Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cathepsin B | 0.162 | 0.3195 | 0.6901 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Echinococcus multilocularis | cathepsin L | 0.1148 | 0.1926 | 0.1805 |
Loa Loa (eye worm) | hypothetical protein | 0.1431 | 0.2689 | 0.2579 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0699 | 0.0716 | 0.0716 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0568 | 0.0363 | 0.0707 |
Plasmodium vivax | vivapain-2 | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.162 | 0.3195 | 0.3093 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.066 | 0.061 | 0.0469 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.0568 | 0.0363 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.4146 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.4146 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4146 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4146 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.2091 | 0.4466 | 0.4383 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0699 | 0.0716 | 0.0858 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Leishmania major | cathepsin L-like protease | 0.2591 | 0.5812 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.066 | 0.061 | 0.0469 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.1148 | 0.1926 | 0.4117 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.162 | 0.3195 | 0.3266 |
Onchocerca volvulus | Cathepsin F homolog | 0.2091 | 0.4466 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1431 | 0.2689 | 0.2579 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1431 | 0.2689 | 0.5883 |
Schistosoma mansoni | cathepsin C | 0.0488 | 0.0148 | 0.0148 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1148 | 0.1926 | 0.1805 |
Schistosoma mansoni | cathepsin B (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0988 | 0.1493 | 0.1365 |
Schistosoma mansoni | cathepsin S (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.162 | 0.3195 | 0.7056 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1148 | 0.1926 | 0.1926 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.061 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.2091 | 0.4466 | 0.4383 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Onchocerca volvulus | 0.1431 | 0.2689 | 0.5883 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2091 | 0.4466 | 0.4466 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.4146 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Echinococcus granulosus | cathepsin L | 0.1148 | 0.1926 | 0.1805 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2091 | 0.4466 | 0.4383 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2591 | 0.5812 | 0.5749 |
Brugia malayi | Cathepsin L-like precursor | 0.1431 | 0.2689 | 0.2579 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1431 | 0.2689 | 0.5883 |
Leishmania major | cathepsin L-like protease | 0.2591 | 0.5812 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.2091 | 0.4466 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1431 | 0.2689 | 0.2579 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2591 | 0.5812 | 0.5749 |
Plasmodium vivax | vivapain-3 | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4146 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.2091 | 0.4466 | 0.4383 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Echinococcus multilocularis | cathepsin b | 0.4146 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0699 | 0.0716 | 0.1314 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1431 | 0.2689 | 0.2579 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0699 | 0.0716 | 0.1314 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Echinococcus multilocularis | cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.2091 | 0.4466 | 0.4383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2091 | 0.4466 | 0.4466 |
Plasmodium vivax | unspecified product | 0.1148 | 0.1926 | 0.4117 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0568 | 0.0363 | 0.0707 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0716 | 0.0762 | 0.1421 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.4117 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.2591 | 0.5812 | 0.5749 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Echinococcus granulosus | cathepsin l1 | 0.2091 | 0.4466 | 0.4383 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Echinococcus granulosus | cysteine protease | 0.1148 | 0.1926 | 0.1805 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0716 | 0.0762 | 0.0623 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.066 | 0.061 | 0.0469 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.061 | 0.0469 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0716 | 0.0762 | 0.1421 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.0568 | 0.0363 | 0.0499 |
Schistosoma mansoni | subfamily C1A non-peptidase homologue (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Brugia malayi | Cathepsin L-like precursor | 0.066 | 0.061 | 0.0469 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0716 | 0.0762 | 0.0623 |
Echinococcus multilocularis | cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.4146 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Loa Loa (eye worm) | hypothetical protein | 0.1431 | 0.2689 | 0.2579 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1148 | 0.1926 | 0.1805 |
Giardia lamblia | Cathepsin B precursor | 0.162 | 0.3195 | 1 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0716 | 0.0762 | 0.0623 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Plasmodium vivax | vivapain-1 | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.162 | 0.3195 | 0.3195 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Toxoplasma gondii | cathepsin CPL | 0.2091 | 0.4466 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.2091 | 0.4466 | 0.4859 |
Loa Loa (eye worm) | ctsf protein | 0.2091 | 0.4466 | 0.4383 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1148 | 0.1926 | 0.1926 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0699 | 0.0716 | 0.1863 |
Onchocerca volvulus | Cathepsin L homolog | 0.2091 | 0.4466 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2091 | 0.4466 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.1805 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.066 | 0.061 | 0.0469 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Loa Loa (eye worm) | fibroinase | 0.2091 | 0.4466 | 0.4383 |
Echinococcus granulosus | cathepsin b | 0.4146 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.1148 | 0.1926 | 0.4117 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1148 | 0.1926 | 0.1926 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1931 | 0.4034 | 0.3944 |
Loa Loa (eye worm) | hypothetical protein | 0.1431 | 0.2689 | 0.2579 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2091 | 0.4466 | 0.4383 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.162 | 0.3195 | 0.3093 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0699 | 0.0716 | 0.1314 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.2091 | 0.4466 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.162 | 0.3195 | 1 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Plasmodium vivax | unspecified product | 0.066 | 0.061 | 0.1071 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Echinococcus granulosus | cathepsin b | 0.4146 | 1 | 1 |
Schistosoma mansoni | cathepsin s | 0.066 | 0.061 | 0.061 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Giardia lamblia | Cathepsin B precursor | 0.162 | 0.3195 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.1148 | 0.1926 | 0.1805 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.2091 | 0.4466 | 0.4383 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0716 | 0.0762 | 0.1421 |
Toxoplasma gondii | cathepsin CPC1 | 0.0699 | 0.0716 | 0.0858 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0699 | 0.0716 | 0.1314 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.1805 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0716 | 0.0762 | 0.1421 |
Loa Loa (eye worm) | cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.2091 | 0.4466 | 0.4383 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Plasmodium vivax | vivapain-2 | 0.2091 | 0.4466 | 1 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.2091 | 0.4466 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Giardia lamblia | Encystation-specific protease | 0.0568 | 0.0363 | 0.0707 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1431 | 0.2689 | 0.2579 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2091 | 0.4466 | 0.4383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0619 | 0.05 | 0.0816 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1431 | 0.2689 | 0.2689 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.1148 | 0.1926 | 0.1805 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.1148 | 0.1926 | 0.1805 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1148 | 0.1926 | 0.1805 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Leishmania major | cathepsin L-like protease | 0.2591 | 0.5812 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.061 | 0.0469 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.4117 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.066 | 0.061 | 0.0469 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0716 | 0.0762 | 0.2014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2591 | 0.5812 | 0.5749 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1431 | 0.2689 | 0.5883 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.4117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.38 ug ml-1 | Concentration required to inhibit the growth of L1210 leukemia cells | ChEMBL. | 2754697 |
ED50 (functional) | = 2.38 ug ml-1 | Concentration required to inhibit the growth of L1210 leukemia cells | ChEMBL. | 2754697 |
Survival (functional) | = 5 | Survivors of CDF1 mice on day 4 after 1st injection of compound 40 at mg/kg in seven mice; 5/7 | ChEMBL. | 2754697 |
Survival (functional) | = 7 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 20 mg/kg in seven mice; 7/7 | ChEMBL. | 2754697 |
Survival (functional) | = 7 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 10 mg/kg in seven mice; 7/7 | ChEMBL. | 2754697 |
Survival (functional) | = 7 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 5 mg/kg in seven mice; 7/7 | ChEMBL. | 2754697 |
Survival (functional) | = 7 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 2.5 mg/kg in seven mice; 7/7 | ChEMBL. | 2754697 |
Survival (functional) | = 7 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 1.25 mg/kg in seven mice; 7/7 | ChEMBL. | 2754697 |
T/C (functional) | = 80 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 40 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 80 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 40 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 170 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 1.25 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 170 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 1.25 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 180 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 2.5 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 180 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 2.5 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 200 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 5 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 200 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 5 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 300 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 20 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 300 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 10 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 300 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 20 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 300 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 10 mg/kg | ChEMBL. | 2754697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.