Detailed information for compound 684925

Basic information

Technical information
  • TDR Targets ID: 684925
  • Name: N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]eth yl]-N'-(2-methoxy-5-methylphenyl)oxamide
  • MW: 429.92 | Formula: C21H20ClN3O3S
  • H donors: 2 H acceptors: 3 LogP: 4.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)C(=O)NCCc1csc(n1)c1ccc(cc1)Cl)C
  • InChi: 1S/C21H20ClN3O3S/c1-13-3-8-18(28-2)17(11-13)25-20(27)19(26)23-10-9-16-12-29-21(24-16)14-4-6-15(22)7-5-14/h3-8,11-12H,9-10H2,1-2H3,(H,23,26)(H,25,27)
  • InChiKey: VLPBSUAQFLWMGN-UHFFFAOYSA-N  

Network

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Synonyms

  • N-[2-[2-(4-chlorophenyl)thiazol-4-yl]ethyl]-N'-(2-methoxy-5-methyl-phenyl)oxamide
  • N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-N'-(2-methoxy-5-methylphenyl)oxamide
  • N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]-N'-(2-methoxy-5-methyl-phenyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0407 0.0407
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1194 0.1334
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.6888
Onchocerca volvulus Matrix metalloproteinase homolog 0.0039 0.4899 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.1646 0.1646
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0064 0.951 0.951
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0304 0.0304
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.3986 0.3986
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0871 0.1984
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0021 0.1628 0.3337
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.8946 0.8946
Loa Loa (eye worm) hypothetical protein 0.006 0.8738 0.8738
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.1194 0.1194
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.1194 0.1194
Onchocerca volvulus 0.0025 0.2297 0.3431
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.3026 0.6201
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0016 0.0686 0.0686
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0016 0.0686 0.0686
Schistosoma mansoni DNA polymerase eta 0.006 0.8738 0.8738
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.2261 1
Schistosoma mansoni hypothetical protein 0.0025 0.2297 0.2297
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.5363 0.5995
Brugia malayi Matrixin family protein 0.0043 0.5549 0.5549
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Leishmania major DNA polymerase eta, putative 0.006 0.8738 0.8738
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0018 0.0938 0.0938
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.4393 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.488 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.4601 0.4601
Echinococcus granulosus dna polymerase eta 0.006 0.8738 0.8738
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Loa Loa (eye worm) proteasome 26S subunit 0.0016 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0015 0.0407 0.0407
Toxoplasma gondii exonuclease III APE 0.0019 0.1194 0.2717
Leishmania major DNA polymerase eta, putative 0.0036 0.4393 0.4393
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1194 0.5279
Echinococcus granulosus bloom syndrome protein 0.0042 0.5363 0.5363
Loa Loa (eye worm) RecQ helicase 0.0042 0.5363 0.5363
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.8738 0.8738
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.5216 1
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0021 0.1628 0.1628
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.3986 0.3986
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Entamoeba histolytica recQ family helicase, putative 0.0032 0.3509 0.3509
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0021 0.1628 0.72
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0042 0.5409 0.5409
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1194 0.1334
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.1194 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Loa Loa (eye worm) hypothetical protein 0.0027 0.2745 0.2745
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.4601 0.4601
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0021 0.1628 0.1628
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.2641 0.2641
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.3509 0.3922
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0407 0.0407
Loa Loa (eye worm) matrixin family protein 0.0039 0.4899 0.4899
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.1194 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0022 0.1646 0.1646
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1194 0.2446
Onchocerca volvulus Matrilysin homolog 0.0039 0.4899 1
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.5363 0.5363
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.3986 0.3986
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0686 0.0686
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.3026 0.58
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.3026
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.1194 0.2288
Loa Loa (eye worm) matrixin family protein 0.0043 0.5549 0.5549
Trypanosoma brucei unspecified product 0.0024 0.203 0.203
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 1 1
Brugia malayi Hemopexin family protein 0.0025 0.2297 0.2297
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.5363 0.5995
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.1194 1
Brugia malayi polk-prov protein 0.0038 0.4601 0.4601
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0016 0.0686 0.1315
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Echinococcus granulosus dna polymerase kappa 0.0061 0.8946 0.8946
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0064 0.951 0.951
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.8738 0.8738
Schistosoma mansoni ap endonuclease 0.0019 0.1194 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.5216 0.5216
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.8738 0.8738
Echinococcus multilocularis dna polymerase eta 0.006 0.8738 0.8738
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.3026
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.1194 0.1194
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0021 0.1628 0.1628
Loa Loa (eye worm) hypothetical protein 0.0029 0.3026 0.3026
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0021 0.1628 0.1628
Schistosoma mansoni DNA helicase recq1 0.0029 0.3026 0.3026
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.4601 0.4601
Echinococcus multilocularis bloom syndrome protein 0.0042 0.5363 0.5363
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.3026 0.3026
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.1194 0.1194
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.8946 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.5216 0.5216
Mycobacterium ulcerans hydrolase 0.0022 0.1646 0.0584
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.8946 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.3026 0.3026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.3986 0.3986
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0407 0.0407
Schistosoma mansoni ap endonuclease 0.0019 0.1194 0.1194
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0016 0.0686 0.0686
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.3986 0.694
Trypanosoma brucei unspecified product 0.0024 0.203 0.203
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.1194 0.1194
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.8946 0.8946
Echinococcus multilocularis dna polymerase kappa 0.0061 0.8946 0.8946
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.1194 0.1194
Leishmania major DNA polymerase kappa, putative 0.0041 0.5216 0.5216
Trypanosoma brucei unspecified product 0.0055 0.7716 0.7716
Echinococcus granulosus transcription factor Dp 1 0.0039 0.4813 0.4813
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.6888
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0016 0.0686 0.0686
Loa Loa (eye worm) matrix metalloproteinase 0.0018 0.0938 0.0938
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0014 0.0304 0.1343
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.2158 0.4912
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.1194 0.5
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 1 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.3026 0.3026
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.4393 0.4393
Schistosoma mansoni DNA helicase recq5 0.0029 0.3026 0.3026
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0021 0.1628 0.1628
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.3026 0.3026
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.8946 1
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 1 1
Giardia lamblia DINP protein human, muc B family 0.0041 0.5216 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.3986 0.3986
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.3986 0.3986
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.1194 0.1194
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0407 0.0927
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0407 0.0407
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.8946 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.7716 0.7716
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0022 0.1646 0.1125
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0021 0.1628 0.1628
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.3026 0.3026
Toxoplasma gondii proteasome regulatory subunit 0.0021 0.1628 0.3707
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.3986 0.3986
Mycobacterium leprae PROBABLE HYDROLASE 0.0022 0.1646 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.4813 0.4813
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0686 0.0686

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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