Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0025 | 0.333 | 0.2481 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0025 | 0.333 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0048 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1831 | 0.0792 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.667 | 0.6246 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.667 | 0.6246 |
Leishmania major | DNA polymerase kappa, putative | 0.0025 | 0.333 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.7799 | 0.7519 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1831 | 0.0792 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0048 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.667 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.004 | 0.7799 | 0.7519 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0017 | 0.1129 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1831 | 0.0792 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.3846 | 0.4904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0017 | 0.1129 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0025 | 0.333 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Brugia malayi | polk-prov protein | 0.0036 | 0.667 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0048 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0048 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.3846 | 0.4904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0048 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0025 | 0.333 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0017 | 0.1129 | 0.5 |
Onchocerca volvulus | 0.0016 | 0.102 | 0.5 | |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0048 | 1 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0017 | 0.1129 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 27.3 uM | Cytotoxic effect on MCF-7 human breast carcinoma cells | ChEMBL. | 8201603 |
IC50 (functional) | = 27.3 uM | Cytotoxic effect on MCF-7 human breast carcinoma cells | ChEMBL. | 8201603 |
IC50 (functional) | = 45.2 uM | Cytotoxic effect on WiDr human colon cells | ChEMBL. | 8201603 |
IC50 (functional) | = 45.2 uM | Cytotoxic effect on WiDr human colon cells | ChEMBL. | 8201603 |
IC50 (functional) | = 71 uM | Cytotoxic effect on v-abl transformed murine ANN-1 cells | ChEMBL. | 8201603 |
IC50 (functional) | = 71 uM | Cytotoxic effect on v-abl transformed murine ANN-1 cells | ChEMBL. | 8201603 |
IC50 (functional) | = 79.5 uM | Cytotoxic effect on 3T3 cells | ChEMBL. | 8201603 |
IC50 (functional) | = 79.5 uM | Cytotoxic effect on 3T3 cells | ChEMBL. | 8201603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.