Detailed information for compound 683194

Basic information

Technical information
  • TDR Targets ID: 683194
  • Name: N-(2,4-dimethylphenyl)-2-[4-(4-fluorophenyl)- 3-oxopyrazin-2-yl]sulfanylacetamide
  • MW: 383.439 | Formula: C20H18FN3O2S
  • H donors: 1 H acceptors: 2 LogP: 3.69 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1C)C)CSc1nccn(c1=O)c1ccc(cc1)F
  • InChi: 1S/C20H18FN3O2S/c1-13-3-8-17(14(2)11-13)23-18(25)12-27-19-20(26)24(10-9-22-19)16-6-4-15(21)5-7-16/h3-11H,12H2,1-2H3,(H,23,25)
  • InChiKey: OTFWLZCIHRNYHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethylphenyl)-2-[4-(4-fluorophenyl)-3-oxo-pyrazin-2-yl]sulfanyl-acetamide
  • N-(2,4-dimethylphenyl)-2-[[4-(4-fluorophenyl)-3-oxo-2-pyrazinyl]thio]acetamide
  • N-(2,4-dimethylphenyl)-2-[[4-(4-fluorophenyl)-3-keto-pyrazin-2-yl]thio]acetamide
  • N-(2,4-dimethylphenyl)-2-[4-(4-fluorophenyl)-3-oxo-pyrazin-2-yl]sulfanyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ferritin 0.0017 0.0046 0.0046
Brugia malayi hypothetical protein 0.0239 0.1629 0.1629
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0006 0.0027
Loa Loa (eye worm) programmed cell death 8 0.0015 0.0034 0.0034
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0696 0.1438
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0006 0.0012
Schistosoma mansoni acetylcholinesterase 0.0239 0.1629 0.1629
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0696 0.1438
Loa Loa (eye worm) acetylcholinesterase 1 0.1416 1 1
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0007 0.0007
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0015 0.0034 0.0167
Echinococcus granulosus geminin 0.0494 0.344 0.344
Trypanosoma cruzi NADH dehydrogenase, putative 0.0015 0.0034 0.0315
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0696 0.2408
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0015 0.0034 0.0071
Brugia malayi PAS domain containing protein 0.0101 0.0643 0.0643
Loa Loa (eye worm) carboxylesterase 0.1416 1 1
Schistosoma mansoni gliotactin 0.0239 0.1629 0.1629
Mycobacterium ulcerans glutaminase 0.0301 0.2069 1
Schistosoma mansoni microtubule-associated protein tau 0.14 0.9886 0.9886
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0696 0.0696
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0034 0.0066
Loa Loa (eye worm) hypothetical protein 0.0052 0.03 0.03
Brugia malayi beta-lactamase family protein 0.0108 0.0696 0.0696
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0101 0.0488
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0015 0.0034 0.0315
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0696 0.1438
Leishmania major hypothetical protein, conserved 0.0015 0.0034 0.0275
Echinococcus multilocularis acetylcholinesterase 0.1416 1 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0696 0.0696
Echinococcus multilocularis musashi 0.0026 0.0114 0.0114
Mycobacterium ulcerans monoxygenase 0.0015 0.0034 0.0167
Brugia malayi AMP-binding enzyme family protein 0.0023 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Onchocerca volvulus 0.0239 0.1629 0.311
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0034
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0067 0.0231
Loa Loa (eye worm) apoptosis regulator protein 0.0088 0.0552 0.0552
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0006 0.0051
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0923 0.0923
Mycobacterium tuberculosis Carboxylesterase LipT 0.0239 0.1629 0.3365
Schistosoma mansoni neuroligin 3 (S09 family) 0.0239 0.1629 0.1629
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0057 0.0332 0.2803
Loa Loa (eye worm) hypothetical protein 0.0239 0.1629 0.1629
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0042 0.0203
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0187 0.1255 0.1255
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0013 0.0013
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0112 0.0891
Trichomonas vaginalis spcc417.12 protein, putative 0.0239 0.1629 0.311
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0101 0.0208
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0006 0.0012
Brugia malayi MH2 domain containing protein 0.0123 0.0799 0.0799
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0696 0.6352
Echinococcus multilocularis neuropeptide s receptor 0.0484 0.337 0.337
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0101 0.0101
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0057 0.0332 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0015 0.0034 0.0071
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0015 0.0034 0.0315
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0057 0.0332 0.303
Onchocerca volvulus 0.0075 0.0457 0.0873
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0696 0.0696
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0015 0.0034 0.0275
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0417 0.2891 1
Loa Loa (eye worm) thioredoxin reductase 0.0164 0.1096 0.1096
Trichomonas vaginalis apoptosis inducing factor, putative 0.0015 0.0034 0.0066
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0111 0.0718 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0057 0.0332 0.303
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0288 0.0288
Brugia malayi beta-lactamase 0.0108 0.0696 0.0696
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0187 0.0386
Brugia malayi hypothetical protein 0.0052 0.03 0.03
Onchocerca volvulus 0.0012 0.0013 0.0025
Trichomonas vaginalis glutathione reductase, putative 0.0057 0.0332 0.0634
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0152 0.0152
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.06 0.06
Brugia malayi glutathione reductase 0.0164 0.1096 0.1096
Echinococcus granulosus acetylcholinesterase 0.1416 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0332 0.303
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0113 0.0113
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0015 0.0034 0.048
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0071 0.0341
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0241 0.0459
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0006 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.1255 0.6066
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0013 0.0013
Plasmodium vivax thioredoxin reductase, putative 0.0164 0.1096 1
Echinococcus multilocularis expressed protein 0.0017 0.0046 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0034 0.0315
Schistosoma mansoni hypothetical protein 0.0451 0.3131 0.3131
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0112 0.054
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0006 0.0012
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0379 0.0379
Echinococcus multilocularis microtubule associated protein 2 0.14 0.9886 0.9886
Echinococcus granulosus neuroligin 0.0239 0.1629 0.1629
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0111 0.0718 1
Brugia malayi cytochrome P450 0.0011 0.0006 0.0006
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0013 0.0013
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0015 0.0034 0.0275
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0113 0.1032
Schistosoma mansoni ferritin 0.0017 0.0046 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0057 0.0332 0.303
Loa Loa (eye worm) hypothetical protein 0.0239 0.1629 0.1629
Mycobacterium ulcerans thioesterase 0.002 0.0072 0.0348
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0088 0.0552 0.0552
Echinococcus granulosus acetylcholinesterase 0.1416 1 1
Schistosoma mansoni ferritin light chain 0.0017 0.0046 0.0046
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0057 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0012 0.0013 0.0025
Mycobacterium tuberculosis Conserved protein 0.0108 0.0696 0.1438
Loa Loa (eye worm) glutaminase 2 0.0301 0.2069 0.2069
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.03 0.2735
Brugia malayi beta-lactamase family protein 0.0108 0.0696 0.0696
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0006 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.06 0.06
Onchocerca volvulus 0.0108 0.0696 0.1329
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0021 0.0021
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0013 0.0025
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0239 0.1629 0.1629
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0113 0.2641
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0015 0.0034 0.0119
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0696 0.1329
Schistosoma mansoni glutamate synthase 0.0015 0.0034 0.0034
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0239 0.1629 0.1629
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0101 0.0208
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0013 0.0013
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0088 0.0552 0.0552
Echinococcus granulosus neuropeptide s receptor 0.0484 0.337 0.337
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0006 0.0045
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0006 0.0027
Mycobacterium ulcerans polyketide synthase 0.0026 0.0112 0.054
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0006 0.0027
Brugia malayi hypoxia-induced factor 1 0.0312 0.2144 0.2144
Brugia malayi Thioredoxin reductase 0.0164 0.1096 0.1096
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0057 0.0332 0.2647
Onchocerca volvulus 0.0015 0.0034 0.0066
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0571 0.0571
Schistosoma mansoni apoptosis regulator bax 0.0088 0.0552 0.0552
Onchocerca volvulus 0.0012 0.0013 0.0025
Brugia malayi Cytochrome P450 family protein 0.002 0.0071 0.0071
Brugia malayi CXXC zinc finger family protein 0.0032 0.0152 0.0152
Onchocerca volvulus 0.0026 0.0114 0.0217
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0113 0.0901
Plasmodium falciparum thioredoxin reductase 0.0164 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0013 0.0013
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0015 0.0034 0.0275
Entamoeba histolytica G protein alpha subunit, putative 0.0012 0.0013 0.018
Plasmodium falciparum thioredoxin reductase 0.0057 0.0332 0.2803
Echinococcus multilocularis ferritin 0.0017 0.0046 0.0046
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0057 0.0332 0.2803
Onchocerca volvulus 0.0239 0.1629 0.311
Mycobacterium ulcerans carboxylesterase, LipT 0.0239 0.1629 0.7875
Brugia malayi intermediate filament protein 0.0026 0.0114 0.0114
Brugia malayi hypothetical protein 0.0338 0.233 0.233
Loa Loa (eye worm) hypothetical protein 0.0239 0.1629 0.1629
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0332 0.303
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0088 0.0552 0.0552
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0187 0.0904
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0239 0.1629 0.3365
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0012 0.0013 0.0025
Brugia malayi RNA binding protein 0.0064 0.0379 0.0379
Echinococcus granulosus expressed protein 0.0017 0.0046 0.0046
Brugia malayi Cytochrome P450 family protein 0.002 0.0071 0.0071
Onchocerca volvulus 0.0043 0.023 0.0439
Onchocerca volvulus 0.0239 0.1629 0.311
Mycobacterium ulcerans NADH dehydrogenase 0.0015 0.0034 0.0167
Mycobacterium ulcerans putative regulatory protein 0.0075 0.0457 0.2209
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0071 0.0071
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0034 0.0315
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0013 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.06 0.06
Loa Loa (eye worm) hypothetical protein 0.0108 0.0696 0.0696
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0239 0.1629 0.1629
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0006 0.0027
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0101 0.0349
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0015 0.0034 0.0034
Echinococcus granulosus BC026374 protein S09 family 0.0239 0.1629 0.1629
Brugia malayi Carboxylesterase family protein 0.0239 0.1629 0.1629
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0113 0.0113
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0015 0.0034 0.0315
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0057 0.0332 0.0332
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0015 0.0034 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0057 0.0332 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0332 0.303
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0112 0.0386
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0021 0.0021
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0034 0.0066
Onchocerca volvulus 0.0026 0.0114 0.0217
Loa Loa (eye worm) RNA binding protein 0.0064 0.0379 0.0379
Echinococcus multilocularis 0.0011 0.0006 0.0006
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0006 0.0006
Echinococcus granulosus para nitrobenzyl esterase 0.0239 0.1629 0.1629
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0006 0.0012
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0067 0.0324
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0057 0.0332 0.0332
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0113 0.0216
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0006 0.0027
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.022 0.022
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0006 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0696 0.0696
Trichomonas vaginalis set domain proteins, putative 0.0747 0.5237 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0013 0.0013
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0072 0.0249
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0375 0.2594 0.5357
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0012 0.0013 0.0025
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0057 0.0332 0.1605
Mycobacterium leprae Probable lipase LipE 0.0108 0.0696 0.2408
Onchocerca volvulus 0.0239 0.1629 0.311
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0006 0.0027
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0034 0.0315
Schistosoma mansoni ferritin 0.0017 0.0046 0.0046
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0013 0.0025
Toxoplasma gondii aldehyde dehydrogenase 0.0187 0.1255 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0113 0.0216
Schistosoma mansoni apoferritin-2 0.0017 0.0046 0.0046
Brugia malayi Carboxylesterase family protein 0.1416 1 1
Treponema pallidum oxidoreductase 0.0015 0.0034 0.1038
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0691 0.4842 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.06 0.06
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.004 0.0317
Onchocerca volvulus 0.0108 0.0696 0.1329
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0006 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.06 0.06
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0696 0.1438
Plasmodium vivax glutathione reductase, putative 0.0164 0.1096 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0015 0.0034 0.048
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0006 0.0027
Onchocerca volvulus 0.0012 0.0013 0.0025
Schistosoma mansoni hypothetical protein 0.0088 0.0552 0.0552
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0034 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1928 0.1928
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0057 0.0332 1
Echinococcus granulosus lamin 0.0026 0.0114 0.0114
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0015 0.0034 0.0034
Entamoeba histolytica thioredoxin reductase, putative 0.0015 0.0034 0.048
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0239 0.1629 0.1629
Entamoeba histolytica disulphide oxidoreductase, putative 0.0015 0.0034 0.048
Loa Loa (eye worm) hypothetical protein 0.0239 0.1629 0.1629
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.022 0.1746
Leishmania major NADH dehydrogenase, putative 0.0015 0.0034 0.0275
Loa Loa (eye worm) hypothetical protein 0.0026 0.0114 0.0114
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0113 0.0216
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0101 0.0488
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0027 0.0027
Loa Loa (eye worm) glutathione reductase 0.0164 0.1096 0.1096
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0112 0.054
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0113 0.1032
Leishmania major hypothetical protein, conserved 0.0015 0.0034 0.0275
Mycobacterium tuberculosis Probable reductase 0.0375 0.2594 0.5357
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0195 0.1516
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0013 0.0013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0402 0.3206
Mycobacterium tuberculosis Probable dehydrogenase 0.0375 0.2594 0.5357
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0696 0.0696
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0034 0.0315
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0015 0.0034 0.0071
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0013 0.0013
Echinococcus multilocularis cpg binding protein 0.0033 0.0165 0.0165
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0006 0.0012
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0013 0.0013
Onchocerca volvulus 0.0239 0.1629 0.311
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0113 0.1032
Trichomonas vaginalis glutaminase, putative 0.0301 0.2069 0.3949
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0239 0.1629 0.311
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0006 0.0012
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0113 0.0113
Onchocerca volvulus 0.0747 0.5237 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0112 0.0231
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0046 0.0158
Schistosoma mansoni ferritin 0.0017 0.0046 0.0046
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0034 0.0066
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0113 0.1032
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0015 0.0034 0.0119
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0013 0.0013
Schistosoma mansoni glutamate synthase 0.0015 0.0034 0.0034
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.009 0.009
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0015 0.0034 0.0071
Brugia malayi Carboxylesterase family protein 0.0239 0.1629 0.1629
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.06 0.06
Echinococcus multilocularis acetylcholinesterase 0.1416 1 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.06 0.06
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0164 0.1096 0.2264
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0006 0.0019
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0006 0.0027
Schistosoma mansoni hypothetical protein 0.0494 0.344 0.344
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0015 0.0034 0.0066
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0072 0.0149
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0042 0.0225 0.0225
Brugia malayi Carboxylesterase family protein 0.0239 0.1629 0.1629
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0113 0.0216
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0015 0.0034 0.0119
Mycobacterium ulcerans polyketide synthase 0.0024 0.0101 0.0488
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.002 0.002
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0015 0.0034 0.0034
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0013 0.0013
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0195 0.2721
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0379 0.0379
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0071 0.0071
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0007 0.0007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0067 0.0324
Schistosoma mansoni sulfide quinone reductase 0.0015 0.0034 0.0034
Onchocerca volvulus 0.0095 0.06 0.1147
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0015 0.0034 0.0167
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0006 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0696 0.1329
Leishmania major hypothetical protein, conserved 0.0052 0.03 0.2389
Schistosoma mansoni ferritin light chain 0.0017 0.0046 0.0046
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0006 0.0045
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.03 0.2499
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0101 0.0488
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0017 0.0017
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0112 0.0386
Brugia malayi Carboxylesterase family protein 0.0239 0.1629 0.1629
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0015 0.0034 0.048
Loa Loa (eye worm) hypothetical protein 0.1416 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0069 0.0143
Toxoplasma gondii selenide, water dikinase 0.0015 0.0034 0.0275
Trypanosoma brucei trypanothione reductase 0.0164 0.1096 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0046 0.138
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.03 0.2499
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0034 0.0275
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0239 0.1629 0.1629
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0281 0.1928 0.1928
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0006 0.0012
Mycobacterium ulcerans hypothetical protein 0.0108 0.0696 0.3366
Echinococcus multilocularis expressed protein 0.0012 0.0013 0.0013
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0088 0.0552 0.0552
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0013 0.0013
Trypanosoma cruzi trypanothione reductase, putative 0.0164 0.1096 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0017 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.1255 0.6066
Schistosoma mansoni hypothetical protein 0.0088 0.0552 0.0552
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0006 0.0027
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0057 0.0332 0.0332
Schistosoma mansoni apoferritin-2 0.0017 0.0046 0.0046
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0239 0.1629 0.3365
Echinococcus multilocularis thioredoxin glutathione reductase 0.0166 0.1107 0.1107
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0006 0.0027
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0015 0.0034 0.1038
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0013 0.0013
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0046 0.138
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.03 0.2735
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0187 0.1255 1
Echinococcus multilocularis neuroligin 0.0239 0.1629 0.1629
Schistosoma mansoni cpg binding protein 0.0032 0.0152 0.0152
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0057 0.0332 0.2647
Onchocerca volvulus 0.0108 0.0696 0.1329
Schistosoma mansoni aryl hydrocarbon receptor 0.0101 0.0643 0.0643
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0015 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Echinococcus granulosus neuropeptide receptor A26 0.0484 0.337 0.337
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0051 0.0405
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0429 0.0429
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.009 0.0185
Entamoeba histolytica hypothetical protein 0.0111 0.0718 1
Echinococcus multilocularis transfer RNA-Lys 0.0075 0.0457 0.0457
Brugia malayi Pre-SET motif family protein 0.0095 0.06 0.06
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.0033 0.0165 0.0165
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0099 0.0099
Brugia malayi hypothetical protein 0.0034 0.0168 0.0168
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0696 0.0696
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0696 0.1329
Mycobacterium ulcerans beta-lactamase 0.0108 0.0696 0.3366
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0114 0.0114
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0696 0.1329
Echinococcus multilocularis BC026374 protein (S09 family) 0.0239 0.1629 0.1629
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0923 0.0923
Brugia malayi Cytochrome P450 family protein 0.0011 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0015 0.0034 0.1038
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0042 0.0203
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0239 0.1629 0.1629
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0113 0.0216
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.0113 0.0216
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0057 0.0332 0.2647
Plasmodium falciparum glutathione reductase 0.0164 0.1096 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0417 0.2891 0.5972
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0375 0.2594 0.8971
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0379 0.0379
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0187 0.1255 0.1255
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.3131 0.3131
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.022 0.042
Echinococcus multilocularis lamin 0.0026 0.0114 0.0114
Toxoplasma gondii thioredoxin reductase 0.0164 0.1096 0.8736
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0013 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0007 0.0007
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0923 0.0923
Trichomonas vaginalis mercuric reductase, putative 0.0057 0.0332 0.0634
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0015 0.0034 0.0167
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.0219
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0696 0.6233
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0015 0.0034 0.0034
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0042 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0332 0.303
Schistosoma mansoni BC026374 protein (S09 family) 0.0239 0.1629 0.1629
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0257 0.0257
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0006 0.0027
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0006 0.0027
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0034 0.0066
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0015 0.0034 0.0066
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0015 0.0034 0.1038
Mycobacterium ulcerans lipase LipD 0.0108 0.0696 0.3366
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0187 0.0386
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0015 0.0034 0.0034
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0015 0.0034 0.0167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0034
Schistosoma mansoni aldehyde dehydrogenase 0.0187 0.1255 0.1255
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0799 0.0799
Brugia malayi glutamate synthase 0.0015 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0006 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0656 0.4593 0.4593
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0057 0.0332 0.303
Schistosoma mansoni lamin 0.0026 0.0114 0.0114
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.0015 0.0034 0.0275
Leishmania major cytochrome p450-like protein 0.002 0.0071 0.0562
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0094 0.0094
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0013 0.0025
Brugia malayi Pre-SET motif family protein 0.0656 0.4593 0.4593
Schistosoma mansoni single-minded 0.0101 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0006 0.0051
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0015 0.0034 0.0315
Treponema pallidum thioredoxin reductase (trxB) 0.0015 0.0034 0.1038
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0895 0.0895
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0027 0.0027
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.03 0.2389
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0088 0.0552 0.0552
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0696 0.1329
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0006 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0006 0.0012
Mycobacterium tuberculosis Conserved protein 0.0108 0.0696 0.1438
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0379 0.0379
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0113 0.1032
Schistosoma mansoni glutamate synthase 0.0015 0.0034 0.0034
Schistosoma mansoni sulfide quinone reductase 0.0015 0.0034 0.0034
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0108 0.0696 0.0696
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0096 0.0197
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0034 0.0315
Echinococcus multilocularis geminin 0.0494 0.344 0.344
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0034 0.0066
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0101 0.0208
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0015 0.0034 0.0034
Giardia lamblia Thioredoxin reductase 0.0015 0.0034 0.1038
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0026 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1928 0.1928
Mycobacterium ulcerans dehydrogenase 0.0015 0.0034 0.0167
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0113 0.0216
Onchocerca volvulus 0.0023 0.009 0.0171
Mycobacterium ulcerans hypothetical protein 0.0015 0.0034 0.0167
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0057 0.0332 0.303
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0006 0.0051
Loa Loa (eye worm) hypothetical protein 0.1416 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0281 0.1928 0.1928
Trypanosoma brucei cytochrome P450, putative 0.002 0.0071 0.0643
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0113 0.0216
Giardia lamblia NADH oxidase lateral transfer candidate 0.0057 0.0332 1
Schistosoma mansoni cytochrome P450 0.0011 0.0006 0.0006
Toxoplasma gondii ABC1 family protein 0.0108 0.0696 0.5549
Giardia lamblia Glutamate synthase 0.0015 0.0034 0.1038
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0015 0.0034 0.0066
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0013 0.0013
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0113 0.0113
Loa Loa (eye worm) glutaminase 0.0301 0.2069 0.2069
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0013 0.0013
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0112 0.0231
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.03 0.2735
Schistosoma mansoni glutaminase 0.0301 0.2069 0.2069
Loa Loa (eye worm) cytochrome P450 0.0011 0.0006 0.0006
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0015 0.0034 0.0167
Echinococcus granulosus dnaJ subfamily B 0.0451 0.3131 0.3131
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0096 0.0197
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0015 0.0034 0.0066
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0007 0.0007
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0013 0.0013
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0015 0.0034 0.048
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0013 0.0013
Echinococcus multilocularis carboxylesterase 5A 0.1416 1 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0112 0.0386
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0034 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0417 0.2891 0.5972
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0375 0.2594 0.5357
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0057 0.0332 0.1605
Brugia malayi hypothetical protein 0.0111 0.0718 0.0718
Mycobacterium leprae Possible regulatory protein 0.0026 0.0113 0.0391
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0332 0.303
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0046 0.0095
Mycobacterium ulcerans ferredoxin reductase 0.0015 0.0034 0.0167
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0071 0.0643
Trypanosoma cruzi NADH dehydrogenase, putative 0.0015 0.0034 0.0315
Leishmania major cytochrome p450-like protein 0.0011 0.0006 0.0045
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0187 0.1255 0.2591
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0114 0.0114
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0696 0.1438
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0015 0.0034 0.0034
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0006 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0696 0.6352
Leishmania major hypothetical protein, conserved 0.0108 0.0696 0.5549
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0015 0.0034 0.0167
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0015 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0006 0.0027
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0006 0.0027
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0696 0.1438
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0101 0.0488
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0015 0.0034 0.0315
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0332 0.303
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0034 0.0315
Mycobacterium tuberculosis Conserved protein 0.0108 0.0696 0.1438
Treponema pallidum NADH oxidase 0.0057 0.0332 1
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0113 0.0216
Brugia malayi hypothetical protein 0.0012 0.0013 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0417 0.2891 0.5972
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0013 0.0013
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0696 0.0696
Trichomonas vaginalis esterase, putative 0.0108 0.0696 0.1329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.1255 0.6066
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0015 0.0034 0.0119
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0113 0.0113
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0046 0.0095
Echinococcus multilocularis neuropeptide receptor A26 0.0484 0.337 0.337
Plasmodium vivax SET domain protein, putative 0.0095 0.06 0.5332
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0112 0.0231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1928 0.1928
Mycobacterium leprae putative cytochrome p450 0.0011 0.0006 0.0019
Schistosoma mansoni disulfide oxidoreductase 0.0015 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0024
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0088 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0108 0.0696 0.0696
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0006 0.0012
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0015 0.0034 0.1038
Toxoplasma gondii NADPH-glutathione reductase 0.0057 0.0332 0.2647
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0013 0.0013
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0057 0.0332 0.2647
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0013 0.0013
Echinococcus granulosus glutamate synthase 0.0015 0.0034 0.0034
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0013 0.0013
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0006 0.0027
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0042 0.0225 0.0225
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0006 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1928 0.1928
Schistosoma mansoni lamin 0.0026 0.0114 0.0114
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0015 0.0034 0.0034
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.022 0.042
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0088 0.0552 0.0552
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0101 0.0349
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0696 0.1438
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0375 0.2594 0.5357
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.06 0.06
Echinococcus granulosus carboxylesterase 5A 0.1416 1 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0015 0.0034 0.0275
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0015 0.0034 0.0167
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0013 0.0013
Loa Loa (eye worm) acetyltransferase 0.014 0.0923 0.0923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1928 0.1928
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0057 0.0332 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0006 0.0012
Echinococcus granulosus cpg binding protein 0.0033 0.0165 0.0165
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0024 0.0094 0.0094
Brugia malayi TAR-binding protein 0.0064 0.0379 0.0379
Schistosoma mansoni intermediate filament proteins 0.0026 0.0114 0.0114
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0799 0.0799
Schistosoma mansoni ferritin 0.0017 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0111 0.0718 1
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0013 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0239 0.1629 0.1629
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0007 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.03 0.2499
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0187 0.0647
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0113
Mycobacterium ulcerans thioesterase TesA 0.002 0.0072 0.0348
Echinococcus granulosus thioredoxin glutathione reductase 0.0166 0.1107 0.1107
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0379 0.0379
Brugia malayi glutaminase DH11.1 0.0301 0.2069 0.2069
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0013 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0379 0.0379
Leishmania major trypanothione reductase 0.0164 0.1096 0.8736
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0013 0.0013
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0013 0.0013
Onchocerca volvulus 0.0032 0.0152 0.029
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0108 0.0696 0.0696
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0057 0.0332 0.0686
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0015 0.0034 0.0034
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0071 0.0643
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0034 0.0315
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0718 0.0718
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.06 0.4786
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0006 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0696 0.3366
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0015 0.0034 0.0034
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.022 0.1752
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0379 0.0379
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0015 0.0034 0.0034
Onchocerca volvulus 0.0026 0.0113 0.0216
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0013 0.0025
Brugia malayi bHLH-PAS transcription factor 0.0075 0.0457 0.0457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1928 0.1928
Schistosoma mansoni hypothetical protein 0.0111 0.0718 0.0718
Loa Loa (eye worm) CYP4Cod1 0.002 0.0071 0.0071
Echinococcus granulosus microtubule associated protein 2 0.14 0.9886 0.9886
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0007 0.0007
Brugia malayi Cytochrome P450 family protein 0.0051 0.0288 0.0288
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0012 0.0013 0.0025
Brugia malayi G-protein alpha subunit 0.0012 0.0013 0.0013
Mycobacterium ulcerans glutamate synthase subunit beta 0.0015 0.0034 0.0167
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0015 0.0034 0.0071
Schistosoma mansoni aldehyde dehydrogenase 0.0187 0.1255 0.1255
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.022 0.1752
Echinococcus granulosus expressed protein 0.0012 0.0013 0.0013
Trypanosoma brucei NADH dehydrogenase 0.0015 0.0034 0.0315
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0375 0.2594 0.5357
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0006 0.0012
Echinococcus granulosus intermediate filament protein 0.0026 0.0114 0.0114
Leishmania major cytochrome p450-like protein 0.0011 0.0006 0.0045
Echinococcus granulosus tar DNA binding protein 0.0064 0.0379 0.0379
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0015 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0494 0.344 0.344
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0088 0.0552 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0113 0.0216
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0057 0.0332 0.2647
Loa Loa (eye worm) beta-lactamase 0.0108 0.0696 0.0696
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0057 0.0332 0.303
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0015 0.0034 0.048
Echinococcus multilocularis glutamate synthase 0.0015 0.0034 0.0034
Schistosoma mansoni cpg binding protein 0.0033 0.0165 0.0165
Trichomonas vaginalis glutamate synthase, putative 0.0015 0.0034 0.0066
Echinococcus multilocularis lamin dm0 0.0026 0.0114 0.0114
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1416 1 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.1629 0.1629
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0006 0.0012
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0113 0.0216
Loa Loa (eye worm) hypothetical protein 0.0108 0.0696 0.0696
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0696 0.6352
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0718 0.0718
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0052 0.0107
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0696 0.3366
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0195 0.5885
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0057 0.0332 0.303
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0379 0.0379
Echinococcus multilocularis para nitrobenzyl esterase 0.0239 0.1629 0.1629
Loa Loa (eye worm) carboxylesterase 0.0239 0.1629 0.1629
Leishmania major protein kinase, putative 0.0026 0.0113 0.0901
Loa Loa (eye worm) hypothetical protein 0.0338 0.233 0.233
Echinococcus granulosus single minded 2 0.0075 0.0457 0.0457
Loa Loa (eye worm) hypoxia-induced factor 1 0.0312 0.2144 0.2144
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0006 0.0051
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0057 0.0332 0.2803
Plasmodium falciparum glutathione reductase 0.0057 0.0332 0.2803
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0006 0.0027
Trichomonas vaginalis ferritin, putative 0.0017 0.0046 0.0088
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0046 0.0222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1928 0.1928
Trichomonas vaginalis glutamate synthase, putative 0.0015 0.0034 0.0066
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0015 0.0034 0.0071
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0034 0.0275
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0006 0.0012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0718 0.0718
Loa Loa (eye worm) carboxylesterase 0.0239 0.1629 0.1629
Echinococcus granulosus lamin dm0 0.0026 0.0114 0.0114
Leishmania major protein kinase, putative 0.0026 0.0113 0.0901
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0021 0.0021
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0013 0.0013
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0113 0.1032
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0046 0.0222
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0057 0.0332 0.1605

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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