Detailed information for compound 682464

Basic information

Technical information
  • TDR Targets ID: 682464
  • Name: N'-(2-fluorophenyl)-N-[2-[2-[4-(trifluorometh yl)phenyl]-1,3-thiazol-4-yl]ethyl]oxamide
  • MW: 437.411 | Formula: C20H15F4N3O2S
  • H donors: 2 H acceptors: 3 LogP: 4.48 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)NCCc1csc(n1)c1ccc(cc1)C(F)(F)F)Nc1ccccc1F
  • InChi: 1S/C20H15F4N3O2S/c21-15-3-1-2-4-16(15)27-18(29)17(28)25-10-9-14-11-30-19(26-14)12-5-7-13(8-6-12)20(22,23)24/h1-8,11H,9-10H2,(H,25,28)(H,27,29)
  • InChiKey: TWHPNVPGPARNJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(2-fluorophenyl)-N-[2-[2-[4-(trifluoromethyl)phenyl]thiazol-4-yl]ethyl]oxamide
  • N'-(2-fluorophenyl)-N-[2-[2-[4-(trifluoromethyl)phenyl]-4-thiazolyl]ethyl]oxamide
  • N'-(2-fluorophenyl)-N-[2-[2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl]ethyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.3726 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0607 0.0668
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.244 0.2149
Plasmodium vivax pyruvate kinase, putative 0.0033 0.3726 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.3726 0.3485
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.3726 0.5
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.3726 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.2831 0.732
Echinococcus granulosus pyruvate kinase 0.0033 0.3726 1
Plasmodium falciparum pyruvate kinase 0.0033 0.3726 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.3726 0.3485
Loa Loa (eye worm) hypothetical protein 0.0082 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0384 0.0531
Echinococcus multilocularis pyruvate kinase 0.0017 0.1657 0.3809
Chlamydia trachomatis pyruvate kinase 0.0033 0.3726 0.5
Giardia lamblia Pyruvate kinase 0.0033 0.3726 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.6409 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.244 0.2149
Schistosoma mansoni pyruvate kinase 0.0033 0.3726 0.5148
Echinococcus granulosus pyruvate kinase 0.0017 0.1657 0.3809
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0593 0.0662
Echinococcus granulosus pyruvate kinase 0.0017 0.1657 0.3809
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.3726 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.3726 0.5
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.3726 0.5
Echinococcus multilocularis pyruvate kinase 0.0017 0.1657 0.3809
Echinococcus multilocularis pyruvate kinase 0.0033 0.3726 1
Leishmania major pyruvate kinase 0.0033 0.3726 0.5
Echinococcus multilocularis cpg binding protein 0.003 0.3344 0.8855
Echinococcus multilocularis pyruvate kinase 0.0033 0.3726 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.3726 1
Leishmania major pyruvate kinase 0.0033 0.3726 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.3135 0.2871
Echinococcus granulosus pyruvate kinase 0.0033 0.3726 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.3726 0.5
Echinococcus granulosus cpg binding protein 0.003 0.3344 0.8855
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.3726 0.4354
Trypanosoma brucei pyruvate kinase 1 0.0033 0.3726 0.5
Loa Loa (eye worm) pyruvate kinase 0.0033 0.3726 0.3485
Schistosoma mansoni pyruvate kinase 0.0017 0.1657 0.2289
Echinococcus multilocularis pyruvate kinase 0.0017 0.1657 0.3809
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.3726 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.3135 0.8238
Echinococcus granulosus pyruvate kinase 0.0017 0.1657 0.3809
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.3726 1
Schistosoma mansoni cpg binding protein 0.0028 0.3135 0.4331
Loa Loa (eye worm) pyruvate kinase 0.0033 0.3726 0.3485
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.3726 0.5
Schistosoma mansoni pyruvate kinase 0.0033 0.3726 0.5148
Schistosoma mansoni cpg binding protein 0.003 0.3344 0.4619
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0607 0.0668
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0761 0.1164
Mycobacterium ulcerans pyruvate kinase 0.0033 0.3726 0.5
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0607 0.0246
Schistosoma mansoni cpg binding protein 0.003 0.3344 0.4619
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.7238 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.3726 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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