Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0671 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0072 | 0.387 | 0.3429 |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.387 | 0.3429 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0671 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0671 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0671 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0671 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.387 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0671 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.387 | 0.3429 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0671 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0671 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.387 | 0.387 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0671 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.387 | 0.3429 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.387 | 0.387 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.