Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome P450 reductase, putative | 0.0428 | 0.8793 | 0.8717 |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 0.5963 | 0.5963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0783 | 0.0783 |
Plasmodium vivax | oxidoreductase NAD-binding domain containing protein | 0.0055 | 0.0591 | 0.0591 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0367 | 0.0367 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0055 | 0.0591 | 0.0591 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0055 | 0.0591 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0367 | 0.0367 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0367 | 0.0367 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0055 | 0.0591 | 0.0591 |
Plasmodium vivax | ferredoxin--NADP reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Trypanosoma brucei | nitrate reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0482 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0783 | 0.0783 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0783 | 0.0783 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0482 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0482 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0783 | 0.0783 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0298 | 0.5939 | 0.5939 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0482 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0239 | 0.4652 | 0.4652 |
Plasmodium vivax | hypothetical protein, conserved | 0.0185 | 0.3445 | 0.3445 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0482 | 1 | 1 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0055 | 0.0591 | 0.5 |
Plasmodium falciparum | NADH-cytochrome b5 reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0055 | 0.0591 | 0.0591 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0367 | 0.0367 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0298 | 0.5939 | 0.5939 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0055 | 0.0591 | 0.0591 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0185 | 0.3445 | 0.3033 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0783 | 0.0783 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0482 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0185 | 0.3445 | 0.5 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0055 | 0.0591 | 0.0591 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Brugia malayi | diaphorase | 0.0055 | 0.0591 | 0.0591 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0055 | 0.0591 | 0.0591 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0482 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0367 | 0.0367 |
Echinococcus granulosus | methionine synthase reductase | 0.0298 | 0.5939 | 0.5939 |
Loa Loa (eye worm) | diaphorase | 0.0055 | 0.0591 | 0.0591 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0055 | 0.0591 | 0.5 |
Treponema pallidum | flavodoxin | 0.0185 | 0.3445 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0482 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0482 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0482 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0367 | 0.0367 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0482 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0482 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0482 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0298 | 0.5939 | 0.5939 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.5963 | 0.5963 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0185 | 0.3445 | 0.3445 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0185 | 0.3445 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0055 | 0.0591 | 0.5 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0185 | 0.3445 | 0.3445 |
Giardia lamblia | Hypothetical protein | 0.0428 | 0.8793 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0428 | 0.8793 | 1 |
Plasmodium falciparum | ferredoxin--NADP reductase | 0.0055 | 0.0591 | 0.0591 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0783 | 0.0783 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0055 | 0.0591 | 0.0591 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0185 | 0.3445 | 0.3445 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0783 | 0.0783 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0185 | 0.3445 | 0.3445 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0367 | 0.0367 |
Brugia malayi | flavodoxin family protein | 0.0185 | 0.3445 | 0.3445 |
Echinococcus multilocularis | methionine synthase reductase | 0.0298 | 0.5939 | 0.5939 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0055 | 0.0591 | 0.0591 |
Brugia malayi | FAD binding domain containing protein | 0.0482 | 1 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.1136 | 0.1136 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 0.5963 | 0.5963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0783 | 0.0783 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0428 | 0.8793 | 0.8793 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0239 | 0.4652 | 1 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0055 | 0.0591 | 0.0591 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0482 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0783 | 0.0783 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0055 | 0.0591 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0428 | 0.8793 | 0.8159 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0482 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0482 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0482 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0783 | 0.0783 |
Onchocerca volvulus | 0.0055 | 0.0591 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0783 | 0.0783 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0185 | 0.3445 | 0.5 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0055 | 0.0591 | 0.0591 |
Chlamydia trachomatis | sulfite reductase | 0.0298 | 0.5939 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0185 | 0.3445 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0299 | 0.5963 | 0.5963 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0055 | 0.0591 | 0.0591 |
Trypanosoma cruzi | p450 reductase, putative | 0.0482 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0482 | 1 | 1 |
Schistosoma mansoni | cytochrome B5 | 0.0055 | 0.0591 | 0.0591 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0055 | 0.0591 | 0.127 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0239 | 0.4652 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0185 | 0.3445 | 0.3033 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0055 | 0.0591 | 0.0591 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0783 | 0.0783 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 1 | 1 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0055 | 0.0591 | 0.127 |
Leishmania major | hypothetical protein, conserved | 0.0185 | 0.3445 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0185 | 0.3445 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0783 | 0.0783 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0482 | 1 | 1 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0055 | 0.0591 | 0.0591 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0185 | 0.3445 | 0.3033 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0243 | 0.4732 | 0.4732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.