Detailed information for compound 678916

Basic information

Technical information
  • TDR Targets ID: 678916
  • Name: N-(5-chloro-2-hydroxyphenyl)-2-ethyl-1,3-diox oisoindole-5-carboxamide
  • MW: 344.749 | Formula: C17H13ClN2O4
  • H donors: 2 H acceptors: 4 LogP: 2.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1C(=O)c2c(C1=O)cc(cc2)C(=O)Nc1cc(Cl)ccc1O
  • InChi: 1S/C17H13ClN2O4/c1-2-20-16(23)11-5-3-9(7-12(11)17(20)24)15(22)19-13-8-10(18)4-6-14(13)21/h3-8,21H,2H2,1H3,(H,19,22)
  • InChiKey: SWMZORNQPRELAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-chloro-2-hydroxy-phenyl)-2-ethyl-1,3-dioxo-isoindoline-5-carboxamide
  • N-(5-chloro-2-hydroxyphenyl)-2-ethyl-1,3-dioxo-5-isoindolinecarboxamide
  • N-(5-chloro-2-hydroxy-phenyl)-2-ethyl-1,3-diketo-isoindoline-5-carboxamide
  • N-(5-chloro-2-hydroxy-phenyl)-2-ethyl-1,3-dioxo-isoindole-5-carboxamide
  • STK224301
  • ZINC00462720

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0024 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.1031 0.297
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2387 0.2387
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0602 0.5844
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.1031 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.1031 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.1031 1
Echinococcus multilocularis geminin 0.0169 1 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0662 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.1907
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2387 0.2387
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0 0.5
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.1031 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.1031 0.297
Toxoplasma gondii propionate-CoA ligase 0.0007 0 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.1031 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.1031 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.347 0.347
Echinococcus multilocularis tar DNA binding protein 0.0063 0.347 0.347
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.1031 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.1031 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.347 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.1031 0.297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0602 0.5844
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0602 0.5844
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2387 0.2387
Brugia malayi TAR-binding protein 0.0063 0.347 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.1031 0.297
Schistosoma mansoni tar DNA-binding protein 0.0063 0.347 0.347
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.1031 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.2387 0.6878
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.1031 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0602 0.5844
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.1907
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0662 0.6421
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.1031 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.1031 0.297
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.1031 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2387 0.2387
Brugia malayi RNA binding protein 0.0063 0.347 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.347 0.347
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.1907
Loa Loa (eye worm) hypothetical protein 0.0024 0.1031 0.297
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0662 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0 0.5
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0 0.5
Loa Loa (eye worm) TAR-binding protein 0.0063 0.347 1
Schistosoma mansoni hypothetical protein 0.0169 1 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.1907
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2387 0.2387
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.2387 0.6878
Mycobacterium ulcerans hypothetical protein 0.0024 0.1031 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.347 0.347
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2387 0.2387
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0 0.5
Loa Loa (eye worm) RNA binding protein 0.0063 0.347 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.347 0.347
Loa Loa (eye worm) hypothetical protein 0.0018 0.0662 0.1907
Schistosoma mansoni hypothetical protein 0.0169 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0662 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0662 0.6421
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.1031 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.347 0.347
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.1031 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.347 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2387 0.2387
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.1031 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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