TDR Targets

Basic information

Technical information

TDR Targets ID: 685784
Name: 6-(4-fluorophenyl)-N-[4-fluoro-3-(trifluorome thyl)phenyl]-3-methylimidazo[2,1-b][1,3]thiaz ole-2-carboxamide
MW: 437.386 | Formula: C20H12F5N3OS
H donors: 1 H acceptors: 2 LogP: 6.18 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)c1nc2n(c1)c(c(s2)C(=O)Nc1ccc(c(c1)C(F)(F)F)F)C
InChi: 1S/C20H12F5N3OS/c1-10-17(18(29)26-13-6-7-15(22)14(8-13)20(23,24)25)30-19-27-16(9-28(10)19)11-2-4-12(21)5-3-11/h2-9H,1H3,(H,26,29)
InChiKey: HJLNVCNZVKLWGN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-(4-fluorophenyl)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-3-methyl-imidazo[2,1-b]thiazole-2-carboxamide
6-(4-fluorophenyl)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-3-methyl-2-imidazo[2,1-b]thiazolecarboxamide
6-(4-fluorophenyl)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-3-methyl-imidazo[2,1-b][1,3]thiazole-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0531	0.0531
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.1246	0.1246
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0316	0.0316
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.1246	0.2359
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.1246	0.2359
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.1246	0.2524
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0839	0.1538
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0316	0.027
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.1246	0.2524
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.1246	0.2359
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0008	0.0633	0.1037
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0633	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.1246	0.2524
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.1246	0.2359
Onchocerca volvulus		0.0008	0.0633	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0316	0.027
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.1246	0.2524
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.1246	0.2359
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.1246	0.2359
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0633	0.1037
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.273	0.6617
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0633	0.1037
Loa Loa (eye worm)	hypothetical protein	0.002	0.273	0.612
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.1246	0.2524
Brugia malayi	ecdysteroid receptor	0.0011	0.1246	0.2524
Echinococcus granulosus	cpg binding protein	0.003	0.4619	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.2541	0.6071
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.3899	0.8953
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.273	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1246	0.2524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.1246	0.2524
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.1246	0.2359
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.1246	0.1246
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.1246	0.2359
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.273	0.6421
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.1246	0.2524
Schistosoma mansoni	nuclear receptor	0.0005	0.0205	0.0205
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.0633	0.0546
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.3899	1
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0633	0.5
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0633	0.0546
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.0633	0.0546
Schistosoma mansoni	cpg binding protein	0.0029	0.4331	0.4331
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.1246	0.2524
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.1246	0.2524
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.1246	0.1246
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0633	0.1037
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.2541	0.6071
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.1246	0.1246
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0531	0.0739
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.3899	1
Onchocerca volvulus		0.0026	0.3899	0.8953
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.1246	0.2524
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.1246	0.2359
Loa Loa (eye worm)	hypothetical protein	0.002	0.273	0.612
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.4331	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1246	0.2524
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0205	0.0205
Brugia malayi	nuclear hormone receptor	0.0011	0.1246	0.2524
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.1246	0.2524
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0839	0.1437
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.3899	0.8953
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0633	0.1037
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0633	0.1037
Mycobacterium ulcerans	hypothetical protein	0.0026	0.3899	1
Schistosoma mansoni	coup transcription factor	0.0011	0.1246	0.1246
Schistosoma mansoni	cpg binding protein	0.003	0.4619	0.4619
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0531	0.0739
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0633	0.1037
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.1246	0.2524
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.1246	0.2359
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.1246	0.2524
Onchocerca volvulus		0.0029	0.4331	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3899	0.8953
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0316	0.027
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.3899	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.1246	0.2524
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.1246	0.2524
Onchocerca volvulus		0.0008	0.0633	0.1037
Schistosoma mansoni	zinc finger protein	0.0005	0.0205	0.0205
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.1246	0.2524
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0633	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.2541	0.6071
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0008	0.0633	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3899	0.8953
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.1246	0.2524
Schistosoma mansoni	nuclear receptor	0.0005	0.0205	0.0205
Brugia malayi	nuclear receptor RXR	0.0006	0.0316	0.027
Loa Loa (eye worm)	hypothetical protein	0.002	0.273	0.612
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0008	0.0633	0.5
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.0633	0.0546
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.3899	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.1246	0.2524
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.1246	0.1246
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.3899	0.8953
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.8854	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0819	0.1489
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.1246	0.1246
Loa Loa (eye worm)	hypothetical protein	0.002	0.273	0.612
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.3899	1
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0633	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.1246	0.1246
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0205	0.0205
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.2541	0.6071
Brugia malayi	nuclear receptor NHR-88	0.0011	0.1246	0.2524
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.1246	0.1246
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.0633	0.0546
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.1246	0.1246
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0316	0.0253
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.3899	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1246	0.2524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.1246	0.2524
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0205	0.0205
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.3899	1
Brugia malayi	hypothetical protein	0.0006	0.0316	0.027
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.1246	0.2524
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0008	0.0633	0.5
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0633	0.5
Onchocerca volvulus		0.0008	0.0633	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1246	0.2524
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.1246	0.2359
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.1246	0.2359
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.1246	0.1246
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0633	0.0546
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.1246	0.1246
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0316	0.027
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1246	0.2524
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.1246	0.2359
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1246	0.2524
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0633	0.1037
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.1246	0.2359
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0839	0.1437
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.0633	0.0546
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0633	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0008	0.0633	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3899	0.8953
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.1246	0.2524
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.3899	1
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.273	1
Onchocerca volvulus		0.0008	0.0633	0.1037
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.0633	0.0546
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.3899	1
Schistosoma mansoni	cpg binding protein	0.003	0.4619	0.4619
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.3899	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.273	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1246	0.2524
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.1246	0.2359
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.1246	0.2524
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.1246	0.2524
Echinococcus multilocularis	cpg binding protein	0.003	0.4619	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0316	0.027
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0008	0.0633	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.1246	0.2359
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0316	0.0316
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.1246	0.2524
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0633	0.1037
Brugia malayi	hypothetical protein	0.0006	0.0316	0.027
Loa Loa (eye worm)	hypothetical protein	0.002	0.273	0.612
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0205	0.0205
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0316	0.027
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0316	0.027
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.3899	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0531	0.0739
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0316	0.0253
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0205	0.0205
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.3899	1
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.0633	0.0546
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.1246	0.2359
Onchocerca volvulus		0.0011	0.1246	0.2524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0633	0.1037
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.1246	0.2359
Brugia malayi	CXXC zinc finger family protein	0.0029	0.4331	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.1246	0.2524
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.3899	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0633	0.0546
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.3899	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.3899	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.3899	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.1246	0.2524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0633	0.1037
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.1246	0.2524
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0633	0.0633
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0531	0.0739
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.3899	1
Brugia malayi	steroid hormone receptor	0.0011	0.1246	0.2524
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.1246	0.1246
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.1246	0.2524
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0316	0.027

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 685784