Detailed information for compound 682140

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.918 | Formula: C21H28ClN3O3
  • H donors: 2 H acceptors: 3 LogP: 1.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)C(c1c(O)cc(n(c1=O)CC)C)c1ccccc1Cl
  • InChi: 1S/C21H28ClN3O3/c1-3-25-15(2)14-18(27)19(21(25)28)20(16-6-4-5-7-17(16)22)24-10-8-23(9-11-24)12-13-26/h4-7,14,20,26-27H,3,8-13H2,1-2H3
  • InChiKey: RWTHUBBZVZBEJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha-glucosidase 0.0138 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0126
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0344 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0015 0.0015
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0057
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0121 0.0814 0.3151
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0057
Brugia malayi Cytochrome P450 family protein 0.0045 0.0266 0.1029
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0062 0.0386 0.1269
Loa Loa (eye worm) hypothetical protein 0.0035 0.0196 0.0761
Onchocerca volvulus 0.0062 0.0386 0.4648
Brugia malayi beta-lactamase family protein 0.0035 0.0196 0.0761
Echinococcus multilocularis cpg binding protein 0.0031 0.0165 0.0165
Schistosoma mansoni cpg binding protein 0.0031 0.0165 0.0165
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0062 0.0386 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0057
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0015 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0196 0.0196
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0062 0.0386 0.0386
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0015 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0198 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1103 0.1103
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0121 0.0814 0.3151
Trichomonas vaginalis spcc417.12 protein, putative 0.0062 0.0386 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0057
Brugia malayi Carboxylesterase family protein 0.0062 0.0386 0.1495
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0015 0.0015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0353 0.1222
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.008 0.008
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.3391 0.3391
Loa Loa (eye worm) beta-lactamase 0.0035 0.0196 0.0761
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0015 0.0057
Onchocerca volvulus 0.0062 0.0386 0.4648
Onchocerca volvulus 0.0062 0.0386 0.4648
Schistosoma mansoni hypothetical protein 0.042 0.2983 0.2983
Onchocerca volvulus 0.0028 0.014 0.1569
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.008 0.008
Echinococcus granulosus neuroligin 0.0062 0.0386 0.0386
Mycobacterium ulcerans bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.0242 0.1691 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0196 0.0196
Schistosoma mansoni lipoxygenase 0.0019 0.008 0.008
Brugia malayi ecdysteroid receptor 0.001 0.0015 0.0057
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0198 0.4619
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0062 0.0386 0.1495
Loa Loa (eye worm) doublecortin family protein 0.0019 0.008 0.0311
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0196 1
Schistosoma mansoni lamin 0.0028 0.014 0.014
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0326 0.126
Echinococcus granulosus acetylcholinesterase 0.0365 0.2584 0.2584
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0196 0.0761
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0353 0.0353
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0015 0.0057
Schistosoma mansoni hypothetical protein 0.0019 0.008 0.008
Mycobacterium ulcerans beta-lactamase 0.0035 0.0196 0.0192
Loa Loa (eye worm) hypothetical protein 0.0365 0.2584 1
Echinococcus granulosus dnaJ subfamily B 0.042 0.2983 0.2983
Loa Loa (eye worm) hypothetical protein 0.0062 0.0386 0.1495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0057
Onchocerca volvulus 0.0035 0.0196 0.2275
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0015
Echinococcus multilocularis BC026374 protein (S09 family) 0.0062 0.0386 0.0386
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0196 0.9935
Echinococcus granulosus RUN 0.0019 0.008 0.008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0015 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0196 0.4589
Brugia malayi beta-lactamase family protein 0.0035 0.0196 0.0761
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0266 0.0266
Echinococcus multilocularis lamin 0.0028 0.014 0.014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0057
Loa Loa (eye worm) carboxylesterase 0.0365 0.2584 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0057
Echinococcus multilocularis microtubule associated protein 2 0.1389 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0198 1
Echinococcus multilocularis acetylcholinesterase 0.0365 0.2584 0.2584
Echinococcus granulosus lamin 0.0028 0.014 0.014
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0015 0.0015
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0198 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1103 0.4267
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0198 0.4619
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0266 0.103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0015
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0015 0.0015
Schistosoma mansoni loxhd1 0.0019 0.008 0.008
Schistosoma mansoni aspartate carbamoyltransferase 0.0031 0.0167 0.0167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0266 0.0266
Echinococcus granulosus para nitrobenzyl esterase 0.0062 0.0386 0.0386
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0015
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0062 0.0386 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0196 0.9935
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0057
Brugia malayi follicle stimulating hormone receptor 0.0231 0.1611 0.6234
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.014 0.0542
Onchocerca volvulus 0.0029 0.0153 0.1732
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0057
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1103 0.1103
Echinococcus granulosus cpg binding protein 0.0031 0.0165 0.0165
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0198 0.4619
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0153 0.0593
Brugia malayi beta-lactamase 0.0035 0.0196 0.0761
Brugia malayi CXXC zinc finger family protein 0.0029 0.0153 0.0593
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.014 0.0542
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.3391 0.3391
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0031 0.0167 0.7481
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0062 0.0386 0.1495
Schistosoma mansoni cpg binding protein 0.0029 0.0153 0.0153
Schistosoma mansoni cpg binding protein 0.0031 0.0165 0.0165
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0353 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0057
Brugia malayi Carboxylesterase family protein 0.0062 0.0386 0.1495
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0047 0.0182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0266 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0057
Schistosoma mansoni alpha-glucosidase 0.0138 0.0941 0.0941
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0198 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1103 0.1103
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0198 0.0198
Trypanosoma brucei glucosidase, putative 0.0036 0.0198 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1582 0.9266
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0057
Onchocerca volvulus 0.0062 0.0386 0.4648
Loa Loa (eye worm) carboxylesterase 0.0062 0.0386 0.1495
Loa Loa (eye worm) hypothetical protein 0.0062 0.0386 0.1495
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0198 0.4619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0057
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0015 0.0015
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0334 0.0334
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0198 0.0765
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0353 0.0353
Mycobacterium ulcerans lipase LipD 0.0035 0.0196 0.0192
Loa Loa (eye worm) hypothetical protein 0.0035 0.0196 0.0761
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0015 0.0015
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.1611 0.6234
Brugia malayi Carboxylesterase family protein 0.0365 0.2584 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0196 0.0192
Brugia malayi Carboxylesterase family protein 0.0062 0.0386 0.1495
Loa Loa (eye worm) intermediate filament protein 0.0028 0.014 0.0542
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0196 0.0192
Mycobacterium tuberculosis Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo 0.0242 0.1691 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0036 0.0262
Loa Loa (eye worm) hypothetical protein 0.0062 0.0386 0.1495
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.008 0.008
Echinococcus granulosus neuropeptide s receptor 0.0477 0.3391 0.3391
Mycobacterium tuberculosis Carboxylesterase LipT 0.0062 0.0386 0.1269
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0036 0.0036
Brugia malayi intermediate filament protein 0.0028 0.014 0.0542
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0196 0.4589
Echinococcus granulosus lamin dm0 0.0028 0.014 0.014
Echinococcus granulosus carboxylesterase 5A 0.0365 0.2584 0.2584
Brugia malayi Carboxylesterase family protein 0.0062 0.0386 0.1495
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0015 0.0015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0198 0.0765
Schistosoma mansoni BC026374 protein (S09 family) 0.0062 0.0386 0.0386
Leishmania major carbamoyl-phosphate synthase, putative 0.0031 0.0167 0.4141
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0062 0.0386 0.0386
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0266 0.1029
Schistosoma mansoni polycystin 1-related 0.0019 0.008 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0196 0.4589
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.008 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0266 0.103
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0198 0.5095
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0353 0.1368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0057
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0198 0.4619
Echinococcus multilocularis RUN 0.0019 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0196 0.0761
Leishmania major hypothetical protein, conserved 0.0035 0.0196 0.5062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0353 0.1222
Echinococcus multilocularis dnaJ subfamily B 0.042 0.2983 0.2983
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0196 0.9935
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0015
Schistosoma mansoni lamin 0.0028 0.014 0.014
Schistosoma mansoni coup transcription factor 0.001 0.0015 0.0015
Echinococcus multilocularis musashi 0.0028 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0057
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0036 0.0036
Onchocerca volvulus Huntingtin homolog 0.0121 0.0814 1
Echinococcus granulosus BC026374 protein S09 family 0.0062 0.0386 0.0386
Schistosoma mansoni lipoxygenase 0.0054 0.0334 0.0334
Onchocerca volvulus 0.0062 0.0386 0.4648
Echinococcus multilocularis acetylcholinesterase 0.0365 0.2584 0.2584
Onchocerca volvulus 0.0093 0.0612 0.7474
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0015 0.0057
Echinococcus granulosus acetylcholinesterase 0.0365 0.2584 0.2584
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0311
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0196 0.4589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0266 0.0266
Brugia malayi Carboxylesterase family protein 0.0365 0.2584 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0015
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0198 0.1714
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0018
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0062 0.0386 0.1495
Brugia malayi MH2 domain containing protein 0.0123 0.0828 0.3204
Mycobacterium leprae Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf 0.0242 0.1691 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0015 0.0015
Brugia malayi hypothetical protein 0.0019 0.008 0.0311
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0057
Onchocerca volvulus 0.0035 0.0196 0.2275
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0138
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.014 0.0542
Onchocerca volvulus 0.0019 0.008 0.082
Onchocerca volvulus 0.0035 0.0196 0.2275
Schistosoma mansoni gliotactin 0.0062 0.0386 0.0386
Loa Loa (eye worm) carboxylesterase 0.0062 0.0386 0.1495
Brugia malayi hypothetical protein 0.0062 0.0386 0.1495
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0365 0.2584 0.2584
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0015
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0353 0.105
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.008 0.008
Schistosoma mansoni acetylcholinesterase 0.0062 0.0386 0.0386
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0047 0.0182
Schistosoma mansoni microtubule-associated protein tau 0.1389 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0198 0.4619
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0198 0.4619
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0062 0.0386 0.0386
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0015 0.0057
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0828 0.3204
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0015 0.0015
Schistosoma mansoni alpha glucosidase 0.0036 0.0198 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0196 0.0196
Echinococcus multilocularis lamin dm0 0.0028 0.014 0.014
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0828 0.3204
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0036 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0198 0.4619
Loa Loa (eye worm) hypothetical protein 0.0035 0.0196 0.0761
Schistosoma mansoni intermediate filament proteins 0.0028 0.014 0.014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0015
Mycobacterium ulcerans carboxylesterase, LipT 0.0062 0.0386 0.1437
Brugia malayi hypothetical protein 0.0019 0.008 0.0311
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0196 0.4589
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0015 0.0015
Trichomonas vaginalis esterase, putative 0.0035 0.0196 0.4589
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0015 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0266 0.0266
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0015
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0062 0.0386 0.0386
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0353 0.0353
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Echinococcus multilocularis carboxylesterase 5A 0.0365 0.2584 0.2584
Plasmodium falciparum carbamoyl phosphate synthetase 0.0031 0.0167 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0057
Onchocerca volvulus Huntingtin homolog 0.0121 0.0814 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0062 0.0386 0.0386
Mycobacterium ulcerans hypothetical protein 0.0035 0.0196 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0057
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0015 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0266 0.0266
Schistosoma mansoni neuroligin 3 (S09 family) 0.0062 0.0386 0.0386
Brugia malayi Doublecortin family protein 0.0019 0.008 0.0311
Onchocerca volvulus 0.0019 0.008 0.082
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.3391 0.3391
Loa Loa (eye worm) acetylcholinesterase 1 0.0365 0.2584 1
Brugia malayi hypothetical protein 0.0121 0.0814 0.3151
Loa Loa (eye worm) hypothetical protein 0.0365 0.2584 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0196 0.0761
Schistosoma mansoni rab6-interacting 0.0019 0.008 0.008
Toxoplasma gondii ABC1 family protein 0.0035 0.0196 0.1654
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0198 0.4619
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0057
Loa Loa (eye worm) hypothetical protein 0.0062 0.0386 0.1495
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0015
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0196 0.0761
Brugia malayi steroid hormone receptor 0.001 0.0015 0.0057
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1103 0.4267
Echinococcus granulosus intermediate filament protein 0.0028 0.014 0.014
Onchocerca volvulus 0.0028 0.014 0.1569
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0266 0.0266
Wolbachia endosymbiont of Brugia malayi AICAR transformylase/IMP cyclohydrolase PurH 0.0242 0.1691 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0136 0.0528
Schistosoma mansoni rab6-interacting 0.0019 0.008 0.008
Echinococcus multilocularis neuroligin 0.0062 0.0386 0.0386
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0062 0.0386 0.1269
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0196 0.0761

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

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