Detailed information for compound 678417

Basic information

Technical information
  • TDR Targets ID: 678417
  • Name: 1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(3-fluorop henyl)thiourea
  • MW: 334.408 | Formula: C17H19FN2O2S
  • H donors: 2 H acceptors: 0 LogP: 3.53 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCNC(=S)Nc2cccc(c2)F)ccc1OC
  • InChi: 1S/C17H19FN2O2S/c1-21-15-7-6-12(10-16(15)22-2)8-9-19-17(23)20-14-5-3-4-13(18)11-14/h3-7,10-11H,8-9H2,1-2H3,(H2,19,20,23)
  • InChiKey: QXFVILIZUNLNFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC04873164

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lamin 0.0027 0.007 0.007
Echinococcus granulosus tar DNA binding protein 0.0062 0.0315 0.0315
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0634 0.1278
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0198 0.1274 0.2709
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0094
Onchocerca volvulus 0.0094 0.0541 0.3083
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0133 0.0757
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1023 0.2108
Echinococcus granulosus acetylcholinesterase 0.0688 0.4723 0.4723
Echinococcus granulosus neuropeptide s receptor 0.0466 0.3156 0.3156
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0309 0.4003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.0495 0.0495
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0133 0.0159
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0116 0.0698 0.1485
Brugia malayi beta-lactamase family protein 0.0107 0.0634 0.1278
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0242 0.3761
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0086 0.0487 0.0965
Echinococcus multilocularis acetylcholinesterase 0.0688 0.4723 0.4723
Echinococcus multilocularis neuroligin 0.0116 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.0107 0.0634 0.1233
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0198 0.1274 0.2709
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0309 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0336
Mycobacterium tuberculosis Conserved protein 0.0107 0.0634 0.1349
Brugia malayi Pre-SET motif family protein 0.0218 0.1411 0.2936
Trypanosoma brucei glucosidase, putative 0.0036 0.0133 0.0774
Schistosoma mansoni lamin 0.0027 0.007 0.007
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0315 0.0315
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.007 0.0074
Plasmodium falciparum thioredoxin reductase 0.0087 0.0491 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0059 0.0336
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0133 0.021
Echinococcus granulosus dnaJ subfamily B 0.04 0.2695 0.2695
Schistosoma mansoni alpha-glucosidase 0.014 0.0864 0.0864
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0309 0.1753
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0086 0.0487 0.0487
Echinococcus granulosus acetylcholinesterase 0.0688 0.4723 0.4723
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0116 0.0698 0.0698
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0116 0.0698 0.3963
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0139 0.0139
Echinococcus multilocularis lamin dm0 0.0027 0.007 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.055 0.055
Echinococcus multilocularis acetylcholinesterase 0.0688 0.4723 0.4723
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0309 0.0309
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0091 1
Onchocerca volvulus 0.0116 0.0698 0.4086
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0242 0.3171
Loa Loa (eye worm) carboxylesterase 0.0116 0.0698 0.137
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0139 0.0881
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0133 0.0774
Brugia malayi Carboxylesterase family protein 0.0116 0.0698 0.1414
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0116 0.0698 0.0698
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.022 0.1429 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0139 0.079
Schistosoma mansoni hypothetical protein 0.0023 0.0042 0.0042
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0077 0.0039
Loa Loa (eye worm) hypoxia-induced factor 1 0.0304 0.2019 0.4202
Loa Loa (eye worm) hypothetical protein 0.0107 0.0634 0.1233
Onchocerca volvulus 0.0032 0.0103 0.028
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0198 0.1274 0.2709
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0091 0.0091
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0103 0.0103
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.0491 0.7356
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0139 0.139
Loa Loa (eye worm) hypothetical protein 0.0116 0.0698 0.137
Schistosoma mansoni cpg binding protein 0.003 0.0089 0.0089
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.0491 0.1044
Brugia malayi glutathione reductase 0.0087 0.0491 0.0972
Mycobacterium leprae Probable lipase LipE 0.0107 0.0634 0.4438
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.0698 0.0698
Brugia malayi PAS domain containing protein 0.0098 0.0571 0.1143
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0634 0.1349
Echinococcus multilocularis para nitrobenzyl esterase 0.0116 0.0698 0.0698
Onchocerca volvulus 0.0027 0.007 0.0068
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0139 0.0139
Brugia malayi TAR-binding protein 0.0062 0.0315 0.0597
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0139 1
Brugia malayi beta-lactamase family protein 0.0107 0.0634 0.1278
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.1532 0.3157
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0091 0.0519
Onchocerca volvulus 0.0116 0.0698 0.4086
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0304 0.0304
Trichomonas vaginalis glutaminase, putative 0.0267 0.1761 1
Brugia malayi Carboxylesterase family protein 0.0688 0.4723 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0091 0.0519
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0091 0.0519
Schistosoma mansoni hypothetical protein 0.0086 0.0487 0.0487
Trichomonas vaginalis esterase, putative 0.0107 0.0634 0.3602
Echinococcus granulosus single minded 2 0.0073 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0688 0.4723 1
Echinococcus granulosus para nitrobenzyl esterase 0.0116 0.0698 0.0698
Brugia malayi jmjC domain containing protein 0.006 0.0304 0.0573
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0315 0.0315
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0198 0.1274 0.2709
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.3156 0.3156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.055 0.055
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0292 0.0292
Onchocerca volvulus 0.0116 0.0698 0.4086
Echinococcus multilocularis transfer RNA-Lys 0.0073 0.0391 0.0391
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.055 0.055
Brugia malayi Carboxylesterase family protein 0.0688 0.4723 1
Brugia malayi hypothetical protein 0.033 0.2199 0.4615
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0133 0.0757
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0634 0.0634
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.055 0.055
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0634 0.0634
Onchocerca volvulus 0.0116 0.0698 0.4086
Onchocerca volvulus 0.0116 0.0698 0.4086
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0091 0.0559
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0103 0.0103
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0133 0.0757
Loa Loa (eye worm) beta-lactamase 0.0107 0.0634 0.1233
Loa Loa (eye worm) carboxylesterase 0.0116 0.0698 0.137
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0133 0.1289
Schistosoma mansoni BC026374 protein (S09 family) 0.0116 0.0698 0.0698
Schistosoma mansoni gliotactin 0.0116 0.0698 0.0698
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.033 0.2199 0.4587
Echinococcus granulosus lamin dm0 0.0027 0.007 0.007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0634 0.1349
Mycobacterium tuberculosis Conserved protein 0.0107 0.0634 0.1349
Brugia malayi glutaminase DH11.1 0.0267 0.1761 0.3682
Loa Loa (eye worm) hypothetical protein 0.0107 0.0634 0.1233
Mycobacterium ulcerans glutaminase 0.0267 0.1761 1
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0242 0.2767
Mycobacterium ulcerans hypothetical protein 0.0107 0.0634 0.3602
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0304 0.0524
Loa Loa (eye worm) hypothetical protein 0.0116 0.0698 0.137
Echinococcus granulosus intermediate filament protein 0.0027 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0027 0.007 0.0023
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0133 0.0757
Brugia malayi Carboxylesterase family protein 0.0116 0.0698 0.1414
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0116 0.0698 0.137
Toxoplasma gondii thioredoxin reductase 0.0087 0.0491 0.7356
Leishmania major trypanothione reductase 0.0087 0.0491 0.7504
Loa Loa (eye worm) acetylcholinesterase 1 0.0688 0.4723 1
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0634 0.3602
Schistosoma mansoni cpg binding protein 0.0028 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0086 0.0487 0.0487
Loa Loa (eye worm) apoptosis regulator protein 0.0086 0.0487 0.0918
Plasmodium falciparum glutathione reductase 0.0087 0.0491 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0103 0.0103
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.0491 0.7504
Mycobacterium ulcerans beta-lactamase 0.0107 0.0634 0.3602
Trypanosoma brucei trypanothione reductase 0.0087 0.0491 0.7356
Schistosoma mansoni glutaminase 0.0267 0.1761 0.1761
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0091 0.0559
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0133 0.0133
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0086 0.0487 0.0918
Echinococcus multilocularis dnaJ subfamily B 0.04 0.2695 0.2695
Schistosoma mansoni hypothetical protein 0.0086 0.0487 0.0487
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0139 0.139
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0634 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0116 0.0698 0.3963
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0091 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0116 0.0698 0.3963
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0634 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0139 0.139
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0091 0.0559
Loa Loa (eye worm) glutathione reductase 0.0087 0.0491 0.0925
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0309 0.4338
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0242 0.3171
Loa Loa (eye worm) intermediate filament protein 0.0027 0.007 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0103 0.0103
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0634 0.1349
Loa Loa (eye worm) hypothetical protein 0.0107 0.0634 0.1233
Brugia malayi hypoxia-induced factor 1 0.0304 0.2019 0.4232
Leishmania major hypothetical protein, conserved 0.0107 0.0634 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0091 0.0559
Echinococcus multilocularis geminin 0.0524 0.3564 0.3564
Onchocerca volvulus 0.0073 0.0391 0.2124
Schistosoma mansoni microtubule-associated protein tau 0.1438 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0315 0.0597
Mycobacterium ulcerans lipase LipD 0.0107 0.0634 0.3602
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0139 0.0139
Onchocerca volvulus 0.0028 0.0077 0.0115
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0139 0.0139
Echinococcus granulosus geminin 0.0524 0.3564 0.3564
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0139 0.0139
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0091 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0086 0.0487 0.0487
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0091 0.0519
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0634 0.0634
Onchocerca volvulus 0.0107 0.0634 0.3679
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0103 0.0103
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0634 0.1349
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0139 0.079
Echinococcus multilocularis cpg binding protein 0.003 0.0089 0.0089
Echinococcus multilocularis microtubule associated protein 2 0.1438 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1023 0.1023
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0304 0.0304
Brugia malayi RNA binding protein 0.0062 0.0315 0.0597
Brugia malayi Carboxylesterase family protein 0.0116 0.0698 0.1414
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0042 0.0042
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0001 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0242 0.2767
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0524 0.3564 0.3564
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0091 0.0559
Schistosoma mansoni acetylcholinesterase 0.0116 0.0698 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0336
Echinococcus multilocularis BC026374 protein (S09 family) 0.0116 0.0698 0.0698
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1411 0.2899
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0315 0.0315
Toxoplasma gondii ABC1 family protein 0.0107 0.0634 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0086 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0015
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0292 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.055 0.055
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0139 0.079
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0133 0.1289
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0309 0.0309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0091 0.0559
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0051 0.0242 0.0391
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0059 0.0336
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.3156 0.3156
Onchocerca volvulus 0.0248 0.1622 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0091 0.0559
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.0698 0.0698
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0091 0.0559
Treponema pallidum NADH oxidase 0.003 0.0091 1
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0634 0.3602
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0103 0.0214
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.3156 0.3156
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0634 1
Onchocerca volvulus 0.0107 0.0634 0.3679
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0315 0.0549
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0688 0.4723 0.4723
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0133 0.0757
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0133 0.0757
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.022 0.1429 0.304
Echinococcus multilocularis carboxylesterase 5A 0.0688 0.4723 0.4723
Echinococcus granulosus BC026374 protein S09 family 0.0116 0.0698 0.0698
Brugia malayi Carboxylesterase family protein 0.0116 0.0698 0.1414
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0042 0.0042
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0059 0.0336
Schistosoma mansoni neuroligin 3 (S09 family) 0.0116 0.0698 0.0698
Mycobacterium tuberculosis Probable oxidoreductase 0.022 0.1429 0.304
Brugia malayi jmjC domain containing protein 0.0059 0.0292 0.0549
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0139 0.0222
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0292 0.0292
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0086 0.0487 0.0487
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0091 0.012
Brugia malayi Pre-SET motif family protein 0.0032 0.0103 0.0145
Schistosoma mansoni apoptosis regulator bax 0.0086 0.0487 0.0487
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0103 0.0103
Brugia malayi beta-lactamase 0.0107 0.0634 0.1278
Echinococcus granulosus carboxylesterase 5A 0.0688 0.4723 0.4723
Schistosoma mansoni lamin 0.0027 0.007 0.007
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0116 0.0698 0.1485
Echinococcus multilocularis musashi 0.0027 0.007 0.007
Schistosoma mansoni aryl hydrocarbon receptor 0.0098 0.0571 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.055 0.055
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0315 0.0315
Echinococcus granulosus cpg binding protein 0.003 0.0089 0.0089
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0634 0.1349
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0139 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0133 0.1289
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.0059 0.0336
Echinococcus granulosus neuroligin 0.0116 0.0698 0.0698
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0634 0.1349
Onchocerca volvulus 0.0107 0.0634 0.3679
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0309 0.1753
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0634 0.3602
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0116 0.0698 0.137
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0091 0.0091
Mycobacterium tuberculosis Probable dehydrogenase 0.0198 0.1274 0.2709
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.0491 0.0925
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1023 0.1023
Loa Loa (eye worm) hypothetical protein 0.0107 0.0634 0.1233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0103 0.0103
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.0698 0.0698
Schistosoma mansoni single-minded 0.0098 0.0571 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0336
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0091 0.0559
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0139 0.0139
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0059 0.0336
Loa Loa (eye worm) hypothetical protein 0.0116 0.0698 0.137
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0198 0.1274 0.8912
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0309 0.1753
Schistosoma mansoni hypothetical protein 0.04 0.2695 0.2695
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0315 0.0549
Brugia malayi CXXC zinc finger family protein 0.0028 0.0077 0.009
Brugia malayi hypothetical protein 0.0051 0.0242 0.044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0634 0.1233
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0059 0.0059
Mycobacterium ulcerans putative regulatory protein 0.0073 0.0391 0.2221
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0059 0.0336
Brugia malayi bHLH-PAS transcription factor 0.0073 0.0391 0.0759
Loa Loa (eye worm) glutaminase 0.0267 0.1761 0.3649
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0139 1
Brugia malayi intermediate filament protein 0.0027 0.007 0.0074
Plasmodium vivax glutathione reductase, putative 0.0087 0.0491 0.7356
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0133 0.0757
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0133 0.0757
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1023 0.1023
Schistosoma mansoni alpha glucosidase 0.0036 0.0133 0.0133
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0634 0.4438
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0634 0.1349
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.022 0.1429 0.304
Loa Loa (eye worm) RNA binding protein 0.0062 0.0315 0.0549
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.055 0.1051
Loa Loa (eye worm) hypothetical protein 0.0688 0.4723 1
Schistosoma mansoni hypothetical protein 0.0524 0.3564 0.3564
Loa Loa (eye worm) carboxylesterase 0.0688 0.4723 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0315 0.0315
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0059 0.0059
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0091 0.0519
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0309 0.0309
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1023 0.2067
Mycobacterium leprae Possible regulatory protein 0.0026 0.0059 0.0415
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0634 0.3602
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0139 0.0139
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0091 0.0559
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.055 0.1097
Loa Loa (eye worm) hypothetical protein 0.0116 0.0698 0.137
Brugia malayi follicle stimulating hormone receptor 0.0235 0.1532 0.3192
Brugia malayi hypothetical protein 0.0033 0.0113 0.0167
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0133 0.0757
Brugia malayi Thioredoxin reductase 0.0087 0.0491 0.0972
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0685 0.4702 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0091 0.0559
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0059 0.0336
Echinococcus granulosus lamin 0.0027 0.007 0.007
Schistosoma mansoni intermediate filament proteins 0.0027 0.007 0.007
Brugia malayi hypothetical protein 0.0116 0.0698 0.1414
Loa Loa (eye worm) hypothetical protein 0.0116 0.0698 0.137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0091 0.0559
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0242 0.3761
Mycobacterium tuberculosis Carboxylesterase LipT 0.0116 0.0698 0.1485
Plasmodium vivax SET domain protein, putative 0.0032 0.0103 0.0214
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0171
Loa Loa (eye worm) hypothetical protein 0.0107 0.0634 0.1233
Mycobacterium tuberculosis Conserved protein 0.0107 0.0634 0.1349
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0309 0.0657
Schistosoma mansoni alpha-glucosidase 0.014 0.0864 0.0864
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0091 0.0194
Leishmania major hypothetical protein, conserved 0.0051 0.0242 0.3171
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0059 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0315 0.0315
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0634 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0634 0.3602
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0091 0.0091
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0133 0.0133
Schistosoma mansoni cpg binding protein 0.003 0.0089 0.0089
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0292 0.0292
Trichomonas vaginalis set domain proteins, putative 0.0248 0.1622 0.9212
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0086 0.0487 0.0487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.055 0.055
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0634 0.3602
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0091 0.0559
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0059 0.0059
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0059 0.0059
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0242 0.2767
Loa Loa (eye worm) glutaminase 2 0.0267 0.1761 0.3649
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0262 0.3146
Mycobacterium tuberculosis Probable reductase 0.0198 0.1274 0.2709
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0634 0.0634
Onchocerca volvulus 0.0027 0.007 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0634 0.3602

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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