Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1671 | 0.1671 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0411 | 0.0411 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.019 | 0.386 | 0.386 |
Echinococcus multilocularis | muscleblind protein | 0.0446 | 1 | 1 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0066 | 0.0875 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0411 | 0.1064 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.4244 | 0.4244 |
Schistosoma mansoni | jun-related protein | 0.0083 | 0.1279 | 0.3314 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.019 | 0.386 | 0.5 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.019 | 0.386 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0102 | 0.1738 | 0.1738 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0102 | 0.1738 | 0.1738 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0411 | 0.0411 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0411 | 0.0411 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.019 | 0.386 | 0.386 |
Brugia malayi | hypothetical protein | 0.008 | 0.1212 | 0.1212 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.019 | 0.386 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.4244 | 0.4244 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0063 | 0.0804 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0207 | 0.4267 | 0.5 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.019 | 0.386 | 0.386 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0124 | 0.2274 | 0.533 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0411 | 0.1064 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.019 | 0.386 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0102 | 0.1738 | 0.1738 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0411 | 0.1064 |
Echinococcus multilocularis | jun protein | 0.0102 | 0.1738 | 0.1738 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0207 | 0.4267 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.019 | 0.386 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0235 | 0.4929 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.019 | 0.386 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0446 | 1 | 1 |
Onchocerca volvulus | 0.008 | 0.1212 | 0.2459 | |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0207 | 0.4267 | 1 |
Onchocerca volvulus | 0.0235 | 0.4929 | 1 | |
Echinococcus multilocularis | muscleblind protein 1 | 0.0446 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0411 | 0.0411 |
Echinococcus granulosus | jun protein | 0.0102 | 0.1738 | 0.1738 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0207 | 0.4267 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.019 | 0.386 | 1 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.019 | 0.386 | 0.386 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.1279 | 0.3314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.