Detailed information for compound 677593

Basic information

Technical information
  • TDR Targets ID: 677593
  • Name: STK036208
  • MW: 475.902 | Formula: C21H18ClN3O6S
  • H donors: 1 H acceptors: 4 LogP: 4.31 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C=C2SC(=NC2=O)NC(=O)C)cc(c1OCc1ccc(cc1)[N+](=O)[O-])Cl
  • InChi: 1S/C21H18ClN3O6S/c1-3-30-17-9-14(10-18-20(27)24-21(32-18)23-12(2)26)8-16(22)19(17)31-11-13-4-6-15(7-5-13)25(28)29/h4-10H,3,11H2,1-2H3,(H,23,24,26,27)/b18-10-
  • InChiKey: VBGZYQXPERTBBT-ZDLGFXPLSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0193 0.0285
Schistosoma mansoni thyroid hormone receptor 0.015 0.2804 0.2783
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0334 0.0566
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0193 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Loa Loa (eye worm) glycogen phosphorylase 0.0115 0.2094 0.3601
Brugia malayi CHE-14 protein 0.0043 0.0638 0.1053
Echinococcus multilocularis cpg binding protein 0.0032 0.0422 0.0326
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0193 0.0165
Loa Loa (eye worm) beta-lactamase 0.0035 0.0477 0.0821
Giardia lamblia Glycogen phosphorylase 0.0115 0.2094 1
Brugia malayi beta-lactamase 0.0035 0.0477 0.0776
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0131 0.1376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0585 0.099
Echinococcus multilocularis expressed conserved protein 0.0094 0.166 0.1576
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.047 0.0976
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0193 0.0285
Entamoeba histolytica hypothetical protein 0.0036 0.051 0.1929
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.03 0.5814 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1688 0.2903
Toxoplasma gondii exonuclease III APE 0.0018 0.0146 0.1524
Schistosoma mansoni glycogen phosphorylase 0.0115 0.2094 0.2071
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0477 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0131 0.0226
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.5907 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.3006 0.7007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0146 0.0394
Onchocerca volvulus 0.003 0.0387 0.042
Chlamydia trachomatis glycogen phosphorylase 0.0115 0.2094 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Echinococcus multilocularis Glycosyl transferase, family 35 0.0115 0.2094 0.2015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0224 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0193 0.0165
Mycobacterium tuberculosis Conserved protein 0.0035 0.0477 0.0911
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0772 1
Brugia malayi Pre-SET motif family protein 0.022 0.4207 0.7222
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0028 0.0048
Brugia malayi hypothetical protein 0.0036 0.051 0.0833
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0585 0.1214
Schistosoma mansoni DNA polymerase eta 0.004 0.0585 0.0558
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0131 0.0033
Echinococcus multilocularis expressed protein 0.0034 0.047 0.0375
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0131 0.0033
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0099 0.1039
Trypanosoma brucei unspecified product 0.0028 0.0334 0.0566
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.005 0.0779 0.2521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0585 0.0947
Loa Loa (eye worm) hypothetical protein 0.0035 0.0477 0.0821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0131 0.0176
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0585 0.0491
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.1688 0.1604
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0585 0.1869
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1812 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0193 0.0285
Leishmania major DNA polymerase kappa, putative 0.004 0.0585 0.0947
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0028 0.0048
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0132 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0264 0.0446
Schistosoma mansoni cpg binding protein 0.0032 0.0422 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0193 0.0332
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0772 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0477 0.0821
Schistosoma mansoni P2X receptor subunit 0.0137 0.2543 0.2522
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0454 0.1644
Schistosoma mansoni P2X receptor subunit 0.0137 0.2543 0.2522
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0585 0.1214
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0146 0.02
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0424 0.0328
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0131 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0477 0.0991
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0585 0.0962
Leishmania major hypothetical protein, conserved 0.0049 0.0772 0.1265
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1093 0.1068
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0193 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0424 0.0397
Toxoplasma gondii hypothetical protein 0.0049 0.0766 0.802
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1781 0.303
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0131 0.0178
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.2388 0.2312
Echinococcus granulosus expressed conserved protein 0.0094 0.166 0.1576
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0424 0.0328
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.5907 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0477 0.0991
Loa Loa (eye worm) hypothetical protein 0.0021 0.0193 0.0332
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.005 0.0779 0.1639
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0146 0.02
Trichomonas vaginalis rotamase, putative 0.0034 0.0454 0.0943
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0146 0.0047
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0146 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0264 0.0236
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0193 0.0095
Echinococcus multilocularis glycogen phosphorylase 0.0115 0.2094 0.2015
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0131 0.0176
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0193 0.0095
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.2678 0.4508
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.064 0.104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0424 0.4442
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0099 0.0171
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.1688 0.1604
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0193 0.0165
Schistosoma mansoni coup transcription factor 0.0021 0.0193 0.0165
Trypanosoma brucei unspecified product 0.0028 0.0334 0.0566
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.064 0.104
Echinococcus granulosus p2X purinoceptor 4 0.0137 0.2543 0.2468
Schistosoma mansoni P2X receptor subunit 0.0137 0.2543 0.2522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0454 0.0769
Brugia malayi beta-lactamase family protein 0.0035 0.0477 0.0776
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0672 0.1113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0193 0.0332
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.2678 0.4508
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0193 0.0165
Loa Loa (eye worm) hypothetical protein 0.0043 0.0638 0.1097
Schistosoma mansoni hypothetical protein 0.0041 0.0607 0.058
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0264 0.2759
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.064 0.104
Schistosoma mansoni hypothetical protein 0.0095 0.1688 0.1664
Entamoeba histolytica glycogen phosphorylase, putative 0.0115 0.2094 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.1688 0.2903
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0387 0.0666
Schistosoma mansoni hypothetical protein 0.0022 0.0224 0.0196
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0585 0.1869
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.051 0.0415
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.051 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0477 0.0821
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0585 0.1171
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0146 0.1578
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1781 0.8408
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0585 0.0947
Schistosoma mansoni hypothetical protein 0.0041 0.0607 0.058
Schistosoma mansoni hypothetical protein 0.0508 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0585 0.0947
Brugia malayi nuclear hormone receptor 0.0021 0.0193 0.0285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0049
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0099 0.0123
Entamoeba histolytica glycogen phosphorylase, putative 0.005 0.0779 0.33
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.1688 0.1604
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0477 0.0382
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0099 0.1039
Brugia malayi Calcitonin receptor-like protein seb-1 0.03 0.5814 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.2678 0.4534
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0131 0.0103
Brugia malayi hypothetical protein 0.0153 0.2853 0.4882
Mycobacterium ulcerans beta-lactamase 0.0035 0.0477 0.1508
Echinococcus multilocularis dna polymerase eta 0.004 0.0585 0.0491
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0146 0.0302
Mycobacterium ulcerans lipase LipD 0.0035 0.0477 0.1508
Echinococcus granulosus dna polymerase kappa 0.004 0.0585 0.0491
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.5907 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0477 0.1508
Schistosoma mansoni hypothetical protein 0.0095 0.1688 0.1664
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0477 0.0991
Brugia malayi carbohydrate phosphorylase 0.0115 0.2094 0.357
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.4248 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0193 0.0285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0196 0.0336
Loa Loa (eye worm) hypothetical protein 0.0035 0.0477 0.0821
Giardia lamblia GTOR 0.0018 0.0131 0.05
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0028 0.0048
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0264 0.04
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0146 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0672 0.0579
Entamoeba histolytica glycogenphosphorylase, putative 0.005 0.0779 0.33
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0772 0.8078
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0193 0.0095
Plasmodium vivax SET domain protein, putative 0.0032 0.0424 0.5328
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0585 0.099
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0585 0.0947
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0099 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0193 0.0332
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0099 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Leishmania major hypothetical protein, conserved 0.0035 0.0477 0.0764
Mycobacterium ulcerans hypothetical protein 0.016 0.3006 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0672 0.0646
Schistosoma mansoni patched 1 0.0043 0.0638 0.0611
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0146 0.025
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.2641 0.2568
Schistosoma mansoni hypothetical protein 0.0041 0.0607 0.058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0193 0.0285
Entamoeba histolytica hypothetical protein 0.0024 0.0264 0.0673
Onchocerca volvulus 0.0035 0.0477 0.0615
Trichomonas vaginalis rotamase, putative 0.0034 0.047 0.0976
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0585 0.1006
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0454 0.0724
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0028 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0193 0.0332
Schistosoma mansoni hypothetical protein 0.0036 0.051 0.0483
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0672 0.0646
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0193 0.0095
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0193 0.0095
Schistosoma mansoni hypothetical protein 0.0041 0.0607 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0048
Schistosoma mansoni hypothetical protein 0.0205 0.3904 0.3887
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0454 0.0724
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0193 0.0095
Echinococcus multilocularis geminin 0.0508 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0477 0.0991
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0638 0.0544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0424 0.0397
Brugia malayi nuclear receptor NHR-88 0.0021 0.0193 0.0285
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0454 0.0724
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0132 0.0177
Entamoeba histolytica hypothetical protein 0.0036 0.051 0.1929
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0028 0.0296
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0131 0.0176
Schistosoma mansoni thyroid hormone receptor 0.015 0.2804 0.2783
Entamoeba histolytica hypothetical protein 0.0036 0.051 0.1929
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0424 0.0397
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0193 0.0332
Schistosoma mansoni cpg binding protein 0.0032 0.0422 0.0395
Brugia malayi beta-lactamase family protein 0.0035 0.0477 0.0776
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0585 0.0947
Echinococcus granulosus p2X purinoceptor 4 0.0137 0.2543 0.2468
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0672 0.0579
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0099 0.0955
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0099 0.0955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0193 0.0332
Echinococcus multilocularis dna polymerase kappa 0.004 0.0585 0.0491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0672 0.0579
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0099 0.0121
Brugia malayi Pre-SET motif family protein 0.0032 0.0424 0.0685
Loa Loa (eye worm) hypothetical protein 0.01 0.1781 0.3064
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0131 0.0176
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0193 0.0095
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.1688 0.1604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0585 0.099
Onchocerca volvulus 0.0035 0.0477 0.0615
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0196 0.0285
Onchocerca volvulus 0.0153 0.2853 0.5753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0131 0.0176
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0193 0.0165
Onchocerca volvulus 0.0035 0.0477 0.0615
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0193 0.0332
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0193 0.0285
Mycobacterium leprae Probable lipase LipE 0.0035 0.0477 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0424 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0334 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0585 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trypanosoma brucei unspecified product 0.004 0.0585 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Onchocerca volvulus 0.0251 0.4817 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0477 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0193 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0638 0.1324
Loa Loa (eye worm) hypothetical protein 0.0153 0.2853 0.4907
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0028 0.0296
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0772 0.1265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0193 0.0095
Loa Loa (eye worm) hypothetical protein 0.0021 0.0193 0.0332
Schistosoma mansoni P2X receptor subunit 0.0137 0.2543 0.2522
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0193 0.0285
Echinococcus multilocularis GPCR, family 2 0.0095 0.1688 0.1604
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0131 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0131 0.0226
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0028 0.0048
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0131 0.0223
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0146 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Entamoeba histolytica glycogen phosphorylase, putative 0.005 0.0779 0.33
Mycobacterium tuberculosis Conserved protein 0.0035 0.0477 0.0911
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0477 0.5
Schistosoma mansoni hypothetical protein 0.0508 1 1
Echinococcus granulosus glycogen phosphorylase 0.0115 0.2094 0.2015
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1781 0.1699
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0146 0.5
Schistosoma mansoni glycogen phosphorylase 0.0115 0.2094 0.2071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Echinococcus granulosus dna polymerase eta 0.004 0.0585 0.0491
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0477 0.0991
Loa Loa (eye worm) hypothetical protein 0.0035 0.0477 0.0821
Loa Loa (eye worm) hypothetical protein 0.0021 0.0193 0.0332
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.1688 0.2868
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0193 0.0165
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.047 0.0764
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0131 0.0223
Loa Loa (eye worm) hypothetical protein 0.0205 0.3904 0.6715
Giardia lamblia DINP protein human, muc B family 0.004 0.0585 0.2695
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0477 0.045
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0772 0.1265
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0193 0.0095
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0638 0.1097
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0131 0.0176
Echinococcus multilocularis protein dispatched 1 0.0049 0.0759 0.0666
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0477 0.0808
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0131 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0264 0.0407
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0131 0.0176
Loa Loa (eye worm) hypothetical protein 0.0052 0.0831 0.1429
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0672 0.0579
Schistosoma mansoni ap endonuclease 0.0018 0.0146 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0424 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Echinococcus multilocularis protein patched 0.0043 0.0638 0.0544
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0099 0.0168
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0224 0.0126
Schistosoma mansoni hypothetical protein 0.0095 0.1688 0.1664
Echinococcus granulosus glycogen phosphorylase 0.0115 0.2094 0.2015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Leishmania major DNA polymerase eta, putative 0.004 0.0585 0.0947
Trichomonas vaginalis glycogen phosphorylase, putative 0.0115 0.2094 0.4347
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.047 0.0809
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0146 0.0047
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0477 0.1508
Echinococcus granulosus GPCR family 2 0.0095 0.1688 0.1604
Brugia malayi hypothetical protein 0.0049 0.0772 0.1285
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0146 0.0246
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0131 0.0223
Schistosoma mansoni hypothetical protein 0.013 0.2388 0.2367
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1781 0.1699
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0477 0.1508
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.2388 0.2312
Loa Loa (eye worm) pigment dispersing factor receptor c 0.03 0.5814 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0387 0.062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0334 0.0566
Trichomonas vaginalis esterase, putative 0.0035 0.0477 0.0991
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0028 0.0296
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0193 0.0165
Brugia malayi steroid hormone receptor 0.0021 0.0193 0.0285
Loa Loa (eye worm) hypothetical protein 0.03 0.5814 1
Schistosoma mansoni glycogen phosphorylase 0.005 0.0779 0.0753
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0193 0.0285
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0585 0.0962
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0585 0.0491
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0264 0.0166
Loa Loa (eye worm) hypothetical protein 0.0035 0.0477 0.0821
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0585 0.0558
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0146 0.1578
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0099 0.0168
Entamoeba histolytica hypothetical protein 0.0036 0.051 0.1929
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0193 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0193 0.0095
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0193 0.0285
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0193 0.0095
Toxoplasma gondii ABC1 family protein 0.0035 0.0477 0.4997
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0146 0.5
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0131 0.0176
Echinococcus multilocularis p2X purinoceptor 4 0.0137 0.2543 0.2468
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0477 0.0911
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Trichomonas vaginalis set domain proteins, putative 0.0251 0.4817 1
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.3904 0.6699
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.5907 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0477 0.0911
Brugia malayi isocitrate dehydrogenase 0.0016 0.0099 0.0123
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0638 0.0544
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0585 0.2311
Echinococcus granulosus cpg binding protein 0.0032 0.0422 0.0326
Entamoeba histolytica glycogen phosphorylase, putative 0.0115 0.2094 1
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0264 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0264 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.4207 0.7235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Echinococcus multilocularis p2X purinoceptor 4 0.0137 0.2543 0.2468
Loa Loa (eye worm) hypothetical protein 0.0021 0.0193 0.0332
Echinococcus granulosus expressed protein 0.0034 0.047 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Schistosoma mansoni hypothetical protein 0.0095 0.1688 0.1664
Schistosoma mansoni ap endonuclease 0.0018 0.0146 0.0118
Echinococcus granulosus Glycosyl transferase family 35 0.0115 0.2094 0.2015
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0131 0.0223
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0772 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0193 0.0095
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0454 0.4752
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0772 0.1307
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0193 0.0285
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0146 0.0568
Mycobacterium tuberculosis Conserved protein 0.0035 0.0477 0.0911
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.2804 0.2731
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0955 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Loa Loa (eye worm) hypothetical protein 0.0032 0.0424 0.073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0193 0.0285
Onchocerca volvulus Glycogen phosphorylase homolog 0.0115 0.2094 0.4111
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0477 0.0776
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0193 0.0285
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0585 0.1171
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0193 0.0332
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0585 0.0947
Schistosoma mansoni cpg binding protein 0.003 0.0387 0.036
Brugia malayi hypothetical protein 0.0032 0.0419 0.0676
Onchocerca volvulus 0.0032 0.0424 0.05
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0193 0.0165
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.2641 0.2568
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0477 0.0382
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0146 0.0203
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0477 0.0911
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0193 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0477 0.6041
Echinococcus multilocularis p2X purinoceptor 4 0.0137 0.2543 0.2468
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.051 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0193 0.0095
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0388 0.0291
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0193 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0131 0.0273
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0131 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0672 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0477 0.0764
Echinococcus multilocularis glycogen phosphorylase 0.0115 0.2094 0.2015
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.064 0.1083
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0131 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0193 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0477 0.0821
Echinococcus granulosus p2X purinoceptor 4 0.0137 0.2543 0.2468
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0638 0.0544
Loa Loa (eye worm) hypothetical protein 0.0021 0.0193 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0477 0.0764
Loa Loa (eye worm) hypothetical protein 0.0049 0.0772 0.1327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0193 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0193 0.0285
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0828 0.1361
Brugia malayi Latrophilin receptor protein 2 0.0095 0.1688 0.2868
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0193 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0193 0.0332
Brugia malayi ecdysteroid receptor 0.0021 0.0193 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0193 0.0285
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0477 0.0911
Loa Loa (eye worm) hypothetical protein 0.004 0.0585 0.1006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0672 0.1156
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0193 0.0095
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0131 0.0176
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0477 0.045
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0131 0.0176
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0477 0.0911
Trichomonas vaginalis glycogen phosphorylase, putative 0.0115 0.2094 0.4347
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0099 0.0121
Schistosoma mansoni rotamase 0.0034 0.047 0.0443
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0585 0.0558
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0146 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0585 0.099
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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