Detailed information for compound 68447

Basic information

Technical information
  • TDR Targets ID: 68447
  • Name: 2-[3-fluoro-5-[(4,5,7-trifluoro-1,3-benzothia zol-2-yl)methyl]phenyl]acetic acid
  • MW: 355.307 | Formula: C16H9F4NO2S
  • H donors: 1 H acceptors: 3 LogP: 4.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1cc(cc(c1)F)Cc1sc2c(n1)c(F)c(cc2F)F
  • InChi: 1S/C16H9F4NO2S/c17-9-2-7(1-8(3-9)5-13(22)23)4-12-21-15-14(20)10(18)6-11(19)16(15)24-12/h1-3,6H,4-5H2,(H,22,23)
  • InChiKey: QTRSOQZYDPPSJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[3-fluoro-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]phenyl]ethanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Aldose reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 335 aa 19.7 %
Onchocerca volvulus Aldose reductase   316 aa 321 aa 40.5 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 279 aa 30.1 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   316 aa 322 aa 26.1 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 278 aa 34.9 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 324 aa 18.5 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 278 aa 34.9 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   316 aa 321 aa 25.5 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   316 aa 288 aa 23.3 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 279 aa 30.1 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 324 aa 18.5 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   316 aa 320 aa 41.6 %
Onchocerca volvulus Aldose reductase   316 aa 313 aa 37.7 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   316 aa 293 aa 26.6 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   316 aa 306 aa 28.8 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   316 aa 313 aa 20.1 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 335 aa 19.7 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 321 aa 20.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0411 0.2563 0.2563
Schistosoma mansoni nuclear receptor 0.0143 0.084 0.084
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0034 0.0137 0.0233
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Echinococcus granulosus Regulator of G protein signaling 20 0.0064 0.033 0.033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Mycobacterium tuberculosis Conserved protein 0.0037 0.016 0.0969
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.016 0.095 0.095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Schistosoma mansoni ferritin 0.0019 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0036 0.0149 0.0252
Echinococcus granulosus beta-adrenergic receptor kinase 0.0064 0.033 0.033
Loa Loa (eye worm) oxidoreductase 0.0038 0.0165 0.0281
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0303 0.1871 0.1871
Echinococcus multilocularis musashi 0.0028 0.0099 0.0099
Brugia malayi polk-prov protein 0.0034 0.0137 0.0226
Echinococcus multilocularis beta adrenergic receptor kinase 0.0064 0.033 0.033
Entamoeba histolytica hypothetical protein 0.0076 0.0409 1
Echinococcus granulosus FTZ F1 alpha 0.0303 0.1871 0.1871
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0165 0.0275
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0325 0.0325
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0207 0.5819
Loa Loa (eye worm) serotonin transporter b 0.0107 0.0607 0.1045
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0037 0.0216
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0031
Echinococcus multilocularis glycine receptor subunit beta 0.0065 0.0341 0.0341
Echinococcus multilocularis glycine receptor subunit beta 0.0065 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0325 0.3942
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Echinococcus granulosus sodium and chloride dependent glycine 0.0018 0.0036 0.0036
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0189 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0162
Onchocerca volvulus 0.0037 0.016 0.0233
Onchocerca volvulus 0.0038 0.0165 0.0241
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Schistosoma mansoni lipoxygenase 0.0118 0.0676 0.0676
Schistosoma mansoni axis inhibition protein axin 0.0064 0.033 0.033
Schistosoma mansoni ferritin light chain 0.0019 0.0043 0.0043
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0073 0.039 0.067
Echinococcus granulosus dna polymerase eta 0.0016 0.0021 0.0021
Echinococcus granulosus expressed protein 0.0019 0.0043 0.0043
Loa Loa (eye worm) oxidoreductase 0.0038 0.0165 0.0281
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0058 0.0293 0.0497
Loa Loa (eye worm) ACC-1 protein 0.0014 0.0007 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.016 0.0187
Schistosoma mansoni sodium/chloride dependent transporter 0.0018 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0303 0.1871 0.3228
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0495 0.0495
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0018 0.0036 0.0051
Schistosoma mansoni nAChR subunit 0.0014 0.0007 0.0007
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0167
Loa Loa (eye worm) hypothetical protein 0.0042 0.0189 0.0323
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0303 0.1871 0.1871
Brugia malayi hypothetical protein 0.0042 0.0189 0.0317
Onchocerca volvulus 0.0037 0.016 0.0233
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0036 0.0036
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Mycobacterium ulcerans oxidoreductase 0.0038 0.0165 0.4337
Onchocerca volvulus 0.0036 0.0149 0.0216
Schistosoma mansoni nuclear receptor nhr-48 0.0143 0.084 0.084
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0037 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.033 0.0447
Brugia malayi hypothetical protein 0.016 0.095 0.1634
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.016 0.0187
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Brugia malayi Cathepsin L-like precursor 0.0036 0.0149 0.0246
Entamoeba histolytica rodhanase-like domain containing protein 0.0062 0.0316 0.7611
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0382 0.0382
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0189 0.0189
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0018 0.0036 0.0036
Echinococcus multilocularis axis inhibition protein axin 0.0064 0.033 0.033
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0149 0.1655
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.1469 0.2537
Mycobacterium tuberculosis Conserved protein 0.0037 0.016 0.0969
Onchocerca volvulus 0.0062 0.0316 0.047
Brugia malayi Pre-SET motif family protein 0.091 0.5783 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0143 0.084 0.084
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0325 0.212
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Loa Loa (eye worm) nuclear hormone receptor 0.0143 0.084 0.1448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Schistosoma mansoni regulator of G protein signaling 0.0064 0.033 0.033
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0187 1
Schistosoma mansoni apoferritin-2 0.0019 0.0043 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0012 0.0012
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0382 0.4679
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0188 0.1127 0.1945
Schistosoma mansoni steroid hormone receptor ad4bp 0.0303 0.1871 0.1871
Brugia malayi hypothetical protein 0.0076 0.0409 0.0697
Brugia malayi nuclear receptor NHR-88 0.0303 0.1871 0.3228
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0018 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0059 0.03 0.0515
Brugia malayi Cathepsin L-like precursor 0.0036 0.0149 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0303 0.1871 0.3228
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0036 0.0036
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0065 0.0341 0.0341
Echinococcus multilocularis dna polymerase eta 0.0016 0.0021 0.0021
Loa Loa (eye worm) PXA domain-containing protein 0.0064 0.033 0.0567
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.016 0.0969
Entamoeba histolytica hypothetical protein 0.0064 0.033 0.7971
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.016 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.016 0.016
Brugia malayi hypothetical protein 0.0064 0.033 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.016 0.0969
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0099 0.0167
Loa Loa (eye worm) hypothetical protein 0.0064 0.033 0.0567
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0045 0.0314
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0081 0.2951
Echinococcus granulosus cathepsin l1 0.0024 0.0073 0.0073
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0062 0.0316 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0303 0.1871 0.3228
Echinococcus granulosus axis inhibition protein axin 0.0064 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0021 0.0021
Loa Loa (eye worm) norepinephrine transporter 0.0107 0.0607 0.1045
Trichomonas vaginalis set domain proteins, putative 0.1036 0.6592 1
Onchocerca volvulus 0.0131 0.0764 0.115
Brugia malayi photoreceptor-specific nuclear receptor 0.0303 0.1871 0.3228
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0165 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0165 0.1007
Loa Loa (eye worm) fibroinase 0.0036 0.0149 0.0252
Echinococcus multilocularis nAChR subunit 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0037 0.0216
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0341 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0303 0.1871 0.3228
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Loa Loa (eye worm) oxidoreductase 0.0038 0.0165 0.0281
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0065 0.0341 0.0584
Onchocerca volvulus 0.0062 0.0316 0.047
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0149 0.0252
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0018 0.0036 0.0036
Plasmodium vivax vivapain-1 0.0018 0.0037 0.002
Echinococcus multilocularis FTZ F1 alpha 0.0303 0.1871 0.1871
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0764 0.0764
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0149 0.0216
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0037 0.0429
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.016 0.095 0.1639
Onchocerca volvulus 0.0062 0.0316 0.047
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.016 0.0969
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.0303 0.1871 0.3228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0764 0.0764
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0187 0.0187
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0062 0.0316 0.0316
Echinococcus granulosus serotonin transporter 0.0107 0.0607 0.0607
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.0272
Mycobacterium ulcerans beta-lactamase 0.0037 0.016 0.4145
Brugia malayi intermediate filament protein 0.0028 0.0099 0.0161
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1871 0.1871
Echinococcus granulosus nuclear receptor nhr 48 0.0143 0.084 0.084
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0149 0.0149
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0189 0.0323
Brugia malayi Nuclear hormone receptor-like 1 0.016 0.095 0.1634
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0014 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0303 0.1871 0.3233
Entamoeba histolytica hypothetical protein 0.0076 0.0409 1
Plasmodium vivax vivapain-2 0.0036 0.0149 0.1549
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0409 0.0409
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0036 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0057
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0037 0.0216
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0037 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0143 0.084 0.084
Schistosoma mansoni ap endonuclease 0.002 0.0045 0.0045
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0149 0.0149
Echinococcus multilocularis cysteine protease 0.0036 0.0149 0.0149
Brugia malayi Regulator of G protein signaling domain containing protein 0.0064 0.033 0.0561
Brugia malayi Nuclear hormone receptor E75 0.0143 0.084 0.1443
Brugia malayi Cathepsin L-like precursor 0.0036 0.0149 0.0246
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0081 0.0783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0073 0.0054
Leishmania major hypothetical protein, conserved 0.0037 0.016 0.1803
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Echinococcus granulosus glycine receptor subunit beta 0.0065 0.0341 0.0341
Onchocerca volvulus 0.0036 0.0149 0.0216
Schistosoma mansoni nAChR subunit 0.0014 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0037 0.0037
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0064 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.0272
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0062 0.0316 0.0426
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0207 0.5819
Schistosoma mansoni hypothetical protein 0.0076 0.0409 0.0409
Brugia malayi nuclear receptor RXR 0.0143 0.084 0.1443
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0189 0.2109
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0143 0.084 0.084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Loa Loa (eye worm) hypothetical protein 0.016 0.095 0.1639
Echinococcus granulosus regulator of G protein signaling 7 0.0073 0.039 0.039
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0021 0.0024
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0064 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0121
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0149 0.0149
Echinococcus multilocularis regulator of G protein signaling 3 0.0064 0.033 0.033
Schistosoma mansoni nAChR subunit 0.0014 0.0007 0.0007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0021 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0325 1
Schistosoma mansoni lipoxygenase 0.0042 0.0189 0.0189
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0081 0.0678
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0045 0.0045
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0382 0.4679
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0014 0.0007 0.0007
Echinococcus granulosus aldehyde reductase 0.0027 0.0094 0.0094
Echinococcus granulosus dnaJ subfamily B 0.0446 0.279 0.279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0303 0.1871 0.3233
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0189 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0064 0.033 0.033
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0062 0.0316 0.0426
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0099 0.0161
Trypanosoma cruzi aldo-keto reductase 0.0038 0.0165 0.1873
Leishmania major prostaglandin f synthase, putative 0.0038 0.0165 0.1873
Brugia malayi hypothetical protein 0.0143 0.084 0.1443
Trichomonas vaginalis cdc25b, putative 0.0062 0.0316 0.0426
Onchocerca volvulus 0.0037 0.016 0.0233
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0081 0.3123
Schistosoma mansoni coup transcription factor 0.0303 0.1871 0.1871
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0149 0.0252
Brugia malayi Rhodanese-like domain containing protein 0.0062 0.0316 0.0536
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0045 0.0073
Onchocerca volvulus 0.0036 0.0149 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Echinococcus granulosus ferritin 0.0019 0.0043 0.0043
Onchocerca volvulus 0.0028 0.0099 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Echinococcus granulosus nAChR subunit 0.0014 0.0007 0.0007
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0143 0.084 0.084
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0018 0.0036 0.0057
Schistosoma mansoni z-protein (S1r protein) 0.0073 0.039 0.039
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0258 0.0435
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.016 0.0969
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Plasmodium vivax hypothetical protein, conserved 0.0037 0.016 0.1706
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Onchocerca volvulus 0.0143 0.084 0.1266
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0303 0.1871 0.1871
Schistosoma mansoni nAChR subunit 0.0014 0.0007 0.0007
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.016 0.0969
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0303 0.1871 0.1871
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.016 0.0187
Onchocerca volvulus 0.0038 0.0165 0.0241
Trypanosoma brucei prostaglandin f synthase 0.0038 0.0165 0.1873
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0325 0.0325
Brugia malayi steroid hormone receptor 0.0303 0.1871 0.3228
Brugia malayi conserved hypotetical protein 0.0143 0.084 0.1443
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0303 0.1871 0.3228
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0057 0.0285 0.0489
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0018 0.0036 0.0036
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0187 0.2158
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0382 0.9309
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0019 0.0043 0.0155
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0165 0.0195
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0014 0.0007 0.0007
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0189 0.0189
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0325 0.0325
Echinococcus granulosus cpg binding protein 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.016 0.095 0.1639
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0165 0.0275
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0014 0.0007 0.0007
Echinococcus granulosus aldo keto reductase 0.0038 0.0165 0.0165
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0045 0.0012
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0149 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0165 0.0281
Brugia malayi cathepsin L-like precursor 0.0024 0.0073 0.0115
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Schistosoma mansoni cpg binding protein 0.0033 0.0132 0.0132
Echinococcus multilocularis aldo keto reductase 0.0038 0.0165 0.0165
Onchocerca volvulus 0.0031 0.0121 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0057
Brugia malayi A-kinase anchor protein 10, precursor 0.0064 0.033 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0073 0.0054
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Echinococcus multilocularis aldehyde reductase 0.0027 0.0094 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0303 0.1871 0.1871
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0045 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0303 0.1871 0.1871
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0012 0.0012
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.0165 0.1873
Echinococcus multilocularis cpg binding protein 0.0033 0.0132 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.0165 0.1873
Brugia malayi Cathepsin L-like precursor 0.0036 0.0149 0.0246
Echinococcus multilocularis expressed protein 0.1244 0.793 0.793
Entamoeba histolytica aldose reductase, putative 0.0038 0.0165 0.3726
Brugia malayi Cytochrome P450 family protein 0.0047 0.0222 0.0373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Entamoeba histolytica hypothetical protein 0.0025 0.0081 0.1557
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0143 0.084 0.084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0131 0.0764 0.0764
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0014 0.0007 0.0006
Leishmania major cathepsin L-like protease 0.0136 0.0794 1
Onchocerca volvulus 0.0303 0.1871 0.2832
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0121
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0058 0.0293 0.0503
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0081 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0165 0.0195
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0187 0.0187
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0325 0.3978
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0303 0.1871 0.1871
Loa Loa (eye worm) hypothetical protein 0.0064 0.033 0.0567
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0062 0.0316 0.0426
Echinococcus multilocularis thyroid hormone receptor alpha 0.0303 0.1871 0.1871
Echinococcus multilocularis nuclear receptor nhr 48 0.0143 0.084 0.084
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0303 0.1871 0.1871
Loa Loa (eye worm) hypothetical protein 0.016 0.095 0.1639
Echinococcus granulosus regulator of G protein signaling 7 0.0073 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0062 0.0316 0.0543
Echinococcus granulosus regulator of G protein signaling 3 0.0064 0.033 0.033
Echinococcus multilocularis expressed protein 0.0019 0.0043 0.0043
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0303 0.1871 0.1871
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0143 0.084 0.084
Schistosoma mansoni nuclear receptor 0.0143 0.084 0.084
Leishmania major cathepsin L-like protease 0.0036 0.0149 0.1655
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.016 0.4145
Brugia malayi Regulator of G protein signaling domain containing protein 0.0064 0.033 0.0561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0165 0.0195
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0064 0.033 0.0561
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0187 0.0187
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.016 0.095 0.1639
Brugia malayi follicle stimulating hormone receptor 0.0241 0.1469 0.2532
Trichomonas vaginalis ferritin, putative 0.0019 0.0043 0.0009
Echinococcus multilocularis axis inhibition protein axin 0.0064 0.033 0.033
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0014 0.0007 0.0007
Loa Loa (eye worm) nuclear receptor NHR-67 0.0143 0.084 0.1448
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0341 0.0341
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0045 0.0169
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0131 0.0764 0.0764
Echinococcus granulosus ecdysone induced protein 78C 0.0303 0.1871 0.1871
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0149 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0012 0.0016
Entamoeba histolytica hypothetical protein 0.0076 0.0409 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0014 0.0007 0.0006
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0037 0.0216
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0187 0.0229
Echinococcus granulosus dna polymerase kappa 0.0045 0.0207 0.0207
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0067 0.0599
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0495 0.0495
Schistosoma mansoni sodium/chloride dependent transporter 0.0018 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Echinococcus multilocularis ferritin 0.0019 0.0043 0.0043
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0124 0.0718 0.9018
Schistosoma mansoni axis inhibition protein axin 0.0064 0.033 0.033
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0149 0.0246
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0207 0.0207
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0064 0.033 0.033
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0014 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0161 0.1815
Schistosoma mansoni sodium-dependent amino acid transporter 0.0018 0.0036 0.0036
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0037 0.0037
Brugia malayi nuclear receptor RXR 0.016 0.095 0.1634
Brugia malayi nuclear hormone receptor family member nhr-6 0.0143 0.084 0.1443
Giardia lamblia Aldose reductase 0.0038 0.0165 0.8453
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0303 0.1871 0.1871
Echinococcus granulosus lamin dm0 0.0028 0.0099 0.0099
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0149 0.0216
Echinococcus granulosus sodium and chloride dependent glycine 0.0018 0.0036 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0037 0.0429
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0382 0.0657
Mycobacterium leprae conserved hypothetical protein 0.0037 0.016 0.9557
Onchocerca volvulus 0.0053 0.0258 0.0381
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Echinococcus granulosus cathepsin l1 0.0036 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0042 0.0189 0.0189
Giardia lamblia Aldose reductase 0.0038 0.0165 0.8453
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0121 0.0204
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0149 0.7345
Loa Loa (eye worm) hypothetical protein 0.0131 0.0764 0.1317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0303 0.1871 0.3233
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0045 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.016 0.1803
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0081 0.0622
Brugia malayi beta-lactamase family protein 0.0037 0.016 0.0266
Brugia malayi nuclear hormone receptor 0.0143 0.084 0.1443
Schistosoma mansoni regulator of G protein signaling 0.0064 0.033 0.033
Onchocerca volvulus 0.0018 0.0036 0.0044
Schistosoma mansoni nAChR subunit 0.0014 0.0007 0.0007
Loa Loa (eye worm) solute carrier family 6 member 4 0.0107 0.0607 0.1045
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0045 0.053
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Onchocerca volvulus 0.0018 0.0036 0.0044
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.0165 0.1873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Entamoeba histolytica hypothetical protein 0.0064 0.033 0.7971
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0045 0.0125
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0037 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0042 0.0189 0.0323
Brugia malayi PXA domain containing protein 0.0064 0.033 0.0561
Loa Loa (eye worm) hypothetical protein 0.0303 0.1871 0.3233
Schistosoma mansoni ferritin light chain 0.0019 0.0043 0.0043
Echinococcus multilocularis lamin 0.0028 0.0099 0.0099
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0021 0.0021
Entamoeba histolytica aldose reductase, putative 0.0038 0.0165 0.3726
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0081 1
Trichomonas vaginalis esterase, putative 0.0037 0.016 0.0187
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.033 0.0447
Schistosoma mansoni ferritin 0.0019 0.0043 0.0043
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0126 0.0729 0.0729
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0303 0.1871 0.1871
Onchocerca volvulus 0.0028 0.0099 0.0141
Brugia malayi orphan nuclear receptor NR2E1 0.0143 0.084 0.1443
Echinococcus granulosus lamin 0.0028 0.0099 0.0099
Leishmania major aldo-keto reductase-like protein 0.0038 0.0165 0.1873
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0187 0.0229
Schistosoma mansoni regulator of G protein signaling 0.0064 0.033 0.033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0303 0.1871 0.3233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0057
Loa Loa (eye worm) hypothetical protein 0.0062 0.0316 0.0543
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0073 0.1341
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.016 0.4145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0045 0.0314
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0165 0.0275
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.016 0.0187
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0019 0.0043 0.0155
Loa Loa (eye worm) cysteine protease 0.0036 0.0149 0.0252
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0064 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0035 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0037 0.0216
Schistosoma mansoni loxhd1 0.0042 0.0189 0.0189
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0036 0.0051
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0409 0.0409
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0081 0.0622
Schistosoma mansoni aldo-keto reductase 0.0038 0.0165 0.0165
Schistosoma mansoni cpg binding protein 0.0031 0.0121 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0187 0.0229
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.016 0.1803
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0149 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0303 0.1871 0.3233
Loa Loa (eye worm) hypothetical protein 0.0303 0.1871 0.3233
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0222 0.0379
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0018 0.0036 0.0036
Plasmodium vivax vivapain-3 0.0018 0.0037 0.002
Onchocerca volvulus 0.0036 0.0149 0.0216
Trichomonas vaginalis cdc25c, putative 0.0062 0.0316 0.0426
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0303 0.1871 0.1871
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0018 0.0036 0.0057
Schistosoma mansoni hypothetical protein 0.0384 0.2394 0.2394
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0058 0.0293 0.0293
Brugia malayi hypothetical protein 0.0042 0.0189 0.0317
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0187 0.0187
Onchocerca volvulus 0.0024 0.0073 0.01
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0058 0.0293 0.0293
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Toxoplasma gondii cathepsin CPL 0.0036 0.0149 0.1549
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.016 0.0272
Loa Loa (eye worm) hypothetical protein 0.0107 0.0607 0.1045
Brugia malayi hypothetical protein 0.0258 0.1579 0.2722
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0014 0.0007 0.0006
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0165 0.0195
Schistosoma mansoni microtubule-associated protein tau 0.1565 1 1
Onchocerca volvulus 0.0018 0.0036 0.0044
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0165 0.1873
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0143 0.084 0.1443
Echinococcus granulosus aldo keto reductase 0.0038 0.0165 0.0165
Brugia malayi hypothetical protein 0.0064 0.033 0.0561
Onchocerca volvulus Bile acid receptor homolog 0.0303 0.1871 0.2832
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0189 0.0189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0303 0.1871 0.1871
Leishmania major cathepsin L-like protease 0.0136 0.0794 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.0149 0.0246
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0011 0.0009
Loa Loa (eye worm) LGC-31 protein 0.0014 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0089 0.0495 0.0852
Brugia malayi ecdysone receptor 0.0143 0.084 0.1443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Echinococcus multilocularis serotonin transporter 0.0107 0.0607 0.0607
Schistosoma mansoni retinoid-x-receptor (RXR) 0.016 0.095 0.095
Toxoplasma gondii ABC1 family protein 0.0037 0.016 0.1706
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0189 0.0189
Echinococcus multilocularis lamin dm0 0.0028 0.0099 0.0099
Loa Loa (eye worm) RGS-3 protein 0.0064 0.033 0.0567
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.1579 0.1579
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.016 0.095 0.1639
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0081 0.1354
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0014 0.0007 0.0007
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0676 0.0676
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Leishmania major cathepsin L-like protease 0.0036 0.0149 0.1655
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0021 0.0021
Leishmania major DNA polymerase kappa, putative 0.0023 0.0067 0.0599
Plasmodium vivax SET domain protein, putative 0.0131 0.0764 1
Entamoeba histolytica hypothetical protein 0.0064 0.033 0.7971
Schistosoma mansoni cpg binding protein 0.0033 0.0132 0.0132
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0073 0.0115
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0187 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.033 0.033
Loa Loa (eye worm) ACC-1 protein 0.0014 0.0007 0.0006
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0014 0.0007 0.0007
Schistosoma mansoni apoferritin-2 0.0019 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Plasmodium vivax unspecified product 0.0018 0.0037 0.002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.016 0.0969
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0303 0.1871 0.2832
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0059 0.03 0.0508
Schistosoma mansoni hypothetical protein 0.0446 0.279 0.279
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.0272
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0187 0.0187
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0018 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Echinococcus granulosus geminin 0.0384 0.2394 0.2394
Schistosoma mansoni ap endonuclease 0.002 0.0045 0.0045
Brugia malayi nuclear hormone receptor family member odr-7 0.0143 0.084 0.1443
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0006 0.0006
Mycobacterium ulcerans hypothetical protein 0.0037 0.016 0.4145
Onchocerca volvulus 0.0042 0.0189 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0303 0.1871 0.3228
Schistosoma mansoni zinc finger protein 0.0143 0.084 0.084
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0149 0.017
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0382 0.4679
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0014 0.0007 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.0303 0.1871 0.3228
Echinococcus granulosus hypothetical protein 0.0038 0.0165 0.0165
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0018 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0137 0.1508
Brugia malayi hypothetical protein 0.016 0.095 0.1634
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0014 0.0007 0.0006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0187 0.2158
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0149 0.0149
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0062 0.0316 0.0426
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0187 0.0187
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0303 0.1871 0.3228
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.016 0.0266
Schistosoma mansoni retinoic acid receptor RXR 0.0411 0.2563 0.2563
Schistosoma mansoni sodium/chloride dependent transporter 0.0107 0.0607 0.0607
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0165 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0143 0.084 0.1266
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0067 0.0322
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0006 0.0006
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.0272
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0341 0.0341
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0081 0.1354
Mycobacterium tuberculosis Conserved protein 0.0037 0.016 0.0969
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0062 0.0316 0.0426
Schistosoma mansoni aldo-keto reductase 0.0038 0.0165 0.0165
Echinococcus multilocularis regulator of G protein signaling 7 0.0073 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0064 0.033 0.0567
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0036 0.0051
Schistosoma mansoni intermediate filament proteins 0.0028 0.0099 0.0099
Schistosoma mansoni nAChR subunit 0.0014 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0303 0.1871 0.3228
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0382 0.0651
Schistosoma mansoni rab6-interacting 0.0042 0.0189 0.0189
Leishmania major cathepsin L-like protease 0.0036 0.0149 0.1655
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Entamoeba histolytica rodhanase-like domain containing protein 0.0062 0.0316 0.7611
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0094 0.4176
Toxoplasma gondii exonuclease III APE 0.002 0.0045 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.033 0.0447
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0045 0.0045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0325 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0018 0.0036 0.0036
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.016 0.0969
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0081 0.0421
Schistosoma mansoni nuclear hormone receptor 0.0143 0.084 0.084
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Entamoeba histolytica rodhanase-like domain containing protein 0.0062 0.0316 0.7611
Trichomonas vaginalis cdc25b, putative 0.0062 0.0316 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0303 0.1871 0.3233
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0064 0.033 0.0447
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Entamoeba histolytica hypothetical protein 0.0076 0.0409 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0149 0.0149
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0014 0.0007 0.0007
Trypanosoma cruzi cruzipain precursor, putative 0.0136 0.0794 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0303 0.1871 0.3228
Loa Loa (eye worm) oxidoreductase 0.0038 0.0165 0.0281
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0165 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0057
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Echinococcus multilocularis regulator of G protein signaling 3 0.0064 0.033 0.033
Brugia malayi Pre-SET motif family protein 0.0131 0.0764 0.1311
Brugia malayi tailless protein 0.0143 0.084 0.1443
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0143 0.084 0.084
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0045 0.0314
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Onchocerca volvulus 0.0107 0.0607 0.0912
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.016 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0137 0.1508
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0303 0.1871 0.3233
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.016 0.016
Brugia malayi regulator of G-protein signaling egl-10 0.0073 0.039 0.0664
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0207 0.0259
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Echinococcus multilocularis cathepsin L 0.0018 0.0037 0.0037
Toxoplasma gondii aldose reductase, putative 0.0038 0.0165 0.178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0325 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0303 0.1871 0.1871
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0258 0.1579 0.2727
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0064 0.033 0.0567
Onchocerca volvulus 0.0038 0.0165 0.0241
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0062 0.0316 0.0316
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0081 0.0622
Mycobacterium leprae Probable lipase LipE 0.0037 0.016 0.9557
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0143 0.084 0.084
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0014 0.0007 0.0007
Schistosoma mansoni DNA polymerase eta 0.0016 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Loa Loa (eye worm) hypothetical protein 0.0303 0.1871 0.3233
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0325 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Brugia malayi beta-lactamase 0.0037 0.016 0.0266
Schistosoma mansoni pol-related 0.0038 0.0165 0.0165
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0303 0.1871 0.1871
Loa Loa (eye worm) ctsf protein 0.0036 0.0149 0.0252
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0207 0.2414
Echinococcus granulosus cysteine protease 0.0018 0.0037 0.0037
Trypanosoma cruzi major cysteine proteinase, putative 0.0107 0.0607 0.7578
Schistosoma mansoni nuclear hormone receptor 0.0303 0.1871 0.1871
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0037 0.0429
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0149 0.3294
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0099 0.0167
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0014 0.0007 0.0007
Brugia malayi Rhodanese-like domain containing protein 0.0062 0.0316 0.0536
Echinococcus granulosus intermediate filament protein 0.0028 0.0099 0.0099
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0341 0.0341
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Schistosoma mansoni nuclear hormone receptor 0.0143 0.084 0.084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0303 0.1871 0.3228
Loa Loa (eye worm) hypothetical protein 0.0107 0.0607 0.1045
Echinococcus multilocularis aldo keto reductase 0.0038 0.0165 0.0165
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0107 0.0607 0.104
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.016 0.1803
Echinococcus multilocularis geminin 0.0384 0.2394 0.2394
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.016 0.095 0.095
Echinococcus multilocularis aldo keto reductase 0.0038 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Brugia malayi Nuclear hormone receptor E75 0.0143 0.084 0.1443
Schistosoma mansoni hypothetical protein 0.0053 0.0258 0.0258
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0165 0.0195
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.025 0.1532 0.1532
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0187 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.033 0.033
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0187 0.0187
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0107 0.0607 0.1045
Echinococcus multilocularis RUN 0.0042 0.0189 0.0189
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.091 0.5783 1
Brugia malayi Cation transporter family protein 0.0065 0.0341 0.0578
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Onchocerca volvulus 0.0036 0.0149 0.0216
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0303 0.1871 0.3228
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0143 0.084 0.1266
Echinococcus granulosus Nuclear hormone receptor HR96 0.0143 0.084 0.084
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0064 0.033 0.0567
Treponema pallidum sodium- and chloride- dependent transporter 0.0107 0.0607 1
Leishmania major cathepsin L-like protease 0.0036 0.0149 0.1655
Schistosoma mansoni hypothetical protein 0.0228 0.1388 0.1388
Loa Loa (eye worm) oxidoreductase 0.0038 0.0165 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.033 0.0447
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0045 0.0012
Brugia malayi Doublecortin family protein 0.0042 0.0189 0.0317
Onchocerca volvulus 0.0089 0.0495 0.0742
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0149 0.7345
Echinococcus granulosus histone lysine methyltransferase setb 0.0131 0.0764 0.0764
Echinococcus granulosus thyroid hormone receptor alpha 0.0143 0.084 0.084
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0303 0.1871 0.3228
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.0272
Brugia malayi CXXC zinc finger family protein 0.0031 0.0121 0.0198
Loa Loa (eye worm) hypothetical protein 0.0303 0.1871 0.3233
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0332 0.4066
Onchocerca volvulus Protein ultraspiracle homolog 0.0303 0.1871 0.2832
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Echinococcus granulosus aldo keto reductase 0.0038 0.0165 0.0165
Echinococcus multilocularis regulator of G protein signaling 0.0064 0.033 0.033
Schistosoma mansoni rab6-interacting 0.0042 0.0189 0.0189
Echinococcus granulosus regulator of G protein signaling 3 0.0064 0.033 0.033
Loa Loa (eye worm) GABA receptor subunit 0.0059 0.03 0.0515
Loa Loa (eye worm) hypothetical protein 0.0064 0.033 0.0567
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0149 0.017
Onchocerca volvulus 0.0036 0.0149 0.0216
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0037 0.0429
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.0319
Plasmodium vivax vivapain-2 0.0036 0.0149 0.1549
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0341 0.0341
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.1127 0.1702
Schistosoma mansoni nAChR subunit 0.0014 0.0007 0.0007
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0341 0.0341
Schistosoma mansoni survival motor neuron protein 0.0053 0.0258 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0035 0.0191
Brugia malayi nuclear hormone receptor 0.0303 0.1871 0.3228
Loa Loa (eye worm) hypothetical protein 0.0303 0.1871 0.3233
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0036 0.0036
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0065 0.0341 0.0341
Schistosoma mansoni ferritin 0.0019 0.0043 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0303 0.1871 0.1871
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0014 0.0007 0.0007
Schistosoma mansoni lamin 0.0028 0.0099 0.0099
Echinococcus granulosus cathepsin L 0.0018 0.0037 0.0037
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0107 0.0607 0.0607
Entamoeba histolytica cysteine protease, putative 0.0036 0.0149 0.3294
Schistosoma mansoni regulator of G protein signaling 0.0073 0.039 0.039
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.1579 0.1579
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.033 0.0447
Echinococcus granulosus RUN 0.0042 0.0189 0.0189
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0187 0.4294
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.033 0.033
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0794 1
Entamoeba histolytica aldose reductase, putative 0.0038 0.0165 0.3726
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0207 0.0259
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0037 0.0053
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Trypanosoma brucei unspecified product 0.0038 0.0161 0.1815
Onchocerca volvulus 0.0038 0.0165 0.0241
Schistosoma mansoni regulator of G protein signaling 0.0064 0.033 0.033
Echinococcus granulosus expressed protein 0.1244 0.793 0.793
Leishmania major cathepsin L-like protease 0.0136 0.0794 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0149 0.017
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0187 0.2158
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.1459 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Echinococcus multilocularis cysteine protease 0.0036 0.0149 0.0149
Loa Loa (eye worm) beta-lactamase 0.0037 0.016 0.0272
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0495 0.0495
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0189 0.0189
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0036 0.0036
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0021 0.0024
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0021 0.0021
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0081 0.0783
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Schistosoma mansoni RAR-like nuclear receptor 0.0303 0.1871 0.1871
Echinococcus multilocularis ecdysone induced protein 78C 0.0303 0.1871 0.1871
Loa Loa (eye worm) hypothetical protein 0.0065 0.0341 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0303 0.1871 0.3228
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0121
Echinococcus multilocularis sodium and chloride dependent glycine 0.0018 0.0036 0.0036
Brugia malayi N-terminal motif family protein 0.0188 0.1127 0.194
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0037 0.0216
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0149 0.0216
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0045 0.0314
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Brugia malayi nuclear receptor NHR-88 0.0143 0.084 0.1443
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0149 0.1655
Giardia lamblia DINP protein human, muc B family 0.0023 0.0067 0.1545
Onchocerca volvulus 0.0143 0.084 0.1266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0303 0.1871 0.3233
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0018 0.0036 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.279 0.279
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Onchocerca volvulus 0.0038 0.0165 0.0241
Schistosoma mansoni lamin 0.0028 0.0099 0.0099
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Brugia malayi nuclear receptor NHR-67 0.0143 0.084 0.1443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0303 0.1871 0.3233
Onchocerca volvulus 0.0038 0.0165 0.0241
Onchocerca volvulus 0.1036 0.6592 1
Loa Loa (eye worm) hypothetical protein 0.0303 0.1871 0.3233
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0035 0.0191
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Echinococcus multilocularis sodium and chloride dependent glycine 0.0018 0.0036 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0131 0.0764 0.0764
Brugia malayi ecdysteroid receptor 0.0303 0.1871 0.3228
Schistosoma mansoni hypothetical protein 0.0384 0.2394 0.2394
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0067 0.0599
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0131 0.0764 1
Brugia malayi hypothetical protein 0.0143 0.084 0.1443
Brugia malayi PXA domain containing protein 0.0064 0.033 0.0561
Brugia malayi Cathepsin L-like precursor 0.0024 0.0073 0.0115
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0382 0.0382
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0064 0.033 0.033
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0045 0.0625
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0794 1
Echinococcus granulosus axis inhibition protein axin 0.0064 0.033 0.033
Brugia malayi Cathepsin L-like precursor 0.0024 0.0073 0.0115
Mycobacterium ulcerans lipase LipD 0.0037 0.016 0.4145
Brugia malayi regulator of G-protein signaling rgs-7 0.0064 0.033 0.0561
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0382 0.4679
Schistosoma mansoni ferritin 0.0019 0.0043 0.0043
Brugia malayi beta-lactamase family protein 0.0037 0.016 0.0266
Echinococcus multilocularis regulator of G protein signaling 7 0.0073 0.039 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.033 0.0447
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0676 0.0676
Echinococcus multilocularis microtubule associated protein 2 0.1565 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0143 0.084 0.1448
Onchocerca volvulus 0.0042 0.0189 0.0278
Loa Loa (eye worm) hypothetical protein 0.0064 0.033 0.0567
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0149 0.017
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0143 0.084 0.084
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0037 0.0216
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0149 0.3294
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.016 0.095 0.095
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0303 0.1871 0.1871
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0429
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Schistosoma mansoni polycystin 1-related 0.0042 0.0189 0.0189
Brugia malayi hypothetical protein 0.0018 0.0036 0.0051
Onchocerca volvulus 0.0062 0.0316 0.047
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0037 0.0429
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0149 0.7345
Loa Loa (eye worm) hypothetical protein 0.0073 0.039 0.067
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0014 0.0007 0.0007
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0187 0.2158
Brugia malayi Nuclear hormone receptor-like 1 0.016 0.095 0.1634
Brugia malayi Cathepsin L-like precursor 0.0036 0.0149 0.0246
Loa Loa (eye worm) hypothetical protein 0.0057 0.0285 0.0489
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0207 0.2414
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0303 0.1871 0.1871
Loa Loa (eye worm) hypothetical protein 0.0143 0.084 0.1448
Onchocerca volvulus 0.0036 0.0149 0.0216
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0794 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0165 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0207 0.2414
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1871 0.1871
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0341 0.0341
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0495 0.0846
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0006
Echinococcus granulosus glycine receptor subunit beta 0.0065 0.0341 0.0341
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0165 0.0165
Loa Loa (eye worm) steroid hormone receptor 0.0303 0.1871 0.3233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0794 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.016 0.016
Leishmania major cathepsin L-like protease 0.0036 0.0149 0.1655
Loa Loa (eye worm) DR-78 0.0143 0.084 0.1448
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0045 0.0591

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.32 mg kg-1 Inhibition of sorbitol accumulation in the sciatic nerve in diabetic rats at peroral dose of 30 mg/kg (curative effect) ChEMBL. No reference
ED50 (functional) = 10 mg kg-1 Inhibition of sorbitol accumulation in the lens in diabetic rats at peroral dose of 30 mg/kg (curative effect) ChEMBL. No reference
IC50 (binding) = 8.8 nM Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate ChEMBL. No reference
IC50 (binding) = 8.8 nM Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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