Detailed information for compound 68558

Basic information

Technical information
  • TDR Targets ID: 68558
  • Name: N-cyclohexyl-N-cyclopropylformamide
  • MW: 167.248 | Formula: C10H17NO
  • H donors: 0 H acceptors: 1 LogP: 2.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CN(C1CC1)C1CCCCC1
  • InChi: 1S/C10H17NO/c12-8-11(10-6-7-10)9-4-2-1-3-5-9/h8-10H,1-7H2
  • InChiKey: QIYCHYLEODZBAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclohexyl-N-cyclopropyl-formamide
  • N-cyclohexyl-N-cyclopropyl-methanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens alcohol dehydrogenase 1A (class I), alpha polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB Get druggable targets OG5_127257 All targets in OG5_127257
Schistosoma mansoni alcohol dehydrogenase Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR Get druggable targets OG5_127257 All targets in OG5_127257
Onchocerca volvulus Putative alcohol dehydrogenase Get druggable targets OG5_127257 All targets in OG5_127257
Candida albicans similar to C termini of C.maltosa FDH1 and S. cerevisiae SFA1 (YDL168W) glutathione-dependent formaldehyde dehydrogenase, long-c Get druggable targets OG5_127257 All targets in OG5_127257
Neospora caninum alcohol dehydrogenase class III, putative Get druggable targets OG5_127257 All targets in OG5_127257
Schistosoma japonicum Alcohol dehydrogenase class-3, putative Get druggable targets OG5_127257 All targets in OG5_127257
Schistosoma japonicum Alcohol dehydrogenase class-3, putative Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB Get druggable targets OG5_127257 All targets in OG5_127257
Toxoplasma gondii Zn-containing alcohol dehydrogenase Get druggable targets OG5_127257 All targets in OG5_127257
Loa Loa (eye worm) alcohol dehydrogenase class III Get druggable targets OG5_127257 All targets in OG5_127257
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase Get druggable targets OG5_127257 All targets in OG5_127257
Brugia malayi Alcohol dehydrogenase class III Get druggable targets OG5_127257 All targets in OG5_127257
Schistosoma japonicum ko:K00001 alcohol dehydrogenase [EC1.1.1.1], putative Get druggable targets OG5_127257 All targets in OG5_127257
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Possible dehydrogenase alcohol dehydrogenase 1A (class I), alpha polypeptide 375 aa 356 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.8673 1
Brugia malayi Dopamine receptor protein 2 0.0078 0.8673 0.8673
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.8673 1
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0088 1 1
Schistosoma mansoni amine GPCR 0.0078 0.8673 0.8673
Trypanosoma cruzi oxidoreductase, putative 0.0011 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.8673 0.8673
Echinococcus multilocularis G protein coupled receptor 139 0.0078 0.8673 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0011 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.8673 1
Onchocerca volvulus 0.0078 0.8673 0.8673
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0011 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.8673 1
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.8673 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis serotonin receptor 0.0078 0.8673 1
Echinococcus multilocularis fmrfamide receptor 0.0078 0.8673 1
Onchocerca volvulus 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Trypanosoma brucei oxidoreductase, putative 0.0011 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.8673 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.8673 0.8673
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Schistosoma mansoni hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.8673 1
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.8673 0.8673
Schistosoma mansoni amine GPCR 0.0078 0.8673 0.8673
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi follicle stimulating hormone receptor 0.0078 0.8673 0.8673
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.8673 1
Schistosoma mansoni opsin-like receptor 0.0078 0.8673 0.8673
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0088 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.8673 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0078 0.8673 0.8673
Schistosoma mansoni biogenic amine receptor 0.0078 0.8673 0.8673
Onchocerca volvulus 0.0078 0.8673 0.8673
Brugia malayi AKH receptor 0.0078 0.8673 0.8673
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0011 0 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.8673 0.8673
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.8673 1
Echinococcus multilocularis serotonin receptor 0.0078 0.8673 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.8673 0.8673
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0078 0.8612 0.8612
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi Cytochrome P450 family protein 0.0023 0.1562 0.1562
Echinococcus multilocularis neuropeptide receptor 0.0078 0.8673 1
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.8673 1
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0011 0 0.5
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0011 0 0.5
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0078 0.8612 0.8612
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.8673 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0078 0.8673 0.8673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.8673 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.8673 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0011 0 0.5
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.8673 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.8673 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.8673 1
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Onchocerca volvulus Putative alcohol dehydrogenase 0.0088 1 1
Echinococcus granulosus neuropeptide s receptor 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi G-protein coupled receptor 0.0078 0.8673 0.8673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.8673 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0088 1 1
Brugia malayi Melatonin receptor type 1A 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0078 0.8673 0.8673
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.8673 0.8673
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi Dopamine receptor 0.0078 0.8673 0.8673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.8673 1
Onchocerca volvulus 0.0078 0.8673 0.8673
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.8673 0.8673
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.8673 0.8673
Echinococcus granulosus neuropeptide receptor 0.0078 0.8673 1
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus multilocularis g protein coupled receptor 0.0078 0.8673 1
Schistosoma mansoni hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.8673 0.8673
Schistosoma mansoni myosin xvIII 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.8673 0.8673
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.8673 0.8673
Trypanosoma brucei oxidoreductase, putative 0.0011 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0078 0.8673 1
Echinococcus multilocularis neuropeptide receptor 0.0078 0.8673 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.8673 0.8673
Schistosoma mansoni histamine h1 receptor 0.0078 0.8673 0.8673
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.8673 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0011 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.8673 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.8673 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.8673 1
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0088 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.8673 1
Schistosoma mansoni hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0088 1 1
Brugia malayi neuropeptide F receptor 0.0078 0.8673 0.8673
Schistosoma mansoni neuropeptide receptor 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Schistosoma mansoni amine GPCR 0.0078 0.8673 0.8673
Schistosoma mansoni neuropeptide receptor 0.0078 0.8673 0.8673
Echinococcus multilocularis neuropeptide receptor A26 0.0078 0.8673 1
Schistosoma mansoni amine GPCR 0.0078 0.8673 0.8673
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.8673 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.8673 1
Echinococcus granulosus g protein coupled receptor 0.0078 0.8673 1
Leishmania major d-xylulose reductase, putative 0.0011 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Schistosoma mansoni hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.8673 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0011 0 0.5
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Schistosoma mansoni biogenic amine receptor 0.0078 0.8673 0.8673
Echinococcus multilocularis neuropeptide s receptor 0.0078 0.8673 1
Brugia malayi RE15519p 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus granulosus g protein coupled receptor 0.0078 0.8673 1
Schistosoma mansoni neuropeptide receptor 0.0078 0.8673 0.8673
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.8673 0.8673
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0011 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.8673 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.8673 0.8673
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0088 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.8673 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.1562 0.1562
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus granulosus somatostatin receptor 0.0078 0.8673 1
Echinococcus multilocularis allatostatin A receptor 0.0078 0.8673 1
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.8673 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.8673 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Brugia malayi Serotonin receptor 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi sulfakinin receptor protein 0.0078 0.8673 0.8673
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.8673 1
Schistosoma mansoni biogenic amine receptor 0.0078 0.8673 0.8673
Echinococcus multilocularis g protein coupled receptor 0.0078 0.8673 1
Echinococcus multilocularis somatostatin receptor 0.0078 0.8673 1
Schistosoma mansoni neuropeptide receptor 0.0078 0.8673 0.8673
Brugia malayi G protein-coupled receptor 0.0078 0.8673 0.8673
Echinococcus granulosus allatostatin A receptor 0.0078 0.8673 1
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0011 0 0.5
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi Serotonin receptor 0.0078 0.8673 0.8673
Schistosoma mansoni amine GPCR 0.0078 0.8673 0.8673
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus granulosus hypothetical protein 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.8673 0.8673
Leishmania major oxidoreductase-like protein 0.0011 0 0.5
Leishmania major quinone oxidoreductase, putative 0.0011 0 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.8673 0.8673
Echinococcus multilocularis g protein coupled receptor 0.0078 0.8673 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.8673 1
Echinococcus granulosus sex peptide receptor 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus granulosus fmrfamide receptor 0.0078 0.8673 1
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Schistosoma mansoni alcohol dehydrogenase 0.0088 1 1
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi GnHR receptor homolog 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi ORL1-like opioid receptor 0.0078 0.8673 0.8673
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.8673 0.8673
Echinococcus granulosus g-protein coupled receptor 0.0078 0.8673 1
Schistosoma mansoni adenoreceptor 0.0078 0.8673 0.8673
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.8673 0.8673
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.8673 0.8673
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.8673 1
Echinococcus granulosus neuropeptide receptor A26 0.0078 0.8673 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.8673 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.8673 0.8673
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.8673 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi Dopamine receptor protein 1 0.0078 0.8673 0.8673
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.8673 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.8673 0.8673
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.8673 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0011 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.8673 0.8673
Echinococcus multilocularis fmrfamide receptor 0.0078 0.8673 1
Echinococcus multilocularis orexin receptor type 2 0.0078 0.8673 1
Leishmania major oxidoreductase, putative 0.0011 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.8673 1
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.8673 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.8673 1
Echinococcus granulosus serotonin receptor 0.0078 0.8673 1
Onchocerca volvulus 0.0078 0.8673 0.8673
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.8673 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.8673 1
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0011 0 0.5
Brugia malayi G-protein coupled receptor 0.0078 0.8673 0.8673
Trypanosoma cruzi oxidoreductase, putative 0.0011 0 0.5
Brugia malayi putative neuropeptide receptor 0.0078 0.8673 0.8673
Brugia malayi neuropeptide F receptor 0.0078 0.8673 0.8673
Schistosoma mansoni opsin-like receptor 0.0078 0.8673 0.8673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Onchocerca volvulus 0.0078 0.8673 0.8673
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0088 1 1
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0011 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.8673 0.8673
Echinococcus granulosus neuropeptide receptor 0.0078 0.8673 1
Schistosoma mansoni opsin-like receptor 0.0078 0.8673 0.8673
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Onchocerca volvulus 0.0078 0.8673 0.8673
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.8673 1
Onchocerca volvulus 0.0078 0.8673 0.8673
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.8673 0.8673
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0011 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.8673 1
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.8673 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.8673 0.8673
Leishmania major zinc binding dehydrogenase-like protein 0.0011 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.8673 0.8673
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.8673 1
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.8673 0.8673
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.8673 1
Onchocerca volvulus 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus granulosus orexin receptor type 2 0.0078 0.8673 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.8673 0.8673
Brugia malayi larval opioid receptor 0.0078 0.8673 0.8673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.8673 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.8673 0.8673
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673
Echinococcus multilocularis sex peptide receptor 0.0078 0.8673 1
Brugia malayi hypothetical protein 0.0078 0.8673 0.8673
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0088 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.8673 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.8673 0.8673

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) uM Inhibitory activity against human alcohol dehydrogenase pi; ND=not determined ChEMBL. 9572895
Ki (binding) 0 uM Inhibitory activity against human alcohol dehydrogenase pi; ND=not determined ChEMBL. 9572895
Ki (binding) = 5.9 uM Inhibition of human alcohol dehydrogenase alpha activity ChEMBL. 9572895
Ki (binding) = 5.9 uM Inhibition of human alcohol dehydrogenase alpha activity ChEMBL. 9572895
Ki (binding) = 120 uM Inhibition of human alcohol dehydrogenase gamma2 activity ChEMBL. 9572895
Ki (binding) = 120 uM Inhibition of human alcohol dehydrogenase gamma2 activity ChEMBL. 9572895
Ki (binding) = 250 uM Inhibition of human alcohol dehydrogenase beta 1 activity ChEMBL. 9572895
Ki (binding) = 250 uM Inhibition of human alcohol dehydrogenase beta 1 activity ChEMBL. 9572895
Ki (binding) = 440 uM Inhibition of horse liver alcohol dehydrogenase activity ChEMBL. 9572895
Ki (binding) = 440 uM Inhibition of horse liver alcohol dehydrogenase activity ChEMBL. 9572895
Ki (binding) = 640 uM Inhibition of human alcohol dehydrogenase sigma activity ChEMBL. 9572895
Ki (binding) = 640 uM Inhibition of human alcohol dehydrogenase sigma activity ChEMBL. 9572895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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