Detailed information for compound 684925

Basic information

Technical information
  • TDR Targets ID: 684925
  • Name: N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]eth yl]-N'-(2-methoxy-5-methylphenyl)oxamide
  • MW: 429.92 | Formula: C21H20ClN3O3S
  • H donors: 2 H acceptors: 3 LogP: 4.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)C(=O)NCCc1csc(n1)c1ccc(cc1)Cl)C
  • InChi: 1S/C21H20ClN3O3S/c1-13-3-8-18(28-2)17(11-13)25-20(27)19(26)23-10-9-16-12-29-21(24-16)14-4-6-15(22)7-5-14/h3-8,11-12H,9-10H2,1-2H3,(H,23,26)(H,25,27)
  • InChiKey: VLPBSUAQFLWMGN-UHFFFAOYSA-N  

Network

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Synonyms

  • N-[2-[2-(4-chlorophenyl)thiazol-4-yl]ethyl]-N'-(2-methoxy-5-methyl-phenyl)oxamide
  • N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-N'-(2-methoxy-5-methylphenyl)oxamide
  • N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]-N'-(2-methoxy-5-methyl-phenyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Loa Loa (eye worm) matrix metalloproteinase 0.0018 0.0938 0.0938
Onchocerca volvulus 0.0025 0.2297 0.3431
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.2641 0.2641
Brugia malayi Matrixin family protein 0.0043 0.5549 0.5549
Trypanosoma brucei unspecified product 0.0055 0.7716 0.7716
Loa Loa (eye worm) matrixin family protein 0.0039 0.4899 0.4899
Leishmania major DNA polymerase eta, putative 0.006 0.8738 0.8738
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.1194 0.1194
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0304 0.0304
Echinococcus granulosus dna polymerase kappa 0.0061 0.8946 0.8946
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.8738 0.8738
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.3026
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.3026 0.3026
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0018 0.0938 0.0938
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.4813 0.4813
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.1194 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 1 1
Schistosoma mansoni DNA helicase recq5 0.0029 0.3026 0.3026
Echinococcus granulosus bloom syndrome protein 0.0042 0.5363 0.5363
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0686 0.0686
Echinococcus granulosus transcription factor Dp 1 0.0039 0.4813 0.4813
Toxoplasma gondii exonuclease III APE 0.0019 0.1194 0.2717
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.1194 1
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0686 0.0686
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0016 0.0686 0.1315
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.5216 0.5216
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.1194 0.2288
Giardia lamblia DINP protein human, muc B family 0.0041 0.5216 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0064 0.951 0.951
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.488 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.5216 1
Loa Loa (eye worm) hypothetical protein 0.006 0.8738 0.8738
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.3986 0.3986
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0407 0.0407
Toxoplasma gondii proteasome regulatory subunit 0.0021 0.1628 0.3707
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.3026 0.3026
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 1 1
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.4393 1
Schistosoma mansoni DNA polymerase eta 0.006 0.8738 0.8738
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0021 0.1628 0.1628
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.1194 0.1194
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.3026 0.3026
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.8946 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.1194 0.1194
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0042 0.5409 0.5409
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1194 0.2446
Echinococcus multilocularis dna polymerase kappa 0.0061 0.8946 0.8946
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.3986 0.3986
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Schistosoma mansoni ap endonuclease 0.0019 0.1194 0.1194
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.8738 0.8738
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.8946 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.2745 0.2745
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.8946 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0407 0.0407
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0021 0.1628 0.1628
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.8946 0.8946
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.1194 0.1194
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.3986 0.3986
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.3026 0.3026
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Onchocerca volvulus Matrilysin homolog 0.0039 0.4899 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.3986 0.3986
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0407 0.0927
Loa Loa (eye worm) proteasome 26S subunit 0.0016 0.0686 0.0686
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.3986 0.694
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.2158 0.4912
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.1194 0.1194
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.1194 0.1194
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0014 0.0304 0.1343
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0022 0.1646 0.1646
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.4393 0.4393
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.3026 0.58
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.1194 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.1194 0.1194
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0021 0.1628 0.3337
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.5363 0.5995
Loa Loa (eye worm) hypothetical protein 0.0029 0.3026 0.3026
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0021 0.1628 0.72
Loa Loa (eye worm) hypothetical protein 0.0022 0.1646 0.1646
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Onchocerca volvulus Matrix metalloproteinase homolog 0.0039 0.4899 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.6888
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0021 0.1628 0.1628
Mycobacterium ulcerans hydrolase 0.0022 0.1646 0.0584
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0871 0.1984
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0016 0.0686 0.0686
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.5363 0.5363
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.5216 0.5216
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0022 0.1646 0.1125
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0016 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0038 0.4601 0.4601
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0021 0.1628 0.1628
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0064 0.951 0.951
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.6888
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0021 0.1628 0.1628
Loa Loa (eye worm) RecQ helicase 0.0042 0.5363 0.5363
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.3026
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.8738 0.8738
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Schistosoma mansoni hypothetical protein 0.0025 0.2297 0.2297
Leishmania major DNA polymerase eta, putative 0.0036 0.4393 0.4393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Mycobacterium leprae PROBABLE HYDROLASE 0.0022 0.1646 0.5
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.3986 0.3986
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0021 0.1628 0.1628
Echinococcus multilocularis dna polymerase eta 0.006 0.8738 0.8738
Brugia malayi Hemopexin family protein 0.0025 0.2297 0.2297
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.3986 0.3986
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.3026 0.6201
Entamoeba histolytica recQ family helicase, putative 0.0032 0.3509 0.3509
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0016 0.0686 0.0686
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0016 0.0686 0.0686
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.3509 0.3922
Schistosoma mansoni DNA helicase recq1 0.0029 0.3026 0.3026
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.4601 0.4601
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.2261 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 1 1
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.3986 0.3986
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.1194 0.1194
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1194 0.1334
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1194 0.1334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 1 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 1 1
Brugia malayi polk-prov protein 0.0038 0.4601 0.4601
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.3026 0.3026
Loa Loa (eye worm) matrixin family protein 0.0043 0.5549 0.5549
Trypanosoma brucei unspecified product 0.0024 0.203 0.203
Echinococcus multilocularis bloom syndrome protein 0.0042 0.5363 0.5363
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0407 0.0407
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Schistosoma mansoni ap endonuclease 0.0019 0.1194 0.1194
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.5363 0.5995
Echinococcus granulosus dna polymerase eta 0.006 0.8738 0.8738
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.8946 1
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.7716 0.7716
Leishmania major DNA polymerase kappa, putative 0.0041 0.5216 0.5216
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0407 0.0407
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1194 0.5279
Trypanosoma brucei unspecified product 0.0024 0.203 0.203
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.4601 0.4601
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0407 0.0407
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.8946 0.8946

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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