Detailed information for compound 679892

Basic information

Technical information
  • TDR Targets ID: 679892
  • Name: (5Z)-3-[(2-chlorophenyl)methyl]-5-[(4-hydroxy phenyl)methylidene]-1,3-thiazolidine-2,4-dion e
  • MW: 345.8 | Formula: C17H12ClNO3S
  • H donors: 1 H acceptors: 3 LogP: 4.14 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C=C1SC(=O)N(C1=O)Cc1ccccc1Cl
  • InChi: 1S/C17H12ClNO3S/c18-14-4-2-1-3-12(14)10-19-16(21)15(23-17(19)22)9-11-5-7-13(20)8-6-11/h1-9,20H,10H2/b15-9-
  • InChiKey: ZXAWSCKTCJUXIH-DHDCSXOGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(2-chlorophenyl)methyl]-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
  • (5Z)-3-[(2-chlorophenyl)methyl]-5-[(4-hydroxyphenyl)methylene]thiazolidine-2,4-dione
  • 3-[(2-chlorophenyl)methyl]-5-[(4-hydroxyphenyl)methylene]thiazolidine-2,4-dione
  • (5Z)-3-(2-chlorobenzyl)-5-(4-hydroxybenzylidene)thiazolidine-2,4-quinone
  • 3-(2-chlorobenzyl)-5-(4-hydroxybenzylidene)thiazolidine-2,4-quinone
  • ZINC01183538

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0197 0.3849 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0427 0.0427
Echinococcus multilocularis muscleblind protein 1 0.0463 1 1
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0214 0.4254 0.8691
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0427 0.1109
Echinococcus granulosus muscleblind protein 0.0463 1 1
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0214 0.4254 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.4189 0.4189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0427 0.0427
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0197 0.3849 0.3849
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.02 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0427 0.1109
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.02 0.02
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0068 0.0877 0.5
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.02 0.02
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0197 0.3849 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0197 0.3849 1
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0197 0.3849 0.3849
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0427 0.0427
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0197 0.3849 0.5
Echinococcus multilocularis muscleblind protein 0.0463 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0427 0.0427
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.02 0.02
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0214 0.4254 0.8691
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0063 0.0763 0.1541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0427 0.1109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0427 0.0427
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0197 0.3849 0.3849
Brugia malayi Pre-SET motif family protein 0.0212 0.4189 0.4189
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.02 0.0521
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.02 0.5
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0214 0.4254 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0065 0.0806 0.1661
Trichomonas vaginalis set domain proteins, putative 0.0241 0.4865 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0214 0.4254 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.02 0.0521
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0463 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.02
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0427 0.0427
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0214 0.4254 1
Loa Loa (eye worm) hypothetical protein 0.0463 1 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0197 0.3849 0.5
Onchocerca volvulus 0.0241 0.4865 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0129 0.227 0.5337
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.02 0.02
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0197 0.3849 1
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0214 0.4254 0.8691
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0197 0.3849 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.02 0.02
Brugia malayi glucose-6-phosphate dehydrogenase 0.0197 0.3849 0.3849

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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