Detailed information for compound 681876

Basic information

Technical information
  • TDR Targets ID: 681876
  • Name: (4-chlorophenyl)-[4-(6-morpholin-4-ylpyridazi n-3-yl)piperazin-1-yl]methanone
  • MW: 387.863 | Formula: C19H22ClN5O2
  • H donors: 0 H acceptors: 3 LogP: 1.94 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)N1CCN(CC1)c1ccc(nn1)N1CCOCC1
  • InChi: 1S/C19H22ClN5O2/c20-16-3-1-15(2-4-16)19(26)25-9-7-23(8-10-25)17-5-6-18(22-21-17)24-11-13-27-14-12-24/h1-6H,7-14H2
  • InChiKey: UMKWHBIQQGQDHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-chlorophenyl)-[4-(6-morpholinopyridazin-3-yl)piperazin-1-yl]methanone
  • (4-chlorophenyl)-[4-(6-morpholino-3-pyridazinyl)-1-piperazinyl]methanone
  • ZINC04583356

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0038 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0482 0.0454
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0104 0.1479
Echinococcus granulosus tumor protein p63 0.0361 0.4663 0.7378
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0306 0.0484
Loa Loa (eye worm) hypothetical protein 0.0115 0.1317 0.1468
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.632 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0038 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0001
Onchocerca volvulus 0.0095 0.1053 0.102
Schistosoma mansoni hypothetical protein 0.0134 0.1577 0.3081
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0306 0.0484
Echinococcus granulosus lamin dm0 0.0026 0.012 0.019
Onchocerca volvulus 0.0037 0.027 0.0233
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0144 0.1711 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.027 0.081
Plasmodium vivax glutathione reductase, putative 0.0057 0.0531 0.4902
Loa Loa (eye worm) calpain 0.0023 0.0075 0.0044
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0038 0.0059
Brugia malayi jmjC domain containing protein 0.0057 0.0541 0.0586
Loa Loa (eye worm) hypothetical protein 0.0119 0.1384 0.1545
Echinococcus granulosus calpain A 0.0023 0.0075 0.0118
Brugia malayi beta-lactamase family protein 0.0037 0.027 0.0276
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.3078 0.3487
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0038 0.0009
Brugia malayi RNA recognition motif domain containing protein 0.0395 0.5116 0.5828
Entamoeba histolytica hypothetical protein 0.0156 0.1883 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.027 0.3292
Schistosoma mansoni nuclear hormone receptor 0.002 0.0038 0.0073
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.1147 0.1814
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0821 0.0794
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0081 0.0863 0.1366
Onchocerca volvulus 0.0026 0.012 0.0083
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.2828 0.3201
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0482 0.5869
Brugia malayi hypothetical protein 0.0483 0.632 0.7208
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0268
Trypanosoma cruzi kinesin, putative 0.0023 0.0075 0.091
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0821 0.1298
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0482 0.5869
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.027 0.0268
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.027 0.0241
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.027 0.081
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.027 0.081
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0268
Schistosoma mansoni coup transcription factor 0.002 0.0038 0.0073
Echinococcus granulosus calpain 7 C02 family 0.0023 0.0075 0.0118
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0686 0.134
Loa Loa (eye worm) calpain family protein 1 0.0077 0.081 0.0887
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.1754 0.2774
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0029 0.0359
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1032 0.1632
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0029 0.0359
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0268
Mycobacterium tuberculosis Conserved protein 0.0037 0.027 0.081
Loa Loa (eye worm) hypothetical protein 0.0046 0.0394 0.0409
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0112 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0029 0.0359
Brugia malayi Calcitonin receptor-like protein seb-1 0.0422 0.5494 0.6261
Echinococcus multilocularis calpain 7 (C02 family) 0.0023 0.0075 0.0118
Loa Loa (eye worm) inositol-1 0.0078 0.0821 0.0899
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0023 0.0075 0.091
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0319 0.0505
Trypanosoma brucei calpain-like protein, putative 0.0023 0.0075 0.091
Brugia malayi hypothetical protein 0.0119 0.1384 0.1552
Echinococcus multilocularis GPCR, family 2 0.0134 0.1577 0.2494
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0687 0.1087
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.027 0.081
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5116 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0027 0.0043
Mycobacterium tuberculosis Conserved protein 0.0037 0.027 0.081
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.1147 0.1814
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0268
Toxoplasma gondii thioredoxin reductase 0.0057 0.0531 0.4493
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0029 0.0046
Onchocerca volvulus 0.0099 0.1101 0.1067
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0038 0.0001
Schistosoma mansoni hypothetical protein 0.0134 0.1577 0.3081
Schistosoma mansoni survival motor neuron protein 0.0099 0.1101 0.2151
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0541 0.0855
Leishmania major hypothetical protein, conserved 0.0037 0.027 0.3292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0038 0.0001
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.057 0.0902
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1101 0.1227
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0134 0.1577 0.2494
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0306 0.0484
Treponema pallidum NADH oxidase 0.002 0.0029 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0027 0.0053
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0306 0.0484
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.027 0.0528
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0156 0.1883 0.2979
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0029 0.0359
Echinococcus granulosus intermediate filament protein 0.0026 0.012 0.019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0129 0.1515 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.071 0.3053
Echinococcus granulosus zinc finger protein 0.0022 0.0066 0.0105
Loa Loa (eye worm) hypothetical protein 0.0478 0.6246 0.712
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0023 0.0075 0.091
Echinococcus multilocularis calpain family protein 1, d 0.0054 0.0498 0.0788
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0531 0.0841
Trypanosoma brucei calpain-like protein, putative 0.0023 0.0075 0.091
Mycobacterium tuberculosis Probable dehydrogenase 0.0129 0.1515 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0104 0.1264
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0038 0.0059
Entamoeba histolytica protein kinase, putative 0.0023 0.0081 0.0036
Echinococcus granulosus tar DNA binding protein 0.0395 0.5116 0.8095
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0541 0.0855
Schistosoma mansoni hypothetical protein 0.0289 0.3681 0.7194
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0129 0.1515 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0482 0.0762
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0038 0.0059
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0038 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0134 0.1577 0.1773
Onchocerca volvulus 0.0037 0.027 0.0233
Toxoplasma gondii ABC1 family protein 0.0037 0.027 0.2155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.1317 0.2574
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0038 0.0009
Loa Loa (eye worm) hypothetical protein 0.0077 0.081 0.0887
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5116 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0038 0.0009
Plasmodium vivax SET domain protein, putative 0.0095 0.1053 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0104 0.0725
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0531 0.0841
Schistosoma mansoni lozenge 0.006 0.0577 0.1127
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0306 0.3729
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0023 0.0075 0.091
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0306 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0482 0.0942
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0531 0.0567
Loa Loa (eye worm) hypothetical protein 0.0134 0.1577 0.1766
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0038 0.0073
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0104 0.0665
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0541 0.1057
Schistosoma mansoni bromodomain containing protein 0.0072 0.0742 0.1451
Brugia malayi hypothetical protein 0.0156 0.1883 0.2123
Echinococcus multilocularis lamin 0.0026 0.012 0.019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.1053 0.9165
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0482 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0038 0.0009
Echinococcus multilocularis tumor protein p63 0.0361 0.4663 0.7378
Trypanosoma brucei calpain-like protein, putative 0.0023 0.0075 0.091
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0038 0.0059
Schistosoma mansoni calpain-7 (C02 family) 0.0029 0.0158 0.0309
Brugia malayi follicle stimulating hormone receptor 0.0226 0.2828 0.3206
Plasmodium vivax hypothetical protein, conserved 0.0037 0.027 0.2351
Brugia malayi beta-lactamase 0.0037 0.027 0.0276
Onchocerca volvulus 0.0054 0.0498 0.0463
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0306 0.128
Schistosoma mansoni zinc finger protein 0.0022 0.0066 0.0129
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0115 0.1317 0.2084
Echinococcus multilocularis Protein lozenge 0.006 0.0577 0.0912
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0482 0.0762
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0481 0.0939
Loa Loa (eye worm) hypothetical protein 0.0025 0.0104 0.0077
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.0821 1
Schistosoma mansoni lamin 0.0026 0.012 0.0235
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0821 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.027 0.3042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0038 0.0001
Echinococcus granulosus calpain 0.0023 0.0075 0.0118
Echinococcus granulosus FTZ F1 alpha 0.002 0.0038 0.0059
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0038 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5116 1
Trypanosoma cruzi kinesin, putative 0.0023 0.0075 0.091
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.027 0.0241
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0038 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.0096
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0306 0.3729
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0092 0.1006 0.1591
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0038 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0755 1 1
Brugia malayi beta-lactamase family protein 0.0037 0.027 0.0276
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0029 0.0359
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0306 0.3729
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.012 0.0096
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0821 0.0794
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.0075 0.091
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0023 0.0075 0.091
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0038 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0144 0.1711 0.5657
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0112 0.0177
Loa Loa (eye worm) hypothetical protein 0.0026 0.0114 0.0088
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.057 0.1114
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1479 0.234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0029 0.0359
Schistosoma mansoni inositol monophosphatase 0.0078 0.0821 0.1604
Schistosoma mansoni hypothetical protein 0.0134 0.1577 0.3081
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0112 0.0219
Brugia malayi MH2 domain containing protein 0.0244 0.3078 0.3493
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.012 0.0104
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0541 0.0855
Leishmania major kinesin, putative 0.0023 0.0075 0.091
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0306 0.0277
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0038 0.0059
Brugia malayi hypothetical protein 0.0025 0.0104 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0038 0.0009
Echinococcus multilocularis lamin dm0 0.0026 0.012 0.019
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.0075 0.091
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0306 0.0277
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.027 0.3042
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0029 0.0359
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0306 0.0277
Mycobacterium tuberculosis Probable oxidoreductase 0.0144 0.1711 0.5657
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0422 0.5494 0.6258
Echinococcus granulosus calpain 5 0.0023 0.0075 0.0118
Schistosoma mansoni calpain (C02 family) 0.0023 0.0075 0.0146
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0029 0.0359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1032 0.1632
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0306 0.6116
Loa Loa (eye worm) hypothetical protein 0.0081 0.0857 0.0941
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0134 0.1577 0.2494
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1147 0.2241
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0023 0.0075 0.091
Schistosoma mansoni Mername-AA248 (C02 family) 0.0023 0.0075 0.0146
Loa Loa (eye worm) hypothetical protein 0.0289 0.3681 0.4179
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0029 0.0359
Entamoeba histolytica hypothetical protein 0.0156 0.1883 1
Echinococcus granulosus GPCR family 2 0.0134 0.1577 0.2494
Mycobacterium ulcerans hypothetical protein 0.0037 0.027 0.3042
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0104 0.1264
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.027 0.081
Schistosoma mansoni intermediate filament proteins 0.0026 0.012 0.0235
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0027 0.0043
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0821 0.1298
Echinococcus multilocularis hypothetical protein 0.0023 0.0075 0.0118
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0029 0.0359
Loa Loa (eye worm) glutathione reductase 0.0057 0.0531 0.0567
Loa Loa (eye worm) RNA binding protein 0.0395 0.5116 0.5825
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0129 0.1515 0.5
Trypanosoma brucei protein kinase, putative 0.0053 0.0482 0.5869
Schistosoma mansoni calpain-7 (C02 family) 0.0029 0.0158 0.0309
Trypanosoma brucei antigen, putative 0.0023 0.0075 0.091
Loa Loa (eye worm) beta-lactamase 0.0037 0.027 0.0268
Schistosoma mansoni hypothetical protein 0.0126 0.1479 0.2891
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0038 0.0009
Onchocerca volvulus Huntingtin homolog 0.0119 0.1384 0.1352
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0038 0.0059
Brugia malayi TAR-binding protein 0.0395 0.5116 0.5828
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0081 0.0863 0.1366
Leishmania major trypanothione reductase 0.0057 0.0531 0.6474
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0129 0.1515 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0156 0.1883 0.368
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0821 1
Schistosoma mansoni thyroid hormone receptor 0.0147 0.1754 0.3427
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0395 0.5116 0.5825
Mycobacterium ulcerans lipase LipD 0.0037 0.027 0.3042
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.027 0.0241
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.1053 0.1666
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5116 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1479 0.234
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0821 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0498 0.0529
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0038 0.0073
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.027 0.3042
Brugia malayi calpain family protein 1 0.0077 0.081 0.0894
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0023 0.0075 0.091
Brugia malayi jmjC domain containing protein 0.0059 0.057 0.0619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1032 0.1632
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1032 0.2017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0038 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1032 0.2017
Trypanosoma brucei calpain-like protein, putative 0.0023 0.0075 0.091
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0821 0.7083
Entamoeba histolytica hypothetical protein 0.0156 0.1883 1
Onchocerca volvulus 0.0037 0.027 0.0233
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.057 0.0612
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0038 0.0059
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0531 0.1689
Loa Loa (eye worm) hypothetical protein 0.0049 0.0423 0.0443
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0482 0.051
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.1147 0.1814
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0038 0.0001
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0023 0.0075 0.091
Loa Loa (eye worm) hypothetical protein 0.0044 0.0357 0.0367
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0319 0.0505
Echinococcus granulosus histone lysine methyltransferase setb 0.0115 0.1317 0.2084
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0038 0.0059
Brugia malayi PHD-finger family protein 0.0028 0.0149 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0038 0.0001
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0821 0.4127
Onchocerca volvulus 0.0053 0.0481 0.0445
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0023 0.0075 0.091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0038 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.027 0.0528
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0038 0.0073
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0029 0.0359
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0038 0.0073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.027 0.0427
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.027 0.0241
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.027 0.0427
Brugia malayi calpain 5 0.0023 0.0075 0.0052
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0083 0.0053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0156 0.1883 0.2979
Schistosoma mansoni hypothetical protein 0.0156 0.1883 0.368
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0081 0.0863 0.1687
Loa Loa (eye worm) hypothetical protein 0.0119 0.1384 0.1545
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0038 0.0059
Echinococcus granulosus calpain A 0.0081 0.0863 0.1366
Brugia malayi Pre-SET motif family protein 0.0095 0.1053 0.1173
Echinococcus multilocularis tar DNA binding protein 0.0395 0.5116 0.8095
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0144 0.1711 0.5657
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0104 0.1479
Brugia malayi calpain family protein 1 0.0077 0.081 0.0894
Onchocerca volvulus 0.0478 0.6246 0.6232
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0482 0.0762
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.3078 0.3487
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0821 0.0794
Echinococcus multilocularis calpain 0.0023 0.0075 0.0118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0134 0.1577 0.1773
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0104 0.1264
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0038 0.0001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.0075 0.091
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0077 0.081 0.1583
Schistosoma mansoni thyroid hormone receptor 0.0147 0.1754 0.3427
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0029 0.0359
Schistosoma mansoni hypothetical protein 0.0134 0.1577 0.3081
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.057 0.1114
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.027 0.3292
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0482 0.5869
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0687 0.1087
Mycobacterium tuberculosis Probable reductase 0.0129 0.1515 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0029 0.0359
Loa Loa (eye worm) hypothetical protein 0.0483 0.632 0.7206
Loa Loa (eye worm) hypothetical protein 0.0068 0.0686 0.0744
Loa Loa (eye worm) hypothetical protein 0.004 0.0306 0.0309
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0498 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0038 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0531 0.6474
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0038 0.0073
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0029 0.0046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.3002 1
Onchocerca volvulus 0.0026 0.012 0.0083
Echinococcus multilocularis calpain A 0.0081 0.0863 0.1366
Schistosoma mansoni lamin 0.0026 0.012 0.0235
Brugia malayi nuclear receptor NHR-88 0.002 0.0038 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.1053 0.2059
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1147 0.2241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0038 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0663 0.8757 1
Plasmodium vivax calpain, putative 0.0023 0.0075 0.0442
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0029 0.0359
Brugia malayi glutathione reductase 0.0057 0.0531 0.0575
Schistosoma mansoni tar DNA-binding protein 0.0395 0.5116 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.027 0.081
Schistosoma mansoni inositol monophosphatase 0.0078 0.0821 0.1604
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0482 0.4048
Brugia malayi Inositol-1 0.0078 0.0821 0.0907
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0509
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0306 0.3729
Schistosoma mansoni hypothetical protein 0.0099 0.1101 0.2151
Loa Loa (eye worm) hypothetical protein 0.0077 0.081 0.0887
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0029 0.0359
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0482 0.0762
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0482 0.0454
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0482 0.5869
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0422 0.5494 0.6261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0038 0.0001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0482 0.5869
Schistosoma mansoni calpain C (C02 family) 0.0023 0.0075 0.0146
Loa Loa (eye worm) TAR-binding protein 0.0395 0.5116 0.5825
Brugia malayi ecdysteroid receptor 0.002 0.0038 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.1317 0.2574
Trichomonas vaginalis esterase, putative 0.0037 0.027 0.0241
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0023 0.0075 0.091
Loa Loa (eye worm) hypothetical protein 0.0422 0.5494 0.6258
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0001
Brugia malayi hypothetical protein 0.0478 0.6246 0.7123
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0821 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0038 0.0009
Echinococcus multilocularis calpain 5 0.0023 0.0075 0.0118
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0134 0.1577 0.2494
Echinococcus multilocularis musashi 0.0026 0.012 0.019
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0038 0.0073
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0134 0.1577 0.2494
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.0075 0.091
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.1053 0.2059
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1147 0.2241
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0027 0.0053
Trypanosoma brucei trypanothione reductase 0.0057 0.0531 0.6474
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0038 0.0059
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0821 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0029 0.0359
Brugia malayi Bromodomain containing protein 0.0086 0.0924 0.1024
Brugia malayi Pre-SET motif family protein 0.0663 0.8757 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0482 0.5869
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1147 0.2241
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0038 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.027 0.0241
Plasmodium falciparum glutathione reductase 0.0057 0.0531 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.012 0.0096
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0686 0.0658
Loa Loa (eye worm) calpain 5 0.0023 0.0075 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0038 0.0059
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0306 0.0317
Toxoplasma gondii melibiase subfamily protein 0.0102 0.1147 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0038 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0289 0.3681 0.4183
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0686 0.134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0038 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0268
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0029 0.0359
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.027 0.3292
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0482 1
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0531 0.4902
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.632 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0482 0.0454
Brugia malayi Thioredoxin reductase 0.0057 0.0531 0.0575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1032 0.2017
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0306 0.0484
Onchocerca volvulus Huntingtin homolog 0.0119 0.1384 0.1352
Echinococcus granulosus lamin 0.0026 0.012 0.019
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0306 0.0598
Schistosoma mansoni hypothetical protein 0.0024 0.0083 0.0161
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.0075 0.091
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0038 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.027 0.0276
Brugia malayi steroid hormone receptor 0.002 0.0038 0.0009
Entamoeba histolytica hypothetical protein 0.0156 0.1883 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1032 0.1148
Brugia malayi Melibiase family protein 0.0068 0.0686 0.0752
Loa Loa (eye worm) hypothetical protein 0.0054 0.0498 0.0529
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0081 0.0863 0.1687
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0029 0.0058
Brugia malayi nuclear hormone receptor 0.002 0.0038 0.0009
Brugia malayi Bromodomain containing protein 0.0044 0.0356 0.0374
Brugia malayi MAP kinase sur-1 0.0053 0.0482 0.0518
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.027 0.081
Echinococcus multilocularis zinc finger protein 0.0022 0.0066 0.0105
Loa Loa (eye worm) hypothetical protein 0.0478 0.6246 0.712
Leishmania major hypothetical protein, conserved 0.0025 0.0104 0.1264
Brugia malayi RNA binding protein 0.0395 0.5116 0.5828
Trypanosoma brucei kinesin, putative 0.0023 0.0075 0.091
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0029 0.5
Plasmodium falciparum thioredoxin reductase 0.0057 0.0531 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0482 0.5869
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0129 0.1515 0.8643
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.071 0.229
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.027 0.081
Brugia malayi intermediate filament protein 0.0026 0.012 0.0104
Loa Loa (eye worm) runx1 0.006 0.0577 0.0619
Loa Loa (eye worm) latrophilin receptor protein 2 0.0134 0.1577 0.1766
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0038 0.0059
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0306 0.0598
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0038 0.0059
Brugia malayi calpain 7 0.0023 0.0075 0.0052
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1032 0.1141
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1032 0.1632
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0038 0.0073
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0023 0.0075 0.091

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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