Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0065 | 0.0184 | 0.0276 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0065 | 0.0184 | 0.0184 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0064 | 0.0172 | 0.0172 |
Onchocerca volvulus | 0.0099 | 0.0641 | 0.2067 | |
Schistosoma mansoni | serine/threonine kinase | 0.0064 | 0.0172 | 0.0257 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0099 | 0.0641 | 0.0723 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0071 | 0.0265 | 0.0265 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0064 | 0.0172 | 0.0172 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0065 | 0.0184 | 0.004 |
Schistosoma mansoni | glycogen phosphorylase | 0.0108 | 0.0765 | 0.1147 |
Echinococcus granulosus | NDR protein kinase | 0.0064 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0099 | 0.0641 | 0.0961 |
Echinococcus multilocularis | expressed protein | 0.0783 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2057 | 0.3084 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Onchocerca volvulus | 0.0279 | 0.3103 | 1 | |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0108 | 0.0765 | 0.2465 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0291 | 0.3271 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0108 | 0.0765 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0291 | 0.3271 | 1 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0065 | 0.0184 | 0.0276 |
Schistosoma mansoni | tyrosinase precursor | 0.0099 | 0.0641 | 0.0961 |
Brugia malayi | protein kinase C II. | 0.0186 | 0.183 | 0.2551 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0064 | 0.0172 | 0.0257 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0157 | 0.1437 | 0.1437 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0065 | 0.0184 | 0.0184 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0172 | 0.0257 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0099 | 0.0641 | 0.0723 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0064 | 0.0172 | 0.0257 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0172 | 0.0257 |
Plasmodium falciparum | lysophospholipase, putative | 0.0291 | 0.3271 | 1 |
Toxoplasma gondii | AGC kinase | 0.0064 | 0.0172 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.054 | 0.6671 | 0.6671 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1437 | 0.2154 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.3103 | 0.4652 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0291 | 0.3271 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186 | 0.183 | 0.2743 |
Plasmodium falciparum | lysophospholipase, putative | 0.0291 | 0.3271 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0172 | 0.0257 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Plasmodium falciparum | esterase, putative | 0.0291 | 0.3271 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0291 | 0.3271 | 1 |
Onchocerca volvulus | 0.0099 | 0.0641 | 0.2067 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0064 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0064 | 0.0172 | 0.0257 |
Echinococcus multilocularis | protein kinase c iota type | 0.011 | 0.0792 | 0.0792 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0064 | 0.0172 | 0.0257 |
Schistosoma mansoni | atypical protein kinase C | 0.011 | 0.0792 | 0.1187 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0186 | 0.183 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.3103 | 0.4652 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0291 | 0.3271 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0172 | 0.0257 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0071 | 0.0265 | 0.0303 |
Loa Loa (eye worm) | amidase | 0.0065 | 0.0184 | 0.0276 |
Echinococcus granulosus | protein kinase C gamma type | 0.0227 | 0.24 | 0.24 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0227 | 0.24 | 0.24 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0065 | 0.0184 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0641 | 0.0961 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0108 | 0.0765 | 0.1915 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0064 | 0.0172 | 0.0257 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0291 | 0.3271 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.054 | 0.6671 | 0.6671 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0065 | 0.0184 | 0.0184 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0065 | 0.0184 | 0.0184 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0108 | 0.0765 | 0.0765 |
Brugia malayi | Protein kinase c protein 2 | 0.021 | 0.2161 | 0.3062 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0108 | 0.0765 | 0.0765 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0641 | 0.0961 |
Brugia malayi | Amidase family protein | 0.0065 | 0.0184 | 0.0019 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0099 | 0.0641 | 0.0961 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0065 | 0.0184 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0108 | 0.0765 | 0.1964 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0291 | 0.3271 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0064 | 0.0172 | 0.0257 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0291 | 0.3271 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0291 | 0.3271 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0273 | 0.302 | 0.4527 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0291 | 0.3271 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0064 | 0.0172 | 0.0257 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0108 | 0.0765 | 0.1964 |
Brugia malayi | putative amidase | 0.0065 | 0.0184 | 0.0019 |
Schistosoma mansoni | glycogen phosphorylase | 0.0108 | 0.0765 | 0.1147 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0108 | 0.0765 | 0.1915 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.3724 | 0.5582 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0108 | 0.0765 | 1 |
Onchocerca volvulus | 0.0099 | 0.0641 | 0.2067 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0099 | 0.0641 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.6671 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.054 | 0.6671 | 0.6671 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.054 | 0.6671 | 1 |
Schistosoma mansoni | amidase | 0.054 | 0.6671 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0099 | 0.0641 | 0.0961 |
Brugia malayi | carbohydrate phosphorylase | 0.0108 | 0.0765 | 0.0913 |
Loa Loa (eye worm) | amidase | 0.0065 | 0.0184 | 0.0276 |
Brugia malayi | Amidase family protein | 0.0065 | 0.0184 | 0.0019 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0291 | 0.3271 | 1 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0064 | 0.0172 | 0.0172 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0064 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0186 | 0.183 | 0.2743 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0108 | 0.0765 | 0.0765 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0099 | 0.0641 | 0.0723 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0273 | 0.302 | 0.302 |
Mycobacterium ulcerans | hypothetical protein | 0.0291 | 0.3271 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0108 | 0.0765 | 0.1147 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0273 | 0.302 | 0.4527 |
Leishmania major | monoglyceride lipase, putative | 0.0291 | 0.3271 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0291 | 0.3271 | 1 |
Brugia malayi | ShTK domain containing protein | 0.0099 | 0.0641 | 0.0723 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0291 | 0.3271 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0134 | 0.1124 | 0.1124 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0064 | 0.0172 | 0.0172 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0186 | 0.183 | 0.183 |
Echinococcus granulosus | glycogen phosphorylase | 0.0108 | 0.0765 | 0.0765 |
Echinococcus granulosus | glycogen phosphorylase | 0.0108 | 0.0765 | 0.0765 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0099 | 0.0641 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.3981 | 0.5968 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0291 | 0.3271 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0099 | 0.0641 | 0.0961 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.054 | 0.6671 | 0.6671 |
Onchocerca volvulus | 0.0099 | 0.0641 | 0.2067 | |
Echinococcus granulosus | protein kinase c iota type | 0.011 | 0.0792 | 0.0792 |
Plasmodium falciparum | lysophospholipase, putative | 0.0291 | 0.3271 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0064 | 0.0172 | 0.0061 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0108 | 0.0765 | 0.0765 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0291 | 0.3271 | 1 |
Plasmodium vivax | PST-A protein | 0.0291 | 0.3271 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0064 | 0.0172 | 0.0172 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0064 | 0.0172 | 0.0172 |
Mycobacterium ulcerans | lysophospholipase | 0.0291 | 0.3271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.3103 | 0.4652 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0157 | 0.1437 | 0.1437 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0157 | 0.1437 | 0.1437 |
Brugia malayi | amidase | 0.054 | 0.6671 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0164 | 0.1541 | 0.231 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0064 | 0.0172 | 0.0172 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0273 | 0.302 | 0.302 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | 0 ug ml-1 | Tested for in vitro antibacterial activity against S. aureus 011 GO64 ofloxacin oxacillin erythromycin resistance phenotype; Not determined | ChEMBL. | 10937727 |
MIC (functional) | 0 ug ml-1 | Tested for in vitro antibacterial activity against S. epidermidis 012GO42 oxacillin resistance phenotype; Not determined | ChEMBL. | 10937727 |
MIC (functional) | < 0.04 ug ml-1 | Tested for in vitro antibacterial activity against S. aureus 011 HT3 phenotype | ChEMBL. | 10937727 |
MIC (functional) | < 0.04 ug ml-1 | Tested for in vitro antibacterial activity against S. pyogenes O2A1UC1 phenotype | ChEMBL. | 10937727 |
MIC (functional) | < 0.04 ug ml-1 | Tested for in vitro antibacterial activity against E. faecium 02D31P2 vanomycin teicoplanin erythromycin resistance phenotype | ChEMBL. | 10937727 |
MIC (functional) | = 0.6 ug ml-1 | Tested for in vitro antibacterial activity against S. aureus 011 HT1 novobiocin resistance phenotype | ChEMBL. | 10937727 |
Ratio (binding) | = 1.7 | IC50 was determined for gyrase B of S. aureus against novobiocin (0.5 mg/mL) as reference; IC50nov/IC50comp | ChEMBL. | 10937727 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.