Detailed information for compound 683306

Basic information

Technical information
  • TDR Targets ID: 683306
  • Name: 2-[7-methoxy-2-oxo-3-[(phenylamino)methyl]qui nolin-1-yl]-N-(2-methoxyphenyl)acetamide
  • MW: 443.494 | Formula: C26H25N3O4
  • H donors: 2 H acceptors: 2 LogP: 3.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)n(CC(=O)Nc1ccccc1OC)c(=O)c(c2)CNc1ccccc1
  • InChi: 1S/C26H25N3O4/c1-32-21-13-12-18-14-19(16-27-20-8-4-3-5-9-20)26(31)29(23(18)15-21)17-25(30)28-22-10-6-7-11-24(22)33-2/h3-15,27H,16-17H2,1-2H3,(H,28,30)
  • InChiKey: KONZGDLSMPMBEC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[7-methoxy-2-oxo-3-[(phenylamino)methyl]-1-quinolyl]-N-(2-methoxyphenyl)acetamide
  • 2-[2-keto-7-methoxy-3-[(phenylamino)methyl]-1-quinolyl]-N-(2-methoxyphenyl)acetamide
  • 2-[7-methoxy-2-oxo-3-[(phenylamino)methyl]quinolin-1-yl]-N-(2-methoxyphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.046 0.1049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0459 0.1047
Plasmodium vivax thioredoxin reductase, putative 0.0157 0.2923 1
Giardia lamblia Pyruvate kinase 0.0032 0.0363 0.4436
Schistosoma mansoni hypothetical protein 0.0031 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0031 0.0338 0.0762
Onchocerca volvulus 0.0039 0.0497 0.1133
Entamoeba histolytica pyruvate kinase, putative 0.0022 0.0164 0.0687
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0838 0.1888
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.1529 0.3443
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.046 0.1574
Echinococcus granulosus pyruvate kinase 0.0032 0.0363 0.1231
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.1303 1
Loa Loa (eye worm) glutathione reductase 0.0157 0.2923 0.6583
Loa Loa (eye worm) inositol-1 0.0037 0.0459 0.1034
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0055 0.0819 0.2774
Leishmania major pyruvate kinase 0.0032 0.0363 0.1244
Loa Loa (eye worm) hypothetical protein 0.0089 0.1519 0.3422
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.008 0.1348 0.3036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0363 0.0819
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0166 0.0569
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0752 0.2546
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0131 0.2385 0.5371
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0294 0.0294
Onchocerca volvulus 0.0039 0.0497 0.1133
Brugia malayi Pre-SET motif family protein 0.0201 0.3819 0.8601
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0294 0.0996
Entamoeba histolytica hypothetical protein 0.0089 0.1529 0.6411
Schistosoma mansoni hypothetical protein 0.0031 0.0338 0.0338
Toxoplasma gondii NADPH-glutathione reductase 0.0055 0.0819 0.2803
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0055 0.0819 0.1042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0459 0.1047
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0131 0.2385 0.8158
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.004 0.0523 0.1179
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0459 0.3524
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.444 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0159 0.2953 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0359 0.7047 0.8958
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.046 0.1558
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.0164 0.0369
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0055 0.0819 0.2803
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0363 0.0828
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0819 0.2803
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.1529 0.6411
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.046 0.1574
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0363 0.0819
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0055 0.0819 0.2803
Trichomonas vaginalis glutathione reductase, putative 0.0055 0.0819 0.1868
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.046 0.046
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0166 0.1276
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.1303 0.4412
Onchocerca volvulus 0.008 0.1348 0.3072
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0042 0.0145
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0166 0.0569
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0363 0.0462
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0928 0.3175
Echinococcus granulosus pyruvate kinase 0.0017 0.0042 0.0144
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.0819 0.2803
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.2385 0.8158
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0363 0.1244
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.0819 0.2803
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0363 0.0828
Schistosoma mansoni lipoxygenase 0.0108 0.1924 0.1924
Trichomonas vaginalis mercuric reductase, putative 0.0055 0.0819 0.1868
Echinococcus granulosus pyruvate kinase 0.0017 0.0042 0.0144
Schistosoma mansoni hypothetical protein 0.0031 0.0338 0.0338
Brugia malayi hypothetical protein 0.0039 0.0497 0.1119
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0131 0.2385 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0752 0.2546
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0363 0.0819
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.3819 0.8601
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0363 0.1244
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1303 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0164 0.0369
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0459 0.1555
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0055 0.0819 0.6289
Schistosoma mansoni inositol monophosphatase 0.0037 0.0459 0.0459
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.1529 0.523
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0108 0.1924 0.6515
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0399 0.7866 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.1529 0.523
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0459 0.1555
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.046 0.1049
Echinococcus granulosus transcription factor Dp 1 0.0076 0.1256 0.4251
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.1348 0.4563
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.2385 0.8158
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0166 0.0211
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0166 0.1276
Plasmodium falciparum glutathione reductase 0.0055 0.0819 0.2803
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0166 0.0569
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0838 0.2838
Brugia malayi glutathione reductase 0.0157 0.2923 0.6583
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0055 0.0819 0.2803
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.046 0.1558
Brugia malayi follicle stimulating hormone receptor 0.0231 0.444 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0363 0.0828
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0338 0.0762
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0294 0.0996
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0762 0.1716
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0042 0.0145
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.046 0.1929
Leishmania major trypanothione reductase 0.0157 0.2923 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0363 0.1244
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0166 0.1276
Echinococcus multilocularis pyruvate kinase 0.0017 0.0042 0.0144
Schistosoma mansoni loxhd1 0.0039 0.0497 0.0497
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0272 0.0922
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.046 0.1049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0819 0.2803
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0752 0.0956
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0055 0.0819 0.6289
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0359 0.7047 0.8958
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1074 0.242
Echinococcus multilocularis pyruvate kinase 0.0017 0.0042 0.0144
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.046 0.1036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0294 0.0294
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0338 0.0762
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2145 0.4831
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0359 0.7047 0.8958
Brugia malayi MH2 domain containing protein 0.0119 0.2145 0.4831
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.1529 0.1529
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0363 0.1244
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.1303 0.1303
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0928 0.3143
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0363 0.0828
Schistosoma mansoni pyruvate kinase 0.0032 0.0363 0.0363
Schistosoma mansoni polycystin 1-related 0.0039 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0089 0.1519 0.3422
Brugia malayi Protein kinase domain containing protein 0.0089 0.1529 0.3443
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1303 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0255 0.0872
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.0819 0.2803
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0363 0.0819
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0838 0.2838
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.1303 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0294 0.1006
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0928 0.7124
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.046 0.1558
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.0838 0.1066
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0459 0.1571
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0928 0.0928
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0819 0.2803
Echinococcus granulosus GPCR family 2 0.0031 0.0338 0.1145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0497 0.1119
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0055 0.0819 0.2774
Schistosoma mansoni hypothetical protein 0.0067 0.1074 0.1074
Giardia lamblia NADH oxidase lateral transfer candidate 0.0055 0.0819 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0928 0.7124
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0255 0.0324
Echinococcus multilocularis pyruvate kinase 0.0017 0.0042 0.0144
Schistosoma mansoni inositol monophosphatase 0.0037 0.0459 0.0459
Giardia lamblia Pyruvate kinase 0.0017 0.0042 0.0518
Trichomonas vaginalis set domain proteins, putative 0.0229 0.4387 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.046 0.1036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1709 0.3849
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.046 0.046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0838 0.6433
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.1348 0.1348
Plasmodium falciparum pyruvate kinase 0.0032 0.0363 0.1244
Mycobacterium tuberculosis Probable reductase 0.0359 0.7047 0.8958
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0363 0.279
Loa Loa (eye worm) thioredoxin reductase 0.0157 0.2923 0.6583
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0752 0.0956
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0359 0.7047 0.8958
Plasmodium falciparum thioredoxin reductase 0.0157 0.2923 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.1303 0.4412
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.046 0.5615
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.004 0.0523 0.1179
Loa Loa (eye worm) hypothetical protein 0.0067 0.1074 0.242
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0399 0.7866 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.0819 0.2803
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0497 0.1682
Loa Loa (eye worm) hypothetical protein 0.0039 0.0497 0.1119
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.1348 0.4563
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0497 0.1682
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0459 0.3524
Schistosoma mansoni hypothetical protein 0.0039 0.0497 0.0497
Schistosoma mansoni rab6-interacting 0.0039 0.0497 0.0497
Echinococcus multilocularis RUN 0.0039 0.0497 0.1682
Echinococcus multilocularis pyruvate kinase 0.0025 0.0225 0.076
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1303 0.4458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0294 0.0294
Entamoeba histolytica protein kinase, putative 0.0089 0.1529 0.6411
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1303 0.4458
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0055 0.0819 0.2803
Brugia malayi Pre-SET motif family protein 0.0029 0.0294 0.0662
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0819 0.2803
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0055 0.0819 0.2803
Entamoeba histolytica hypothetical protein 0.0023 0.0166 0.0697
Trypanosoma brucei trypanothione reductase 0.0157 0.2923 1
Leishmania major pyruvate kinase 0.0032 0.0363 0.1244
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.046 0.1558
Plasmodium falciparum thioredoxin reductase 0.0055 0.0819 0.2803
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0131 0.2385 0.8074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.0819 0.2803
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.2385 0.8158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0294 0.0294
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1303 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.0838 0.2868
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.1348 0.3036
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.1529 0.523
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0166 0.0569
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0363 0.1244
Treponema pallidum NADH oxidase 0.0055 0.0819 0.6289
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0166 0.1276
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0497 0.1682
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0055 0.0819 0.0819
Brugia malayi Doublecortin family protein 0.0039 0.0497 0.1119
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0131 0.2385 0.5371
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0338 0.1145
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.038 0.0483
Schistosoma mansoni pyruvate kinase 0.0017 0.0042 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0338 0.1145
Toxoplasma gondii thioredoxin reductase 0.0157 0.2923 1
Schistosoma mansoni rab6-interacting 0.0039 0.0497 0.0497
Brugia malayi hypothetical protein 0.0039 0.0497 0.1119
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0459 0.1571
Chlamydia trachomatis pyruvate kinase 0.0032 0.0363 0.279
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0399 0.7866 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0055 0.0819 0.6289
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0363 0.0819
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0363 0.1244
Echinococcus multilocularis thioredoxin glutathione reductase 0.0159 0.2953 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0055 0.0819 0.2803
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0166 0.0569
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.046 0.1558
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.0838 0.0838
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0042 0.0145
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0363 0.0819
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0166 0.0569
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0838 0.6433
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0459 0.1571
Echinococcus multilocularis pyruvate kinase 0.0032 0.0363 0.1231
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0255 0.1956
Plasmodium falciparum glutathione reductase 0.0157 0.2923 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.0819 0.2803
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0055 0.0819 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0819 0.2803
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0459 0.1571
Brugia malayi Thioredoxin reductase 0.0157 0.2923 0.6583
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0166 0.0211
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0497 0.1119
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0459 0.1047
Onchocerca volvulus 0.0029 0.0294 0.067
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.1256 0.4251
Echinococcus multilocularis pyruvate kinase 0.0032 0.0363 0.1231
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0055 0.0819 0.1846
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0819 0.2803
Onchocerca volvulus 0.0229 0.4387 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0928 0.3143
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0497 0.17
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0459 0.1571
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0255 0.0872
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0497 0.1682
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0055 0.0819 0.2803
Loa Loa (eye worm) hypothetical protein 0.0098 0.1709 0.3849
Echinococcus multilocularis dual specificity 0.0089 0.1529 0.5176
Loa Loa (eye worm) hypothetical protein 0.0029 0.0294 0.0662
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0359 0.7047 0.8958
Trypanosoma cruzi trypanothione reductase, putative 0.0157 0.2923 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.046 0.1574
Entamoeba histolytica protein kinase, putative 0.0089 0.1529 0.6411
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0359 0.7047 0.8958
Brugia malayi Probable ClpP-like protease 0.0078 0.1303 0.2935
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0497 0.17
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0363 0.0828
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.1303 0.4458
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0752 0.0956
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1709 0.3849
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.046 0.1574
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.046 0.1558
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0055 0.0819 0.2803
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0108 0.1924 0.6515
Echinococcus multilocularis GPCR, family 2 0.0031 0.0338 0.1145
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0497 0.1682
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0294 0.0996
Plasmodium vivax glutathione reductase, putative 0.0157 0.2923 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0338 0.0762
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0157 0.2923 0.3716
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0819 0.2803
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1709 0.3849
Toxoplasma gondii hypothetical protein 0.0027 0.0255 0.0872
Echinococcus granulosus pyruvate kinase 0.0017 0.0042 0.0144
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.1303 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0363 0.0462
Mycobacterium tuberculosis Probable oxidoreductase 0.0399 0.7866 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0459 0.1925
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.1303 0.1656
Schistosoma mansoni hypothetical protein 0.0031 0.0338 0.0338
Echinococcus granulosus dual specificity 0.0089 0.1529 0.5176
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2145 0.4831
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0338 0.1145
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0928 0.118
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0928 0.3175
Loa Loa (eye worm) hypothetical protein 0.0078 0.1303 0.2935
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0055 0.0819 0.6289
Schistosoma mansoni pyruvate kinase 0.0032 0.0363 0.0363
Brugia malayi Inositol-1 0.0037 0.0459 0.1034
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0131 0.2385 0.8074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0055 0.0819 0.6289
Echinococcus granulosus pyruvate kinase 0.0032 0.0363 0.1231
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.038 0.0483
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0131 0.2385 0.2385
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0166 0.1276
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0928 0.7124
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0338 0.1145
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0294 0.1006
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0497 0.1682
Schistosoma mansoni lipoxygenase 0.0039 0.0497 0.0497
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.1529 0.523
Echinococcus granulosus RUN 0.0039 0.0497 0.1682
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1303 0.4458
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0055 0.0819 0.6289

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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