Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0064 | 0.0918 | 0.2302 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0017 | 0.0161 | 0.0389 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0472 | 0.0333 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0472 | 0.1173 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0161 | 0.0246 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0472 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0008 | 0.0008 | 0.0012 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.0698 | 0.1063 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0017 | 0.0161 | 0.0246 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.0698 | 0.1063 |
Onchocerca volvulus | 0.0036 | 0.0472 | 0.7083 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0472 | 0.1173 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0144 | 0.0219 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0008 | 0.0012 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.0771 | 0.1174 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0698 | 0.1063 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0029 | 0.0044 |
Onchocerca volvulus | 0.0029 | 0.0353 | 0.5266 | |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0037 | 0.0075 |
Brugia malayi | MH2 domain containing protein | 0.0253 | 0.3964 | 1 |
Onchocerca volvulus | 0.0036 | 0.0472 | 0.7083 | |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0472 | 0.0333 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0344 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0161 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0472 | 0.1173 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0472 | 0.0333 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0472 | 0.1173 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0472 | 0.1173 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0472 | 0.0718 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0472 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0008 | 0.0008 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0472 | 0.1173 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.016 | 0.2458 | 0.6193 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0663 | 0.1009 |
Loa Loa (eye worm) | nuclear factor I | 0.001 | 0.0037 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1643 | 0.4134 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0663 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.0771 | 0.1174 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0161 | 0.0246 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0161 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0698 | 0.1063 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0627 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0472 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0512 | 0.0779 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0161 | 0.0389 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0918 | 0.1399 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0017 | 0.0161 | 0.0246 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0512 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0512 | 0.0779 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0008 | 0.0008 | 0.0012 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0472 | 0.0333 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0698 | 0.1063 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.0771 | 0.1174 |
Onchocerca volvulus | 0.0036 | 0.0472 | 0.7083 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0472 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0663 | 0.1009 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0472 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.0698 | 0.1745 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0663 | 0.1009 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0472 | 0.0718 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0353 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0472 | 0.1173 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0627 | 1 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0008 | 0.0008 | 0.0012 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.0879 | 0.1338 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0161 | 0.0389 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0918 | 0.2302 |
Loa Loa (eye worm) | Smad1 | 0.0017 | 0.0161 | 0.0389 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.0698 | 0.1745 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0029 | 0.0053 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0918 | 0.2302 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0017 | 0.0161 | 0.0246 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0219 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0353 | 0.0537 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0472 | 0.0333 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0918 | 0.2302 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0472 | 0.1173 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.0698 | 0.1745 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.0771 | 0.1174 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0663 | 0.1009 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0663 | 0.1009 |
Echinococcus granulosus | smad | 0.0017 | 0.0161 | 0.0246 |
Echinococcus multilocularis | smad | 0.0017 | 0.0161 | 0.0246 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0472 | 0.0718 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0144 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0017 | 0.0161 | 0.0246 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0472 | 0.0333 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.016 | 0.2458 | 0.6193 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0219 |
Schistosoma mansoni | smad | 0.0008 | 0.0008 | 0.0012 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0472 | 0.1173 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0472 | 0.0333 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0663 | 0.1009 |
Schistosoma mansoni | smad | 0.0017 | 0.0161 | 0.0246 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0233 | 0.3642 | 0.3549 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0512 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0512 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0472 | 0.1173 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0161 | 0.0389 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0353 | 0.0872 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.1643 | 0.4134 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0472 | 0.0333 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0472 | 0.1173 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0512 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0472 | 0.1173 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0253 | 0.3964 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0414 | 0.6567 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0294 | 0.4621 | 0.7038 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0414 | 0.6567 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0918 | 0.1399 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0037 | 0.0075 |
Brugia malayi | Smad1 | 0.0017 | 0.0161 | 0.0389 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0918 | 0.2302 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0663 | 0.1656 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0027 | 0.0048 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0344 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0472 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0472 | 0.5 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0663 | 0.1009 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0472 | 1 |
Echinococcus granulosus | Smad4 | 0.0017 | 0.0161 | 0.0246 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0219 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0918 | 0.2302 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0379 | 0.0578 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.0771 | 0.1174 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0918 | 0.1399 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0379 | 0.0578 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.016 | 0.2458 | 0.6193 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0379 | 0.0578 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0472 | 0.0333 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.019 | 0.2955 | 0.45 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.2458 | 0.6193 |
Schistosoma mansoni | Smad4 | 0.0017 | 0.0161 | 0.0246 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0379 | 0.0578 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0663 | 0.1656 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0918 | 0.1399 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0663 | 0.1656 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0472 | 0.5 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0627 | 1 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0017 | 0.0161 | 0.0246 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0472 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0918 | 0.1399 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0253 | 0.3964 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.0771 | 0.1929 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0472 | 0.0333 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.0698 | 0.1063 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6567 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.0698 | 0.1063 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0219 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.0698 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0771 | 0.1929 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.019 | 0.2955 | 0.45 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0219 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.0771 | 0.1929 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0017 | 0.0161 | 0.0389 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0344 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0037 | 0.0075 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0472 | 0.0718 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0512 | 0.1274 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0017 | 0.0161 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0698 | 0.1745 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0029 | 0.0044 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0472 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0663 | 0.1656 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0512 | 0.0779 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0698 | 0.1063 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.1643 | 0.2502 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0472 | 0.0333 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0512 | 0.0779 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.0698 | 0.1063 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0918 | 0.1399 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.0772 | 0.0638 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0918 | 0.1399 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0008 | 0.0012 |
Onchocerca volvulus | 0.0048 | 0.0663 | 1 | |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0144 | 0.0219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.