Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutaminase | 0.0268 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.4672 | 0.0689 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0134 | 0.4672 | 1 |
Schistosoma mansoni | glutaminase | 0.0268 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0347 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0268 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0347 | 0.0347 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0347 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0347 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.4672 | 0.0689 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0347 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.4278 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0347 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0347 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0347 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0347 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.