Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.1639 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1639 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1639 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1639 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1639 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1639 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1639 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1639 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1639 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1639 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1639 | 1 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.06 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1639 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 500 uM | In vitro for antimalarial activity against chloroquine sensitive Plasmodium falciparum strain | ChEMBL. | 12067541 |
IC50 (functional) | > 500 uM | In vitro for antimalarial activity against chloroquine sensitive Plasmodium falciparum strain | ChEMBL. | 12067541 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.