Detailed information for compound 67727

Basic information

Technical information
  • TDR Targets ID: 67727
  • Name: N-1-Methylheptylformamide
  • MW: 157.253 | Formula: C9H19NO
  • H donors: 1 H acceptors: 1 LogP: 3.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCC(NC=O)C
  • InChi: 1S/C9H19NO/c1-3-4-5-6-7-9(2)10-8-11/h8-9H,3-7H2,1-2H3,(H,10,11)
  • InChiKey: YWFHDUFNGSJLTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2R)-octan-2-yl]formamide
  • N-octan-2-ylformamide
  • N-(1-methylheptyl)formamide
  • N-octan-2-ylmethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens alcohol dehydrogenase 1B (class I), beta polypeptide Starlite/ChEMBL References
Homo sapiens alcohol dehydrogenase 1A (class I), alpha polypeptide Starlite/ChEMBL References
Equus caballus Alcohol dehydrogenase Starlite/ChEMBL References
Homo sapiens alcohol dehydrogenase 1C (class I), gamma polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00001 alcohol dehydrogenase [EC1.1.1.1], putative Get druggable targets OG5_127257 All targets in OG5_127257
Schistosoma japonicum Alcohol dehydrogenase class-3, putative Get druggable targets OG5_127257 All targets in OG5_127257
Neospora caninum alcohol dehydrogenase class III, putative Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 Get druggable targets OG5_127257 All targets in OG5_127257
Loa Loa (eye worm) alcohol dehydrogenase class III Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB Get druggable targets OG5_127257 All targets in OG5_127257
Toxoplasma gondii Zn-containing alcohol dehydrogenase Get druggable targets OG5_127257 All targets in OG5_127257
Schistosoma japonicum Alcohol dehydrogenase class-3, putative Get druggable targets OG5_127257 All targets in OG5_127257
Brugia malayi Alcohol dehydrogenase class III Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 Get druggable targets OG5_127257 All targets in OG5_127257
Schistosoma mansoni alcohol dehydrogenase Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD Get druggable targets OG5_127257 All targets in OG5_127257
Candida albicans similar to C termini of C.maltosa FDH1 and S. cerevisiae SFA1 (YDL168W) glutathione-dependent formaldehyde dehydrogenase, long-c Get druggable targets OG5_127257 All targets in OG5_127257
Onchocerca volvulus Putative alcohol dehydrogenase Get druggable targets OG5_127257 All targets in OG5_127257
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Possible dehydrogenase Alcohol dehydrogenase   374 aa 350 aa 26.0 %
Onchocerca volvulus Putative ATP-dependent RNA helicase DDX52 Alcohol dehydrogenase   374 aa 337 aa 21.4 %
Toxoplasma gondii quinone oxidoreductase, putative Alcohol dehydrogenase   374 aa 323 aa 23.8 %
Mycobacterium tuberculosis Possible dehydrogenase alcohol dehydrogenase 1C (class I), gamma polypeptide 375 aa 342 aa 27.8 %
Mycobacterium tuberculosis Possible dehydrogenase alcohol dehydrogenase 1A (class I), alpha polypeptide 375 aa 356 aa 27.0 %
Mycobacterium tuberculosis Possible dehydrogenase alcohol dehydrogenase 1B (class I), beta polypeptide 375 aa 352 aa 26.4 %
Trypanosoma cruzi oxidoreductase, putative Alcohol dehydrogenase   374 aa 318 aa 20.1 %
Candida albicans likely Zinc-binding dehydrogenase, one of two genes similar to S. cerevisiae YAL060W and BDH1 (YAL060W) butanediol dehydrogenase Alcohol dehydrogenase   374 aa 366 aa 24.6 %
Onchocerca volvulus Alcohol dehydrogenase   374 aa 376 aa 48.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0017
Loa Loa (eye worm) AGC/PKN protein kinase 0.007 0.0376 0.0658
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) RhoGAP domain-containing protein 0.005 0.0247 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Echinococcus granulosus regulator of G protein signaling 3 0.0044 0.0212 0.0212
Schistosoma mansoni vav2 0.005 0.0247 0.0247
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.0024 0.0083 0.0083
Onchocerca volvulus 0.0247 0.1488 0.6505
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0073 0.0166
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0247 0.1488 0.2606
Leishmania major hypothetical protein, conserved 0.0091 0.0506 0.2107
Loa Loa (eye worm) hypothetical protein 0.0107 0.0611 0.1069
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0073 0.0166
Toxoplasma gondii phospholipase/carboxylesterase 0.0022 0.0073 0.0165
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0179 0.1058 0.1853
Mycobacterium ulcerans hypothetical protein 0.0022 0.0073 0.0047
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Echinococcus granulosus G protein coupled receptor 139 0.0247 0.1488 0.1488
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0219 0.0383
Schistosoma mansoni myosin xvIII 0.0247 0.1488 0.1488
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0194 0.0707
Onchocerca volvulus 0.0247 0.1488 0.6505
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0073 0.0166
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Entamoeba histolytica hypothetical protein 0.0035 0.0158 0.0548
Schistosoma mansoni cpg binding protein 0.003 0.0123 0.0123
Echinococcus granulosus abhydrolase domain containing protein 13 0.0022 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0071 0.0384 0.0672
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.0036 0.0063
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis neuropeptides capa receptor 0.0247 0.1488 0.1488
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.2266 1
Loa Loa (eye worm) raf kinase 0.005 0.0247 0.0432
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0065 0.0341 0.0401
Echinococcus granulosus tm gpcr rhodopsin 0.0247 0.1488 0.1488
Plasmodium falciparum exported lipase 1 0.0022 0.0073 0.0166
Onchocerca volvulus 0.005 0.0247 0.1079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0158 0.0154
Loa Loa (eye worm) variant SH3 domain-containing protein 0.005 0.0247 0.0432
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Onchocerca volvulus Fatty acid synthase homolog 0.0041 0.0194 0.0846
Loa Loa (eye worm) hypothetical protein 0.0041 0.0194 0.0339
Brugia malayi RhoGAP domain containing protein 0.005 0.0247 0.0432
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0128
Brugia malayi RhoGAP domain containing protein 0.005 0.0247 0.0432
Onchocerca volvulus Putative alcohol dehydrogenase 0.0375 0.2288 1
Plasmodium falciparum BEM46-like protein, putative 0.0022 0.0073 0.0166
Schistosoma mansoni biogenic amine receptor 0.0247 0.1488 0.1488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0063
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Plasmodium vivax PST-A protein 0.0022 0.0073 0.0166
Leishmania major hypothetical protein, conserved 0.0024 0.0083 0.0212
Echinococcus granulosus tachykinin peptides receptor 99D 0.0247 0.1488 0.1488
Echinococcus multilocularis serine:threonine protein kinase 38 0.007 0.0376 0.0376
Echinococcus multilocularis rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0154 0.0904 0.1583
Loa Loa (eye worm) ShTK domain-containing protein 0.0107 0.0611 0.1069
Plasmodium falciparum esterase, putative 0.0371 0.2266 1
Entamoeba histolytica hypothetical protein 0.0044 0.0212 0.0789
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0065 0.0341 0.1369
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Toxoplasma gondii hypothetical protein 0.0022 0.0073 0.0165
Brugia malayi C1-like domain containing protein 0.0051 0.0256 0.0449
Schistosoma mansoni hypothetical protein 0.0247 0.1488 0.1488
Echinococcus granulosus axis inhibition protein axin 0.0044 0.0212 0.0212
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0056 0.029 0.029
Loa Loa (eye worm) ShTK domain-containing protein 0.0107 0.0611 0.1069
Trypanosoma cruzi serine peptidase, putative 0.0022 0.0073 0.0166
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.007 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0375 0.2288 0.2832
Onchocerca volvulus 0.0247 0.1488 0.6505
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0158 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0212 0.0789
Schistosoma mansoni hypothetical protein 0.0035 0.0158 0.0158
Entamoeba histolytica hypothetical protein 0.0044 0.0212 0.0789
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0371 0.2266 1
Onchocerca volvulus 0.0107 0.0611 0.2668
Brugia malayi G-protein coupled receptor 0.0247 0.1488 0.2606
Mycobacterium tuberculosis Possible dehydrogenase 0.0065 0.0341 0.0401
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Echinococcus multilocularis fmrfamide receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.005 0.0247 0.0432
Schistosoma mansoni protein kinase C 0.0056 0.029 0.029
Schistosoma mansoni diacylglycerol kinase theta 0.005 0.0247 0.0247
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0044 0.0212 0.0212
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0065 0.0341 0.0384
Echinococcus multilocularis protein kinase c eta type 0.005 0.0247 0.0247
Trypanosoma brucei Trans-2-enoyl-ACP reductase 1, putative 0.0024 0.0083 0.0212
Schistosoma mansoni opsin-like receptor 0.0247 0.1488 0.1488
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0022 0.0073 0.0166
Loa Loa (eye worm) hypothetical protein 0.0355 0.2165 0.3791
Echinococcus multilocularis serine threonine protein kinase 0.0247 0.1489 0.1489
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0194 0.0707
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Schistosoma mansoni unc-13 (munc13) 0.0056 0.029 0.029
Brugia malayi G protein-coupled receptor 0.0247 0.1488 0.2606
Echinococcus granulosus rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0128
Mycobacterium ulcerans amidase 0.0091 0.0506 0.0591
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0236 0.0236
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0247 0.1488 0.2606
Trypanosoma cruzi monoglyceride lipase, putative 0.0371 0.2266 1
Schistosoma mansoni neuropeptide receptor 0.0247 0.1488 0.1488
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.1282 0.7988 1
Leishmania major d-xylulose reductase, putative 0.0065 0.0341 0.1369
Mycobacterium ulcerans oxidoreductase 0.0024 0.0083 0.0059
Echinococcus granulosus orexin receptor type 2 0.0247 0.1488 0.1488
Brugia malayi Latrophilin receptor protein 2 0.0071 0.0384 0.0672
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0247 0.1488 0.1488
Brugia malayi putative neuropeptide receptor NPR1 0.0247 0.1488 0.2606
Onchocerca volvulus 0.0035 0.0158 0.0691
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0065 0.0341 0.1369
Schistosoma mansoni hypothetical protein 0.0068 0.0363 0.0363
Brugia malayi Serotonin receptor 0.0247 0.1488 0.2606
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0113 0.0198
Echinococcus multilocularis expressed protein 0.0856 0.5313 0.5313
Echinococcus multilocularis serine:threonine protein kinase N2 0.0146 0.0855 0.0855
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0065 0.0341 0.0401
Schistosoma mansoni biogenic amine receptor 0.0247 0.1488 0.1488
Echinococcus granulosus regulator of G protein signaling 3 0.0044 0.0212 0.0212
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1357 0.1676
Schistosoma mansoni opsin-like receptor 0.0247 0.1488 0.1488
Echinococcus granulosus dro:myosuppressin receptor 0.0247 0.1488 0.1488
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.2266 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0212 0.0789
Plasmodium falciparum lysophospholipase, putative 0.0022 0.0073 0.0166
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Plasmodium falciparum esterase, putative 0.0022 0.0073 0.0166
Brugia malayi G-protein coupled receptor 0.0247 0.1488 0.2606
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0073 0.0166
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0247 0.1488 0.2606
Mycobacterium ulcerans hypothetical protein 0.0022 0.0073 0.0047
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0247 0.1488 0.1488
Schistosoma mansoni biogenic amine receptor 0.0247 0.1488 0.1488
Brugia malayi ShTK domain containing protein 0.0107 0.0611 0.1069
Toxoplasma gondii hypothetical protein 0.0022 0.0073 0.0165
Echinococcus multilocularis g-protein coupled receptor 0.0247 0.1488 0.1488
Mycobacterium ulcerans lysophospholipase 0.0371 0.2266 0.2805
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0016 0.0036 0.0017
Echinococcus granulosus serine:threonine protein kinase N2 0.007 0.0376 0.0376
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0371 0.2266 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0065 0.0341 0.1369
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0065 0.0341 0.1369
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0065 0.0341 0.0341
Plasmodium vivax PST-A protein 0.0022 0.0073 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Echinococcus granulosus Regulator of G protein signaling 20 0.0044 0.0212 0.0212
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0073 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0376 0.0376
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0073 0.0166
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0022 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Onchocerca volvulus 0.0107 0.0611 0.2668
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0247 0.1488 0.1488
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0022 0.0073 0.0166
Loa Loa (eye worm) G-protein coupled receptor 0.0247 0.1488 0.2606
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0045 0.0221 0.0388
Loa Loa (eye worm) G-protein coupled receptor 0.0247 0.1488 0.2606
Onchocerca volvulus 0.0247 0.1488 0.6505
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0017
Brugia malayi CXXC zinc finger family protein 0.0028 0.0113 0.0198
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0091 0.0506 0.0608
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0051 0.0256 0.0449
Echinococcus multilocularis G-protein coupled receptor, putative 0.0247 0.1488 0.1488
Echinococcus multilocularis sex peptide receptor 0.0247 0.1488 0.1488
Mycobacterium tuberculosis Conserved protein 0.0035 0.0158 0.0171
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0158 0.0171
Echinococcus multilocularis Phospholipase carboxylesterase 0.0022 0.0073 0.0073
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0022 0.0073 0.0166
Plasmodium falciparum exported lipase 2 0.0022 0.0073 0.0166
Echinococcus granulosus serine:threonine protein kinase N2 0.0078 0.0425 0.0425
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0065 0.0341 0.0597
Echinococcus granulosus neuropeptide Y receptor 0.0247 0.1488 0.1488
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0056 0.029 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0212 0.0212
Leishmania major hypothetical protein, conserved 0.0022 0.0073 0.0166
Schistosoma mansoni protein kinase C mu 0.005 0.0247 0.0247
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0022 0.0073 0.5
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Plasmodium falciparum epoxide hydrolase 2 0.0022 0.0073 0.0166
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0069 0.0366 0.1481
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0091 0.0506 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0247 0.1488 0.6505
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0158 0.0158
Brugia malayi diacylglycerol kinase 0.005 0.0247 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0371 0.2266 1
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0044 0.0212 0.0371
Brugia malayi Serotonin receptor 0.0247 0.1488 0.2606
Echinococcus multilocularis axis inhibition protein axin 0.0044 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Schistosoma mansoni hypothetical protein 0.0071 0.0384 0.0384
Schistosoma mansoni amidase 0.0753 0.4663 0.4663
Brugia malayi PXA domain containing protein 0.0044 0.0212 0.0371
Echinococcus multilocularis Rac GTPase activating protein 1 0.005 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.005 0.0247 0.0247
Brugia malayi Melatonin receptor type 1A 0.0247 0.1488 0.2606
Brugia malayi Protein kinase domain containing protein 0.007 0.0376 0.0658
Mycobacterium ulcerans quinone oxidoreductase 0.0065 0.0341 0.0384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0024 0.0083 0.0146
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis neuropeptide Y receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis serotonin receptor 0.0247 0.1488 0.1488
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0065 0.0341 0.0401
Schistosoma mansoni alcohol dehydrogenase 0.0375 0.2288 0.2288
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0091 0.0506 0.0506
Echinococcus granulosus RNA directed DNA polymerase 0.017 0.1006 0.1006
Onchocerca volvulus 0.0306 0.1854 0.8104
Onchocerca volvulus 0.0247 0.1488 0.6505
Brugia malayi regulator of G-protein signaling rgs-7 0.0044 0.0212 0.0371
Entamoeba histolytica hypothetical protein 0.0035 0.0158 0.0548
Entamoeba histolytica hypothetical protein 0.0044 0.0212 0.0789
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0065 0.0341 0.1369
Trypanosoma cruzi serine peptidase, putative 0.0022 0.0073 0.0166
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0065 0.0341 0.1369
Leishmania major quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein 0.0024 0.0083 0.0212
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Brugia malayi Tachykinin-like peptides receptor 99D 0.0247 0.1488 0.2606
Echinococcus granulosus rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0065 0.0341 0.1355
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0158 0.0548
Plasmodium vivax lysophospholipase, putative 0.0022 0.0073 0.0166
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0247 0.1488 0.1488
Brugia malayi Hr1 repeat family protein 0.007 0.0376 0.0658
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0158 0.0542
Brugia malayi p70 ribosomal S6 kinase beta 0.007 0.0376 0.0658
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Onchocerca volvulus Neuropeptide F receptor homolog 0.0247 0.1488 0.6505
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0065 0.0341 0.1369
Echinococcus granulosus fatty acid amide hydrolase 1 0.0753 0.4663 0.4663
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0212 0.0212
Onchocerca volvulus 0.0048 0.0236 0.1033
Brugia malayi RE15519p 0.0247 0.1488 0.2606
Schistosoma mansoni protein kinase C mu 0.0051 0.0256 0.0256
Toxoplasma gondii type I fatty acid synthase 0.0024 0.0083 0.021
Mycobacterium leprae Probable lipase LipE 0.0035 0.0158 0.0542
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0091 0.0506 0.0506
Brugia malayi MGC83647 protein 0.0022 0.0073 0.0128
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0065 0.0341 0.0401
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Plasmodium falciparum prodrug activation and resistance esterase 0.0022 0.0073 0.0166
Loa Loa (eye worm) neuropeptide F receptor 0.0247 0.1488 0.2606
Schistosoma mansoni amine GPCR 0.0247 0.1488 0.1488
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.007 0.0376 0.0376
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0083 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0073 0.0166
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0158 0.0548
Brugia malayi hypothetical protein 0.0066 0.0348 0.061
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0071 0.0384 0.0672
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0091 0.0506 0.2087
Brugia malayi diacylglycerol kinase 0.005 0.0247 0.0432
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0753 0.4663 0.4663
Loa Loa (eye worm) hypothetical protein 0.0048 0.0236 0.0414
Echinococcus multilocularis regulator of G protein signaling 7 0.0044 0.0212 0.0212
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0194 0.0339
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0065 0.0341 0.0384
Trypanosoma brucei oxidoreductase, putative 0.0065 0.0341 0.1369
Brugia malayi beta-lactamase family protein 0.0035 0.0158 0.0277
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0051 0.0256 0.0449
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.1488 0.2606
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0083 0.0212
Leishmania major hypothetical protein, conserved 0.0022 0.0073 0.0166
Onchocerca volvulus 0.0016 0.0036 0.0157
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0247 0.1488 0.1488
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0247 0.1488 0.1488
Toxoplasma gondii ABC1 family protein 0.0035 0.0158 0.0542
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Echinococcus granulosus myotubularin protein 13 0.005 0.0247 0.0247
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0017
Onchocerca volvulus 0.0247 0.1488 0.6505
Toxoplasma gondii AGC kinase 0.007 0.0376 0.1508
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Brugia malayi neuropeptide F receptor 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0277
Echinococcus multilocularis rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0158 0.0158
Onchocerca volvulus 0.0247 0.1488 0.6505
Echinococcus multilocularis N chimaerin 0.005 0.0247 0.0247
Trypanosoma cruzi amidase, putative 0.0091 0.0506 0.2107
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0247 0.1488 0.1488
Brugia malayi MGC79044 protein 0.0022 0.0073 0.0128
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Entamoeba histolytica diacylglycerol kinase, putative 0.005 0.0247 0.0945
Echinococcus multilocularis myotubularin protein 13 0.005 0.0247 0.0247
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0375 0.2288 0.2832
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0158 0.0158
Entamoeba histolytica protein kinase, putative 0.007 0.0376 0.1523
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0016 0.0036 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Brugia malayi putative neuropeptide receptor 0.0247 0.1488 0.2606
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0091 0.0506 0.2107
Loa Loa (eye worm) beta-lactamase 0.0035 0.0158 0.0277
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0091 0.0506 0.0608
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.18 0.18
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0158 0.0548
Echinococcus granulosus neuropeptide s receptor 0.0247 0.1488 0.1488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0044 0.0212 0.0371
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0017
Loa Loa (eye worm) AGC/AKT protein kinase 0.007 0.0376 0.0658
Echinococcus multilocularis serine:threonine protein kinase N2 0.007 0.0376 0.0376
Echinococcus granulosus fmrfamide receptor 0.0247 0.1488 0.1488
Echinococcus granulosus 7TM GPCR rhodopsin 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0016 0.0036 0.0017
Onchocerca volvulus 0.0247 0.1488 0.6505
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0375 0.2288 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0158 0.0171
Brugia malayi latrophilin 2 splice variant baaae 0.0154 0.0904 0.1583
Schistosoma mansoni rac gtpase activating protein 0.005 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Brugia malayi hypothetical protein 0.0044 0.0212 0.0371
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Brugia malayi ORL1-like opioid receptor 0.0247 0.1488 0.2606
Brugia malayi protein kinase C II. 0.0203 0.1209 0.2117
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0247 0.1488 0.1488
Echinococcus granulosus protein kinase c iota type 0.012 0.0687 0.0687
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0247 0.1488 0.1488
Schistosoma mansoni growth hormone secretagogue receptor 0.0247 0.1488 0.1488
Brugia malayi Alcohol dehydrogenase class III 0.0375 0.2288 0.4006
Trypanosoma brucei monoglyceride lipase, putative 0.0371 0.2266 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Trypanosoma cruzi oxidoreductase, putative 0.0065 0.0341 0.1369
Toxoplasma gondii phospholipase 0.0022 0.0073 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0212 0.0789
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0219 0.0219
Mycobacterium ulcerans lipase LipD 0.0035 0.0158 0.0154
Brugia malayi GnHR receptor homolog 0.0247 0.1488 0.2606
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.0036 0.0017
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0371 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0212 0.0371
Loa Loa (eye worm) AGC/NDR protein kinase 0.007 0.0376 0.0658
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0375 0.2288 0.2832
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0277
Brugia malayi Amidase family protein 0.0091 0.0506 0.0886
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.1282 0.7988 1
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0091 0.0506 0.0608
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0065 0.0341 0.0401
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0194 0.0707
Echinococcus granulosus raf serine:threonine protein kinase 0.005 0.0247 0.0247
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0065 0.0341 0.1369
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Entamoeba histolytica hypothetical protein 0.0035 0.0158 0.0548
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Entamoeba histolytica hypothetical protein 0.0022 0.0073 0.0166
Mycobacterium ulcerans oxidoreductase 0.0065 0.0341 0.0384
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Echinococcus granulosus GPCR family 2 0.0071 0.0384 0.0384
Schistosoma mansoni neuropeptide f receptor 76f 0.0247 0.1488 0.1488
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0065 0.0341 0.1369
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0044 0.0212 0.0789
Loa Loa (eye worm) hypothetical protein 0.022 0.1317 0.2306
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0375 0.2288 0.4006
Echinococcus granulosus tm gpcr rhodopsin 0.0247 0.1488 0.1488
Leishmania major monoglyceride lipase, putative 0.0371 0.2266 1
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Trypanosoma cruzi amidase, putative 0.0091 0.0506 0.2107
Echinococcus granulosus rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0158 0.0154
Brugia malayi Protein kinase domain containing protein 0.007 0.0376 0.0658
Toxoplasma gondii type I fatty acid synthase, putative 0.0067 0.0355 0.1417
Brugia malayi Amidase family protein 0.0091 0.0506 0.0886
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0044 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0065 0.0341 0.0597
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0044 0.0212 0.0212
Echinococcus granulosus g protein coupled receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis somatostatin receptor 0.0247 0.1488 0.1488
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0022 0.0073 0.0166
Echinococcus granulosus tm gpcr rhodopsin 0.0247 0.1488 0.1488
Echinococcus multilocularis axis inhibition protein axin 0.0044 0.0212 0.0212
Schistosoma mansoni zinc binding dehydrogenase 0.0065 0.0341 0.0341
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0158 0.0158
Echinococcus granulosus abhydrolase domain containing 3 0.0022 0.0073 0.0073
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0247 0.1488 0.1488
Toxoplasma gondii quinone oxidoreductase, putative 0.0065 0.0341 0.1355
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0065 0.0341 0.0401
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0247 0.1488 0.1488
Onchocerca volvulus 0.0016 0.0036 0.0157
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0091 0.0506 0.0591
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0247 0.1488 0.1488
Brugia malayi Variant SH3 domain containing protein 0.005 0.0247 0.0432
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0158 0.0548
Entamoeba histolytica diacylglycerol kinase, putative 0.005 0.0247 0.0945
Brugia malayi Regulator of G protein signaling domain containing protein 0.0044 0.0212 0.0371
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0073 0.0166
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0212 0.0212
Echinococcus granulosus neuropeptides capa receptor 0.0247 0.1488 0.1488
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0073 0.0166
Echinococcus multilocularis neuropeptide FF receptor 2 0.0247 0.1488 0.1488
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0091 0.0506 0.2107
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0022 0.0073 0.0166
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0203 0.1209 0.2117
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Echinococcus multilocularis abhydrolase domain containing 3 0.0022 0.0073 0.0073
Mycobacterium tuberculosis Probable oxidoreductase 0.0065 0.0341 0.0401
Loa Loa (eye worm) hypothetical protein 0.0576 0.3551 0.6216
Mycobacterium ulcerans amidase 0.0091 0.0506 0.0591
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0065 0.0341 0.0401
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0065 0.0341 0.1369
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0065 0.0341 0.1369
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0065 0.0341 0.0401
Brugia malayi protein kinase C3,putative 0.0051 0.0256 0.0449
Plasmodium falciparum lysophospholipase, putative 0.0371 0.2266 1
Echinococcus granulosus Phospholipase carboxylesterase 0.0022 0.0073 0.0073
Schistosoma mansoni z-protein (S1r protein) 0.0044 0.0212 0.0212
Echinococcus granulosus expressed protein 0.0856 0.5313 0.5313
Echinococcus multilocularis tumor protein p63 0.0327 0.199 0.199
Schistosoma mansoni hypothetical protein 0.0071 0.0384 0.0384
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0091 0.0506 1
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0065 0.0341 0.0384
Mycobacterium ulcerans oxidoreductase 0.0041 0.0194 0.0198
Brugia malayi follicle stimulating hormone receptor 0.0247 0.1488 0.2606
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0158 0.0158
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0073 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0154 0.0904 0.0904
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0194 0.0339
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0277
Echinococcus multilocularis Diacylglycerol kinase theta 0.005 0.0247 0.0247
Loa Loa (eye worm) tyrosinase 1 0.0107 0.0611 0.1069
Onchocerca volvulus 0.0107 0.0611 0.2668
Echinococcus multilocularis serotonin receptor 0.0247 0.1488 0.1488
Schistosoma mansoni axis inhibition protein axin 0.0044 0.0212 0.0212
Echinococcus granulosus somatostatin receptor 0.0247 0.1488 0.1488
Leishmania major oxidoreductase-like protein 0.0065 0.0341 0.1369
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0065 0.0341 0.0597
Brugia malayi regulator of G-protein signaling egl-10 0.0044 0.0212 0.0371
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0128
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0016 0.0036 0.0017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0247 0.1488 0.1488
Leishmania major quinone oxidoreductase, putative 0.0065 0.0341 0.1369
Echinococcus granulosus tumor protein p63 0.0327 0.199 0.199
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0091 0.0506 0.0506
Echinococcus multilocularis neuropeptide Y receptor 0.0247 0.1488 0.1488
Onchocerca volvulus 0.0035 0.0158 0.0691
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0376 0.0376
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0247 0.1488 0.1488
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0158 0.0548
Echinococcus granulosus g-protein coupled receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Mycobacterium leprae Probable polyketide synthase Pks1 0.0065 0.0341 0.1355
Onchocerca volvulus 0.0247 0.1488 0.6505
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0107 0.0611 0.1069
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.007 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0044 0.0212 0.0371
Leishmania major zinc binding dehydrogenase-like protein 0.0065 0.0341 0.1369
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.017 0.1006 0.1006
Schistosoma mansoni hypothetical protein 0.0247 0.1488 0.1488
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0065 0.0341 0.0597
Echinococcus granulosus Protein kinase C brain isozyme 0.0297 0.18 0.18
Echinococcus multilocularis protein kinase c iota type 0.012 0.0687 0.0687
Mycobacterium ulcerans short-chain dehydrogenase 0.0065 0.0341 0.0384
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0107 0.0611 0.1069
Trypanosoma brucei monoglyceride lipase, putative 0.0371 0.2266 1
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis protein kinase c epsilon type 0.0203 0.1209 0.1209
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0091 0.0506 0.2087
Brugia malayi beta-lactamase family protein 0.0035 0.0158 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0256 0.0256
Loa Loa (eye worm) acyl carrier protein 0.0041 0.0194 0.0339
Mycobacterium ulcerans hydrolase 0.0022 0.0073 0.0047
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Onchocerca volvulus 0.0028 0.0113 0.0495
Mycobacterium ulcerans quinone reductase Qor 0.0065 0.0341 0.0384
Echinococcus granulosus N chimaerin 0.005 0.0247 0.0247
Mycobacterium ulcerans dehydrogenase 0.0065 0.0341 0.0384
Trypanosoma cruzi quinone oxidoreductase, putative 0.0024 0.0083 0.0212
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.005 0.0247 0.0247
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0073 0.0166
Brugia malayi neuropeptide F receptor 0.0247 0.1488 0.2606
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0371 0.2266 0.9903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Toxoplasma gondii hypothetical protein 0.0022 0.0073 0.0165
Brugia malayi Common central domain of tyrosinase family protein 0.0107 0.0611 0.1069
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0051 0.0256 0.0256
Mycobacterium tuberculosis Possible dehydrogenase 0.0065 0.0341 0.0401
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0272 0.1049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0063
Echinococcus multilocularis neuropeptide s receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0247 0.1488 0.1488
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0044 0.0212 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0219 0.0219
Plasmodium vivax PST-A protein 0.0022 0.0073 0.0166
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Echinococcus granulosus regulator of G protein signaling 7 0.0044 0.0212 0.0212
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0461 0.0461
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0158 0.0548
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0107 0.0611 0.1069
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0212 0.0212
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0158 0.0277
Brugia malayi Dopamine receptor protein 1 0.0247 0.1488 0.2606
Echinococcus multilocularis neuropeptide receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0247 0.1488 0.1488
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0212 0.0789
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0022 0.0073 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Echinococcus multilocularis orexin receptor type 2 0.0247 0.1488 0.1488
Schistosoma mansoni acetyl-CoA synthetase 0.0016 0.0036 0.0036
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.0247 0.0247
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0016 0.0036 0.0017
Echinococcus granulosus biogenic amine 5HT receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0297 0.18 0.18
Echinococcus granulosus regulator of G protein signaling 7 0.0044 0.0212 0.0212
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0022 0.0073 0.0166
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0065 0.0341 0.0401
Onchocerca volvulus 0.005 0.0247 0.1079
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Toxoplasma gondii peptidase S15, putative 0.0022 0.0073 0.0165
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0247 0.1488 0.1488
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0221 0.0221
Mycobacterium ulcerans beta-lactamase 0.0035 0.0158 0.0154
Echinococcus granulosus protein kinase C gamma type 0.0247 0.1489 0.1489
Brugia malayi amidase 0.0753 0.4663 0.8163
Loa Loa (eye worm) RasGEF domain-containing protein 0.005 0.0247 0.0432
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0461 0.0461
Onchocerca volvulus 0.0016 0.0036 0.0157
Mycobacterium ulcerans hypothetical protein 0.0371 0.2266 0.2805
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0221 0.0221
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0158 0.0548
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Schistosoma mansoni atypical protein kinase C 0.012 0.0687 0.0687
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0073 0.0166
Entamoeba histolytica protein kinase, putative 0.007 0.0376 0.1523
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0766 0.4744 0.4744
Loa Loa (eye worm) hypothetical protein 0.0753 0.4663 0.8163
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0065 0.0341 0.0401
Loa Loa (eye worm) melatonin receptor type 1A 0.0247 0.1488 0.2606
Schistosoma mansoni peptidase 0.0022 0.0073 0.0073
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0277
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Brugia malayi Regulator of G protein signaling domain containing protein 0.0044 0.0212 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0158 0.0548
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0036 0.0063
Brugia malayi Dopamine receptor protein 2 0.0247 0.1488 0.2606
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0247 0.1488 0.1488
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Echinococcus multilocularis regulator of G protein signaling 7 0.0044 0.0212 0.0212
Echinococcus granulosus unc 13 munc13 0.0056 0.029 0.029
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.4946 0.4946
Entamoeba histolytica PH domain containing protein kinase, putative 0.0078 0.0425 0.1743
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0158 0.0158
Loa Loa (eye worm) amidase 0.0091 0.0506 0.0886
Trypanosoma cruzi quinone oxidoreductase, putative 0.0024 0.0083 0.0212
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0158 0.0171
Onchocerca volvulus 0.0016 0.0036 0.0157
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0073 0.0166
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0051 0.0256 0.0256
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0107 0.0611 0.1069
Loa Loa (eye worm) hypothetical protein 0.0306 0.1854 0.3246
Plasmodium falciparum lysophospholipase, putative 0.0371 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0212 0.0371
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0247 0.1488 0.2606
Leishmania major hypothetical protein, conserved 0.0024 0.0083 0.0212
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0065 0.0341 0.1355
Schistosoma mansoni neuropeptide F-like receptor 0.0247 0.1488 0.1488
Trichomonas vaginalis AGC family protein kinase 0.007 0.0376 0.1523
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Trypanosoma cruzi oxidoreductase, putative 0.0065 0.0341 0.1369
Onchocerca volvulus 0.0247 0.1488 0.6505
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0247 0.1488 0.2606
Echinococcus multilocularis regulator of G protein signaling 3 0.0044 0.0212 0.0212
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.007 0.0376 0.0658
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0277
Echinococcus granulosus rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0022 0.0073 0.0165
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0044 0.0212 0.0371
Brugia malayi Ras association domain family 1 isoform A 0.005 0.0247 0.0432
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0073 0.0166
Schistosoma mansoni neuropeptide receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0063
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.005 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Brugia malayi Protein kinase domain containing protein 0.0051 0.0256 0.0449
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0247 0.1488 0.2606
Echinococcus multilocularis regulator of G protein signaling 0.0044 0.0212 0.0212
Schistosoma mansoni tyrosinase precursor 0.0107 0.0611 0.0611
Plasmodium vivax unspecified product 0.0022 0.0073 0.0166
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0091 0.0506 0.5
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0753 0.4663 0.4663
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0212 0.0789
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0091 0.0506 0.0608
Loa Loa (eye worm) hypothetical protein 0.0306 0.1854 0.3246
Mycobacterium tuberculosis Possible lysophospholipase 0.0371 0.2266 0.2818
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0073 0.0166
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0022 0.0073 0.0166
Mycobacterium ulcerans polyketide synthase 0.0065 0.0341 0.0384
Loa Loa (eye worm) oxidoreductase 0.0016 0.0036 0.0063
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis neuropeptide receptor 0.1603 1 1
Echinococcus granulosus NDR protein kinase 0.007 0.0376 0.0376
Onchocerca volvulus 0.0035 0.0158 0.0691
Brugia malayi Protein kinase domain containing protein 0.007 0.0376 0.0658
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0065 0.0341 0.0401
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0376 0.0376
Onchocerca volvulus 0.0107 0.0611 0.2668
Toxoplasma gondii diacylglycerol kinase, putative 0.005 0.0247 0.0936
Mycobacterium ulcerans amidase 0.0091 0.0506 0.0591
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0065 0.0341 0.0401
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0071 0.0384 0.0384
Brugia malayi Dopamine receptor 0.0247 0.1488 0.2606
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.18 0.18
Plasmodium vivax PST-A protein 0.0022 0.0073 0.0166
Schistosoma mansoni quinone oxidoreductase 0.0024 0.0083 0.0083
Schistosoma mansoni neuropeptide receptor 0.0247 0.1488 0.1488
Echinococcus granulosus axis inhibition protein axin 0.0044 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Brugia malayi small heat shock protein 0.0576 0.3551 0.6216
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0212 0.0212
Leishmania major oxidoreductase, putative 0.0065 0.0341 0.1369
Echinococcus multilocularis raf serine:threonine protein kinase 0.005 0.0247 0.0247
Entamoeba histolytica ;Alias 0.0022 0.0073 0.0166
Plasmodium vivax lysophospholipase, putative 0.0022 0.0073 0.0166
Onchocerca volvulus 0.0247 0.1488 0.6505
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0247 0.1488 0.1488
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0073 0.0166
Mycobacterium ulcerans alcohol dehydrogenase AdhA 0.0024 0.0083 0.0059
Loa Loa (eye worm) hypothetical protein 0.0081 0.0447 0.0782
Brugia malayi bZIP transcription factor family protein 0.0084 0.0461 0.0808
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0212 0.0789
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.0194 0.0198
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0065 0.0341 0.0401
Entamoeba histolytica hypothetical protein 0.0022 0.0073 0.0166
Loa Loa (eye worm) hypothetical protein 0.0107 0.0611 0.1069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0277
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0065 0.0341 0.1355
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0022 0.0073 0.0166
Mycobacterium ulcerans amidase 0.0091 0.0506 0.0591
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0158 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0256 0.0256
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0158 0.0171
Loa Loa (eye worm) hypothetical protein 0.0056 0.029 0.0507
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0091 0.0506 0.2107
Schistosoma mansoni hypothetical protein 0.0247 0.1488 0.1488
Schistosoma mansoni fatty-acid amide hydrolase 0.0091 0.0506 0.0506
Echinococcus granulosus hypothetical protein 0.0247 0.1488 0.1488
Brugia malayi PXA domain containing protein 0.0044 0.0212 0.0371
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.007 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Brugia malayi RhoGEF domain containing protein 0.005 0.0247 0.0432
Echinococcus granulosus peptide allatostatin:somatostatin 0.0247 0.1488 0.1488
Schistosoma mansoni jun-related protein 0.0068 0.0363 0.0363
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0375 0.2288 0.2845
Brugia malayi A-kinase anchor protein 10, precursor 0.0044 0.0212 0.0371
Echinococcus granulosus alpha 1A adrenergic receptor 0.0247 0.1488 0.1488
Trypanosoma brucei oxidoreductase, putative 0.0065 0.0341 0.1369
Trichomonas vaginalis esterase, putative 0.0035 0.0158 0.0548
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0247 0.1488 0.1488
Echinococcus multilocularis dro:myosuppressin receptor 0.0247 0.1488 0.1488
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0375 0.2288 0.2832
Loa Loa (eye worm) amidase 0.0091 0.0506 0.0886
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0065 0.0341 0.0401
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0065 0.0341 0.0384
Echinococcus multilocularis g protein coupled receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis neuropeptide receptor A26 0.0247 0.1488 0.1488
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0073 0.0166
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.0247 0.0247
Onchocerca volvulus 0.0247 0.1488 0.6505
Brugia malayi sulfakinin receptor protein 0.0247 0.1488 0.2606
Leishmania major hypothetical protein, conserved 0.0035 0.0158 0.0548
Echinococcus granulosus rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Echinococcus multilocularis G protein coupled receptor 139 0.1603 1 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Onchocerca volvulus 0.0056 0.029 0.1266
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0226 0.1353 0.2368
Echinococcus multilocularis rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Echinococcus multilocularis jun protein 0.0084 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Brugia malayi G protein-coupled receptor F59B2.13 0.0247 0.1488 0.2606
Onchocerca volvulus 0.0041 0.0194 0.0846
Onchocerca volvulus 0.0247 0.1488 0.6505
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0247 0.1488 0.1488
Mycobacterium tuberculosis Conserved protein 0.0035 0.0158 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0158 0.0548
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Plasmodium falciparum esterase, putative 0.0022 0.0073 0.0166
Loa Loa (eye worm) hypothetical protein 0.017 0.1006 0.1761
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0045 0.0221 0.0388
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0022 0.0073 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0247 0.1488 0.2606
Brugia malayi AKH receptor 0.0247 0.1488 0.2606
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0219 0.0219
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0219 0.0219
Echinococcus multilocularis cpg binding protein 0.003 0.0123 0.0123
Echinococcus granulosus neuropeptide Y receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) TYRA-2 protein 0.0247 0.1488 0.2606
Toxoplasma gondii protein c14orf29, putative 0.0022 0.0073 0.0165
Entamoeba histolytica protein kinase, putative 0.007 0.0376 0.1523
Onchocerca volvulus 0.0066 0.0348 0.1523
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0375 0.2288 0.2832
Brugia malayi beta-lactamase 0.0035 0.0158 0.0277
Trypanosoma brucei rac serine-threonine kinase, putative 0.007 0.0376 0.1523
Echinococcus granulosus 7tm_1 domain containing protein 0.0247 0.1488 0.1488
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0045 0.0221 0.0388
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.007 0.0376 0.0658
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0194 0.0707
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0158 0.0171
Echinococcus granulosus neuropeptides capa receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.0036 0.0036
Echinococcus multilocularis beta adrenergic receptor kinase 0.0045 0.0221 0.0221
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0158 0.0277
Entamoeba histolytica hypothetical protein 0.0035 0.0158 0.0548
Schistosoma mansoni cpg binding protein 0.0028 0.0113 0.0113
Echinococcus granulosus neuropeptide receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) oxidoreductase 0.0024 0.0083 0.0146
Schistosoma mansoni amine GPCR 0.0247 0.1488 0.1488
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.092 0.5712 1
Plasmodium falciparum lysophospholipase, putative 0.0371 0.2266 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0753 0.4663 0.4663
Brugia malayi hypothetical protein 0.0035 0.0158 0.0277
Schistosoma mansoni amine GPCR 0.0247 0.1488 0.1488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Mycobacterium ulcerans hypothetical protein 0.0035 0.0158 0.0154
Echinococcus granulosus sex peptide receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.007 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0044 0.0212 0.0371
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0766 0.4744 0.4744
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0036 0.0017
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0022 0.0073 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0073 0.0064
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0065 0.0341 0.1369
Loa Loa (eye worm) hypothetical protein 0.0376 0.2294 0.4016
Schistosoma mansoni histamine h1 receptor 0.0247 0.1488 0.1488
Mycobacterium ulcerans oxidoreductase FadB5 0.0065 0.0341 0.0384
Echinococcus granulosus serotonin receptor 0.0247 0.1488 0.1488
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0065 0.0341 0.0384
Loa Loa (eye worm) hypothetical protein 0.0065 0.0341 0.0597
Schistosoma mansoni cpg binding protein 0.003 0.0123 0.0123
Schistosoma mansoni neuropeptide receptor 0.1603 1 1
Echinococcus granulosus g protein coupled receptor 0.0247 0.1488 0.1488
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0065 0.0341 0.0384
Brugia malayi Calcitonin receptor-like protein seb-1 0.0226 0.1353 0.2368
Brugia malayi putative amidase 0.0091 0.0506 0.0886
Echinococcus granulosus Diacylglycerol kinase theta 0.005 0.0247 0.0247
Schistosoma mansoni neuropeptide F-like receptor 0.0247 0.1488 0.1488
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0065 0.0341 0.1355
Onchocerca volvulus 0.0247 0.1488 0.6505
Echinococcus granulosus rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Mycobacterium ulcerans peptide amidase, GatA 0.0091 0.0506 0.0591
Plasmodium vivax PST-A protein 0.0022 0.0073 0.0166
Plasmodium falciparum lysophospholipase, putative 0.0022 0.0073 0.0166
Schistosoma mansoni axis inhibition protein axin 0.0044 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0016 0.0036 0.0017
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0073 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0247 0.1488 0.1488
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.031 0.1883 0.2336
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0247 0.1488 0.2606
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0073 0.0166
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Echinococcus multilocularis unc 13 (munc13) 0.0056 0.029 0.029
Schistosoma mansoni hypothetical protein 0.0071 0.0384 0.0384
Schistosoma mansoni opsin-like receptor 0.0247 0.1488 0.1488
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0073 0.0166
Mycobacterium leprae Probable oxidireductase 0.0065 0.0341 0.1355
Echinococcus multilocularis neuropeptides capa receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Entamoeba histolytica protein kinase, putative 0.007 0.0376 0.1523
Echinococcus granulosus jun protein 0.0084 0.0461 0.0461
Onchocerca volvulus 0.0247 0.1488 0.6505
Schistosoma mansoni tyrosinase precursor 0.0107 0.0611 0.0611
Brugia malayi Protein kinase c protein 2 0.0228 0.1369 0.2397
Echinococcus granulosus protein kinase c eta type 0.005 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.0432
Echinococcus granulosus neuropeptide receptor A26 0.0247 0.1488 0.1488
Echinococcus granulosus cpg binding protein 0.003 0.0123 0.0123
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0247 0.1488 0.1488
Schistosoma mansoni alpha-1 adrenergic receptor 0.0247 0.1488 0.1488
Onchocerca volvulus 0.0247 0.1488 0.6505
Echinococcus multilocularis fmrfamide receptor 0.0247 0.1488 0.1488
Entamoeba histolytica hypothetical protein 0.005 0.0247 0.0945
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0071 0.0384 0.0384
Echinococcus multilocularis GPCR, family 2 0.0071 0.0384 0.0384
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0247 0.1488 0.1488
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0247 0.1488 0.2606
Brugia malayi Protein C20orf22 0.0022 0.0073 0.0128
Loa Loa (eye worm) hypothetical protein 0.0306 0.1854 0.3246
Echinococcus granulosus fatty acid amide hydrolase 1 0.0091 0.0506 0.0506
Toxoplasma gondii hypothetical protein 0.0022 0.0073 0.0165
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.2266 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0158 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0247 0.1488 0.1488
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0073 0.0166
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0247 0.1488 0.1488
Loa Loa (eye worm) PXA domain-containing protein 0.0044 0.0212 0.0371
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0036 0.0063
Echinococcus granulosus neuropeptide FF receptor 2 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0247 0.1488 0.1488
Brugia malayi hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0065 0.0341 0.0341
Loa Loa (eye worm) neuropeptide F receptor 0.0247 0.1488 0.2606
Loa Loa (eye worm) latrophilin receptor protein 2 0.0071 0.0384 0.0672
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0158 0.0171
Onchocerca volvulus 0.0065 0.0341 0.1491
Echinococcus granulosus Rac GTPase activating protein 1 0.005 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.031 0.1883 0.2336
Brugia malayi larval opioid receptor 0.0247 0.1488 0.2606
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0065 0.0341 0.1369
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0022 0.0073 0.0165
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0247 0.1488 0.1488
Echinococcus multilocularis regulator of G protein signaling 3 0.0044 0.0212 0.0212
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0091 0.0506 0.0506
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0313 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0073 0.0166
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis g protein coupled receptor 0.0247 0.1488 0.1488
Schistosoma mansoni serine/threonine kinase 0.007 0.0376 0.0376
Schistosoma mansoni hypothetical protein 0.0071 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0063
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0022 0.0073 0.0073
Schistosoma mansoni adenoreceptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.007 0.0376 0.0658
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0247 0.1488 0.1488
Echinococcus granulosus fatty acid amide hydrolase 1 0.0753 0.4663 0.4663
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0219 0.0219
Echinococcus granulosus beta-adrenergic receptor kinase 0.0045 0.0221 0.0221
Mycobacterium ulcerans quinone oxidoreductase 0.0065 0.0341 0.0384
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0091 0.0506 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Trichomonas vaginalis conserved hypothetical protein 0.0371 0.2266 1
Onchocerca volvulus 0.0247 0.1488 0.6505
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis Regulator of G protein signaling 20 0.0044 0.0212 0.0212
Schistosoma mansoni amine GPCR 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.092 0.5712 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.007 0.0376 0.0658
Echinococcus multilocularis allatostatin A receptor 0.0247 0.1488 0.1488
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0221 0.0221
Trypanosoma cruzi oxidoreductase, putative 0.0024 0.0083 0.0212
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0219 0.0383
Schistosoma mansoni biogenic amine (5HT) receptor 0.0247 0.1488 0.1488
Schistosoma mansoni unc-13 (munc13) 0.0056 0.029 0.029
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0065 0.0341 0.0401
Echinococcus granulosus g protein coupled receptor 0.0247 0.1488 0.1488
Plasmodium vivax lysophospholipase, putative 0.0022 0.0073 0.0166
Mycobacterium ulcerans amidase 0.0091 0.0506 0.0591
Brugia malayi Pleckstrin Homology Domain 0.005 0.0247 0.0432
Echinococcus granulosus biogenic amine 5HT receptor 0.0247 0.1488 0.1488
Schistosoma mansoni amine GPCR 0.0247 0.1488 0.1488
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0073 0.0166
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0051 0.0256 0.0449
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0022 0.0073 0.0073
Echinococcus granulosus protein kinase c epsilon type 0.0203 0.1209 0.1209
Plasmodium vivax PST-A protein 0.0371 0.2266 1
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.0024 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0247 0.1488 0.2606
Echinococcus multilocularis g protein coupled receptor 0.0247 0.1488 0.1488
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.007 0.0376 0.0376
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0247 0.1488 0.1488
Schistosoma mansoni diacylglycerol kinase theta 0.005 0.0247 0.0247
Echinococcus granulosus allatostatin A receptor 0.0247 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0063
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0375 0.2288 1
Onchocerca volvulus 0.0016 0.0036 0.0157
Brugia malayi hypothetical protein 0.0044 0.0212 0.0371
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0044 0.0212 0.0212
Plasmodium vivax unspecified product 0.0022 0.0073 0.0166
Echinococcus multilocularis RNA directed DNA polymerase 0.017 0.1006 0.1006
Loa Loa (eye worm) RGS-3 protein 0.0044 0.0212 0.0371

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.41 uM Inhibition of human alcohol dehydrogenase gamma2 activity ChEMBL. 9572895
Ki (binding) = 0.41 uM Inhibition of human alcohol dehydrogenase gamma2 activity ChEMBL. 9572895
Ki (binding) = 1.7 uM Inhibition of human alcohol dehydrogenase beta 1 activity ChEMBL. 9572895
Ki (binding) = 1.7 uM Inhibition of human alcohol dehydrogenase beta 1 activity ChEMBL. 9572895
Ki (binding) = 5.4 uM Inhibition of horse liver alcohol dehydrogenase activity ChEMBL. 9572895
Ki (binding) = 5.4 uM Inhibition of horse liver alcohol dehydrogenase activity ChEMBL. 9572895
Ki (binding) = 7 uM Inhibition of human alcohol dehydrogenase alpha activity ChEMBL. 9572895
Ki (binding) = 7 uM Inhibition of human alcohol dehydrogenase alpha activity ChEMBL. 9572895
Ki (binding) = 40 uM Inhibition of human alcohol dehydrogenase pi activity ChEMBL. 9572895
Ki (binding) = 40 uM Inhibition of human alcohol dehydrogenase pi activity ChEMBL. 9572895
Ki (binding) = 100 uM Inhibition of human alcohol dehydrogenase sigma activity ChEMBL. 9572895
Ki (binding) = 100 uM Inhibition of human alcohol dehydrogenase sigma activity ChEMBL. 9572895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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