Detailed information for compound 682563

Basic information

Technical information
  • TDR Targets ID: 682563
  • Name: 3-[4-(4-methoxy-3-methylphenyl)sulfonylpipera zin-1-yl]-6-pyrrolidin-1-ylpyridazine
  • MW: 417.525 | Formula: C20H27N5O3S
  • H donors: 0 H acceptors: 4 LogP: 2.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C)S(=O)(=O)N1CCN(CC1)c1ccc(nn1)N1CCCC1
  • InChi: 1S/C20H27N5O3S/c1-16-15-17(5-6-18(16)28-2)29(26,27)25-13-11-24(12-14-25)20-8-7-19(21-22-20)23-9-3-4-10-23/h5-8,15H,3-4,9-14H2,1-2H3
  • InChiKey: JKBFORFHPMRPQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[4-(4-methoxy-3-methyl-phenyl)sulfonylpiperazin-1-yl]-6-pyrrolidin-1-yl-pyridazine
  • 3-[4-(4-methoxy-3-methylphenyl)sulfonyl-1-piperazinyl]-6-1-pyrrolidinylpyridazine
  • ZINC04571083

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0445 0.0445
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0096 0.0134
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.1151 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0666 0.5
Onchocerca volvulus 0.0066 0.0445 0.0675
Onchocerca volvulus 0.0523 0.526 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0096 0.0134
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0185 0.0185
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.2414 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.035 0.4744
Loa Loa (eye worm) beta-lactamase 0.004 0.0167 0.0167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0096 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0096 0.0095
Echinococcus multilocularis snurportin 1 0.0345 0.3383 0.3383
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0167 0.544
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0122 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0096 0.0096
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0091 0.2935
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.0666 0.0666
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0096 0.0095
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0096 0.0096
Toxoplasma gondii exonuclease III APE 0.0041 0.0185 0.1606
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1139 0.1138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0096 0.0096
Onchocerca volvulus 0.0198 0.1841 0.3379
Schistosoma mansoni survival motor neuron protein 0.0198 0.1841 0.257
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0066 0.0976
Echinococcus multilocularis thyroid hormone receptor alpha 0.0312 0.304 0.304
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0096 0.0096
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0096 0.0096
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0026 0.0048
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.035 0.035
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0307 0.2662
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0096 0.0095
Mycobacterium leprae conserved hypothetical protein 0.004 0.0167 0.1693
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0096 0.0096
Schistosoma mansoni ran 0.0024 0.0001 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1139 0.1138
Plasmodium vivax SET domain protein, putative 0.0066 0.0445 0.6675
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0345 0.3383 0.4724
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0096 0.0134
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0095
Echinococcus granulosus survival motor neuron protein 1 0.0972 1 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.0666 0.0666
Schistosoma mansoni importin beta-1 0.0032 0.0091 0.0127
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0095
Brugia malayi hypothetical protein 0.0053 0.0307 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0096 0.0095
Brugia malayi RNA, U transporter 1 0.0092 0.0718 0.0717
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0167 0.0317
Loa Loa (eye worm) hypothetical protein 0.0087 0.0666 0.0665
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0279 0.2694 0.2694
Echinococcus multilocularis geminin 0.0703 0.7163 0.7163
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0185 0.0351
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0307 0.4604
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.0121
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0666 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0096 0.0095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0096 0.0095
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.0666 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0419 0.0419
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0167 0.0317
Plasmodium vivax hypothetical protein, conserved 0.004 0.0167 0.2504
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.1151 0.4376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.1806 0.2522
Echinococcus granulosus importin subunit beta 1 0.0032 0.0091 0.0091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0294 0.0293
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0185 0.0185
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0096 0.0096
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0307 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0096 0.0095
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.0666 0.093
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0096 0.0096
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0185 0.1995
Brugia malayi beta-lactamase 0.004 0.0167 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0096 0.0095
Loa Loa (eye worm) hypothetical protein 0.0066 0.0445 0.0444
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0185 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0096 0.0096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0167 0.0234
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0167 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0096 0.0095
Brugia malayi beta-lactamase family protein 0.004 0.0167 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0096 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0167 0.0167
Brugia malayi hypothetical protein 0.0034 0.011 0.0109
Schistosoma mansoni hypothetical protein 0.0035 0.0122 0.017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.1806 0.1806
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0307 0.4604
Trichomonas vaginalis set domain proteins, putative 0.0523 0.526 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0666 0.5783
Schistosoma mansoni coup transcription factor 0.0033 0.0096 0.0134
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0026 0.0833
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0095
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0459 0.4591 0.459
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.1151 0.1151
Schistosoma mansoni hypothetical protein 0.0703 0.7163 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0091 0.0091
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.1151 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0445 0.0621
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0185 1
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0307 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0445 0.0621
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1151 0.1607
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0091 0.2935
Brugia malayi Probable ClpP-like protease 0.0087 0.0666 0.0665
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0294 0.0293
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0185 0.0351
Loa Loa (eye worm) hypothetical protein 0.0052 0.0294 0.0293
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0666 0.5069
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0445 0.0445
Echinococcus multilocularis survival motor neuron protein 1 0.0972 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0096 0.0096
Trichomonas vaginalis esterase, putative 0.004 0.0167 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0096 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0096 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0445 0.0621
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0096 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1151 1
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0096 0.0095
Schistosoma mansoni thyroid hormone receptor 0.0312 0.304 0.4244
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0096 0.0095
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0095
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0096 0.0134
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0096 0.0096
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0666 1
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.035 0.035
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.035 0.0815
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0666 0.5
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0167 0.544
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0167 0.0167
Onchocerca volvulus 0.004 0.0167 0.0138
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.1806 0.1806
Loa Loa (eye worm) hypothetical protein 0.0032 0.0091 0.009
Schistosoma mansoni ap endonuclease 0.0041 0.0185 0.0259
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0095
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0026 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1151 1
Schistosoma mansoni thyroid hormone receptor 0.0312 0.304 0.4244
Schistosoma mansoni hypothetical protein 0.0703 0.7163 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0096 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0096 0.0095
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1151 0.1607
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0167 0.0317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.1806 0.2522
Echinococcus granulosus snurportin 1 0.0345 0.3383 0.3383
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0096 0.0096
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.035 0.0815
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0096 0.0095
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0096 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.1806 0.1806
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0294 0.0293
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0185 0.6032
Loa Loa (eye worm) hypothetical protein 0.0053 0.0307 0.0306
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0095
Brugia malayi steroid hormone receptor 0.0033 0.0096 0.0095
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.3383 0.3383
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0167 0.0167
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0666 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0095
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0096 0.0134
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0666 0.5069
Echinococcus granulosus geminin 0.0703 0.7163 0.7163
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0307 0.4604
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0445 0.0445
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0091 0.0781
Mycobacterium leprae Probable lipase LipE 0.004 0.0167 0.1693
Brugia malayi nuclear hormone receptor 0.0033 0.0096 0.0095
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0198 0.1841 0.184
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0096 0.0095
Plasmodium vivax importin-beta 2, putative 0.0032 0.0091 0.1351
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0096 0.0095
Schistosoma mansoni hypothetical protein 0.0198 0.1841 0.257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.1806 0.1806
Brugia malayi Pre-SET motif family protein 0.0459 0.4591 0.459
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0096 0.0095
Entamoeba histolytica hypothetical protein 0.0026 0.0026 0.138
Schistosoma mansoni ap endonuclease 0.0041 0.0185 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0096 0.0095
Brugia malayi Pre-SET motif family protein 0.0066 0.0445 0.0444
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0972 1 1
Brugia malayi beta-lactamase family protein 0.004 0.0167 0.0167
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0096 0.0134
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0185 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1151 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0066 0.0976
Schistosoma mansoni hypothetical protein 0.0279 0.2694 0.3761
Leishmania major hypothetical protein, conserved 0.004 0.0167 0.1448
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0167 0.544
Brugia malayi MH2 domain containing protein 0.0132 0.1139 0.1138
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0185 0.2777
Toxoplasma gondii hypothetical protein 0.003 0.0066 0.0565
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0096 0.0134
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0185 0.6032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0167 0.0234
Schistosoma mansoni ran 0.0024 0.0001 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0096 0.0096
Onchocerca volvulus 0.004 0.0167 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0096 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.1806 0.1806
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0096 0.0134
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.1151 0.1151
Brugia malayi Importin beta-1 subunit 0.0032 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0185 0.1606
Brugia malayi nuclear receptor NHR-88 0.0033 0.0096 0.0095
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0279 0.2694 0.2694
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0167 0.0317
Onchocerca volvulus 0.004 0.0167 0.0138
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0001 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0167 0.0317
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0666 0.5783
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0445 0.386
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0096 0.0096
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.0666 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0026 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0185 0.6032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0185 0.2777
Toxoplasma gondii ABC1 family protein 0.004 0.0167 0.1448
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0096 0.0095
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0185 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.1806 0.2522
Brugia malayi ecdysteroid receptor 0.0033 0.0096 0.0095
Plasmodium falciparum importin beta, putative 0.0032 0.0091 0.1351
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0445 0.0621
Leishmania major hypothetical protein, conserved 0.0053 0.0307 0.2662
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0096 0.0134
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.1806 0.1806
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0185 0.0185
Leishmania major importin beta-1 subunit, putative 0.0026 0.0026 0.0222
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0096 0.0134

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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