Detailed information for compound 684925

Basic information

Technical information
  • TDR Targets ID: 684925
  • Name: N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]eth yl]-N'-(2-methoxy-5-methylphenyl)oxamide
  • MW: 429.92 | Formula: C21H20ClN3O3S
  • H donors: 2 H acceptors: 3 LogP: 4.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)C(=O)NCCc1csc(n1)c1ccc(cc1)Cl)C
  • InChi: 1S/C21H20ClN3O3S/c1-13-3-8-18(28-2)17(11-13)25-20(27)19(26)23-10-9-16-12-29-21(24-16)14-4-6-15(22)7-5-14/h3-8,11-12H,9-10H2,1-2H3,(H,23,26)(H,25,27)
  • InChiKey: VLPBSUAQFLWMGN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[2-(4-chlorophenyl)thiazol-4-yl]ethyl]-N'-(2-methoxy-5-methyl-phenyl)oxamide
  • N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-N'-(2-methoxy-5-methylphenyl)oxamide
  • N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]-N'-(2-methoxy-5-methyl-phenyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.2158 0.4912
Toxoplasma gondii proteasome regulatory subunit 0.0021 0.1628 0.3707
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.8738 0.8738
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.8946 1
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.1194 0.1194
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.1194 0.1194
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0022 0.1646 0.1646
Trypanosoma brucei unspecified product 0.0024 0.203 0.203
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0042 0.5409 0.5409
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.1194 0.1194
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0021 0.1628 0.1628
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Schistosoma mansoni DNA polymerase eta 0.006 0.8738 0.8738
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0021 0.1628 0.3337
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1194 0.1334
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.2641 0.2641
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.3026 0.3026
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.3986 0.3986
Echinococcus granulosus dna polymerase eta 0.006 0.8738 0.8738
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0021 0.1628 0.1628
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0021 0.1628 0.1628
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0304 0.0304
Mycobacterium leprae PROBABLE HYDROLASE 0.0022 0.1646 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.4601 0.4601
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.3986 0.3986
Onchocerca volvulus Matrix metalloproteinase homolog 0.0039 0.4899 1
Toxoplasma gondii exonuclease III APE 0.0019 0.1194 0.2717
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.1194 0.1194
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1194 0.2446
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.3509 0.3922
Echinococcus multilocularis dna polymerase eta 0.006 0.8738 0.8738
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.7716 0.7716
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.1194 0.2288
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0016 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.006 0.8738 0.8738
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0022 0.1646 0.1125
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Loa Loa (eye worm) matrix metalloproteinase 0.0018 0.0938 0.0938
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0021 0.1628 0.1628
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.1194 0.1194
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.1194 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.1194 0.5
Echinococcus granulosus transcription factor Dp 1 0.0039 0.4813 0.4813
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.4813 0.4813
Entamoeba histolytica recQ family helicase, putative 0.0032 0.3509 0.3509
Loa Loa (eye worm) hypothetical protein 0.0015 0.0407 0.0407
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0407 0.0407
Echinococcus multilocularis dna polymerase kappa 0.0061 0.8946 0.8946
Trypanosoma brucei unspecified product 0.0055 0.7716 0.7716
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0014 0.0304 0.1343
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0016 0.0686 0.0686
Leishmania major DNA polymerase eta, putative 0.0036 0.4393 0.4393
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.1194 0.1194
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.4393 0.4393
Leishmania major DNA polymerase kappa, putative 0.0041 0.5216 0.5216
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.6888
Onchocerca volvulus 0.0025 0.2297 0.3431
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.3986 0.3986
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0016 0.0686 0.1315
Brugia malayi Hemopexin family protein 0.0025 0.2297 0.2297
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0064 0.951 0.951
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0686 0.0686
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.8946 1
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.8946 0.8946
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1194 0.1334
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.3026 0.3026
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.3986 0.3986
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.5216 0.5216
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.5363 0.5363
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0407 0.0407
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.3026 0.3026
Loa Loa (eye worm) hypothetical protein 0.0022 0.1646 0.1646
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.6888
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0016 0.0686 0.0686
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0027 0.2745 0.2745
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.3986 0.3986
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0021 0.1628 0.1628
Schistosoma mansoni hypothetical protein 0.0025 0.2297 0.2297
Loa Loa (eye worm) hypothetical protein 0.0038 0.4601 0.4601
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.3026 0.3026
Mycobacterium ulcerans hydrolase 0.0022 0.1646 0.0584
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0407 0.0407
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.3026
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.8738 0.8738
Leishmania major DNA polymerase eta, putative 0.006 0.8738 0.8738
Schistosoma mansoni ap endonuclease 0.0019 0.1194 0.1194
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.1194 0.1194
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Giardia lamblia DINP protein human, muc B family 0.0041 0.5216 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.488 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0871 0.1984
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.2261 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.3026 0.3026
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.4601 0.4601
Loa Loa (eye worm) matrixin family protein 0.0043 0.5549 0.5549
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.3986 0.3986
Schistosoma mansoni DNA helicase recq1 0.0029 0.3026 0.3026
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.4393 1
Brugia malayi Matrixin family protein 0.0043 0.5549 0.5549
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 1 1
Loa Loa (eye worm) RecQ helicase 0.0042 0.5363 0.5363
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0064 0.951 0.951
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.3026 0.3026
Echinococcus granulosus bloom syndrome protein 0.0042 0.5363 0.5363
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.3026 0.6201
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Schistosoma mansoni ap endonuclease 0.0019 0.1194 0.1194
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0016 0.0686 0.0686
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0018 0.0938 0.0938
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.8946 0.8946
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0407 0.0927
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.5363 0.5995
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0021 0.1628 0.1628
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.5216 1
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0016 0.0686 0.0767
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1194 0.5279
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.8946 1
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0686 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.3261 0.3261
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0021 0.1628 0.72
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Trypanosoma brucei unspecified product 0.0024 0.203 0.203
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.3986 0.3986
Onchocerca volvulus Matrilysin homolog 0.0039 0.4899 1
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.8738 0.8738
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.3986 0.694
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 1 1
Echinococcus granulosus dna polymerase kappa 0.0061 0.8946 0.8946
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.5216 0.5216
Brugia malayi Matrixin family protein 0.0018 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0029 0.3026 0.3026
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.5363 0.5995
Loa Loa (eye worm) proteasome 26S subunit 0.0016 0.0686 0.0686
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 1 1
Loa Loa (eye worm) matrixin family protein 0.0039 0.4899 0.4899
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.8946 1
Schistosoma mansoni DNA helicase recq5 0.0029 0.3026 0.3026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.1194 0.1194
Brugia malayi polk-prov protein 0.0038 0.4601 0.4601
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Echinococcus multilocularis bloom syndrome protein 0.0042 0.5363 0.5363
Loa Loa (eye worm) hypothetical protein 0.0018 0.0938 0.0938
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.3026 0.58
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.3509 0.3509
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.8946 0.8946
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0407 0.0407

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.