Detailed information for compound 680375

Basic information

Technical information
  • TDR Targets ID: 680375
  • Name: propan-2-yl (Z)-3-furan-2-yl-2-[[(E)-3-phenyl prop-2-enoyl]amino]prop-2-enoate
  • MW: 325.358 | Formula: C19H19NO4
  • H donors: 1 H acceptors: 2 LogP: 3.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)C(=Cc1ccco1)NC(=O)C=Cc1ccccc1)C
  • InChi: 1S/C19H19NO4/c1-14(2)24-19(22)17(13-16-9-6-12-23-16)20-18(21)11-10-15-7-4-3-5-8-15/h3-14H,1-2H3,(H,20,21)/b11-10+,17-13-
  • InChiKey: VUHNLQXOFSCIEL-HNMBUVAWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • isopropyl (Z)-3-(2-furyl)-2-[[(E)-3-phenylprop-2-enoyl]amino]prop-2-enoate
  • (Z)-3-(2-furyl)-2-[[(E)-1-oxo-3-phenylprop-2-enyl]amino]prop-2-enoic acid isopropyl ester
  • (Z)-3-(2-furyl)-2-[[(E)-3-phenylacryloyl]amino]acrylic acid isopropyl ester
  • ZINC02996897

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.2241 0.6504
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0071
Schistosoma mansoni wnt related 0.0013 0.0024 0.000000000039276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0353 0.1026
Loa Loa (eye worm) hypothetical protein 0.0063 0.0619 0.1795
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0628 0.0713
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0128 0.1394 0.1617
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0089 0.0259
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.036
Schistosoma mansoni Smad4 0.0017 0.0069 0.0053
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0097 0.0085
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0619 0.1795
Loa Loa (eye worm) hypothetical protein 0.0035 0.0284 0.0824
Schistosoma mansoni tar DNA-binding protein 0.026 0.2962 0.3468
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.005 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0353 0.1026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0284 0.0306
Schistosoma mansoni hypothetical protein 0.0063 0.0619 0.0702
Brugia malayi hypothetical protein 0.0019 0.0097 0.028
Loa Loa (eye worm) CWN-2 protein 0.0013 0.0024 0.0071
Schistosoma mansoni hypothetical protein 0.0063 0.0619 0.0702
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Loa Loa (eye worm) hypothetical protein 0.02 0.2241 0.6504
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0097 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1001 0.1153
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0353 0.7582
Mycobacterium tuberculosis Conserved protein 0.0035 0.0284 0.0943
Echinococcus multilocularis GPCR, family 2 0.0063 0.0619 0.0596
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0284 0.0824
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0097 0.0085
Loa Loa (eye worm) Smad1 0.0017 0.0069 0.02
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0211 0.7407
Brugia malayi Isocitrate dehydrogenase 0.0015 0.005 0.0145
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0211 0.0611
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Onchocerca volvulus Alhambra homolog 0.0029 0.0211 0.3367
Brugia malayi hypothetical protein 0.0022 0.0124 0.036
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.005 0.0026
Echinococcus multilocularis tar DNA binding protein 0.026 0.2962 0.2945
Loa Loa (eye worm) hypothetical protein 0.0109 0.1164 0.3378
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0353 0.1026
Onchocerca volvulus 0.003 0.0226 0.3823
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0353 0.1026
Loa Loa (eye worm) wnt-4 protein 0.0013 0.0024 0.0071
Schistosoma mansoni nuclear receptor 0.0019 0.0097 0.0085
Schistosoma mansoni nuclear receptor 0.0019 0.0097 0.0085
Echinococcus granulosus geminin 0.0165 0.1828 0.213
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0284 0.5
Schistosoma mansoni hypothetical protein 0.0048 0.0435 0.0485
Onchocerca volvulus 0.0035 0.0284 0.5529
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0226 0.0656
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0353 0.1026
Echinococcus granulosus peregrin 0.0029 0.0211 0.022
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0097 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0353 0.033
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0284 0.0943
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0069 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0284 0.0307
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0069 0.0053
Schistosoma mansoni tar DNA-binding protein 0.026 0.2962 0.3468
Brugia malayi wnt family protein 0.0013 0.0024 0.0071
Brugia malayi steroid hormone receptor 0.0041 0.0353 0.1026
Brugia malayi Bromodomain containing protein 0.0029 0.0211 0.0611
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Brugia malayi nuclear receptor RXR 0.0022 0.0124 0.036
Brugia malayi nuclear receptor NHR-67 0.0019 0.0097 0.028
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.8494 0.849
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0069 0.0053
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.1026
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0097 0.0085
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0211 0.022
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0097 0.028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1001 0.2905
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.005 0.1724
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0124 0.0118
Brugia malayi jmjC domain containing protein 0.0095 0.0992 0.2879
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0284 0.0943
Onchocerca volvulus 0.0048 0.0435 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.1026
Brugia malayi nuclear hormone receptor 0.0019 0.0097 0.028
Schistosoma mansoni smad1 5 8 and 0.0017 0.0069 0.0053
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0353 0.0389
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.026 0.2962 0.8595
Entamoeba histolytica hypothetical protein 0.0035 0.0284 0.5
Schistosoma mansoni hypothetical protein 0.0029 0.0211 0.022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0284 0.0824
Toxoplasma gondii ABC1 family protein 0.0035 0.0284 0.4704
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1001 0.2905
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0284 0.0943
Brugia malayi PHD-finger family protein 0.0029 0.0211 0.0611
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0071
Schistosoma mansoni smad 0.0017 0.0069 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0353 0.0389
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0353 0.033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0165 0.1836 0.1816
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0284 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0097 0.0085
Echinococcus granulosus smad 0.0017 0.0069 0.0053
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2653 0.3103
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0353 0.0389
Onchocerca volvulus 0.0035 0.0284 0.5529
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1001 0.0979
Schistosoma mansoni cpg binding protein 0.003 0.0226 0.0238
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0097 0.028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Loa Loa (eye worm) hypothetical protein 0.0136 0.149 0.4325
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0211 0.0187
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0619 0.0596
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0283 0.0259
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0069 0.0052
Echinococcus multilocularis zinc finger transcription factor gli2 0.0301 0.3446 0.343
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0353 0.7582
Brugia malayi MH1 domain containing protein 0.0017 0.0069 0.02
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0619 0.0702
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0284 0.0824
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0619 0.0702
Entamoeba histolytica hypothetical protein 0.0035 0.0284 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.2241 0.6504
Schistosoma mansoni tar DNA-binding protein 0.026 0.2962 0.3468
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.005 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0353 0.1026
Brugia malayi nuclear receptor RXR 0.0019 0.0097 0.028
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.135 0.1329
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0353 0.1026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0097 0.028
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0284 0.0943
Brugia malayi Wnt-2 protein precursor 0.0013 0.0024 0.0071
Brugia malayi RNA binding protein 0.026 0.2962 0.8595
Echinococcus granulosus cpg binding protein 0.0032 0.0247 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0353 0.1026
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0097 0.028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0353 0.0389
Loa Loa (eye worm) hypothetical protein 0.0234 0.2653 0.7697
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0761 0.087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0619 0.0596
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0097 0.028
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0353 0.0389
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0353 0.0389
Mycobacterium ulcerans beta-lactamase 0.0035 0.0284 0.5
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0097 0.028
Loa Loa (eye worm) beta-lactamase 0.0035 0.0284 0.0824
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.1026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1001 0.1153
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0353 0.7582
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0353 0.0389
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.149 0.4325
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0097 0.0085
Schistosoma mansoni thyroid hormone receptor 0.0165 0.1836 0.2139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0353 0.033
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0097 0.0072
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0284 0.0306
Echinococcus granulosus dnaJ subfamily B 0.043 0.4978 0.5849
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.005 0.0026
Brugia malayi beta-lactamase 0.0035 0.0284 0.0824
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0353 0.0389
Brugia malayi hypothetical protein 0.0022 0.0124 0.036
Brugia malayi hypothetical protein 0.0019 0.0097 0.028
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0124 0.036
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0097 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0097 0.0072
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0124 0.036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0303 0.033
Loa Loa (eye worm) Wnt2 protein 0.0013 0.0024 0.0071
Brugia malayi hypothetical protein 0.0234 0.2653 0.7697
Schistosoma mansoni smad1 5 8 and 0.0017 0.0069 0.0053
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0284 0.5
Echinococcus granulosus zinc finger transcription factor gli2 0.0301 0.3446 0.404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0353 0.1026
Plasmodium falciparum phd finger protein, putative 0.0029 0.0211 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0992 0.097
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0353 0.0389
Echinococcus multilocularis peregrin 0.0029 0.0211 0.0187
Brugia malayi nuclear receptor NHR-88 0.0019 0.0097 0.028
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0069 0.0053
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0284 0.0943
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0576 0.1672
Brugia malayi wnt family protein 0.0013 0.0024 0.0071
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0284 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0097 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1001 0.1153
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0124 0.0118
Brugia malayi TAR-binding protein 0.026 0.2962 0.8595
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.2241 0.6504
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0353 0.0389
Brugia malayi nuclear receptor NHR-88 0.0041 0.0353 0.1026
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0284 0.5
Brugia malayi jmjC domain containing protein 0.0037 0.0303 0.088
Echinococcus multilocularis smad 0.0017 0.0069 0.0045
Brugia malayi Zinc finger, C2H2 type family protein 0.0301 0.3446 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0284 0.0824
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0124 0.01
Schistosoma mansoni cpg binding protein 0.0032 0.0247 0.0262
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0284 0.5
Echinococcus granulosus GPCR family 2 0.0063 0.0619 0.0702
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0284 0.0307
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.005 0.0145
Loa Loa (eye worm) RNA binding protein 0.026 0.2962 0.8595
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0992 0.1143
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0303 0.033
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.1026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0069 0.0045
Echinococcus granulosus Smad4 0.0017 0.0069 0.0053
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0211 0.323
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0353 0.1026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0353 0.1026
Brugia malayi MH1 domain containing protein 0.0017 0.0069 0.02
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0345 0.0322
Brugia malayi ecdysone receptor 0.0019 0.0097 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0284 0.0824
Brugia malayi Wnt-4 protein precursor 0.0013 0.0024 0.0071
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0211 0.022
Schistosoma mansoni coup transcription factor 0.0041 0.0353 0.0389
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0303 0.088
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2529 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0284 0.0943
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0124 0.0118
Schistosoma mansoni hypothetical protein 0.043 0.4978 0.5849
Mycobacterium ulcerans lipase LipD 0.0035 0.0284 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0353 0.1026
Entamoeba histolytica hypothetical protein 0.0035 0.0284 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0284 1
Brugia malayi MH2 domain containing protein 0.0017 0.0069 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0069 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0211 0.0611
Loa Loa (eye worm) hypothetical protein 0.0049 0.0456 0.1323
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0211 0.323
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0097 0.0072
Brugia malayi Steroid receptor seven-up type 2 0.0128 0.1394 0.4044
Brugia malayi tailless protein 0.0019 0.0097 0.028
Echinococcus granulosus tar DNA binding protein 0.026 0.2962 0.3468
Loa Loa (eye worm) zinc finger protein 0.0301 0.3446 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0097 0.028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.005 0.0026
Schistosoma mansoni survival motor neuron protein 0.0048 0.0435 0.0485
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1001 0.0979
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.005 0.003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0353 0.1026
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0097 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1001 0.1153
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0353 0.1026
Brugia malayi isocitrate dehydrogenase 0.0015 0.005 0.0145
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.1026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0284 0.026
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0353 0.033
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0284 0.0943
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0353 0.0389
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.8494 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0353 0.1026
Brugia malayi wnt family protein 0.0013 0.0024 0.0071
Echinococcus granulosus microtubule associated protein 2 0.0725 0.8494 1
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0353 0.0389
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.1026
Loa Loa (eye worm) DR-78 0.0019 0.0097 0.028
Schistosoma mansoni tar DNA-binding protein 0.026 0.2962 0.3468
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0284 0.026
Brugia malayi CXXC zinc finger family protein 0.003 0.0226 0.0656
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0353 0.033
Mycobacterium leprae Probable lipase LipE 0.0035 0.0284 0.5
Onchocerca volvulus 0.0041 0.0353 0.7582
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0284 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0353 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0353 0.1026
Leishmania major hypothetical protein, conserved 0.0035 0.0284 1
Brugia malayi beta-lactamase family protein 0.0035 0.0284 0.0824
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0284 0.0307
Brugia malayi RNA recognition motif domain containing protein 0.026 0.2962 0.8595
Schistosoma mansoni hypothetical protein 0.0035 0.0284 0.0306
Brugia malayi MH2 domain containing protein 0.0249 0.2826 0.8201
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0353 0.033
Schistosoma mansoni hypothetical protein 0.0165 0.1828 0.213
Loa Loa (eye worm) hypothetical protein 0.0035 0.0284 0.0824
Loa Loa (eye worm) TAR-binding protein 0.026 0.2962 0.8595
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0353 0.1026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.1026
Echinococcus multilocularis Smad4 0.0017 0.0069 0.0045
Brugia malayi Smad1 0.0017 0.0069 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1001 0.1153
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0071
Schistosoma mansoni hypothetical protein 0.0125 0.135 0.1565
Mycobacterium tuberculosis Conserved protein 0.0035 0.0284 0.0943
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0619 0.1795
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.028
Onchocerca volvulus 0.0035 0.0284 0.5529
Echinococcus multilocularis dnaJ subfamily B 0.043 0.4978 0.4966
Schistosoma mansoni hypothetical protein 0.0063 0.0619 0.0702
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0303 0.033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0284 0.0824
Giardia lamblia PHD finger protein 15 0.0029 0.0211 0.5
Mycobacterium ulcerans hypothetical protein 0.0035 0.0284 0.5
Echinococcus granulosus jumonji domain containing protein 0.004 0.0345 0.0379
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0097 0.0085
Schistosoma mansoni hypothetical protein 0.0165 0.1828 0.213
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0097 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0353 0.1026
Schistosoma mansoni zinc finger protein 0.0019 0.0097 0.0085
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0097 0.0072
Brugia malayi wnt family protein 0.0013 0.0024 0.0071
Brugia malayi hypothetical protein 0.0035 0.0284 0.0823
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.1026
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0097 0.028
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.005 0.2328
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.036
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0097 0.0072
Echinococcus multilocularis geminin 0.0165 0.1828 0.1808
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0547 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0128 0.1394 0.1373
Brugia malayi nuclear hormone receptor 0.0041 0.0353 0.1026
Schistosoma mansoni smad1 5 8 and 0.0017 0.0069 0.0053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0353 0.033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0353 0.0389
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.2826 0.8201
Loa Loa (eye worm) nuclear hormone receptor 0.0107 0.1137 0.3298
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0069 0.02
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0353 0.0389
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0353 0.1026
Brugia malayi MH2 domain containing protein 0.0017 0.0069 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0353 0.1026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0284 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.036
Entamoeba histolytica hypothetical protein 0.0035 0.0284 0.5
Schistosoma mansoni hypothetical protein 0.0136 0.149 0.1731
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0353 0.0389
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0284 1
Brugia malayi beta-lactamase family protein 0.0035 0.0284 0.0824
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.005 0.003
Schistosoma mansoni cpg binding protein 0.0032 0.0247 0.0262
Echinococcus multilocularis cpg binding protein 0.0032 0.0247 0.0223
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0435 0.1263
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0284 0.0943
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0353 0.1026
Schistosoma mansoni hypothetical protein 0.0063 0.0619 0.0702
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2653 0.2635
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.135 0.1565
Brugia malayi ecdysteroid receptor 0.0041 0.0353 0.1026
Schistosoma mansoni thyroid hormone receptor 0.0165 0.1836 0.2139
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0124 0.036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.036
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.2826 0.8201
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0353 0.0389
Schistosoma mansoni tar DNA-binding protein 0.026 0.2962 0.3468
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0353 0.0389
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0619 0.1795
Trichomonas vaginalis esterase, putative 0.0035 0.0284 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0353 0.1026
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0284 0.5
Brugia malayi conserved hypotetical protein 0.0019 0.0097 0.028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0353 0.1026

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.