Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.285 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.285 | 0.047 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.285 | 0.2772 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.285 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0108 | 0.0434 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.002 | 0.285 | 0.047 |
Brugia malayi | Bloom's syndrome protein homolog | 0.002 | 0.285 | 0.047 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2497 | 0.8713 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.285 | 0.047 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.002 | 0.285 | 0.047 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.285 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.2497 | 0.8762 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2497 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.285 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.285 | 0.2772 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.285 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.285 | 0.285 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.002 | 0.285 | 0.047 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.285 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.285 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.285 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0108 | 0.0381 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2497 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0108 | 0.0108 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2497 | 0.8713 |
Echinococcus granulosus | bloom syndrome protein | 0.002 | 0.285 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0108 | 0.0000000023308 |
Echinococcus multilocularis | bloom syndrome protein | 0.002 | 0.285 | 0.047 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2497 | 0.8762 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2497 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2497 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.002 | 0.285 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.285 | 0.2772 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2497 | 0.2415 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.285 | 0.285 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.285 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0108 | 0.0381 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.285 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.285 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2497 | 0.2497 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.002 | 0.285 | 0.047 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2497 | 0.2497 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.