Detailed information for compound 681846

Basic information

Technical information
  • TDR Targets ID: 681846
  • Name: N-[2-[[4-(4-methylphenyl)-3H-imidazol-2-yl]su lfanyl]ethyl]-3-(trifluoromethyl)benzamide
  • MW: 405.437 | Formula: C20H18F3N3OS
  • H donors: 2 H acceptors: 2 LogP: 4.61 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1c[nH]c(n1)SCCNC(=O)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C20H18F3N3OS/c1-13-5-7-14(8-6-13)17-12-25-19(26-17)28-10-9-24-18(27)15-3-2-4-16(11-15)20(21,22)23/h2-8,11-12H,9-10H2,1H3,(H,24,27)(H,25,26)
  • InChiKey: AMTOKDIRPGYNIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[[4-(4-methylphenyl)-3H-imidazol-2-yl]thio]ethyl]-3-(trifluoromethyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.147 0.2314
Onchocerca volvulus 0.0053 0.049 0.0452
Brugia malayi hypothetical protein 0.012 0.1403 0.1564
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0825 0.1296
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0039 0.0057
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0114 0.1317 0.2072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1047 0.1159
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0039 0.0003
Entamoeba histolytica hypothetical protein 0.0113 0.1299 1
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0825 0.1296
Brugia malayi Pre-SET motif family protein 0.0095 0.1054 0.1164
Loa Loa (eye worm) hypothetical protein 0.0037 0.0268 0.0266
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0714 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.1054 0.2049
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0268 0.3254
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0039 0.0057
Brugia malayi MAP kinase sur-1 0.0053 0.0491 0.0518
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0039 0.0057
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0318 0.0495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0039 0.0003
Loa Loa (eye worm) hypothetical protein 0.0069 0.0697 0.0758
Onchocerca volvulus 0.0474 0.6208 0.6193
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.1163 0.226
Loa Loa (eye worm) runx1 0.0059 0.0573 0.0615
Schistosoma mansoni lozenge 0.0059 0.0573 0.1113
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0313 0.0046
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0027 0.0052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0039 0.0077
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0039 0.0077
Echinococcus granulosus p2X purinoceptor 4 0.0156 0.1888 0.2973
Brugia malayi hypothetical protein 0.0474 0.6208 0.7076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0114 0.1317 0.2559
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1106 0.1223
Schistosoma mansoni P2X receptor subunit 0.0156 0.1888 0.3669
Loa Loa (eye worm) beta-lactamase 0.0037 0.0268 0.0266
Loa Loa (eye worm) hypothetical protein 0.0115 0.1327 0.148
Echinococcus granulosus lamin dm0 0.0027 0.0125 0.0192
Onchocerca volvulus 0.0037 0.0268 0.023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.2863 0.3241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.1327 0.2088
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0039 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0039 0.0003
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.0825 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0039 0.0057
Brugia malayi RNA recognition motif domain containing protein 0.0395 0.5146 0.5857
Plasmodium vivax SET domain protein, putative 0.0095 0.1054 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0825 0.5188
Loa Loa (eye worm) TAR-binding protein 0.0395 0.5146 0.5859
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0313 0.0046
Loa Loa (eye worm) hypothetical protein 0.0037 0.0268 0.0266
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0111 0.017
Echinococcus multilocularis Protein lozenge 0.0059 0.0573 0.0898
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0039 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0268 0.0522
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0039 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0268 0.0522
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5146 1
Echinococcus multilocularis lamin 0.0027 0.0125 0.0192
Loa Loa (eye worm) RNA binding protein 0.0395 0.5146 0.5859
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0003
Loa Loa (eye worm) hypothetical protein 0.0114 0.1317 0.1468
Schistosoma mansoni hypothetical protein 0.0115 0.1327 0.2579
Echinococcus multilocularis p2X purinoceptor 4 0.0156 0.1888 0.2973
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0313 0.0609
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0697 0.1355
Brugia malayi Bromodomain containing protein 0.0043 0.0354 0.0361
Onchocerca volvulus Huntingtin homolog 0.012 0.1403 0.1369
Brugia malayi beta-lactamase 0.0037 0.0268 0.0263
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0661 0.8758 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0313 0.0489
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.1163 0.226
Schistosoma mansoni inositol monophosphatase 0.0078 0.0825 0.1603
Schistosoma mansoni coup transcription factor 0.002 0.0039 0.0077
Loa Loa (eye worm) hypothetical protein 0.0037 0.0268 0.0266
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.2984 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0268 0.0418
Echinococcus multilocularis p2X purinoceptor 4 0.0156 0.1888 0.2973
Brugia malayi Bromodomain containing protein 0.0085 0.0919 0.1009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1047 0.1156
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0268 0.0266
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0491 0.5955
Brugia malayi follicle stimulating hormone receptor 0.0228 0.2863 0.3238
Brugia malayi jmjC domain containing protein 0.0058 0.0551 0.0587
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0825 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0125 0.0243
Schistosoma mansoni inositol monophosphatase 0.0078 0.0825 0.1603
Loa Loa (eye worm) hypothetical protein 0.0037 0.0268 0.0266
Schistosoma mansoni hypothetical protein 0.0115 0.1327 0.2579
Brugia malayi PHD-finger family protein 0.0028 0.0148 0.0124
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0313 0.3797
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.058 0.1128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1047 0.1647
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0039 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1299 0.2045
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.1327 0.2088
Schistosoma mansoni lamin 0.0027 0.0125 0.0243
Onchocerca volvulus 0.0099 0.1106 0.1071
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0003
Loa Loa (eye worm) hypothetical protein 0.012 0.1403 0.1567
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.1054 0.2049
Echinococcus multilocularis lamin dm0 0.0027 0.0125 0.0192
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0551 0.0864
Schistosoma mansoni hypothetical protein 0.0115 0.1327 0.2579
Schistosoma mansoni P2X receptor subunit 0.0156 0.1888 0.3669
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0039 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0491 0.0229
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0039 0.0077
Brugia malayi RNA binding protein 0.0395 0.5146 0.5857
Echinococcus granulosus zinc finger protein 0.0022 0.0066 0.0098
Loa Loa (eye worm) hypothetical protein 0.012 0.1403 0.1567
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0683 0.1073
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0825 0.0572
Schistosoma mansoni P2X receptor subunit 0.0156 0.1888 0.3669
Brugia malayi TAR-binding protein 0.0395 0.5146 0.5857
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0313 0.0489
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0551 0.0864
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5146 1
Loa Loa (eye worm) hypothetical protein 0.0483 0.6341 0.7229
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0313 0.0489
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0039 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0268 0.1689
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0313 0.0489
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0317
Schistosoma mansoni hypothetical protein 0.0248 0.314 0.6102
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0109 0.5
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0491 0.0769
Echinococcus multilocularis zinc finger protein 0.0022 0.0066 0.0098
Schistosoma mansoni hypothetical protein 0.0023 0.0082 0.016
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.058 0.0624
Schistosoma mansoni nuclear hormone receptor 0.002 0.0039 0.0077
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0125 0.0102
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1299 0.2045
Schistosoma mansoni hypothetical protein 0.0125 0.147 0.2857
Loa Loa (eye worm) hypothetical protein 0.0037 0.0268 0.0266
Echinococcus granulosus tumor protein p63 0.0364 0.4721 0.7444
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0313 0.3797
Brugia malayi intermediate filament protein 0.0027 0.0125 0.0098
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.1054 0.8971
Brugia malayi jmjC domain containing protein 0.006 0.058 0.062
Brugia malayi hypothetical protein 0.0113 0.1299 0.1445
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.1054 0.1658
Leishmania major hypothetical protein, conserved 0.0025 0.0109 0.1318
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0313 0.0489
Echinococcus granulosus lamin 0.0027 0.0125 0.0192
Echinococcus granulosus p2X purinoceptor 4 0.0156 0.1888 0.2973
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0697 0.044
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0039 0.0057
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.1163 0.226
Brugia malayi beta-lactamase family protein 0.0037 0.0268 0.0263
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.3086 0.3497
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0491 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0039 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0109 0.1318
Brugia malayi Latrophilin receptor protein 2 0.0115 0.1327 0.1477
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0491 0.0521
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0491 0.3628
Brugia malayi Melibiase family protein 0.0069 0.0697 0.0754
Echinococcus granulosus histone lysine methyltransferase setb 0.0114 0.1317 0.2072
Brugia malayi hypothetical protein 0.0025 0.0109 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0363 0.4703 0.5349
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0825 0.6793
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.1745 0.2748
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.6341 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0268 0.0418
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0039 0.0057
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.1163 0.1829
Echinococcus multilocularis musashi 0.0027 0.0125 0.0192
Entamoeba histolytica hypothetical protein 0.0113 0.1299 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0109 0.1318
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0082 0.0052
Toxoplasma gondii melibiase subfamily protein 0.0103 0.1163 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.1327 0.2088
Schistosoma mansoni P2X receptor subunit 0.0156 0.1888 0.3669
Onchocerca volvulus Huntingtin homolog 0.012 0.1403 0.1369
Toxoplasma gondii ABC1 family protein 0.0037 0.0268 0.1515
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0491 0.5955
Loa Loa (eye worm) hypothetical protein 0.0474 0.6208 0.7077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.1327 0.2088
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1299 0.2525
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0125 0.0098
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0551 0.0864
Brugia malayi beta-lactamase family protein 0.0037 0.0268 0.0263
Schistosoma mansoni thyroid hormone receptor 0.0146 0.1745 0.3391
Echinococcus granulosus p2X purinoceptor 4 0.0156 0.1888 0.2973
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.1007 0.1583
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0111 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0268 0.3254
Trypanosoma brucei protein kinase, putative 0.0053 0.0491 0.5955
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0039 0.0057
Echinococcus multilocularis tumor protein p63 0.0364 0.4721 0.7444
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0491 0.0229
Leishmania major hypothetical protein, conserved 0.0037 0.0268 0.3254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0039 0.0003
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.1163 0.1829
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0683 0.1073
Onchocerca volvulus 0.0027 0.0125 0.0086
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0491 0.0769
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0395 0.5146 0.5859
Schistosoma mansoni survival motor neuron protein 0.0099 0.1106 0.2149
Schistosoma mansoni bromodomain containing protein 0.0072 0.0738 0.1435
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0313 0.0489
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.058 0.091
Echinococcus multilocularis p2X purinoceptor 4 0.0156 0.1888 0.2973
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0039 0.0003
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0491 0.5955
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0039 0.0077
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.147 0.2314
Brugia malayi hypothetical protein 0.0483 0.6341 0.7228
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5146 1
Trichomonas vaginalis set domain proteins, putative 0.0752 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0109 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1047 0.2035
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0313 0.0046
Schistosoma mansoni lamin 0.0027 0.0125 0.0243
Echinococcus multilocularis tar DNA binding protein 0.0395 0.5146 0.8115
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0125 0.0102
Loa Loa (eye worm) hypothetical protein 0.0046 0.0392 0.0407
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0027 0.0052
Onchocerca volvulus 0.0095 0.1054 0.1019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0039 0.0057
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0825 0.0572
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0714 0.164
Echinococcus granulosus intermediate filament protein 0.0027 0.0125 0.0192
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0268 0.0266
Onchocerca volvulus 0.0027 0.0125 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0039 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1047 0.2035
Loa Loa (eye worm) hypothetical protein 0.008 0.0853 0.0936
Loa Loa (eye worm) hypothetical protein 0.0248 0.314 0.3559
Loa Loa (eye worm) inositol-1 0.0078 0.0825 0.0904
Echinococcus granulosus FTZ F1 alpha 0.002 0.0039 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5146 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0313 0.3797
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0825 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.1327 0.1477
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0039 0.0057
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.1327 0.148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1047 0.1647
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0111 0.017
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0039 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0491 0.0229
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1047 0.2035
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0491 0.5955
Brugia malayi MH2 domain containing protein 0.0244 0.3086 0.3495
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0039 0.0057
Schistosoma mansoni zinc finger protein 0.0022 0.0066 0.0128
Onchocerca volvulus 0.0037 0.0268 0.023
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.052
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0109 0.1318
Loa Loa (eye worm) hypothetical protein 0.0048 0.0421 0.0441
Loa Loa (eye worm) hypothetical protein 0.0363 0.4703 0.535
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.1163 0.1829
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.049 0.0952
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0491 0.5955
Echinococcus multilocularis GPCR, family 2 0.0115 0.1327 0.2088
Brugia malayi Inositol-1 0.0078 0.0825 0.0901
Brugia malayi Pre-SET motif family protein 0.0661 0.8758 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0491 0.5955
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0365
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0491 0.0769
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0491 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0039 0.0057
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0491 0.5955
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0039 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0825 1
Entamoeba histolytica hypothetical protein 0.0113 0.1299 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0039 0.0003
Schistosoma mansoni hypothetical protein 0.0115 0.1327 0.2579
Entamoeba histolytica hypothetical protein 0.0113 0.1299 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0363 0.4703 0.535
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0039 0.0057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0825 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0825 0.0572
Brugia malayi latrophilin 2 splice variant baaae 0.0248 0.314 0.3557
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0825 1
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.3086 0.3497
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1047 0.1647
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0268 0.0263
Schistosoma mansoni hypothetical protein 0.0113 0.1299 0.2525
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0083
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0491 0.0769
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.058 0.1128
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.1163 0.226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1047 0.1647
Schistosoma mansoni hypothetical protein 0.0099 0.1106 0.2149
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0039 0.0057
Echinococcus granulosus tar DNA binding protein 0.0395 0.5146 0.8115
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0027 0.0037
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0027 0.0037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0318 0.0495
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0313 0.3797
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0697 0.1355
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.6341 1
Onchocerca volvulus 0.0037 0.0268 0.023
Echinococcus granulosus GPCR family 2 0.0115 0.1327 0.2088
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0313 0.0609
Schistosoma mansoni thyroid hormone receptor 0.0146 0.1745 0.3391
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5146 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0268 0.3254
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0551 0.1071
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0313 0.0314
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0114 0.1317 0.2559
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0491 0.0955
Loa Loa (eye worm) hypothetical protein 0.0474 0.6208 0.7077
Brugia malayi Calcitonin receptor-like protein seb-1 0.0363 0.4703 0.5349

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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