TDR Targets

Basic information

Technical information

TDR Targets ID: 681981
Name: (4-ethoxyphenyl)-[4-(6-piperidin-1-ylpyridazi n-3-yl)piperazin-1-yl]methanone
MW: 395.498 | Formula: C22H29N5O2
H donors: 0 H acceptors: 3 LogP: 2.87 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)C(=O)N1CCN(CC1)c1ccc(nn1)N1CCCCC1
InChi: 1S/C22H29N5O2/c1-2-29-19-8-6-18(7-9-19)22(28)27-16-14-26(15-17-27)21-11-10-20(23-24-21)25-12-4-3-5-13-25/h6-11H,2-5,12-17H2,1H3
InChiKey: PZJZTECRFXXNTE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(4-ethoxyphenyl)-[4-[6-(1-piperidyl)pyridazin-3-yl]piperazin-1-yl]methanone
(4-ethoxyphenyl)-[4-[6-(1-piperidyl)-3-pyridazinyl]-1-piperazinyl]methanone
(4-ethoxyphenyl)-[4-(6-piperidinopyridazin-3-yl)piperazin-1-yl]methanone
ZINC04583251

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0076	0.0947	0.7178
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0092	0.1302	0.3434
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0092	0.1302	0.3434
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.3627	1
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0092	0.1302	1
Giardia lamblia	Hypothetical protein	0.0082	0.1071	0.5
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0092	0.1302	1
Brugia malayi	FAD binding domain containing protein	0.0092	0.1302	0.2625
Loa Loa (eye worm)	RNA binding protein	0.0197	0.3627	0.7485
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0086	0.0319
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0092	0.1302	0.3434
Loa Loa (eye worm)	beta-lactamase	0.0076	0.0947	0.1884
Mycobacterium ulcerans	beta-lactamase	0.0076	0.0947	0.7085
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0947	0.7178
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0076	0.0947	0.0947
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.0947	0.7178
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0947	0.1884
Loa Loa (eye worm)	TAR-binding protein	0.0197	0.3627	0.7485
Brugia malayi	TAR-binding protein	0.0197	0.3627	0.7485
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0947	0.0947
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0092	0.1302	0.2625
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0086	1
Leishmania major	cytochrome P450 reductase, putative	0.0082	0.1071	0.8159
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0947	0.1884
Loa Loa (eye worm)	transcription factor SMAD2	0.0252	0.4831	1
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.3627	1
Mycobacterium tuberculosis	Probable hydrolase	0.0076	0.0947	0.0947
Brugia malayi	beta-lactamase family protein	0.0076	0.0947	0.1884
Mycobacterium ulcerans	hypothetical protein	0.0076	0.0947	0.7085
Trypanosoma cruzi	p450 reductase, putative	0.0092	0.1302	1
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0947	0.0947
Mycobacterium ulcerans	esterase/lipase LipP	0.0076	0.0947	0.7085
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0057	0.0524	0.0999
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0086	0.0319
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.3627	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0076	0.0947	0.1884
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0092	0.1302	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0086	0.0319
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.3627	1
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0092	0.1302	1
Schistosoma mansoni	cytochrome P450 reductase	0.0092	0.1302	0.3434
Trichomonas vaginalis	sulfite reductase, putative	0.0092	0.1302	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0947	0.1884
Echinococcus multilocularis	tar DNA binding protein	0.0197	0.3627	1
Mycobacterium leprae	conserved hypothetical protein	0.0076	0.0947	1
Toxoplasma gondii	ABC1 family protein	0.0076	0.0947	1
Plasmodium vivax	hypothetical protein, conserved	0.0076	0.0947	0.7178
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0947	0.7178
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0947	0.7178
Onchocerca volvulus		0.0076	0.0947	0.5
Brugia malayi	MH2 domain containing protein	0.0252	0.4831	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0076	0.0947	0.1884
Echinococcus granulosus	tar DNA binding protein	0.0197	0.3627	1
Brugia malayi	RNA binding protein	0.0197	0.3627	0.7485
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0046	0.0292	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0947	0.1884
Loa Loa (eye worm)	inositol-1	0.0037	0.0086	0.0084
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.0947	0.2433
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0057	0.0524	0.1237
Mycobacterium tuberculosis	Probable esterase LipL	0.0076	0.0947	0.0947
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.0947	0.2433
Mycobacterium tuberculosis	Probable lipase LipE	0.0076	0.0947	0.0947
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0092	0.1302	1
Brugia malayi	flavodoxin family protein	0.0092	0.1302	0.2625
Toxoplasma gondii	flavodoxin domain-containing protein	0.0046	0.0277	0.222
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0092	0.1302	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0947	0.7178
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0086	0.0319
Plasmodium falciparum	nitric oxide synthase, putative	0.0092	0.1302	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0086	0.0319
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0092	0.1302	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0947	0.1884
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0947	0.0947
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0086	0.0319
Brugia malayi	FAD binding domain containing protein	0.0057	0.0524	0.0999
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0092	0.1302	1
Brugia malayi	Inositol-1	0.0037	0.0086	0.0084
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0086	0.0319
Trichomonas vaginalis	esterase, putative	0.0076	0.0947	0.7178
Plasmodium vivax	flavodoxin domain containing protein	0.0082	0.1071	0.8159
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0947	0.7178
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1302	0.2625
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.0947	0.7178
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0076	0.0947	0.7085
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0092	0.1302	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0252	0.4831	1
Brugia malayi	beta-lactamase	0.0076	0.0947	0.1884
Schistosoma mansoni	diflavin oxidoreductase	0.0046	0.0277	0.054
Toxoplasma gondii	flavodoxin domain-containing protein	0.0046	0.0277	0.222
Echinococcus granulosus	methionine synthase reductase	0.0057	0.0524	0.1237
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0076	0.0947	0.2433
Leishmania major	p450 reductase, putative	0.0092	0.1302	1
Giardia lamblia	Nitric oxide synthase, inducible	0.0082	0.1071	0.5
Brugia malayi	beta-lactamase family protein	0.0076	0.0947	0.1884
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0076	0.0947	0.0947
Chlamydia trachomatis	sulfite reductase	0.0057	0.0524	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0076	0.0947	0.2433
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0076	0.0947	0.0947
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0082	0.1071	0.8159
Mycobacterium tuberculosis	Probable lipase LipD	0.0076	0.0947	0.0947
Onchocerca volvulus		0.0076	0.0947	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.3627	1
Brugia malayi	RNA recognition motif domain containing protein	0.0197	0.3627	0.7485
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.0947	0.7178
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0092	0.1302	1
Treponema pallidum	flavodoxin	0.0035	0.0046	0.5
Onchocerca volvulus		0.0076	0.0947	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0197	0.3627	0.7485
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0086	0.5
Echinococcus multilocularis	methionine synthase reductase	0.0057	0.0524	0.1237
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0092	0.1302	0.3434
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0947	0.1884
Mycobacterium leprae	Probable lipase LipE	0.0076	0.0947	1
Mycobacterium ulcerans	lipase LipD	0.0076	0.0947	0.7085

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 681981