Detailed information for compound 67844

Basic information

Technical information
  • TDR Targets ID: 67844
  • Name: 1-[(2-butoxy-4-tert-butylphenyl)methyl]-3-[[3 -fluoro-4-(methanesulfonamido)phenyl]methyl]t hiourea
  • MW: 495.673 | Formula: C24H34FN3O3S2
  • H donors: 2 H acceptors: 2 LogP: 5.35 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1cc(ccc1C/N=C(/NCc1ccc(c(c1)F)NS(=O)(=O)C)\S)C(C)(C)C
  • InChi: 1S/C24H34FN3O3S2/c1-6-7-12-31-22-14-19(24(2,3)4)10-9-18(22)16-27-23(32)26-15-17-8-11-21(20(25)13-17)28-33(5,29)30/h8-11,13-14,28H,6-7,12,15-16H2,1-5H3,(H2,26,27,32)
  • InChiKey: LSGKJQGQPNJQJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2-butoxy-4-tert-butyl-phenyl)methyl]-3-[[3-fluoro-4-(methanesulfonamido)phenyl]methyl]thiourea
  • 1-[(2-butoxy-4-tert-butyl-phenyl)methyl]-3-[[3-fluoro-4-(methylsulfonylamino)phenyl]methyl]thiourea
  • 1-(2-butoxy-4-tert-butyl-benzyl)-3-[3-fluoro-4-(methanesulfonamido)benzyl]thiourea
  • 1-[(2-butoxy-4-tert-butylphenyl)methyl]-3-[(3-fluoro-4-methanesulfonamidophenyl)methyl]thiourea
  • 1-[(2-butoxy-4-tert-butyl-phenyl)methyl]-3-[(3-fluoro-4-methanesulfonamido-phenyl)methyl]thiourea
  • 1-(2-butoxy-4-tert-butyl-benzyl)-3-(3-fluoro-4-methanesulfonamido-benzyl)thiourea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Vanilloid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hyperpolarization activated cyclic 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0004 0.0949 0.0949
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0004 0.0949 0.0949
Echinococcus multilocularis voltage dependent calcium channel 0.0004 0.0949 0.0949
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel protein 0.0004 0.0949 0.0949
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0004 0.0949 0.0949
Schistosoma mansoni transient receptor potential channel 0.0004 0.0949 0.0949
Echinococcus granulosus calcium activated potassium channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.1125 0.1125
Echinococcus granulosus TRP transient receptor potential channel 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0004 0.0949 0.0949
Brugia malayi Isocitrate dehydrogenase 0.0019 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus granulosus transient receptor potential cation channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0004 0.0949 0.0949
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 1 1
Leishmania major hypothetical protein, unknown function 0.0004 0.0949 0.0949
Echinococcus granulosus sodium leak channel non selective protein 0.0004 0.0949 0.0949
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0004 0.0949 0.0949
Brugia malayi ion channel NompC 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Loa Loa (eye worm) ion channel NompC 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Toxoplasma gondii isocitrate dehydrogenase 0.0019 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel protein 0.0004 0.0949 0.0949
Loa Loa (eye worm) voltage-dependent calcium channel 0.0004 0.0949 0.0949
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0004 0.0949 0.5
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0004 0.0949 0.0949
Echinococcus multilocularis hyperpolarization activated cyclic 0.0004 0.0949 0.0949
Echinococcus granulosus voltage dependent calcium channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0004 0.0949 0.0949
Echinococcus granulosus hypothetical protein 0.0004 0.0949 0.0949
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 1 0.5
Echinococcus granulosus voltage gated hydrogen channel 1 0.0004 0.0949 0.0949
Schistosoma mansoni hypothetical protein 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0004 0.0949 0.0949
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Loa Loa (eye worm) voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 1 1
Schistosoma mansoni transient receptor potential channel 4 0.0004 0.0949 0.0949
Brugia malayi voltage-dependent calcium channel 0.0004 0.0949 0.0949
Schistosoma mansoni transient receptor potential channel 0.0004 0.1125 0.1125
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0004 0.0949 0.0949
Brugia malayi Cyclic-nucleotide gated cation channel 0.0004 0.0949 0.0949
Schistosoma mansoni 60S ribosomal protein L21 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0004 0.0949 0.0949
Echinococcus granulosus short transient receptor potential channel 6 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-dependent calcium channel 0.0004 0.0949 0.0949
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0004 0.0949 0.0949
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0004 0.0949 0.0949
Echinococcus granulosus transient receptor potential cation channel 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0004 0.0949 0.0949
Echinococcus multilocularis two pore calcium channel protein 1 0.0004 0.0949 0.0949
Echinococcus granulosus voltage gated potassium channel 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus granulosus shaker cognate 0.0004 0.0949 0.0949
Echinococcus granulosus sodium channel protein 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0004 0.0949 0.0949
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0004 0.0949 0.0949
Echinococcus multilocularis sodium channel protein 0.0004 0.0949 0.0949
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 1 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0004 0.0949 0.0949
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0004 0.0949 0.0949
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0004 0.0949 0.0949
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0004 0.0949 0.0949
Brugia malayi cation channel family protein 0.0004 0.0949 0.0949
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel protein 0.0004 0.0949 0.0949
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 1 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0004 0.0949 0.0949
Onchocerca volvulus 0.0004 0.0949 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0004 0.0949 0.0949
Echinococcus multilocularis short transient receptor potential channel 6 0.0004 0.1125 0.1125
Echinococcus granulosus potassium large conductance calcium activated 0.0004 0.0949 0.0949
Echinococcus multilocularis two pore calcium channel protein 2 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Schistosoma mansoni vesicular amine transporter 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0004 0.0949 0.0949
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0004 0.0949 0.0949
Echinococcus multilocularis calcium activated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.1125 0.1125
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0004 0.0949 0.0949
Echinococcus multilocularis conserved hypothetical protein 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus granulosus transient receptor potential gamma protein 0.0004 0.0949 0.0949
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 1 1
Echinococcus granulosus voltage gated potassium channel 0.0004 0.0949 0.0949
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0004 0.0949 0.0949
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0004 0.0949 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus granulosus transient receptor potential cation channel 0.0004 0.0949 0.0949
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0004 0.0949 0.0949
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0019 1 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0004 0.0949 0.0949
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 1 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus granulosus ryanodine receptor 44f 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel protein 0.0004 0.0949 0.0949
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) voltage-gated calcium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.0949 0.0949
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0004 0.0949 0.0949
Echinococcus multilocularis sodium leak channel non selective protein 0.0004 0.0949 0.0949
Schistosoma mansoni calcium-activated potassium channel 0.0004 0.0949 0.0949
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0004 0.0949 0.0949
Loa Loa (eye worm) voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis ryanodine receptor 44f 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0004 0.0949 0.0949
Echinococcus granulosus hyperpolarization activated cyclic 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus granulosus two pore calcium channel protein 1 0.0004 0.0949 0.0949
Entamoeba histolytica tartrate dehydrogenase, putative 0.0002 0 0.5
Echinococcus granulosus voltage dependent calcium channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel protein 0.0004 0.0949 0.0949
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0002 0 0.5
Echinococcus multilocularis potassium large conductance calcium activated 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel protein 0.0004 0.0949 0.0949
Leishmania major hypothetical protein, conserved 0.0004 0.0949 0.0949
Brugia malayi Transient-receptor-potential like protein 0.0004 0.0949 0.0949
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0002 0 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0004 0.0949 0.0949
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) ryanodine receptor 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0004 0.0949 0.0949
Echinococcus multilocularis voltage dependent calcium channel 0.0004 0.0949 0.0949
Brugia malayi cation channel family protein 0.0004 0.0949 0.0949
Echinococcus multilocularis voltage gated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0004 0.0949 0.0949
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0004 0.0949 0.0949
Echinococcus multilocularis transient receptor potential gamma protein 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus granulosus short transient receptor potential channel 6 0.0004 0.1125 0.1125
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 1 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0004 0.0949 0.0949
Echinococcus multilocularis hyperpolarization activated cyclic 0.0004 0.0949 0.0949
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel protein 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Schistosoma mansoni ryanodine receptor related 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel protein 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus multilocularis shaker cognate 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0004 0.0949 0.0949
Loa Loa (eye worm) calcium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.1125 0.1125
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0004 0.0949 0.0949
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.0949 0.0949
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0004 0.0949 0.0949
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0004 0.0949 0.0949
Echinococcus multilocularis voltage gated potassium channel 0.0004 0.0949 0.0949
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0004 0.0949 0.5
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0004 0.0949 0.0949
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0004 0.0949 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0004 0.0949 0.0949
Schistosoma mansoni transient receptor potential channel 0.0004 0.0949 0.0949
Echinococcus multilocularis transfer RNA-Gly 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel protein 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated potassium channel 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0004 0.0949 0.0949
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0004 0.0949 0.0949
Schistosoma mansoni two-pore calcium channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0004 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated cation channel 0.0004 0.0949 0.0949
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0004 0.0949 0.0949
Schistosoma mansoni voltage-gated ion channel 0.0004 0.0949 0.0949
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0004 0.0949 0.0949
Echinococcus granulosus two pore calcium channel protein 2 0.0004 0.0949 0.0949
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.0949 0.0949
Brugia malayi olfactory channel protein osm-9 0.0004 0.1125 0.1125
Echinococcus granulosus transient receptor potential cation channel 0.0004 0.1125 0.1125
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 1 1
Brugia malayi hypothetical protein 0.0004 0.0949 0.0949
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0002 0 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 0 nM In vitro induction of 45 [Ca2+] influx in rat DRG neurons (ineffective at 30microM, partial activity) ChEMBL. 15026052
IC50 (functional) = 20 nM In vitro inhibitory concentration was determined against [45Ca2+]- influx in rat DRG neurons ChEMBL. 15026052
IC50 (functional) = 20 nM In vitro inhibitory concentration was determined against [45Ca2+]- influx in rat DRG neurons ChEMBL. 15026052

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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