Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0502 | 0.1014 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0502 | 0.1014 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.495 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0502 | 0.1014 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0502 | 0.1014 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0502 | 0.1014 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0502 | 0.1014 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.495 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.495 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.495 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.495 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.495 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.495 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.495 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0502 | 0.1014 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.495 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0132 | 0.495 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.495 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.495 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.495 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0502 | 0.1014 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0502 | 0.1014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.