Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2482 | 0.2482 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.008 | 0.5 |
Echinococcus granulosus | lamin | 0.0026 | 0.1182 | 0.2325 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5313 | 0.5313 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.4273 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.4273 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2663 | 0.2663 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0584 | 0.0584 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.008 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0246 | 0.0366 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.4611 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0765 | 0.151 |
Onchocerca volvulus | 0.0026 | 0.1182 | 0.5 | |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0246 | 0.0366 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.2252 | 0.2252 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.5717 | 0.5717 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1182 | 0.1182 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2236 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.1182 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0246 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0584 | 0.1112 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0484 | 0.0592 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0765 | 0.1287 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.2236 | 0.4758 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1182 | 0.2325 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2236 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2236 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1182 | 0.2325 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2236 | 0.4758 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.2236 | 0.4942 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1182 | 0.1182 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1136 | 0.1136 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0988 | 0.0988 |
Schistosoma mansoni | lamin | 0.0026 | 0.1182 | 0.2432 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0484 | 0.0592 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2029 | 0.4427 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0304 | 0.0304 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.008 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.2236 | 0.4942 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2029 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2259 | 0.2259 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1182 | 0.1182 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0.008 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1182 | 0.1182 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1182 | 0.1182 |
Brugia malayi | hypothetical protein | 0.0037 | 0.2236 | 0.2236 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0484 | 0.0891 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1182 | 0.2325 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0246 | 0.0366 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0765 | 0.1287 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0246 | 0.0366 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.1182 | 0.2432 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1182 | 0.2325 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2236 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1182 | 0.2325 |
Onchocerca volvulus | 0.0026 | 0.1182 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.