Detailed information for compound 679787

Basic information

Technical information
  • TDR Targets ID: 679787
  • Name: N-[3-(8-methylimidazo[1,2-a]pyridin-2-yl)phen yl]-3-nitrobenzamide
  • MW: 372.377 | Formula: C21H16N4O3
  • H donors: 1 H acceptors: 4 LogP: 4.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)[N+](=O)[O-])Nc1cccc(c1)c1cn2c(n1)c(C)ccc2
  • InChi: 1S/C21H16N4O3/c1-14-5-4-10-24-13-19(23-20(14)24)15-6-2-8-17(11-15)22-21(26)16-7-3-9-18(12-16)25(27)28/h2-13H,1H3,(H,22,26)
  • InChiKey: KNPFRSQCROXMLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl]-3-nitro-benzamide
  • N-[3-(8-methyl-2-imidazo[1,2-a]pyridinyl)phenyl]-3-nitrobenzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni immunophilin 0.0436 0.5515 0.6372
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0172
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0119 0.0216
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.006 0.065 0.1179
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.017 0.0138
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.006 0.065 1
Onchocerca volvulus 0.006 0.065 1
Echinococcus multilocularis 0.006 0.065 0.065
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Loa Loa (eye worm) FKBP5 protein 0.0436 0.5515 1
Trichomonas vaginalis fk506-binding protein, putative 0.006 0.065 0.0984
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.006 0.065 0.0984
Leishmania major peptidylprolyl isomerase-like protein 0.0436 0.5515 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Leishmania major fk506-binding protein 1-like protein 0.0436 0.5515 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0436 0.5515 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.006 0.065 0.1024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.017 0.0138
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0172
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0436 0.5515 0.6372
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0095 0.0213
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0436 0.5515 0.6372
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0119 0.0139
Echinococcus granulosus microtubule associated protein 2 0.0679 0.8655 1
Onchocerca volvulus 0.006 0.065 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.006 0.065 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Mycobacterium ulcerans hypothetical protein 0.006 0.065 0.1024
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0308
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.006 0.065 0.5
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0436 0.5515 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0795 0.0918
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Onchocerca volvulus 0.0023 0.017 0.2612
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0119 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0119 0.0139
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0436 0.5515 1
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.006 0.065 0.0984
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.006 0.065 0.0984
Trichomonas vaginalis fk506-binding protein, putative 0.006 0.065 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.006 0.065 0.0984
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.006 0.065 0.0984
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.017 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0094
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0795 0.0918
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0172
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0436 0.5515 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0436 0.5515 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0436 0.5515 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0436 0.5515 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0376 0.4739 0.5475
Loa Loa (eye worm) hypothetical protein 0.006 0.065 0.1179
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.006 0.065 0.0984
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.006 0.065 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0119 0.0119
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0119 0.0045
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0119 0.0119
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0119 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0138
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0436 0.5515 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.017 0.0094
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0436 0.5515 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0491 0.0891
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.006 0.065 0.0984
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.006 0.065 0.1179
Loa Loa (eye worm) hypothetical protein 0.0376 0.4739 0.8592
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0436 0.5515 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.017 0.0094
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.017 0.1532
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.8655 0.8655
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0138
Echinococcus granulosus dna polymerase kappa 0.0019 0.0119 0.0138
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0308
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0795 0.0795
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0436 0.5515 1
Echinococcus granulosus tumor protein p63 0.0326 0.4093 0.4729
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0436 0.5515 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0119 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0138
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0308
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.006 0.065 0.5
Trypanosoma brucei hypothetical protein, conserved 0.006 0.065 0.1109
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0436 0.5515 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0119 0.064
Schistosoma mansoni hypothetical protein 0.006 0.065 0.0751
Trichomonas vaginalis immunophilin, putative 0.0436 0.5515 1
Trypanosoma brucei unspecified product 0.0019 0.0119 0.0139
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0119 0.0138
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.006 0.065 0.1179
Brugia malayi hypothetical protein 0.0071 0.0795 0.1441
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0172
Schistosoma mansoni DNA polymerase eta 0.0019 0.0119 0.0138
Schistosoma mansoni hypothetical protein 0.0071 0.0795 0.0918
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.006 0.065 0.1109
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.006 0.065 0.0751
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.8655 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0436 0.5515 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0436 0.5515 1
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.006 0.065 0.065
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0436 0.5515 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.006 0.065 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.006 0.065 0.0984
Trichomonas vaginalis conserved hypothetical protein 0.006 0.065 0.0984
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0376 0.4739 0.4739
Echinococcus granulosus dna polymerase eta 0.0019 0.0119 0.0138
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0119 0.064
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0436 0.5515 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.017 0.0138
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.006 0.065 0.0984
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.017 0.0094
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0436 0.5515 0.6372
Entamoeba histolytica hypothetical protein 0.0071 0.0795 0.1252
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0094
Echinococcus granulosus FK506 binding protein 2 0.006 0.065 0.0751
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0216
Schistosoma mansoni immunophilin 0.0436 0.5515 0.6372
Echinococcus multilocularis fk506 binding protein 0.0436 0.5515 0.5515
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0119 0.0139
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.006 0.065 0.0984
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0436 0.5515 0.5515
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0119 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.017 0.1532
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0119 0.0139
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0436 0.5515 1
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.006 0.065 0.1024
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.006 0.065 0.1109
Entamoeba histolytica hypothetical protein 0.0071 0.0795 0.1252
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0436 0.5515 1
Trichomonas vaginalis fk506-binding protein, putative 0.0436 0.5515 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.006 0.065 0.0984
Entamoeba histolytica hypothetical protein 0.0071 0.0795 0.1252
Schistosoma mansoni fk506 binding protein 0.006 0.065 0.0751
Trichomonas vaginalis fk506 binding protein, putative 0.006 0.065 0.0984
Entamoeba histolytica hypothetical protein 0.0071 0.0795 0.1252
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.006 0.065 0.1179
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.006 0.065 0.0984
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.006 0.065 0.5
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.006 0.065 0.1179
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.006 0.065 1
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.006 0.065 0.0984
Onchocerca volvulus 0.0048 0.0491 0.7558
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0119 0.0216
Schistosoma mansoni immunophilin 0.0376 0.4739 0.5475
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.006 0.065 0.5
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.006 0.065 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Echinococcus multilocularis tumor protein p63 0.0326 0.4093 0.4093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.006 0.065 0.1109
Giardia lamblia Hypothetical protein 0.006 0.065 0.0984
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0172
Mycobacterium ulcerans hypothetical protein 0.0023 0.017 0.0138
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0491 0.0568
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.006 0.065 0.1179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0119 0.0139
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0308
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0308

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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