Detailed information for compound 682881

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.558 | Formula: C23H27N5O2S
  • H donors: 1 H acceptors: 4 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Nc1cc(C)nc(n1)N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C23H27N5O2S/c1-17-4-8-20(9-5-17)25-22-16-19(3)24-23(26-22)27-12-14-28(15-13-27)31(29,30)21-10-6-18(2)7-11-21/h4-11,16H,12-15H2,1-3H3,(H,24,25,26)
  • InChiKey: CUYMQNKCCBPTJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.123 0.2137
Brugia malayi hypothetical protein 0.0039 0.0339 0.0581
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0743 0.1292
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0119
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0209 0.0168
Leishmania major trypanothione reductase 0.0093 0.1065 0.3802
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.0475 0.1046
Brugia malayi Thioredoxin reductase 0.0093 0.1065 0.1843
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0258 0.0258
Echinococcus granulosus dna polymerase kappa 0.002 0.0073 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0016 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0258 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) hypothetical protein 0.0163 0.2014 0.3501
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0169 0.0128
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0068 0.0727 0.1263
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0073 0.0118
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0169 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus multilocularis microtubule associated protein 2 0.0752 1 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0025 0.0151 0.0263
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.123 0.213
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.154 0.5566
Onchocerca volvulus Huntingtin homolog 0.0133 0.1617 0.2216
Onchocerca volvulus Huntingtin homolog 0.0133 0.1617 0.2216
Brugia malayi jmjC domain containing protein 0.0027 0.0169 0.0285
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0209 0.0404
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0243 0.0751
Toxoplasma gondii thioredoxin reductase 0.0093 0.1065 0.247
Loa Loa (eye worm) hypothetical protein 0.0063 0.0669 0.1162
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0475 0.1046
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0243 0.0751
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0243 0.0488
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0169 0.0293
Echinococcus multilocularis cpg binding protein 0.0033 0.0256 0.0256
Giardia lamblia Pyruvate kinase 0.0036 0.03 0.0297
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0041 0.0062
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0669 0.1514
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0316 0.0377
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0193 0.0193
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.03 0.388 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0119
Entamoeba histolytica hypothetical protein 0.0049 0.0475 0.0498
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.154 0.3852
Schistosoma mansoni pyruvate kinase 0.0036 0.03 0.026
Brugia malayi cytochrome b 0.0323 0.4186 0.7273
Treponema pallidum fructose-bisphosphate aldolase 0.0615 0.8144 1
Echinococcus granulosus cytochrome B 0.0323 0.4186 0.4186
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.154 0.154
Brugia malayi Bromodomain containing protein 0.003 0.0209 0.0354
Schistosoma mansoni hypothetical protein 0.0172 0.2138 0.2106
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0041 0.0071
Schistosoma mansoni cpg binding protein 0.0031 0.0232 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Brugia malayi jmjC domain containing protein 0.0027 0.0169 0.0285
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0169 0.0128
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.03 0.0514
Echinococcus granulosus peregrin 0.003 0.0209 0.0209
Echinococcus multilocularis lamin 0.0029 0.0206 0.0206
Echinococcus granulosus lamin dm0 0.0029 0.0206 0.0206
Brugia malayi isocitrate dehydrogenase 0.0017 0.0041 0.0062
Leishmania major hypothetical protein, conserved 0.0216 0.2734 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0073 0.0119
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0041
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0232 0.0403
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.03 0.0358
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.0061
Plasmodium vivax cytochrome b 0.0323 0.4186 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0615 0.8144 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0439 0.5753 1
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0145 0.0167
Trypanosoma brucei trypanothione reductase 0.0093 0.1065 0.3802
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.0061
Schistosoma mansoni inositol monophosphatase 0.0037 0.0316 0.0276
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0386 0.0463
Echinococcus granulosus lamin 0.0029 0.0206 0.0206
Onchocerca volvulus 0.0165 0.204 0.288
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0175 0.2179 0.3782
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0188 0.022
Plasmodium vivax JmjC domain containing protein 0.0027 0.0169 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.0475 0.0587
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0243 0.0527
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.154 0.3616
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0345 0.0413
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.03 0.0676
Toxoplasma gondii cytochrome b 0.0323 0.4186 1
Echinococcus multilocularis lysine specific demethylase 5A 0.01 0.1162 0.1162
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0203
Mycobacterium tuberculosis Probable dehydrogenase 0.0211 0.2675 0.6862
Schistosoma mansoni cytochrome b 0.0323 0.4186 0.4162
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0243 0.0488
Entamoeba histolytica hypothetical protein 0.0039 0.0339 0.033
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0145 0.0188
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0145 0.0385
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.154 0.3852
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0034 0.0267 0.0841
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0243 0.0488
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0217
Echinococcus granulosus intermediate filament protein 0.0029 0.0206 0.0206
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex 0.0323 0.4186 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.0061
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0021 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) hypothetical protein 0.0072 0.078 0.1355
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0206 0.0358
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0316 0.0637
Echinococcus multilocularis L aminoadipate semialdehyde 0.0175 0.2179 0.2179
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.078 0.1348
Schistosoma mansoni jumonji domain containing protein 0.0141 0.172 0.1686
Echinococcus granulosus phd:f box containing protein 0.0027 0.0169 0.0169
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0475 0.1046
Echinococcus multilocularis pyruvate kinase 0.0029 0.0197 0.0197
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0211 0.2675 0.6862
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0316 0.0301
Loa Loa (eye worm) hypothetical protein 0.0165 0.204 0.3545
Echinococcus multilocularis dna polymerase eta 0.002 0.0073 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0316 0.0316
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0258 0.0439
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.03 0.0514
Entamoeba histolytica hypothetical protein 0.0039 0.0339 0.033
Loa Loa (eye worm) RNA binding protein 0.0069 0.0743 0.1292
Loa Loa (eye worm) pyruvate kinase 0.0036 0.03 0.0522
Echinococcus multilocularis pyruvate kinase 0.0036 0.03 0.03
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0169 0.0128
Schistosoma mansoni hypothetical protein 0.003 0.0209 0.0168
Trypanosoma brucei unspecified product 0.002 0.0073 0.0119
Schistosoma mansoni pyruvate kinase 0.0036 0.03 0.026
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0151 0.0263
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0169 0.0169
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0316 0.102
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.154 0.1505
Schistosoma mansoni cytochrome b 0.0323 0.4186 0.4162
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0243 0.0414
Echinococcus multilocularis peregrin 0.003 0.0209 0.0209
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.03 0.0148
Echinococcus multilocularis muscleblind protein 1 0.0163 0.2014 0.2014
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0169 0.0169
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0366 0.0366
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0169 0.0474
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.03 0.0105
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0475 0.0587
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0049 0.0475 1
Echinococcus multilocularis geminin 0.0172 0.2138 0.2138
Leishmania major hypothetical protein, conserved 0.0041 0.0367 0.121
Entamoeba histolytica hypothetical protein 0.0039 0.0339 0.033
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0235 0.2995 0.7554
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0041
Plasmodium falciparum pyruvate kinase 0.0036 0.03 0.0626
Echinococcus multilocularis musashi 0.0029 0.0206 0.0206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Trypanosoma brucei pyruvate kinase 1 0.0036 0.03 0.0963
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0243
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0169 0.0128
Onchocerca volvulus 0.0175 0.2179 0.3099
Trichomonas vaginalis set domain proteins, putative 0.0499 0.6573 0.8069
Giardia lamblia Fructose-bisphosphate aldolase 0.0615 0.8144 1
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0243 0.0288
Brugia malayi TAR-binding protein 0.0069 0.0743 0.1284
Loa Loa (eye worm) hypothetical protein 0.0105 0.123 0.2137
Brugia malayi hypothetical protein 0.0133 0.1617 0.2804
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.03 0.0963
Echinococcus granulosus chromobox protein 1 0.0071 0.0766 0.0766
Echinococcus multilocularis abhydrolase domain containing protein 0.0041 0.0367 0.0367
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Brugia malayi Pre-SET motif family protein 0.0439 0.5753 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.2014 0.3501
Trypanosoma brucei hypothetical protein, conserved 0.0216 0.2734 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0145 0.027
Echinococcus multilocularis chromobox protein 1 0.0071 0.0766 0.0766
Schistosoma mansoni chromobox protein 0.0071 0.0766 0.0728
Schistosoma mansoni intermediate filament proteins 0.0029 0.0206 0.0166
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0021 0.0028
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.03 0.0963
Loa Loa (eye worm) glutathione reductase 0.0093 0.1065 0.1851
Loa Loa (eye worm) hypothetical protein 0.0029 0.0206 0.0358
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0073 0.0073
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0169 0.0169
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0243 0.0751
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0345 0.0218
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0145 0.0145
Schistosoma mansoni inositol monophosphatase 0.0037 0.0316 0.0276
Echinococcus granulosus lysine specific demethylase 5A 0.0102 0.1186 0.1186
Onchocerca volvulus Alhambra homolog 0.003 0.0209 0.0004
Loa Loa (eye worm) inositol-1 0.0037 0.0316 0.0549
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0128 0.0213
Onchocerca volvulus 0.0075 0.0825 0.0973
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0339 0.0299
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0151 0.0097
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0316 0.0377
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0169 0.0474
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0386 0.0463
Plasmodium vivax SET domain protein, putative 0.0063 0.0669 0.1514
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0073 0.0084
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0061 0.0047
Plasmodium vivax glutathione reductase, putative 0.0093 0.1065 0.247
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.1072 0.1072
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0751
Brugia malayi jmjC domain containing protein 0.0102 0.1186 0.2054
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0766 0.1331
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.1065 0.2667
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0316 0.102
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0243 0.0488
Giardia lamblia DINP protein human, muc B family 0.002 0.0073 0.0016
Echinococcus granulosus dnaJ subfamily B 0.0446 0.5849 0.5849
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0316 0.102
Loa Loa (eye worm) cytochrome b 0.0323 0.4186 0.7275
Plasmodium falciparum thioredoxin reductase 0.0032 0.0243 0.0488
Brugia malayi intermediate filament protein 0.0029 0.0206 0.0349
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0243 0.0751
Toxoplasma gondii apocytochrome b, putative 0.0323 0.4186 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0161 0.199 0.199
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0073 0.0119
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.1186 0.115
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0743 0.1284
Loa Loa (eye worm) pyruvate kinase 0.0036 0.03 0.0522
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0316 0.102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0199 0.0346
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0258 0.0258
Schistosoma mansoni hypothetical protein 0.0446 0.5849 0.5832
Brugia malayi PHD-finger family protein 0.003 0.0209 0.0354
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0739 0.0701
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0145 0.0385
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0206 0.0349
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0316 0.0184
Schistosoma mansoni DNA polymerase eta 0.002 0.0073 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0169 0.0293
Echinococcus multilocularis muscleblind protein 0.0163 0.2014 0.2014
Echinococcus granulosus dna polymerase eta 0.002 0.0073 0.0073
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.0061
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0073 0.0127
Echinococcus granulosus muscleblind protein 0.0163 0.2014 0.2014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0669 0.0669
Leishmania major pyruvate kinase 0.0036 0.03 0.0963
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.0061
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0169 0.0308
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0258 0.0439
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0169 0.0169
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0615 0.8144 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0169 0.0308
Brugia malayi jmjC domain containing protein 0.0027 0.0169 0.0285
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.0475 0.113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.1072 0.1072
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.03 0.0148
Echinococcus granulosus L aminoadipate semialdehyde 0.0175 0.2179 0.2179
Echinococcus multilocularis pyruvate kinase 0.0036 0.03 0.03
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0161 0.199 0.199
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0145 0.0145
Mycobacterium tuberculosis Probable oxidoreductase 0.0235 0.2995 0.7695
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0073 0.0032
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0211 0.2675 0.6669
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0366 0.0366
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0049 0.0475 0.0293
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0669 0.0669
Onchocerca volvulus 0.0031 0.0229 0.0036
Entamoeba histolytica hypothetical protein 0.0039 0.0339 0.033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0076 0.0035
Loa Loa (eye worm) hydrolase 0.0041 0.0367 0.0638
Leishmania major hypothetical protein, conserved 0.0027 0.0169 0.0474
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0169 0.0308
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.1065 0.3802
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0243 0.0751
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.0398
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0475 0.1611
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0743 0.0743
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Brugia malayi hydrolase, alpha/beta fold family protein 0.0041 0.0367 0.0629
Leishmania major pyruvate kinase 0.0036 0.03 0.0963
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0169 0.0169
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0316 0.0316
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.0475 0.1046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Schistosoma mansoni lamin 0.0029 0.0206 0.0166
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0258 0.0448
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0211 0.2675 0.6862
Plasmodium falciparum thioredoxin reductase 0.0093 0.1065 0.247
Schistosoma mansoni cpg binding protein 0.0033 0.0256 0.0216
Echinococcus granulosus cpg binding protein 0.0033 0.0256 0.0256
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0235 0.2995 0.7695
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0016 0.0009
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.0475 0.1055
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.03 0.0963
Onchocerca volvulus 0.0034 0.0267 0.0096
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Onchocerca volvulus 0.0031 0.0232 0.0041
Loa Loa (eye worm) hypothetical protein 0.0036 0.03 0.0522
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.01 0.0164
Echinococcus multilocularis dna polymerase kappa 0.002 0.0073 0.0073
Brugia malayi chromobox protein homolog 3 0.004 0.0345 0.0591
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0243 0.0447
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0825 0.0787
Plasmodium falciparum phd finger protein, putative 0.003 0.0209 0.0404
Schistosoma mansoni chromobox protein 0.0071 0.0766 0.0728
Brugia malayi jmjC domain containing protein 0.0027 0.0169 0.0285
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.0475 0.1055
Echinococcus multilocularis chromobox protein 1 0.0071 0.0766 0.0766
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.063
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.154 0.1505
Mycobacterium ulcerans hypothetical protein 0.0025 0.0145 0.0188
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0073 0.0032
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0061 0.0047
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0061 0.0047
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0217
Brugia malayi CXXC zinc finger family protein 0.0031 0.0232 0.0394
Mycobacterium ulcerans hypothetical protein 0.0025 0.0145 0.0188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.154 0.3852
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0243 0.0288
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0041 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0119
Brugia malayi jmjC domain containing protein 0.0161 0.199 0.3452
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0209 0.0363
Schistosoma mansoni microtubule-associated protein tau 0.0752 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0235 0.2995 0.7695
Echinococcus multilocularis GPCR, family 2 0.0033 0.0258 0.0258
Schistosoma mansoni pyruvate kinase 0.0019 0.0061 0.002
Plasmodium falciparum epoxide hydrolase 1 0.0041 0.0367 0.0786
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0061 0.0063
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0243 0.0751
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0073 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Echinococcus granulosus pyruvate kinase 0.0036 0.03 0.03
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0211 0.2675 0.6862
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.03 0.0626
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0206 0.0358
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.1065 0.247
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0636 0.1105
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.0475 0.1611
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0211 0.2675 0.6862
Echinococcus granulosus chromobox protein 1 0.0071 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.003 0.0209 0.0363
Schistosoma mansoni hydrolase 0.0041 0.0367 0.0327
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0751
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0188 0.022
Mycobacterium tuberculosis Conserved protein 0.0025 0.0145 0.027
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0316 0.0377
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) hypothetical protein 0.0027 0.0169 0.0293
Loa Loa (eye worm) hypothetical protein 0.0027 0.0169 0.0293
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0145 0.0188
Schistosoma mansoni hypothetical protein 0.0172 0.2138 0.2106
Schistosoma mansoni hypothetical protein 0.0072 0.078 0.0742
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0073 0.0079
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0258 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0169 0.0293
Mycobacterium ulcerans pyruvate kinase 0.0036 0.03 0.0597
Brugia malayi hypothetical protein 0.0165 0.204 0.3539
Plasmodium falciparum cytochrome b 0.0323 0.4186 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0169 0.0169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0339 0.0339
Brugia malayi Heterochromatin protein 1 0.0071 0.0766 0.1324
Brugia malayi Muscleblind-like protein 0.0163 0.2014 0.3495
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0743 0.1292
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.5849 0.5849
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0169 0.0474
Schistosoma mansoni cpg binding protein 0.0033 0.0256 0.0216
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0145 0.0385
Plasmodium vivax hypothetical protein, conserved 0.003 0.0209 0.0404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.063
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0145 0.0188
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0061 0.0063
Echinococcus granulosus pyruvate kinase 0.0036 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.06
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.1065 0.1851
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0345 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.2734 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0339 0.0339
Chlamydia trachomatis pyruvate kinase 0.0036 0.03 0.2467
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Loa Loa (eye worm) hypothetical protein 0.0133 0.1617 0.2811
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0643 0.1452
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus granulosus abhydrolase domain containing protein 0.0041 0.0367 0.0367
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0243 0.0488
Schistosoma mansoni hypothetical protein 0.0039 0.0339 0.0299
Brugia malayi glutathione reductase 0.0093 0.1065 0.1843
Echinococcus granulosus tar DNA binding protein 0.0069 0.0743 0.0743
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Brugia malayi Inositol-1 0.0037 0.0316 0.054
Loa Loa (eye worm) hypothetical protein 0.0175 0.2179 0.3788
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0073 0.0084
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0766 0.093
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.03 0.388 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0628 0.0628
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.154 0.3904
Schistosoma mansoni lamin 0.0029 0.0206 0.0166
Echinococcus granulosus geminin 0.0172 0.2138 0.2138
Loa Loa (eye worm) pyruvate kinase 0.0036 0.03 0.0522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Plasmodium vivax pyruvate kinase, putative 0.0036 0.03 0.0626
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0263 0.0577
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.1186 0.115
Brugia malayi RNA binding protein 0.0069 0.0743 0.1284
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0128 0.0213
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0073 0.0079
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0041 0.0041
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0669 0.0669
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) hypothetical protein 0.0033 0.0258 0.0448
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Plasmodium falciparum glutathione reductase 0.0032 0.0243 0.0488
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0127
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.154 0.154
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0243 0.0751
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0386 0.0282
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0316 0.0663
Plasmodium falciparum glutathione reductase 0.0093 0.1065 0.247
Brugia malayi Pre-SET motif family protein 0.0063 0.0669 0.1154
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0766 0.093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.123 0.213
Leishmania major DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0209 0.0209
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0073 0.0073
Loa Loa (eye worm) jmjC domain-containing protein 0.0102 0.1186 0.2061
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0243 0.0488
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0243 0.0447
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0169 0.0169
Giardia lamblia PHD finger protein 15 0.003 0.0209 0.0183
Mycobacterium tuberculosis Probable reductase 0.0211 0.2675 0.6862
Leishmania major DNA polymerase eta, putative 0.002 0.0073 0.0119
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0243 0.0226
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0175 0.2179 0.2147
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.03 0.0358
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.03 0.0148
Loa Loa (eye worm) hypothetical protein 0.0133 0.1617 0.2811
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.2734 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0217
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.03 0.388 1
Echinococcus granulosus GPCR family 2 0.0033 0.0258 0.0258
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0209 0.0404
Onchocerca volvulus 0.0499 0.6573 1
Echinococcus multilocularis lamin dm0 0.0029 0.0206 0.0206

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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