0.0034 0.0067 0.0119
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0146 0.0814 0.5299
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.0445
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0127 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1776 0.5193
Loa Loa (eye worm) hypothetical protein 0.0075 0.0339 0.0715
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0782 0.1688
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0146 0.0814 0.2171
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0095 0.0095
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0043 0.0127 0.135
Loa Loa (eye worm) hypothetical protein 0.005 0.0172 0.035
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0261 0.0261
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0359 1
Plasmodium vivax SET domain protein, putative 0.003 0.0039 0.0472
Entamoeba histolytica acyl-CoA synthetase, putative 0.0146 0.0814 0.4544
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0261 0.0544
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0121 0.0237
Brugia malayi Pre-SET motif family protein 0.003 0.0039 0.0058
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0043 0.0127 0.0127
Echinococcus multilocularis sterol regulatory element binding protein 0.0193 0.1126 0.1126
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0095 0.0241
Brugia malayi TAR-binding protein 0.0063 0.0261 0.0544
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0095 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0079 0.0146
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1829 0.3984
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0034 0.0624
Loa Loa (eye worm) hypothetical protein 0.0108 0.0557 0.1193
Echinococcus multilocularis jumonji domain containing protein 0.004 0.011 0.011
Brugia malayi Pre-SET motif family protein 0.0207 0.1219 0.2646
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0095 0.0095
Plasmodium vivax acetyl-CoA synthetase, putative 0.0043 0.0127 0.2056
Loa Loa (eye worm) hypothetical protein 0.0146 0.0814 0.1758
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0127 0.135
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0043 0.0127 0.0289
Mycobacterium ulcerans acyl-CoA synthetase 0.0146 0.0814 0.2171
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0914 0.1976
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.1458 1
Brugia malayi Bromodomain containing protein 0.0032 0.0051 0.0084
Echinococcus granulosus tumor protein p63 0.0735 0.4727 0.4727
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0127 0.0336
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0146 0.0814 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0179
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0039 0.0039
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0043 0.0127 0.0289
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0243 0.0449
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0243 0.0449
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.0445
Echinococcus granulosus tar DNA binding protein 0.0063 0.0261 0.0261
Brugia malayi RNA binding protein 0.0063 0.0261 0.0544
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0032 0.0032
Toxoplasma gondii hypothetical protein 0.0027 0.002 0.0201
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0146 0.0814 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0261 0.0261
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0079 0.0079
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0261 0.0544
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0914 0.0914
Echinococcus multilocularis tumor protein p63 0.0735 0.4727 0.4727
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0528 0.3217
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0261 0.0544
Onchocerca volvulus 0.0038 0.0095 0.0437
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.1776 1
Onchocerca volvulus 0.0108 0.0557 0.3798
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1776 0.5193
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0127 0.0098
Onchocerca volvulus 0.0043 0.0127 0.0673
Schistosoma mansoni hypothetical protein 0.0122 0.0656 0.0656
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0095 0.0053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0146 0.0814 0.4544
Brugia malayi jmjC domain containing protein 0.0037 0.0089 0.0166
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0127 0.025
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0043 0.0127 0.0289
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0528 0.3217
Brugia malayi AMP-binding enzyme family protein 0.0146 0.0814 0.1758
Trichomonas vaginalis conserved hypothetical protein 0.0193 0.1126 0.3278
Entamoeba histolytica acyl-coA synthetase, putative 0.0146 0.0814 0.4544
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0127 0.025
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0095 0.0095
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1829 0.3984
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0089 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0109 0.0568 0.1429
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0528 0.3217
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0632 0.1358
Loa Loa (eye worm) hypothetical protein 0.0146 0.0814 0.1758
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0786 0.5099
Schistosoma mansoni hypothetical protein 0.0038 0.0091 0.0091
Echinococcus granulosus jumonji domain containing protein 0.004 0.011 0.011
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0043 0.0127 0.0289
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0278 0.0583
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0359 0.0798
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0278 0.0278
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0127 0.025
Loa Loa (eye worm) hypothetical protein 0.0469 0.2961 0.6469
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.002 0.0125
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0181 0.0681
Mycobacterium ulcerans hypothetical protein 0.0146 0.0814 0.2171
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0278 0.0583
Loa Loa (eye worm) glutaminase 2 0.0537 0.3408 0.745
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.1829 0.3984
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.0445
Brugia malayi glutaminase DH11.1 0.0537 0.3408 0.745
Brugia malayi beta-lactamase 0.0038 0.0095 0.0179
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0034 0.0624
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0243 0.1138
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0359 0.5
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0181 0.2027
Trypanosoma brucei C-8 sterol isomerase, putative 0.0711 0.457 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0043 0.0127 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0146 0.0814 0.1758
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0171 0.0348
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1219 0.2646
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0243 0.0243
Brugia malayi hypothetical protein 0.0038 0.0091 0.0172
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0721 0.0721
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0473 0.0473
Mycobacterium tuberculosis Conserved protein 0.0038 0.0095 0.0053
Loa Loa (eye worm) hypothetical protein 0.0078 0.0359 0.076
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0127 0.025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0179
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0171 0.0348
Schistosoma mansoni microtubule-associated protein tau 0.1528 1 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0568 0.1218
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0127 0.025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0179
Schistosoma mansoni acetyl-CoA synthetase 0.0043 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.0034 0.0067 0.0067
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0469 0.2961 0.8652
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0094 0.0094
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0127 0.025
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0656 0.0656
Plasmodium vivax acyl-CoA synthetase, putative 0.0109 0.0568 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1776 0.5193
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0473 0.0473
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0095 0.0942
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0034 0.0034
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0469 0.2961 0.6469
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0181 0.0181
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0043 0.0127 0.0289
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0127 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0095 0.1472
Brugia malayi Bromodomain containing protein 0.0041 0.0111 0.0215
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0656 0.0656
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0127 0.025
Loa Loa (eye worm) beta-lactamase 0.0038 0.0095 0.0179
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0261 0.0261
Onchocerca volvulus 0.0093 0.0462 0.3107
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0075 0.0075
Echinococcus multilocularis protein dispatched 1 0.0193 0.1126 0.1126
Brugia malayi beta-lactamase family protein 0.0038 0.0095 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0146 0.0814 0.2171
Giardia lamblia PHD finger protein 15 0.0029 0.0034 0.0123
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0095 0.0179
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0127 0.0289
Loa Loa (eye worm) hypothetical protein 0.0043 0.0127 0.025
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0243 0.0243
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.1829 0.3984
Plasmodium falciparum phd finger protein, putative 0.0029 0.0034 0.0389
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.024 0.0498
Toxoplasma gondii propionate-CoA ligase 0.0043 0.0127 0.3297
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0109 0.0568 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0261 0.0261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1776 0.5193
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0095 0.0179
Loa Loa (eye worm) hypothetical protein 0.0109 0.0568 0.1218
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0469 0.2961 0.6469
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0721 0.0721
Brugia malayi Bromodomain containing protein 0.0079 0.0369 0.0781
Loa Loa (eye worm) glutaminase 0.0537 0.3408 0.745
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0171 0.0348
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.1776 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0095 0.0241
Mycobacterium ulcerans hypothetical protein 0.0157 0.0888 0.2395
Mycobacterium leprae Probable lipase LipE 0.0038 0.0095 0.0942
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0091 0.0091
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0039 0.0757
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0095 0.0053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0127 0.025
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0079 0.0196
Schistosoma mansoni hypothetical protein 0.0029 0.0034 0.0034
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0469 0.2961 0.2961
Onchocerca volvulus 0.0038 0.0095 0.0437
Loa Loa (eye worm) hypothetical protein 0.0043 0.0127 0.025
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0278 0.1506
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0127 0.0336
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0127 0.3297
Brugia malayi PHD-finger family protein 0.0026 0.0017 0.0008
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0043 0.0127 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0095 0.0179
Echinococcus multilocularis peregrin 0.0032 0.0051 0.0051
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0914 0.1976
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.022 0.1305 0.733
Loa Loa (eye worm) hypothetical protein 0.0048 0.0159 0.0321
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0359 0.0359
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0243 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0127 0.0098
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0469 0.2961 0.2961
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0079 0.0079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0146 0.0814 0.1758
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0079 0.0196
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0079 0.1922
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.002 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0079 0.0146
Onchocerca volvulus 0.0043 0.0127 0.0673
Echinococcus multilocularis microtubule associated protein 2 0.1528 1 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.1126 0.2442
Toxoplasma gondii hypothetical protein 0.0048 0.0162 0.4308
Onchocerca volvulus 0.0146 0.0814 0.567
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0179
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0146 0.0814 0.2171
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0193 0.1126 0.2442
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0261 0.0261
Brugia malayi CHE-14 protein 0.0193 0.1126 0.2442
Plasmodium falciparum acyl-CoA synthetase 0.0109 0.0568 1
Schistosoma mansoni alpha-glucosidase 0.0139 0.0764 0.0764
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0039 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0127 0.0098
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0359 0.0359
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0782 0.1688
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0127 0.0098
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0095 0.0241
Brugia malayi MH2 domain containing protein 0.0119 0.0632 0.1358
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0127 0.025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0121 0.0237
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0079 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0146 0.0814 0.1758
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0711 0.457 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0146 0.0814 0.1758
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0179
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0278 0.0583
Schistosoma mansoni bromodomain containing protein 0.0067 0.0286 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0159 0.0159
Brugia malayi beta-lactamase family protein 0.0038 0.0095 0.0179
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0243 0.0243
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.0445
Mycobacterium tuberculosis Conserved protein 0.0038 0.0095 0.0053
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0216
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0188 0.0384
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0359 0.6235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0146 0.0814 0.5299
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0786 0.2088
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0079 0.0146
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0079 0.0377
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1409 0.4113
Loa Loa (eye worm) oxidoreductase 0.0043 0.0127 0.025
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0914 0.0914
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0127 0.025
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0034 0.0034
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0043 0.0127 0.0127
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0127 0.0289
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0127 0.025
Onchocerca volvulus 0.0236 0.1409 1
Trichomonas vaginalis glutaminase, putative 0.0537 0.3408 1
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0013 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1776 0.5193
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0121 0.0237
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0121 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0261 0.0261
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0469 0.2961 0.2961
Schistosoma mansoni patched 1 0.0193 0.1126 0.1126
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0079 0.0377
Schistosoma mansoni alpha-glucosidase 0.0139 0.0764 0.0764
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0095 0.0053
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0043 0.0127 0.3297
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0278 0.0583
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.005 0.0171 0.0348
Mycobacterium ulcerans glutaminase 0.0537 0.3408 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0278 0.0278
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.1776 1
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0469 0.2961 0.6469
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0711 0.457 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0159 0.0159
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0089 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0095 0.0179
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0043 0.0127 0.0098
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0047
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0043 0.0127 0.0289
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0193 0.1126 0.1126
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0359 0.0798
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0528 0.3217
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0095 0.0053
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0043 0.0127 0.135
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0261 0.0261
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0127 0.0289
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0127 0.0289
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0079 0.0196
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0181 0.0181
Brugia malayi Cytochrome P450 family protein 0.0052 0.0188 0.0384
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1776 0.5193
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0181 0.0681
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0469 0.2961 0.6469
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0091 0.0091
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0721 0.0721
Mycobacterium ulcerans acetyl-CoA synthetase 0.0043 0.0127 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0079 0.0196
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0344 0.0344
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0079 0.0196
Leishmania major hypothetical protein, conserved 0.0038 0.0095 0.0179
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0043 0.0127 0.025
Schistosoma mansoni alpha glucosidase 0.0036 0.0079 0.0079
Mycobacterium ulcerans acyl-CoA synthetase 0.0146 0.0814 0.2171
Echinococcus multilocularis Niemann Pick C1 protein 0.0193 0.1126 0.1126
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0043 0.0127 0.0098
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0043 0.0127 0.0098
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.022 0.1305 0.3806
Loa Loa (eye worm) hypothetical protein 0.0109 0.0568 0.1218
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0095 0.0179
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0034 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0632 0.1358
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0109 0.0568 0.3506
Trichomonas vaginalis esterase, putative 0.0038 0.0095 0.0241
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0079 0.0196
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0079 0.0146
Onchocerca volvulus 0.0043 0.0127 0.0673
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.1776 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0091 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0127 0.0098
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0243 0.6658
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1776 0.5193
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0278 0.0583
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0043 0.0127 0.2056
Onchocerca volvulus 0.0038 0.0095 0.0437
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0095 0.0241
Onchocerca volvulus 0.003 0.0039 0.0034
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0043 0.0127 0.0098
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0079 0.0196
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0182 0.0371
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0359 0.6235
Loa Loa (eye worm) hypothetical protein 0.0109 0.0568 0.1218
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0127 0.025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0039 0.0039
Brugia malayi jmjC domain containing protein 0.0095 0.0473 0.1011
Brugia malayi Probable ClpP-like protease 0.0078 0.0359 0.076
Loa Loa (eye worm) hypothetical protein 0.0045 0.0141 0.0282
Echinococcus granulosus Protein patched homolog 1 0.0193 0.1126 0.1126
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0095 0.0053
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0146 0.0814 0.2171
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0095 0.0053
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0888 0.5841
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0127 0.0098
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0782 0.1688
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0095 0.0053
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0094 0.0094
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0079 0.0196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0179

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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