Detailed information for compound 685195

Basic information

Technical information
  • TDR Targets ID: 685195
  • Name: 4-methylsulfonyl-N-(6-methyl-4,5,6,7-tetrahyd ro-1,3-benzothiazol-2-yl)benzamide
  • MW: 350.456 | Formula: C16H18N2O3S2
  • H donors: 1 H acceptors: 4 LogP: 2.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCc2c(C1)sc(n2)NC(=O)c1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C16H18N2O3S2/c1-10-3-8-13-14(9-10)22-16(17-13)18-15(19)11-4-6-12(7-5-11)23(2,20)21/h4-7,10H,3,8-9H2,1-2H3,(H,17,18,19)
  • InChiKey: OTOLPAZNFDDUMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-mesyl-N-(6-methyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1093 1 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0026 0.027
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0009 0.0009
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0039 0.0264 0.1699
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.0343
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0254 0.0254
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0264 0.279
Echinococcus granulosus neuroligin 0.0185 0.1608 0.1608
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0264 0.279
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0009 0.0009
Echinococcus granulosus microtubule associated protein 2 0.0702 0.6391 0.6391
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.124 0.124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0264 0.279
Loa Loa (eye worm) glutathione reductase 0.0113 0.0947 0.0947
Schistosoma mansoni hypothetical protein 0.0084 0.0681 0.0681
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.1278 0.1278
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0009 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0987 0.0987
Echinococcus multilocularis BC026374 protein (S09 family) 0.0185 0.1608 0.1608
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0681 0.0681
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0168 0.0168
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0738 0.0738
Mycobacterium leprae Possible regulatory protein 0.0013 0.0026 0.01
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0019 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0231 0.0231
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0002 0.0002
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0681 0.0681
Loa Loa (eye worm) glutaminase 2 0.0289 0.2571 0.2571
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.1554 0.6047
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0264 0.279
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0148 0.1565
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0009 0.0009
Onchocerca volvulus 0.0036 0.0231 0.0343
Schistosoma mansoni hypothetical protein 0.0084 0.0681 0.0681
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0026 0.0165
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0231 0.0906
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0039 0.0264 0.1452
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0231 0.0906
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0231 0.0231
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0026 0.0025
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0026 0.0025
Mycobacterium ulcerans carboxylesterase, LipT 0.0185 0.1608 0.6257
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0026 0.0026
Toxoplasma gondii ABC1 family protein 0.0036 0.0231 0.1487
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0258 0.2285 0.8958
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.0343
Echinococcus multilocularis acetylcholinesterase 0.1093 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0307 0.1974
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0987 0.0987
Brugia malayi Cytochrome P450 family protein 0.0049 0.0352 0.0352
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0039 0.0264 0.1699
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0081 0.0853
Schistosoma mansoni BC026374 protein (S09 family) 0.0185 0.1608 0.1608
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.1278 0.1278
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0009 0.0009
Echinococcus multilocularis acetylcholinesterase 0.1093 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0702 0.6391 0.6391
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0026 0.0026
Brugia malayi beta-lactamase 0.0036 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0185 0.1608 0.1608
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0009 0.0009
Brugia malayi Carboxylesterase family protein 0.0185 0.1608 0.1608
Loa Loa (eye worm) thioredoxin reductase 0.0113 0.0947 0.0947
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0002
Brugia malayi glutathione reductase 0.0113 0.0947 0.0947
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0039 0.0264 0.1035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0179 0.1554 0.1554
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1093 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0113 0.0947 1
Toxoplasma gondii aldehyde dehydrogenase 0.0179 0.1554 1
Echinococcus multilocularis expressed protein 0.0012 0.0009 0.0009
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0307 0.1986
Onchocerca volvulus 0.0038 0.0254 0.0377
Brugia malayi Pre-SET motif family protein 0.009 0.0738 0.0738
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0039 0.0264 0.1028
Brugia malayi hypothetical protein 0.0106 0.0883 0.0883
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0039 0.0264 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.1554 0.6047
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0009 0.0009
Echinococcus granulosus carboxylesterase 5A 0.1093 1 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0159 0.1372 0.1372
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0185 0.1608 0.6305
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.0343
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.4084 0.4084
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0307 0.1974
Loa Loa (eye worm) carboxylesterase 0.1093 1 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0009 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0264 0.279
Echinococcus granulosus dnaJ subfamily B 0.0432 0.3895 0.3895
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0009 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0738 0.0738
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0264 0.1699
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0039 0.0264 0.1452
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0039 0.0264 0.1699
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0009 0.0009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0258 0.2285 0.8958
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0039 0.0264 0.1452
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0681 0.0681
Echinococcus multilocularis cpg binding protein 0.0032 0.0198 0.0198
Echinococcus multilocularis neuroligin 0.0185 0.1608 0.1608
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0883 0.0883
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0287 0.2551 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0039 0.0264 0.0264
Echinococcus granulosus acetylcholinesterase 0.1093 1 1
Plasmodium vivax SET domain protein, putative 0.009 0.0738 0.738
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0026
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0738 0.4745
Leishmania major protein kinase, putative 0.0013 0.0026 0.0165
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0009 0.0009
Schistosoma mansoni neuroligin 3 (S09 family) 0.0185 0.1608 0.1608
Leishmania major protein kinase, putative 0.0013 0.0026 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.027 0.2392 0.2392
Brugia malayi Cytochrome P450 family protein 0.0019 0.0081 0.0081
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0113 0.0947 0.3711
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.1093 1 1
Onchocerca volvulus 0.0185 0.1608 0.2468
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0681 0.0681
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0264 0.279
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0681 0.0681
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0264 0.279
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0231 0.0899
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0009 0.0009
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0009 0.0009
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0906
Onchocerca volvulus 0.0036 0.0231 0.0343
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0081 0.0081
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0009 0.0009
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0182 0.0182
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0009 0.0009
Trichomonas vaginalis mercuric reductase, putative 0.0039 0.0264 0.0394
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.0432 0.3895 0.3895
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2004 0.7857
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0026 0.0025
Trypanosoma brucei trypanothione reductase 0.0113 0.0947 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0258 0.2285 0.8958
Loa Loa (eye worm) hypothetical protein 0.0185 0.1608 0.1608
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.027 0.2392 0.2392
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0026 0.0025
Brugia malayi Thioredoxin reductase 0.0113 0.0947 0.0947
Brugia malayi hypothetical protein 0.0172 0.1495 0.1495
Trichomonas vaginalis glutathione reductase, putative 0.0039 0.0264 0.0394
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0497 0.3201
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0231 0.0906
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.027 0.2392 0.2392
Onchocerca volvulus 0.0185 0.1608 0.2468
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0039 0.0264 0.0264
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0039 0.0264 0.1452
Loa Loa (eye worm) acetyltransferase 0.0149 0.1278 0.1278
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0883 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0026 0.0025
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0009 0.0009
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.1278 0.1278
Brugia malayi Carboxylesterase family protein 0.0185 0.1608 0.1608
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0009 0.0009
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0039 0.0264 0.0264
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0254 0.0254
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0231 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0231 0.2442
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.3895 0.3895
Brugia malayi Carboxylesterase family protein 0.0185 0.1608 0.1608
Brugia malayi PAS domain containing protein 0.0051 0.0377 0.0377
Plasmodium falciparum thioredoxin reductase 0.0113 0.0947 1
Loa Loa (eye worm) glutaminase 0.0289 0.2571 0.2571
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0258 0.2285 0.8958
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.027 0.2392 0.2392
Leishmania major trypanothione reductase 0.0113 0.0947 0.6091
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0264 0.5
Echinococcus granulosus thioredoxin glutathione reductase 0.0115 0.0961 0.0961
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0681 0.0681
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0231 0.0231
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.1554 0.1554
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0627 0.569 0.569
Entamoeba histolytica hypothetical protein 0.0106 0.0883 1
Onchocerca volvulus 0.0185 0.1608 0.2468
Leishmania major hypothetical protein, conserved 0.0036 0.0231 0.1487
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0231 0.2442
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0026 0.0025
Brugia malayi Cytochrome P450 family protein 0.0019 0.0081 0.0081
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0287 0.2551 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0009 0.0009
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0009 0.0009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0179 0.1554 0.6093
Schistosoma mansoni gliotactin 0.0185 0.1608 0.1608
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0185 0.1608 0.1608
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0258 0.2285 0.8958
Loa Loa (eye worm) hypothetical protein 0.0185 0.1608 0.1608
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0231 0.0343
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0009 0.0009
Onchocerca volvulus 0.0185 0.1608 0.2468
Loa Loa (eye worm) carboxylesterase 0.0185 0.1608 0.1608
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0273 0.1564
Brugia malayi Pre-SET motif family protein 0.0627 0.569 0.569
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0009 0.0009
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0106 0.0883 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0148 0.0954
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0264 0.279
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0009 0.0009
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0273 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0081 0.0314
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0026 0.027
Trichomonas vaginalis esterase, putative 0.0036 0.0231 0.0343
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0002 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0081 0.0081
Mycobacterium tuberculosis Probable oxidoreductase 0.0287 0.2551 1
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0081 0.0853
Brugia malayi Carboxylesterase family protein 0.0185 0.1608 0.1608
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0883 0.0883
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0013 0.0013
Schistosoma mansoni single-minded 0.0051 0.0377 0.0377
Onchocerca volvulus 0.0185 0.1608 0.2468
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0009 0.0009
Onchocerca volvulus 0.0713 0.6489 1
Mycobacterium tuberculosis Probable reductase 0.0258 0.2285 0.8958
Plasmodium vivax glutathione reductase, putative 0.0113 0.0947 1
Echinococcus granulosus single minded 2 0.0038 0.0254 0.0254
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0009 0.0009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0115 0.0961 0.0961
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0009 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0081 0.0081
Mycobacterium ulcerans beta-lactamase 0.0036 0.0231 0.0899
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0009 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0231 0.0231
Leishmania major cytochrome p450-like protein 0.0019 0.0081 0.0519
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0906
Loa Loa (eye worm) hypothetical protein 0.009 0.0738 0.0738
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0039 0.0264 0.1028
Toxoplasma gondii thioredoxin reductase 0.0113 0.0947 0.6091
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0018 0.0018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0039 0.0264 0.279
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.4084 0.4084
Onchocerca volvulus 0.0013 0.0026 0.0025
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0009 0.0009
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0148 0.1565
Schistosoma mansoni cpg binding protein 0.003 0.0182 0.0182
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.027 0.2392 0.2392
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0681 0.0681
Loa Loa (eye worm) carboxylesterase 0.0185 0.1608 0.1608
Echinococcus granulosus expressed protein 0.0012 0.0009 0.0009
Treponema pallidum NADH oxidase 0.0039 0.0264 0.5
Loa Loa (eye worm) beta-lactamase 0.0036 0.0231 0.0231
Entamoeba histolytica hypothetical protein 0.0106 0.0883 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0026 0.0025
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0081 0.0853
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0231 0.1039
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0026 0.0026
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0009 0.0009
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0185 0.1608 0.1608
Plasmodium falciparum glutathione reductase 0.0113 0.0947 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0026 0.0026
Brugia malayi beta-lactamase family protein 0.0036 0.0231 0.0231
Mycobacterium ulcerans lipase LipD 0.0036 0.0231 0.0899
Loa Loa (eye worm) acetylcholinesterase 1 0.1093 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0019 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.1554 0.6047
Echinococcus granulosus neuropeptide s receptor 0.0453 0.4084 0.4084
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0681 0.0681
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0273 0.302
Brugia malayi beta-lactamase family protein 0.0036 0.0231 0.0231
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0185 0.1608 0.1608
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0264 0.5
Echinococcus granulosus para nitrobenzyl esterase 0.0185 0.1608 0.1608
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0738 0.0738
Schistosoma mansoni cpg binding protein 0.0032 0.0198 0.0198
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0039 0.0264 0.279
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0026 0.0026
Brugia malayi hypoxia-induced factor 1 0.0159 0.1372 0.1372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.027 0.2392 0.2392
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0738 0.0738
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0264 0.279
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0148 0.1565
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0026 0.0025
Trichomonas vaginalis glutaminase, putative 0.0289 0.2571 0.3953
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0039 0.0264 0.1028
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0185 0.1608 0.1608
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0377 0.0377
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0231 0.0899
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0009 0.0009
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0026 0.027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0026 0.027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.027 0.2392 0.2392
Onchocerca volvulus 0.003 0.0182 0.0268
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0231 0.0906
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0179 0.1554 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0527 0.0527
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0168 0.0168
Schistosoma mansoni acetylcholinesterase 0.0185 0.1608 0.1608
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0231 0.0231
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0026 0.027
Mycobacterium tuberculosis Carboxylesterase LipT 0.0185 0.1608 0.6305
Brugia malayi hypothetical protein 0.0012 0.0009 0.0009
Plasmodium falciparum glutathione reductase 0.0039 0.0264 0.1452
Loa Loa (eye worm) hypothetical protein 0.0185 0.1608 0.1608
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0307 0.0307
Mycobacterium ulcerans glutaminase 0.0289 0.2571 1
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.4084 0.4084
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0185 0.1608 0.1608
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0264 0.279
Echinococcus multilocularis carboxylesterase 5A 0.1093 1 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0026 0.0025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0701 0.0701
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0013 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0713 0.6489 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0231 0.0906
Brugia malayi MH2 domain containing protein 0.0117 0.0987 0.0987
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0013
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0258 0.2285 0.8958
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0738 0.0738
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0019 0.0019
Toxoplasma gondii NADPH-glutathione reductase 0.0039 0.0264 0.1699
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0231 0.0343
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0231 0.0906
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.1554 0.1554
Plasmodium falciparum thioredoxin reductase 0.0039 0.0264 0.1452
Schistosoma mansoni cpg binding protein 0.0032 0.0198 0.0198
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0307 0.0459
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0179 0.1554 0.1554
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0185 0.1608 0.1608
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0009 0.0009
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0254 0.0987
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0106 0.0883 0.0883
Leishmania major hypothetical protein, conserved 0.0027 0.0148 0.0954
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0185 0.1608 0.6305
Schistosoma mansoni glutaminase 0.0289 0.2571 0.2571
Schistosoma mansoni hypothetical protein 0.0084 0.0681 0.0681
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0906
Loa Loa (eye worm) hypothetical protein 0.0185 0.1608 0.1608
Echinococcus granulosus BC026374 protein S09 family 0.0185 0.1608 0.1608
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.027 0.2392 0.2392
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0026 0.027
Plasmodium vivax thioredoxin reductase, putative 0.0113 0.0947 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0264 0.1699
Trichomonas vaginalis spcc417.12 protein, putative 0.0185 0.1608 0.2468
Entamoeba histolytica hypothetical protein 0.0106 0.0883 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.027 0.2392 0.2392
Brugia malayi hypothetical protein 0.0027 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0027 0.0148 0.0148
Mycobacterium leprae Probable lipase LipE 0.0036 0.0231 0.0906
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0084 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus granulosus acetylcholinesterase 0.1093 1 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0231 0.0906
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0264 0.279
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Onchocerca volvulus 0.009 0.0738 0.1124
Mycobacterium ulcerans hypothetical protein 0.0036 0.0231 0.0899
Brugia malayi hypothetical protein 0.0185 0.1608 0.1608
Loa Loa (eye worm) hypothetical protein 0.0172 0.1495 0.1495
Brugia malayi glutaminase DH11.1 0.0289 0.2571 0.2571
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0026 0.0025
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0039 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0185 0.1608 0.1608
Brugia malayi Carboxylesterase family protein 0.1093 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0231 0.0906
Echinococcus multilocularis microtubule associated protein 2 0.0702 0.6391 0.6391
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0287 0.2551 1
Onchocerca volvulus 0.0036 0.0231 0.0343
Brugia malayi CXXC zinc finger family protein 0.003 0.0182 0.0182
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0185 0.1608 0.2468
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0026 0.0025
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0009 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0352 0.0352
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0307 0.0459
Echinococcus granulosus cpg binding protein 0.0032 0.0198 0.0198
Brugia malayi G-protein alpha subunit 0.0012 0.0009 0.0009
Echinococcus multilocularis para nitrobenzyl esterase 0.0185 0.1608 0.1608
Brugia malayi hypothetical protein 0.0017 0.0061 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0231 0.2442

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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