Detailed information for compound 685112

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 497.383 | Formula: C19H17BrN2O5S2
  • H donors: 0 H acceptors: 4 LogP: 3.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Cn1c(=NC(=O)c2ccccc2S(=O)(=O)C)sc2c1ccc(c2)Br
  • InChi: 1S/C19H17BrN2O5S2/c1-3-27-17(23)11-22-14-9-8-12(20)10-15(14)28-19(22)21-18(24)13-6-4-5-7-16(13)29(2,25)26/h4-10H,3,11H2,1-2H3/b21-19-
  • InChiKey: ZGOMWRPSBCQZBJ-VZCXRCSSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0035 0.0376 0.3165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0041 0.0092
Echinococcus granulosus smad 0.0009 0.0003 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0187 0.0428
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0376 0.0836
Onchocerca volvulus 0.0026 0.0249 0.2098
Brugia malayi RNA, U transporter 1 0.0087 0.1111 0.2539
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0068 0.1755
Leishmania major GTP-binding protein, putative 0.0023 0.0199 0.5168
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0092
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0026 0.0243 0.0539
Leishmania major hypothetical protein, conserved 0.0035 0.0376 0.9759
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0383 0.0383
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0148 0.0337
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0041 0.0041
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0041 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0041 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0386 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0092 0.2392
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.052 0.6934
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0199 0.0199
Mycobacterium ulcerans hypothetical protein 0.0035 0.0376 0.9759
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0148 0.0484
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0836
Brugia malayi hypothetical protein 0.0016 0.0112 0.0255
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0041 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0041 0.0348
Entamoeba histolytica Ran family GTPase 0.0023 0.0199 0.4266
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.2056 0.2056
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0199 0.0443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1238 0.1238
Mycobacterium ulcerans beta-lactamase 0.0035 0.0376 0.9759
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0012 0.0028
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0068 0.1755
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0041 0.0094
Mycobacterium tuberculosis Conserved protein 0.0035 0.0376 0.1235
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0187 0.4011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0068 0.13
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0059 0.0059
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0199 0.0455
Loa Loa (eye worm) hypothetical protein 0.0031 0.0313 0.0697
Loa Loa (eye worm) acetyltransferase 0.0154 0.2056 0.4568
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0376 0.9759
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0312 0.0693
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0041 0.0041
Brugia malayi CXXC zinc finger family protein 0.003 0.0312 0.0712
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.2142 0.476
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0041 0.0041
Schistosoma mansoni DNA polymerase eta 0.0022 0.0187 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0376 0.9759
Echinococcus granulosus dna polymerase kappa 0.0022 0.0187 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0376 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0041 0.0041
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0148 0.2835
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0386 0.5136
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0041 0.0041
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1238 0.1238
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0238 0.5102
Brugia malayi MH2 domain containing protein 0.0009 0.0003 0.0007
Echinococcus multilocularis lamin dm0 0.0026 0.0249 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0318 0.4377 0.4377
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0068 0.13
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0376 0.7229
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0199 0.5168
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0041 0.0041
Brugia malayi Smad1 0.0009 0.0003 0.0007
Onchocerca volvulus 0.0092 0.1189 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0041 0.0348
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0383 0.0383
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0187 0.0187
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0148 0.3159
Mycobacterium tuberculosis Conserved protein 0.0035 0.0376 0.1235
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.052 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0041 0.0041
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.1995 0.1995
Giardia lamblia DINP protein human, muc B family 0.0022 0.0187 0.4011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0187 0.486
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0376 0.7229
Brugia malayi TAR-binding protein 0.0318 0.4377 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0187 0.486
Schistosoma mansoni eyes absent homolog 0.0088 0.1124 0.1124
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0383 0.7351
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0383 0.085
Brugia malayi beta-lactamase family protein 0.0035 0.0376 0.086
Schistosoma mansoni lamin 0.0026 0.0249 0.0249
Schistosoma mansoni alpha-glucosidase 0.0138 0.1827 0.1827
Schistosoma mansoni hypothetical protein 0.0327 0.45 0.45
Schistosoma mansoni hypothetical protein 0.0434 0.6018 0.6018
Brugia malayi RNA recognition motif domain containing protein 0.0318 0.4377 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0249 0.0554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0041 0.0041
Toxoplasma gondii exonuclease III APE 0.0019 0.0148 0.1966
Schistosoma mansoni smad1 5 8 and 0.0009 0.0003 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0232 0.4451
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0041 0.0094
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0003 0.0003
Schistosoma mansoni Smad4 0.0009 0.0003 0.0003
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0313 0.8132
Trypanosoma brucei unspecified product 0.0015 0.0092 0.2392
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0148 0.3827
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0187 0.486
Onchocerca volvulus 0.003 0.0312 0.2623
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0836
Schistosoma mansoni hypothetical protein 0.0355 0.4904 0.4904
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0041 0.0094
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0386 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0068 0.13
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0376 0.1235
Mycobacterium leprae Probable lipase LipE 0.0035 0.0376 1
Echinococcus multilocularis musashi 0.0026 0.0249 0.0249
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0078 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0041 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1672 0.3716
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.45 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0467 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0383 0.7351
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0041 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0041 0.0348
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0238 0.6182
Brugia malayi MH2 domain containing protein 0.0127 0.1672 0.3821
Onchocerca volvulus 0.0047 0.054 0.4542
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Brugia malayi nuclear receptor NHR-88 0.0011 0.0041 0.0094
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0199 0.5168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1238 0.1238
Echinococcus multilocularis cpg binding protein 0.0032 0.0336 0.0336
Echinococcus multilocularis smad 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.0088 0.1124 0.2567
Loa Loa (eye worm) beta-lactamase 0.0035 0.0376 0.0836
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0014
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0386 0.7408
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0148 0.3827
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0376 0.1235
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0007
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0187 0.486
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0003 0.0003
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0187 0.0187
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0041 0.0041
Schistosoma mansoni inositol monophosphatase 0.0036 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0836
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0376 0.7229
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0041 0.0094
Entamoeba histolytica hypothetical protein 0.0025 0.0232 0.4959
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0836
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0238 0.3175
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0383 0.7351
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0068 0.13
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0318 0.4377 0.4377
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0148 0.2835
Brugia malayi Inositol-1 0.0036 0.0386 0.0881
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0041 0.0041
Schistosoma mansoni survival motor neuron protein 0.0047 0.054 0.054
Schistosoma mansoni hypothetical protein 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1238 0.2829
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0249 0.0554
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0383 0.7351
Schistosoma mansoni importin beta-1 0.0031 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0088 0.1124 0.2497
Schistosoma mansoni microtubule-associated protein tau 0.0715 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0238 0.6182
Brugia malayi intermediate filament protein 0.0026 0.0249 0.057
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0386 0.7408
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0041 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0041 0.0094
Brugia malayi MH2 domain containing protein 0.0009 0.0003 0.0007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0003 0.0003
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.2056 0.2056
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0068 0.0155
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.052 0.6934
Schistosoma mansoni smad1 5 8 and 0.0009 0.0003 0.0003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0148 0.0148
Schistosoma mansoni ap endonuclease 0.0019 0.0148 0.0148
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0148 0.0148
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0383 0.819
Echinococcus granulosus tar DNA binding protein 0.0318 0.4377 0.4377
Schistosoma mansoni alpha glucosidase 0.0035 0.0383 0.0383
Schistosoma mansoni smad1 5 8 and 0.0009 0.0003 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0376 0.9759
Echinococcus granulosus snurportin 1 0.0327 0.45 0.45
Schistosoma mansoni lamin 0.0026 0.0249 0.0249
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0068 0.13
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0199 0.5168
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0187 0.486
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0383 0.5097
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0041 0.0041
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0238 0.053
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0148 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0041 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0041 0.0094
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0199 0.4266
Schistosoma mansoni coup transcription factor 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0318 0.4377 0.4377
Mycobacterium ulcerans lipase LipD 0.0035 0.0376 0.9759
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0047 0.054 0.054
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0148 0.3827
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.052 0.052
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0041 0.0092
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0376 0.1235
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0187 0.0187
Schistosoma mansoni ap endonuclease 0.0019 0.0148 0.0148
Toxoplasma gondii ABC1 family protein 0.0035 0.0376 0.5013
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0376 0.1235
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0333 0.8841
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2142 0.2142
Trypanosoma brucei unspecified product 0.0015 0.0092 0.2392
Leishmania major DNA polymerase eta, putative 0.0022 0.0187 0.486
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0238 0.5102
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0228 0.3112 0.6916
Echinococcus granulosus importin subunit beta 1 0.0031 0.0313 0.0313
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0187 0.36
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0041 0.0094
Echinococcus granulosus intermediate filament protein 0.0026 0.0249 0.0249
Echinococcus multilocularis microtubule associated protein 2 0.0715 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0187 0.0416
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0372 0.0372
Schistosoma mansoni ran 0.0023 0.0199 0.0199
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0068 0.0569
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0041 0.0094
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0041 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0318 0.4377 0.4377
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0068 0.1755
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0187 0.36
Plasmodium vivax importin-beta 2, putative 0.0031 0.0313 0.6024
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0092 0.2392
Onchocerca volvulus 0.0035 0.0376 0.3165
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0383 0.7351
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0148 0.0328
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0372 0.0372
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0187 0.486
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0148 0.3159
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0238 0.6182
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0199 0.4266
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Onchocerca volvulus 0.0035 0.0376 0.3165
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0376 0.9759
Schistosoma mansoni smad 0.0009 0.0003 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3046 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0383 0.7351
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0148 0.3159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0041 0.0092
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0249 0.057
Loa Loa (eye worm) RNA binding protein 0.0318 0.4377 0.9726
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0187 0.486
Brugia malayi beta-lactamase family protein 0.0035 0.0376 0.086
Brugia malayi beta-lactamase 0.0035 0.0376 0.086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0376 0.0376
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0386 0.8253
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0383 0.7351
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0068 0.1449
Loa Loa (eye worm) Smad1 0.0009 0.0003 0.0006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0187 0.0187
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0068 0.13
Brugia malayi RNA binding protein 0.0318 0.4377 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0092
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0078 0.0179
Schistosoma mansoni cpg binding protein 0.003 0.0312 0.0312
Onchocerca volvulus 0.0026 0.0249 0.2098
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0376 0.0376
Brugia malayi hypothetical protein 0.0025 0.0238 0.0545
Schistosoma mansoni hypothetical protein 0.0355 0.4904 0.4904
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.052 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0249 0.0554
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1238 0.1238
Echinococcus multilocularis Smad4 0.0009 0.0003 0.0003
Trichomonas vaginalis ran, putative 0.0023 0.0199 0.3829
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0383 0.9923
Echinococcus multilocularis tar DNA binding protein 0.0318 0.4377 0.4377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0041 0.0092
Echinococcus granulosus lamin 0.0026 0.0249 0.0249
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0467 1
Trypanosoma brucei glucosidase, putative 0.0035 0.0383 0.9923
Echinococcus multilocularis snurportin 1 0.0327 0.45 0.45
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.3112 0.3112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0041 0.0092
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0372 0.0372
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0383 0.0874
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0041 0.0041
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0333 0.1092
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.052 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0376 0.7229
Schistosoma mansoni cpg binding protein 0.0032 0.0336 0.0336
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.6018 0.6018
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0068 0.13
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0313 0.4177
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0313 0.8132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0148 0.3827
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0376 0.9759
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0041 0.0092
Echinococcus granulosus cpg binding protein 0.0032 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0416
Trichomonas vaginalis esterase, putative 0.0035 0.0376 0.7229
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0386 0.0386
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0187 0.0428
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0795 0.0795
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0386 1
Brugia malayi hypothetical protein 0.0228 0.3112 0.7111
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0148 0.3827
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0836
Entamoeba histolytica hypothetical protein 0.0035 0.0372 0.7973
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0383 0.819
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2142 0.2142
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.2142 0.2142
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0003 0.0006
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0199 0.2655
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0376 0.7229
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0238 0.4579
Loa Loa (eye worm) inositol-1 0.0036 0.0386 0.0857
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0115
Brugia malayi steroid hormone receptor 0.0011 0.0041 0.0094
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0187 0.486
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0187 0.0615
Chlamydia trachomatis metal transport ATPase 0.0008 0 0.5
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0068 0.1755
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0041 0.0094
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.3112 0.3112
Entamoeba histolytica hypothetical protein 0.0035 0.0372 0.7973
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0092
Leishmania major DNA polymerase kappa, putative 0.0022 0.0187 0.486
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0041 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1238 0.1238
Loa Loa (eye worm) hypothetical protein 0.0013 0.0068 0.015
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0007
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0003 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0434 0.6018 0.6018
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0232 0.4451
Schistosoma mansoni inositol monophosphatase 0.0036 0.0386 0.0386
Brugia malayi ecdysteroid receptor 0.0011 0.0041 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0092 0.2392
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0199 0.3829
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0386 1
Trypanosoma brucei unspecified product 0.0022 0.0187 0.486
Echinococcus multilocularis dna polymerase eta 0.0022 0.0187 0.0187
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0376 0.0376
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.054 0.1234
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0041 0.0041
Schistosoma mansoni alpha-glucosidase 0.0138 0.1827 0.1827
Echinococcus granulosus Smad4 0.0009 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.0035 0.0376 0.1235
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0386 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0383 0.7351
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0068 0.13
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0187 0.486
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0003 0.0006
Schistosoma mansoni intermediate filament proteins 0.0026 0.0249 0.0249
Entamoeba histolytica hypothetical protein 0.0035 0.0372 0.7973
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0187 0.486
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.2056 0.4697
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0041 0.0041
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0148 0.2835
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0376 0.7229
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0232 0.6009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0041 0.0041
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.2142 0.4894
Echinococcus granulosus dna polymerase eta 0.0022 0.0187 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0383 0.9923
Brugia malayi nuclear hormone receptor 0.0011 0.0041 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0751 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0059 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0383 0.9923
Schistosoma mansoni cpg binding protein 0.0032 0.0336 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0041 0.0094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0836
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0386 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0376 0.1235
Leishmania major hypothetical protein, conserved 0.0025 0.0238 0.6182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0041 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0041 0.0094
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0386 0.7408
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0035 0.0372 0.7973
Schistosoma mansoni ran 0.0023 0.0199 0.0199
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0035 0.0372 0.0372
Loa Loa (eye worm) TAR-binding protein 0.0318 0.4377 0.9726
Plasmodium falciparum importin beta, putative 0.0031 0.0313 0.6711
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0383 0.7351
Loa Loa (eye worm) hypothetical protein 0.0013 0.0059 0.013
Echinococcus granulosus lamin dm0 0.0026 0.0249 0.0249
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0376 0.1235
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1238 0.2751
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.486
Brugia malayi hypothetical protein 0.0035 0.0372 0.0851
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0187 0.486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1238 0.1238
Echinococcus multilocularis geminin 0.0355 0.4904 0.4904
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0014 0.0031
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0318 0.4377 0.9726
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0041 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0041 0.0092
Loa Loa (eye worm) hypothetical protein 0.0088 0.1124 0.2497
Leishmania major importin beta-1 subunit, putative 0.0025 0.0232 0.6009
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0003 0.0003
Brugia malayi Importin beta-1 subunit 0.0031 0.0313 0.0716
Echinococcus granulosus geminin 0.0355 0.4904 0.4904
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0467 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0386 0.0386
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0187 0.486
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0376 0.1235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1238 0.1238
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0232 0.4451
Onchocerca volvulus 0.0011 0.0041 0.0348
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0376 0.0376
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1672 0.3716
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0041 0.0094
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0187 0.0615
Echinococcus multilocularis lamin 0.0026 0.0249 0.0249
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0041 0.0041
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0376 0.086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0041 0.0041
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0187 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0318 0.4377 0.4377

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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