Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2647 | 0.5266 |
Onchocerca volvulus | 0.0048 | 0.1346 | 0.5 | |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0026 | 0.0653 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.3116 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0653 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.3116 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0111 | 0.016 |
Brugia malayi | hypothetical protein | 0.0106 | 0.3116 | 0.4487 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0111 | 0.0177 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0111 | 0.016 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.2647 | 0.263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2647 | 0.5266 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0026 | 0.0653 | 0.094 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.5005 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.2647 | 0.263 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0111 | 0.016 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.2647 | 0.3811 |
Brugia malayi | XPG I-region family protein | 0.0005 | 0.0023 | 0.0033 |
Echinococcus granulosus | smad | 0.0008 | 0.0111 | 0.0088 |
Brugia malayi | follicle stimulating hormone receptor | 0.0231 | 0.6945 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1346 | 0.1939 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0111 | 0.0177 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0231 | 0.6945 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0331 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.5005 | 0.4994 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.2647 | 0.263 |
Plasmodium falciparum | flap endonuclease 1 | 0.0026 | 0.0653 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0653 | 1 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0111 | 0.0088 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0111 | 0.0177 |
Brugia malayi | Flap endonuclease-1 | 0.0026 | 0.0653 | 0.094 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0653 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.3116 | 0.6208 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.3511 | 0.5056 |
Schistosoma mansoni | smad | 0.0008 | 0.0111 | 0.0177 |
Echinococcus multilocularis | smad | 0.0008 | 0.0111 | 0.0088 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0111 | 0.0088 |
Brugia malayi | Smad1 | 0.0008 | 0.0111 | 0.016 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.2647 | 0.3811 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0106 | 0.3116 | 0.6208 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0111 | 0.016 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2647 | 0.5266 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.5005 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0111 | 0.016 |
Echinococcus granulosus | flap endonuclease 1 | 0.0026 | 0.0653 | 0.0631 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.3116 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.1346 | 0.2656 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0111 | 0.0177 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0026 | 0.0653 | 1 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0111 | 0.0088 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.2647 | 0.263 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0026 | 0.0653 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0026 | 0.0653 | 0.0631 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.3511 | 0.5056 |
Echinococcus granulosus | geminin | 0.0168 | 0.5005 | 0.4994 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0106 | 0.3116 | 0.31 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0111 | 0.0088 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.3116 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.0577 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0023 | 0.0033 |
Loa Loa (eye worm) | XPG I-region family protein | 0.0005 | 0.0023 | 0.0033 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0111 | 0.0088 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.3511 | 0.5056 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0111 | 0.0177 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0111 | 0.0088 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0111 | 0.016 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0111 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0023 | 0.0033 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0106 | 0.3116 | 0.31 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0026 | 0.0653 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0026 | 0.0653 | 0.2036 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.