Detailed information for compound 678122

Basic information

Technical information
  • TDR Targets ID: 678122
  • Name: ZINC01150035
  • MW: 425.905 | Formula: C19H21ClFN3O3S
  • H donors: 0 H acceptors: 3 LogP: 2.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)N(S(=O)(=O)C)CC(=O)N1CCN(CC1)c1ccccc1F
  • InChi: 1S/C19H21ClFN3O3S/c1-28(26,27)24(16-8-6-15(20)7-9-16)14-19(25)23-12-10-22(11-13-23)18-5-3-2-4-17(18)21/h2-9H,10-14H2,1H3
  • InChiKey: BNCUCBZRKKIIGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0192 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1934 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1934 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0326 0.0947
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0134 0.0389
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1934 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.2535 0.4763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0785 0.2675
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0326 0.137
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0081 0.0056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0192 0.0651
Loa Loa (eye worm) hypothetical protein 0.0071 0.1378 0.2589
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0192 0.0651
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2374 0.6891
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0435 0.313
Toxoplasma gondii ABC1 family protein 0.0071 0.1378 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0134 0.0338
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0192 0.0469
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1378 0.1261
Leishmania major hypothetical protein, conserved 0.0071 0.1378 0.7018
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0004 0.0013
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0134 0.0943
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1378 0.7018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.3445 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0192 0.0651
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0573 0.1951
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1164 0.3378
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0004 0.0013
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1164 0.3378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0785 0.2675
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0211 0.0718
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0192 0.0558
Echinococcus granulosus bloom syndrome protein 0.0024 0.0326 0.0947
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0435 0.1261
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0192 0.0059
Trypanosoma brucei polo-like protein kinase 0.0096 0.1934 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0134 0.0389
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0785 0.1475
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0081 0.0056
Toxoplasma gondii exonuclease III APE 0.0018 0.0192 0.1367
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.3445 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.1927 0.5594
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1934 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.1378 0.1261
Schistosoma mansoni lipoxygenase 0.0115 0.2374 0.809
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0592 0.2797
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0192 0.0231
Loa Loa (eye worm) RecQ helicase 0.0024 0.0326 0.0613
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1934 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0134 0.0389
Onchocerca volvulus 0.0071 0.1378 0.7128
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1378 0.7018
Mycobacterium ulcerans hypothetical protein 0.0071 0.1378 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1378 0.2589
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1378 0.1261
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0592 0.4277
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0592 0.1718
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0592 0.0992
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0592 0.2797
Loa Loa (eye worm) hypothetical protein 0.0029 0.0435 0.0816
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1934 0.5612
Trichomonas vaginalis esterase, putative 0.0071 0.1378 0.7018
Schistosoma mansoni rab6-interacting 0.0019 0.0212 0.0724
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1934 0.5612
Loa Loa (eye worm) hypothetical protein 0.0019 0.0212 0.0399
Echinococcus granulosus RUN 0.0019 0.0212 0.0616
Echinococcus multilocularis RUN 0.0019 0.0212 0.0616
Brugia malayi Doublecortin family protein 0.0019 0.0212 0.0616
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0785 0.2279
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1164 0.8192
Onchocerca volvulus 0.0071 0.1378 0.7128
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1378 0.4
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0212 0.063
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0246 0.5324 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0592 0.2797
Schistosoma mansoni hypothetical protein 0.0029 0.0435 0.1481
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0212 0.0616
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1378 0.4697
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0081 0.0056
Brugia malayi hypothetical protein 0.0019 0.0212 0.0616
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0134 0.0943
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1378 0.2589
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1164 0.8192
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0212 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1934 0.6589
Schistosoma mansoni kinase 0.0049 0.0874 0.2977
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0081 0.002
Onchocerca volvulus 0.0019 0.0212 0.1098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0592 0.2797
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.1927 0.5594
Schistosoma mansoni polycystin 1-related 0.0019 0.0212 0.0724
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0081 0.0153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0785 0.2279
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0592 0.1718
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0212 0.0399
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0435 0.0816
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0192 0.0651
Schistosoma mansoni alpha glucosidase 0.0036 0.0592 0.2017
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0573 0.1662
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0081 0.0056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0592 0.2797
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1378 0.7018
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1378 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0134 0.0389
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1378 0.1261
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0326 0.137
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1934 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0592 0.2797
Schistosoma mansoni jumonji domain containing protein 0.0076 0.1486 0.5063
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0212 0.0616
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0592 0.2797
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0134 0.0389
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0785 0.2675
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0192 0.4368
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1934 0.3546
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0081 0.0056
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0134 0.0338
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0592 0.1112
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0592 0.1718
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1378 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0785 0.2279
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0081 0.0056
Schistosoma mansoni hypothetical protein 0.0019 0.0212 0.0724
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0692 0.2007
Schistosoma mansoni DNA helicase recq1 0.001 0.0004 0.0015
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0573 0.1662
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0081 0.0056
Trypanosoma brucei glucosidase, putative 0.0036 0.0592 0.2797
Schistosoma mansoni DNA helicase recq5 0.001 0.0004 0.0015
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0592 0.0992
Loa Loa (eye worm) hypothetical protein 0.0246 0.5324 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0192 0.0558
Onchocerca volvulus 0.0094 0.1899 0.9822
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0081 0.0236
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0081 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1934 1
Onchocerca volvulus 0.0071 0.1378 0.7128
Giardia lamblia Kinase, PLK 0.0096 0.1934 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.3445 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0192 0.0974
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0134 0.0252
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1378 0.7018
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0246 0.5324 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0326 0.0947
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0192 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1164 0.1044
Loa Loa (eye worm) hypothetical protein 0.0071 0.1378 0.2589
Plasmodium falciparum phd finger protein, putative 0.0029 0.0435 1
Schistosoma mansoni loxhd1 0.0019 0.0212 0.0724
Echinococcus granulosus peregrin 0.0029 0.0435 0.1261
Schistosoma mansoni ap endonuclease 0.0018 0.0192 0.0655
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0081 0.0056
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1378 0.1261
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1378 0.1261
Brugia malayi PHD-finger family protein 0.0029 0.0435 0.1261
Brugia malayi jmjC domain containing protein 0.0035 0.0573 0.1662
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1934 0.5612
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0212 0.4833
Loa Loa (eye worm) hypothetical protein 0.005 0.0903 0.1697
Schistosoma mansoni rab6-interacting 0.0019 0.0212 0.0724
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1934 0.3632
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0134 0.0389
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0081 0.0056
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1378 0.4
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1164 0.3966
Loa Loa (eye worm) hypothetical protein 0.0019 0.0212 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1934 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1934 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0081 0.0056
Giardia lamblia PHD finger protein 15 0.0029 0.0435 0.2229
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0134 0.0389
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0144 0.1018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1378 0.4697
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0192 0.0651
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0134 0.0456
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1378 0.1261
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0592 0.2797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0785 0.2279
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1934 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0592 0.2797
Brugia malayi beta-lactamase family protein 0.0071 0.1378 0.4
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0435 0.1261
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0192 0.0651
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2374 0.6891
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0573 0.1076
Mycobacterium ulcerans beta-lactamase 0.0071 0.1378 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0134 0.0338
Schistosoma mansoni lipoxygenase 0.008 0.1593 0.5429
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1378 0.4
Mycobacterium ulcerans lipase LipD 0.0071 0.1378 1
Schistosoma mansoni alpha-glucosidase 0.014 0.2935 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0212 0.0616
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0149 0.0119
Loa Loa (eye worm) beta-lactamase 0.0071 0.1378 0.2589
Mycobacterium tuberculosis Conserved protein 0.0071 0.1378 0.1261
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1133 0.2129
Mycobacterium leprae conserved hypothetical protein 0.0071 0.1378 0.5
Brugia malayi beta-lactamase family protein 0.0071 0.1378 0.4
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0081 0.0056
Loa Loa (eye worm) hypothetical protein 0.0071 0.1378 0.2589
Mycobacterium tuberculosis Conserved protein 0.0071 0.1378 0.1261
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1164 0.3966
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.00000000074955
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0081 0.0421
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1164 0.5867
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0134 0.0338
Schistosoma mansoni alpha-glucosidase 0.014 0.2935 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1378 0.2589
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.3445 1
Onchocerca volvulus Alhambra homolog 0.0029 0.0435 0.2247
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0435 0.1481
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0592 0.2797
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1934 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1164 0.8192
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.3445 0.6472
Loa Loa (eye worm) hypothetical protein 0.0071 0.1378 0.2589
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0192 0.0361
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0212 0.0616
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0435 0.2416
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0192 0.0558
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0134 0.0338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0785 0.2279
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0212 0.0616
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0592 0.2797
Brugia malayi beta-lactamase 0.0071 0.1378 0.4
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0845 0.4157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0134 0.0389
Echinococcus multilocularis peregrin 0.0029 0.0435 0.1261
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0573 0.1951
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0004 0.0013
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0004 0.0013
Echinococcus granulosus jumonji domain containing protein 0.004 0.0692 0.2007
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.026 0.5932
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1378 0.7018
Brugia malayi hypothetical protein 0.0019 0.0212 0.0616
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1378 0.7018
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1378 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1378 0.7018
Brugia malayi Bromodomain containing protein 0.0029 0.0435 0.1261
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0592 0.2797
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0004 0.0008
Brugia malayi jmjC domain containing protein 0.0095 0.1927 0.5594
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0134 0.3011
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1164 0.8439
Mycobacterium leprae Probable lipase LipE 0.0071 0.1378 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0845 0.4157
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0435 0.313
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1378 0.1261
Onchocerca volvulus 0.0019 0.0212 0.1098
Schistosoma mansoni ap endonuclease 0.0018 0.0192 0.0655
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1378 0.7018
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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