TDR Targets

Basic information

Technical information

TDR Targets ID: 682519
Name: N-(4-methylphenyl)-6-[4-(4-methylphenyl)sulfo nylpiperazin-1-yl]pyridazin-3-amine
MW: 423.531 | Formula: C22H25N5O2S
H donors: 1 H acceptors: 4 LogP: 3.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)Nc1ccc(nn1)N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C
InChi: 1S/C22H25N5O2S/c1-17-3-7-19(8-4-17)23-21-11-12-22(25-24-21)26-13-15-27(16-14-26)30(28,29)20-9-5-18(2)6-10-20/h3-12H,13-16H2,1-2H3,(H,23,24)
InChiKey: ZIMCOAMGPZDYMU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-methylphenyl)-6-[4-(4-methylphenyl)sulfonyl-1-piperazinyl]-3-pyridazinamine
(4-methylphenyl)-[6-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]pyridazin-3-yl]amine
ZINC04304099

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1152	0.2229
Echinococcus granulosus	cpg binding protein	0.0033	0.4678	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.1152	0.1054
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.1152	0.2086
Onchocerca volvulus		0.0031	0.4393	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.1152	0.2229
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.1152	0.1054
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1152	0.2229
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.1152	0.2229
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.1152	0.2229
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.1152	0.2229
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0322	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1152	0.2229
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.1152	0.1054
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.1152	0.2086
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.1152	0.2086
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.1152	0.2229
Brugia malayi	CXXC zinc finger family protein	0.0031	0.4393	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.1152	0.2229
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.1152	0.2229
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.1152	0.2086
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.1152	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.092	0.1672
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0634	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1152	0.2229
Echinococcus multilocularis	cpg binding protein	0.0033	0.4678	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1152	0.2229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.1152	0.2229
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.1152	0.2229
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.1152	0.1054
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0525	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.1152	0.1054
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0939	0.1609
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.1152	0.2229
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0222	0.0114
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.1152	0.2086
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.4393	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0634	0.0925
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.1152	0.2229
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0322	0.0215
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.1152	0.1054
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.1152	0.2229
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0634	0.0925
Onchocerca volvulus		0.0011	0.1152	0.2229
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.1152	0.2229
Schistosoma mansoni	nuclear receptor	0.0005	0.0222	0.0114
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.1152	0.2086
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.1152	0.1054
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.1152	0.2229
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.1152	0.1054
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0634	0.0925
Schistosoma mansoni	cpg binding protein	0.0031	0.4393	0.4331
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.1152	0.2086
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.1152	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1152	0.2229
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.1152	0.2229
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.1152	0.2086
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.1152	0.2086
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.1152	0.2086
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0322	0.0223
Schistosoma mansoni	zinc finger protein	0.0005	0.0222	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0222	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1152	0.2229
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0939	0.1609
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.1152	0.2229
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0939	0.1719
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.1152	0.2229
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0222	0.0114
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.1152	0.1054
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0322	0.0223
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.1152	0.2086
Schistosoma mansoni	cpg binding protein	0.0033	0.4678	0.4619
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.1152	0.2229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.1152	0.2229
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.1152	0.2086
Schistosoma mansoni	nuclear receptor	0.0005	0.0222	0.0114
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.1152	0.2086
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.1152	0.1054
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0222	0.0114
Schistosoma mansoni	cpg binding protein	0.0033	0.4678	0.4619
Brugia malayi	nuclear receptor NHR-88	0.0011	0.1152	0.2229
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Brugia malayi	ecdysteroid receptor	0.0011	0.1152	0.2229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.1152	0.2229
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.1152	0.2229
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.1152	0.2086
Brugia malayi	nuclear receptor RXR	0.0006	0.0322	0.0239
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.1152	0.2086
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Brugia malayi	nuclear hormone receptor	0.0011	0.1152	0.2229
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0634	0.0925
Brugia malayi	steroid hormone receptor	0.0011	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.1152	0.2229
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0322	0.0239
Schistosoma mansoni	coup transcription factor	0.0011	0.1152	0.1054
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.1152	0.2086
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.1152	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0322	0.0215
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.1152	0.2229
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.1152	0.1054
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.8867	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0322	0.0239
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0222	0.0114
Brugia malayi	hypothetical protein	0.0006	0.0322	0.0239
Brugia malayi	hypothetical protein	0.0006	0.0322	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1152	0.2229
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 682519