Detailed information for compound 683329

Basic information

Technical information
  • TDR Targets ID: 683329
  • Name: [2-[(3-fluorophenyl)amino]-2-oxoethyl] 3-acet ylindolizine-1-carboxylate
  • MW: 354.332 | Formula: C19H15FN2O4
  • H donors: 1 H acceptors: 3 LogP: 3.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)F)COC(=O)c1cc(n2c1cccc2)C(=O)C
  • InChi: 1S/C19H15FN2O4/c1-12(23)17-10-15(16-7-2-3-8-22(16)17)19(25)26-11-18(24)21-14-6-4-5-13(20)9-14/h2-10H,11H2,1H3,(H,21,24)
  • InChiKey: HRYXZHNILFDPMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(3-fluorophenyl)amino]-2-oxo-ethyl] 3-acetylindolizine-1-carboxylate
  • 3-acetyl-1-indolizinecarboxylic acid [2-[(3-fluorophenyl)amino]-2-oxoethyl] ester
  • 3-acetylindolizine-1-carboxylic acid [2-[(3-fluorophenyl)amino]-2-keto-ethyl] ester
  • [2-[(3-fluorophenyl)amino]-2-oxo-ethyl] 3-ethanoylindolizine-1-carboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus thioredoxin glutathione reductase 0.0116 0.0841 0.0841
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0224 0.1466
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.026 0.2016 0.3438
Brugia malayi glutathione reductase 0.0114 0.0829 0.0824
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0224 0.0218
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0289 0.2252 0.389
Plasmodium vivax thioredoxin reductase, putative 0.0114 0.0829 1
Brugia malayi Cytochrome P450 family protein 0.0049 0.03 0.0294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0275 0.2134 0.2134
Mycobacterium ulcerans lipase LipD 0.0107 0.0769 0.3227
Brugia malayi beta-lactamase family protein 0.0107 0.0769 0.0764
Onchocerca volvulus 0.0038 0.0213 0.0347
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0107 0.0769 0.0763
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0114 0.0829 0.1161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0224 0.2595
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0454 0.0454
Schistosoma mansoni BC026374 protein (S09 family) 0.021 0.1609 0.1609
Entamoeba histolytica hypothetical protein 0.0111 0.0803 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0224 0.2595
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0769 0.1046
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0224 0.0224
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1363 0.5932
Brugia malayi Cytochrome P450 family protein 0.0019 0.006 0.0055
Echinococcus multilocularis para nitrobenzyl esterase 0.021 0.1609 0.1609
Loa Loa (eye worm) hypothetical protein 0.021 0.1609 0.1603
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0007 0.0007
Onchocerca volvulus 0.003 0.015 0.0239
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0769 0.3227
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.015 0.0143
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.5632 0.5632
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.2134 0.2134
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0224 0.2595
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.006 0.0599
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0769 0.3381
Loa Loa (eye worm) hypothetical protein 0.021 0.1609 0.1603
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.021 0.1609 0.2657
Loa Loa (eye worm) hypothetical protein 0.0173 0.1308 0.1302
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0012 0.0012
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.04 0.0395
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.059 0.0584
Echinococcus granulosus acetylcholinesterase 0.1244 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0769 0.1046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0275 0.2134 0.2134
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0682 0.5437 1
Loa Loa (eye worm) hypothetical protein 0.1244 1 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.059 0.059
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0769 0.1046
Schistosoma mansoni hypothetical protein 0.0111 0.0803 0.0803
Echinococcus multilocularis BC026374 protein (S09 family) 0.021 0.1609 0.1609
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0224 0.1466
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0769 0.1046
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.004 0.0224 1
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0224 0.0837
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0224 0.0224
Loa Loa (eye worm) glutaminase 2 0.029 0.2256 0.2251
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0652 0.428
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0652 0.0652
Brugia malayi hypothetical protein 0.0173 0.1308 0.1303
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0224 0.2124
Loa Loa (eye worm) hypothetical protein 0.0085 0.059 0.0584
Echinococcus granulosus dnaJ subfamily B 0.0434 0.3424 0.3424
Brugia malayi Carboxylesterase family protein 0.021 0.1609 0.1604
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0224 0.157
Schistosoma mansoni gliotactin 0.021 0.1609 0.1609
Loa Loa (eye worm) RNA binding protein 0.0061 0.04 0.0394
Mycobacterium tuberculosis Conserved protein 0.0107 0.0769 0.1046
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0012 0.0005
Brugia malayi hypothetical protein 0.0111 0.0803 0.0798
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.012 0.1323
Trichomonas vaginalis spcc417.12 protein, putative 0.021 0.1609 0.2755
Mycobacterium tuberculosis Putative ferredoxin reductase 0.026 0.2016 0.3438
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.021 0.1609 0.1603
Loa Loa (eye worm) beta-lactamase 0.0107 0.0769 0.0763
Schistosoma mansoni tar DNA-binding protein 0.0061 0.04 0.04
Toxoplasma gondii aldehyde dehydrogenase 0.018 0.1363 1
Toxoplasma gondii thioredoxin reductase 0.0114 0.0829 0.5705
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.018 0.1363 0.1363
Echinococcus multilocularis tar DNA binding protein 0.0061 0.04 0.04
Schistosoma mansoni cpg binding protein 0.003 0.015 0.015
Brugia malayi Carboxylesterase family protein 0.021 0.1609 0.1604
Loa Loa (eye worm) glutathione reductase 0.0114 0.0829 0.0823
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.004 0.0224 0.5
Schistosoma mansoni apoptosis regulator bax 0.0085 0.059 0.059
Echinococcus granulosus carboxylesterase 5A 0.1244 1 1
Brugia malayi hypothetical protein 0.021 0.1609 0.1604
Toxoplasma gondii ABC1 family protein 0.0107 0.0769 0.5222
Mycobacterium ulcerans hypothetical protein 0.0107 0.0769 0.3227
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0138 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.0652 0.0652
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0769 0.1306
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0769 0.3227
Loa Loa (eye worm) CYP4Cod1 0.0019 0.006 0.0054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0224 0.2595
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0224 0.0743
Loa Loa (eye worm) hypothetical protein 0.021 0.1609 0.1603
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.018 0.1363 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0275 0.2134 0.2134
Schistosoma mansoni single-minded 0.0052 0.0321 0.0321
Schistosoma mansoni neuroligin 3 (S09 family) 0.021 0.1609 0.1609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.2134 0.2134
Loa Loa (eye worm) carboxylesterase 0.1244 1 1
Plasmodium falciparum glutathione reductase 0.004 0.0224 0.1466
Echinococcus multilocularis cpg binding protein 0.0032 0.0164 0.0164
Trichomonas vaginalis esterase, putative 0.0107 0.0769 0.1306
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.059 0.059
Trichomonas vaginalis set domain proteins, putative 0.0728 0.581 1
Leishmania major cytochrome p450-like protein 0.0019 0.006 0.0362
Brugia malayi Thioredoxin reductase 0.0114 0.0829 0.0824
Echinococcus granulosus neuropeptide s receptor 0.0477 0.3771 0.3771
Brugia malayi hypoxia-induced factor 1 0.016 0.1199 0.1194
Brugia malayi hypothetical protein 0.0017 0.0043 0.0037
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0275 0.2134 0.2134
Loa Loa (eye worm) hypothetical protein 0.021 0.1609 0.1603
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0224 0.157
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.3771 0.3771
Schistosoma mansoni tar DNA-binding protein 0.0061 0.04 0.04
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0007 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.03 0.0294
Treponema pallidum NADH oxidase 0.004 0.0224 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0769 0.0769
Echinococcus granulosus single minded 2 0.0038 0.0213 0.0213
Echinococcus granulosus para nitrobenzyl esterase 0.021 0.1609 0.1609
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.026 0.2016 0.3438
Schistosoma mansoni hypothetical protein 0.0085 0.059 0.059
Loa Loa (eye worm) hypothetical protein 0.0107 0.0769 0.0763
Onchocerca volvulus 0.0092 0.0652 0.1104
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0012 0.0012
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.021 0.1609 0.1609
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0224 0.2124
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.5632 0.5632
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.059 0.059
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.021 0.1609 0.1609
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.021 0.1609 0.2657
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.04 0.0394
Loa Loa (eye worm) hypothetical protein 0.1244 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0769 0.1306
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0224 0.2595
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.006 0.0599
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0652 0.0652
Loa Loa (eye worm) hypoxia-induced factor 1 0.016 0.1199 0.1193
Entamoeba histolytica hypothetical protein 0.0111 0.0803 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.012 0.0113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0639 0.5093 0.509
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0224 0.2595
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1244 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.004 0.0224 0.5
Schistosoma mansoni hypothetical protein 0.0085 0.059 0.059
Plasmodium falciparum glutathione reductase 0.0114 0.0829 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0224 0.157
Brugia malayi Cytochrome P450 family protein 0.0019 0.006 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0652 0.0652
Brugia malayi Pre-SET motif family protein 0.0639 0.5093 0.509
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0895 0.0889
Trypanosoma cruzi trypanothione reductase, putative 0.0114 0.0829 1
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0803 0.0803
Mycobacterium ulcerans glutaminase 0.029 0.2256 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0138 0.0133
Brugia malayi TAR-binding protein 0.0061 0.04 0.0395
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0224 0.2124
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0769 0.9153
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0895 0.0889
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0224 0.0837
Loa Loa (eye worm) carboxylesterase 0.021 0.1609 0.1603
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.006 0.0054
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.021 0.1609 0.2755
Entamoeba histolytica hypothetical protein 0.0111 0.0803 0.5
Mycobacterium tuberculosis Conserved protein 0.0107 0.0769 0.1046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0652 0.0652
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.3424 0.3424
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0224 0.5
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0224 0.1466
Loa Loa (eye worm) TAR-binding protein 0.0061 0.04 0.0394
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0769 0.9265
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0289 0.2252 0.389
Loa Loa (eye worm) thioredoxin reductase 0.0114 0.0829 0.0823
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0769 0.0769
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0769 0.1046
Brugia malayi hypothetical protein 0.0027 0.012 0.0114
Mycobacterium tuberculosis Conserved protein 0.0107 0.0769 0.1046
Loa Loa (eye worm) hypothetical protein 0.0092 0.0652 0.0646
Onchocerca volvulus 0.0107 0.0769 0.1306
Echinococcus granulosus BC026374 protein S09 family 0.021 0.1609 0.1609
Mycobacterium ulcerans beta-lactamase 0.0107 0.0769 0.3227
Loa Loa (eye worm) hypothetical protein 0.0107 0.0769 0.0763
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0803 0.0803
Echinococcus multilocularis acetylcholinesterase 0.1244 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.018 0.1363 0.2185
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.021 0.1609 0.1609
Echinococcus granulosus cpg binding protein 0.0032 0.0164 0.0164
Loa Loa (eye worm) glutaminase 0.029 0.2256 0.2251
Plasmodium vivax glutathione reductase, putative 0.0114 0.0829 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0289 0.2252 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0224 0.2124
Echinococcus granulosus tar DNA binding protein 0.0061 0.04 0.04
Brugia malayi MH2 domain containing protein 0.0122 0.0895 0.089
Brugia malayi glutaminase DH11.1 0.029 0.2256 0.2252
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0012 0.0012
Plasmodium falciparum thioredoxin reductase 0.0114 0.0829 1
Entamoeba histolytica hypothetical protein 0.0111 0.0803 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0803 0.0803
Schistosoma mansoni cpg binding protein 0.0032 0.0164 0.0164
Onchocerca volvulus 0.021 0.1609 0.2755
Brugia malayi Carboxylesterase family protein 0.021 0.1609 0.1604
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0213 0.0693
Loa Loa (eye worm) hypothetical protein 0.021 0.1609 0.1603
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.012 0.1323
Echinococcus multilocularis thioredoxin glutathione reductase 0.0116 0.0841 0.0841
Onchocerca volvulus 0.021 0.1609 0.2755
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1363 0.1363
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0224 0.0743
Brugia malayi beta-lactamase family protein 0.0107 0.0769 0.0764
Loa Loa (eye worm) hypothetical protein 0.0107 0.0769 0.0763
Plasmodium vivax SET domain protein, putative 0.0092 0.0652 0.7501
Loa Loa (eye worm) carboxylesterase 0.021 0.1609 0.1603
Leishmania major hypothetical protein, conserved 0.0107 0.0769 0.5604
Echinococcus multilocularis carboxylesterase 5A 0.1244 1 1
Trichomonas vaginalis glutaminase, putative 0.029 0.2256 0.3871
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0321 0.0321
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.3771 0.3771
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0769 0.0764
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0769 0.1306
Brugia malayi Pre-SET motif family protein 0.0092 0.0652 0.0647
Brugia malayi PAS domain containing protein 0.0052 0.0321 0.0316
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.021 0.1609 0.1609
Brugia malayi Carboxylesterase family protein 0.1244 1 1
Schistosoma mansoni hypothetical protein 0.0085 0.059 0.059
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.026 0.2016 0.8947
Onchocerca volvulus 0.0728 0.581 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0652 0.0652
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1363 0.1363
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.006 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0061 0.04 0.04
Mycobacterium tuberculosis Probable oxidoreductase 0.0289 0.2252 0.389
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0769 0.1046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0224 0.2595
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0275 0.2134 0.2129
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0224 0.1466
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.059 0.059
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0769 0.9218
Mycobacterium tuberculosis Carboxylesterase LipT 0.021 0.1609 0.2657
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1363 0.5932
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0769 0.1306
Schistosoma mansoni acetylcholinesterase 0.021 0.1609 0.1609
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0769 0.0763
Echinococcus granulosus family S9 non peptidase ue S09 family 0.021 0.1609 0.1609
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0769 0.0769
Onchocerca volvulus 0.0107 0.0769 0.1306
Brugia malayi CXXC zinc finger family protein 0.003 0.015 0.0144
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0224 0.0224
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.012 0.0771
Mycobacterium tuberculosis Probable reductase 0.026 0.2016 0.3438
Schistosoma mansoni glutaminase 0.029 0.2256 0.2256
Trypanosoma brucei trypanothione reductase 0.0114 0.0829 1
Plasmodium falciparum thioredoxin reductase 0.004 0.0224 0.1466
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0224 0.0743
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.018 0.1363 0.1363
Echinococcus granulosus neuroligin 0.021 0.1609 0.1609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0275 0.2134 0.2129
Onchocerca volvulus 0.021 0.1609 0.2755
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0224 0.0366
Echinococcus granulosus acetylcholinesterase 0.1244 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.04 0.04
Onchocerca volvulus 0.021 0.1609 0.2755
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0224 0.2595
Mycobacterium leprae Probable lipase LipE 0.0107 0.0769 0.3381
Brugia malayi Carboxylesterase family protein 0.021 0.1609 0.1604
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0224 0.2595
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0652 0.0652
Echinococcus multilocularis acetylcholinesterase 0.1244 1 1
Mycobacterium ulcerans carboxylesterase, LipT 0.021 0.1609 0.7052
Loa Loa (eye worm) hypothetical protein 0.021 0.1609 0.1603
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0398 0.2242
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0213 0.0207
Schistosoma mansoni hypothetical protein 0.0434 0.3424 0.3424
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0769 0.1046
Leishmania major trypanothione reductase 0.0114 0.0829 0.6049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.2134 0.2134
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0224 0.0366
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.059 0.0585
Mycobacterium tuberculosis Probable dehydrogenase 0.026 0.2016 0.3438
Schistosoma mansoni tar DNA-binding protein 0.0061 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0107 0.0769 0.0763
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1363 0.5932
Echinococcus granulosus microtubule associated protein 2 0.0706 0.5632 0.5632
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0769 0.1306
Loa Loa (eye worm) hypothetical protein 0.0107 0.0769 0.0763
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0224 0.157
Schistosoma mansoni cpg binding protein 0.0032 0.0164 0.0164
Echinococcus multilocularis neuroligin 0.021 0.1609 0.1609
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0769 0.9265
Brugia malayi RNA binding protein 0.0061 0.04 0.0395
Loa Loa (eye worm) acetylcholinesterase 1 0.1244 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.3771 0.3771
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0213 0.0213
Onchocerca volvulus 0.021 0.1609 0.2755
Onchocerca volvulus 0.0107 0.0769 0.1306
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.026 0.2016 0.3438
Leishmania major hypothetical protein, conserved 0.0027 0.012 0.08
Brugia malayi beta-lactamase 0.0107 0.0769 0.0764
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.059 0.059

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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