Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Onchocerca volvulus | Matrilysin homolog | 0.0039 | 0.4899 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0031 | 0.3509 | 0.3509 |
Plasmodium falciparum | 26S proteasome regulatory subunit RPN11, putative | 0.0021 | 0.1628 | 0.3337 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0041 | 0.5363 | 0.5363 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0034 | 0.3986 | 0.3986 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0034 | 0.3986 | 0.694 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.3261 | 0.3261 |
Trichomonas vaginalis | Clan MP, family M67, Poh1-like metallopeptidase | 0.0016 | 0.0686 | 0.0767 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.4601 | 0.4601 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Leishmania major | DNA polymerase eta, putative | 0.0059 | 0.8738 | 0.8738 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.1194 | 0.1194 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0034 | 0.3986 | 0.3986 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0029 | 0.3026 | 0.3026 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0407 | 0.0407 |
Trichomonas vaginalis | Clan MP, family M67, Poh1-like metallopeptidase | 0.0016 | 0.0686 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0938 | 0.0938 |
Trypanosoma brucei | unspecified product | 0.0054 | 0.7716 | 0.7716 |
Echinococcus multilocularis | 26S proteasome regulatory subunit N11 | 0.0016 | 0.0686 | 0.0686 |
Mycobacterium ulcerans | DNA polymerase IV | 0.006 | 0.8946 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0407 | 0.0407 |
Echinococcus multilocularis | bloom syndrome protein | 0.0041 | 0.5363 | 0.5363 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.5216 | 0.5216 |
Loa Loa (eye worm) | 26S proteasome regulatory subunit rpn11 | 0.0021 | 0.1628 | 0.1628 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0054 | 0.7716 | 0.7716 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0059 | 0.8738 | 0.8738 |
Giardia lamblia | DINP protein human, muc B family | 0.004 | 0.5216 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.004 | 0.5216 | 1 |
Leishmania major | proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 | 0.0016 | 0.0686 | 0.0686 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.1194 | 0.2288 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0036 | 0.4393 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.006 | 0.8946 | 0.8946 |
Brugia malayi | Matrixin family protein | 0.0017 | 0.0938 | 0.0938 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1194 | 0.1194 |
Brugia malayi | 26S proteasome regulatory subunit rpn11 | 0.0021 | 0.1628 | 0.1628 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0063 | 0.951 | 0.951 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0029 | 0.3026 | 0.3026 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 1 | 1 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0017 | 0.0871 | 0.1984 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.3261 | 0.3261 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0038 | 0.488 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0059 | 0.8738 | 0.8738 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Brugia malayi | Matrixin family protein | 0.0017 | 0.0938 | 0.0938 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1194 | 0.1334 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0021 | 0.1646 | 0.1646 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4601 | 0.4601 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0059 | 0.8738 | 0.8738 |
Echinococcus granulosus | dna polymerase kappa | 0.006 | 0.8946 | 0.8946 |
Entamoeba histolytica | 26S proteasome non-ATPase regulatory subunit 14, putative | 0.0021 | 0.1628 | 0.1628 |
Echinococcus granulosus | 26S proteasome regulatory subunit N11 | 0.0021 | 0.1628 | 0.1628 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0015 | 0.0407 | 0.0407 |
Leishmania major | DNA polymerase eta, putative | 0.0036 | 0.4393 | 0.4393 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.006 | 0.8946 | 0.8946 |
Loa Loa (eye worm) | proteasome 26S subunit | 0.0016 | 0.0686 | 0.0686 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1194 | 0.5279 |
Entamoeba histolytica | recQ family helicase, putative | 0.0031 | 0.3509 | 0.3509 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.203 | 0.203 |
Echinococcus granulosus | 26S proteasome regulatory subunit N11 | 0.0016 | 0.0686 | 0.0686 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0029 | 0.3026 | 0.6888 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0034 | 0.3986 | 0.3986 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0021 | 0.1646 | 0.1125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Toxoplasma gondii | proteasome regulatory subunit | 0.0021 | 0.1628 | 0.3707 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.1194 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.1194 | 0.2717 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 1 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0029 | 0.3026 | 0.58 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0031 | 0.3509 | 0.3922 |
Trypanosoma brucei | proteasome regulatory non-ATPase subunit 11 | 0.0016 | 0.0686 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2745 | 0.2745 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0034 | 0.3986 | 0.3986 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0034 | 0.3986 | 0.3986 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0063 | 0.951 | 0.951 |
Brugia malayi | Matrixin family protein | 0.0017 | 0.0938 | 0.0938 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.4813 | 0.4813 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0039 | 0.4899 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0041 | 0.5363 | 0.5363 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0059 | 0.8738 | 0.8738 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.006 | 0.8946 | 0.8946 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0029 | 0.3026 | 0.3026 |
Plasmodium vivax | 26S proteasome regulatory subunit RPN11, putative | 0.0021 | 0.1628 | 0.72 |
Mycobacterium ulcerans | DNA polymerase IV | 0.006 | 0.8946 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0029 | 0.3026 | 0.3026 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1194 | 0.1194 |
Trypanosoma brucei | proteasome regulatory non-ATPase subunit 11 | 0.0016 | 0.0686 | 0.0686 |
Mycobacterium ulcerans | hydrolase | 0.0021 | 0.1646 | 0.0584 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.1194 | 0.1194 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.1194 | 0.1194 |
Loa Loa (eye worm) | matrixin family protein | 0.0039 | 0.4899 | 0.4899 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0015 | 0.0407 | 0.0927 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0041 | 0.5409 | 0.5409 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.1194 | 0.1194 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.006 | 0.8946 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0017 | 0.0938 | 0.0938 |
Echinococcus granulosus | dna polymerase eta | 0.0059 | 0.8738 | 0.8738 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1194 | 0.1194 |
Trypanosoma cruzi | proteasome regulatory non-ATPase subunit 11, putative | 0.0016 | 0.0686 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0938 | 0.0938 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.006 | 0.8946 | 1 |
Brugia malayi | polk-prov protein | 0.0037 | 0.4601 | 0.4601 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.3261 | 0.3261 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.2158 | 0.4912 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0029 | 0.3026 | 0.6888 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.1194 | 0.1194 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0024 | 0.2261 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.4813 | 0.4813 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0041 | 0.5363 | 0.5995 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0031 | 0.3509 | 0.3509 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0034 | 0.3986 | 0.3986 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1194 | 0.2446 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0027 | 0.2641 | 0.2641 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.5549 | 0.5549 |
Loa Loa (eye worm) | matrixin family protein | 0.0042 | 0.5549 | 0.5549 |
Brugia malayi | Hemopexin family protein | 0.0025 | 0.2297 | 0.2297 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.4601 | 0.4601 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0036 | 0.4393 | 0.4393 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0407 | 0.0407 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.1194 | 0.1194 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0034 | 0.3986 | 0.3986 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0031 | 0.3509 | 0.3509 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0041 | 0.5363 | 0.5995 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1194 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0938 | 0.0938 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.8738 | 0.8738 |
Brugia malayi | Matrixin family protein | 0.0017 | 0.0938 | 0.0938 |
Onchocerca volvulus | 0.0025 | 0.2297 | 0.3431 | |
Giardia lamblia | Non ATPase subunit MPR1 of 26S proteasome | 0.0016 | 0.0686 | 0.1315 |
Schistosoma mansoni | DNA helicase recq5 | 0.0029 | 0.3026 | 0.3026 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.2297 | 0.2297 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1646 | 0.1646 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0029 | 0.3026 | 0.6201 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0021 | 0.1646 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0029 | 0.3026 | 0.3026 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0029 | 0.3026 | 0.3026 |
Schistosoma mansoni | DNA polymerase eta | 0.0059 | 0.8738 | 0.8738 |
Trichomonas vaginalis | Clan MP, family M67, Poh1-like metallopeptidase | 0.0016 | 0.0686 | 0.0767 |
Brugia malayi | Hypothetical 35.8 kDa protein F37A4.5 in chromosome III | 0.0021 | 0.1628 | 0.1628 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 1 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0015 | 0.0407 | 0.0407 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.1194 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0304 | 0.0304 |
Leishmania major | DNA polymerase kappa, putative | 0.004 | 0.5216 | 0.5216 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.203 | 0.203 |
Plasmodium vivax | ATP-dependent DNA helicase Q1, putative | 0.0014 | 0.0304 | 0.1343 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.1194 | 0.1194 |
Echinococcus multilocularis | 26S proteasome regulatory subunit N11 | 0.0021 | 0.1628 | 0.1628 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3026 | 0.3026 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1194 | 0.1194 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.8946 | 0.8946 |
Schistosoma mansoni | DNA helicase recq1 | 0.0029 | 0.3026 | 0.3026 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0029 | 0.3026 | 0.3026 |
Loa Loa (eye worm) | RecQ helicase | 0.0041 | 0.5363 | 0.5363 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0017 | 0.0938 | 0.0938 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.004 | 0.5216 | 0.5216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.